dermatologic disorders
Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)
Etiology of SJS and TEN
Drugs precipitate over 50% of SJS cases and up to 95% of TEN cases. The most common drug causes include Sulfa drugs (eg,sulfasalazine) Other antibiotics (eg, aminopenicillins [usuallyampicillinoramoxicillin], fluoroquinolones, cephalosporins) Antiseizure drugs (eg,phenytoin,carbamazepine,phenobarbital,valproic acidand its derivatives,lamotrigine) Nonsteroidal anti-inflammatory drugs (eg,piroxicam,meloxicam) Antiretroviral drugs (eg,nevirapine) Miscellaneous individual drugs (eg,allopurinol, chlormezanone) Cases that are not caused by drugs are attributed to Infection (mostly withMycoplasma pneumoniae) Vaccination Graft-vs-host disease (GVHD) None Rarely, a cause cannot be identified. 