pediatrics
Neurofibromatosis
Introduction
Neurofibromatosis refers to several related genetic disorders that have overlapping clinical manifestations. It causes various types of benign or malignant tumors that involve central or peripheral nerves and often causes pigmented skin macules and sometimes other manifestations. Diagnosis is primarily clinical based on specific criteria. Benign tumors can be removed surgically, and malignant tumors (which are less common) can be treated with radiation therapy or chemotherapy. Neurofibromatosis is a neurocutaneous syndrome (a syndrome with neurologic and cutaneous manifestations). 