neurologic disorders
Narcolepsy
Key Points
Narcolepsy may be caused by autoimmune destruction of hypocretin-containing neurons in the lateral hypothalamus. The main symptoms are excessive daytime sleepiness (EDS), cataplexy, hypnagogic and hypnopompic hallucinations, sleep paralysis, and disturbed nocturnal sleep. Confirm the diagnosis by polysomnography and multiple sleep latency testing. EDS usually responds tomodafinilor another wake-promoting drug; cataplexy responds topitolisantor oxybates. 