neurologic disorders
Isaacs Syndrome
Introduction
Isaacs syndrome is an autoimmune peripheral nerve disorder that causes neuromuscular manifestations, including continuous muscle twitching (myokymia). (See also Overview of Peripheral Nervous System Disorders .) Isaacs syndrome (neuromyotonia) is an autoimmune peripheral nerve hyperexcitability syndrome, generally thought to be a voltage-gated potassium channelopathy; it sometimes occurs as a Paraneoplastic Syndromes . It may also accompany other disorders (eg, Cause of Isaacs syndrome is unknown. Abnormalities are thought to originate in Overview of Peripheral Nervous System Disorders because abnormalities are abolished by curare but usually persist after general anesthesia. 