hematology and oncology
Glycolytic Pathway Defects
Treatment of Glycolytic Pathway Defects
Folic acidduring acute hemolysis Transfusions if needed Sometimes splenectomy There is no specific therapy for hemolytic anemias caused by glycolytic pathway defects. Most patients require no treatment other than supplementalfolic acid1 mg orally once a day during acute hemolysis. In severe cases, patients may be transfusion dependent, in which case, splenectomy may be done. Hemolysis and anemia persist after splenectomy, although some improvement may occur, particularly in patients with pyruvate kinase deficiency. 