cardiovascular disorders
Thromboangiitis Obliterans
Treatment of Thromboangiitis Obliterans
Smoking cessation Local measures Sometimes medication therapy Treatment is Smoking Cessation . Continuing to use tobacco inevitably leads to disease progression and severe ischemia, often requiring amputation. Other measures include Avoiding cold Avoiding drugs that can cause vasoconstriction Avoiding thermal, chemical, and mechanical injury, especially that due to poorly fitting footwear For patients in the first phase of smoking cessation,iloprost0.5 to 2 ng/kg/minute IV infusion over 6 hours may help prevent amputation.Pentoxifylline, calcium channel blockers, and thromboxane inhibitors may be tried empirically, but no data support their use. Use of antiendothelial cell antibody measurements to follow the course of disease is being studied. When other options fail, lumbar sympathetic chemical ablation or surgical sympathectomy can alleviate ischemic pain and enhance ulcer healing in about 70% of patients with an ankle-brachial pressure index≥0.35 and no diabetes mellitus. 