infectious diseases
Fluoroquinolones
Indications for Fluoroquinolones
Fluoroquinolones are active against the following: Haemophilus Infections None Moraxella catarrhalis Infection None Mycoplasmas species Chlamydia species Chlamydophilaspecies Legionella Infections species Enterobacterales (formerly Enterobacteriaceae) Pseudomonas and Related Infections (particularly Tuberculosis (TB) None Some atypical mycobacteria Some methicillin-sensitive Staphylococcal Infections None Nosocomial methicillin-resistant staphylococci (MRSA) are usually resistant. Older fluoroquinolones have poor activity against streptococci and anaerobes. Newer fluoroquinolones have reliable activity against Streptococcal Infections (including Delafloxacin, the most recently approved fluoroquinolone, is the most broad-spectrum fluoroquinolone with activity against Gram-negative bacteria including Pseudomonas and Related Infections None Gram-positive bacteria including MRSA, as well as atypical respiratory tract pathogens Overview of Anaerobic Bacteria None species. Nonetheless, fluoroquinolones have many clinical uses (see table Some Clinical Uses of Fluoroquinolones ). Fluoroquinolones are no longer recommended for empiric treatment of gonorrhea because of increasing resistance worldwide. However, a single dose ofciprofloxacinis highly effective in treating gonococcal infections caused by strains ofN. gonorrhoeaethat are susceptible to the drug. 