infectious diseases
Lincosamides, Oxazolidinones, and Streptogramins
Introduction
Lincosamides ( Clindamycin ), oxazolidinones ( Certain methyl-transferase enzymes can mediate resistance to multiple members of the above classes. Theerythromycinresistance methylase(erm) gene commonly mediates resistance to macrolides,clindamycin, and quinupristin but not the oxazolidinones or dalfopristin. Thechloramphenicol-florfenicol resistance(cfr) gene mediates resistance tochloramphenicol, dalfopristin,clindamycin, and oxazolidinones, buttedizolidmay retain susceptibility in some strains. Certain multidrug efflux pumps can also produce cross-resistance between some of these classes as well. 