immunology allergic disorders
Chronic Granulomatous Disease (CGD)
Symptoms and Signs of CGD
Chronic granulomatous disease usually begins with recurrent abscesses during early childhood, but in a few patients, onset is delayed until the early teens. Typical pathogens are catalase-producing organisms (eg,Staphylococcus aureus,Escherichia coli,Serratia,Klebsiella,Pseudomonas, fungi).Aspergillusinfections are the leading cause of death. Multiple granulomatous lesions occur in the lungs, liver, lymph nodes, and gastrointestinal and genitourinary tracts (causing obstruction). Suppurative lymphadenitis, hepatosplenomegaly, pneumonia, and hematologic evidence of chronic infection are common. Skin, lymph node, lung, liver, and perianal abscesses; stomatitis; and osteomyelitis also occur. Growth may be delayed. chronic granulomatous disease may be asymptomatic or develop various usually less severe symptoms, including joint pain with a lupus-like syndrome, aphthous ulcers, chorioretinal lesions, and photosensitivity ( Symptoms and signs reference ). 1.Battersby AC, Braggins H, Pearce MS, et al: Inflammatory and autoimmune manifestations in X-linked carriers of chronic granulomatous disease in the United Kingdom.J Allergy Clin Immunol140:628–630, 2017. 