pediatrics
Congenital and Perinatal Cytomegalovirus Infection (CMV)
Symptoms and Signs of Congenital and Perinatal CMV Infection
Many women who become infected with CMV during pregnancy are asymptomatic, but some develop a Infectious Mononucleosis -like illness. About 10% of infants with congenital CMV infection are symptomatic at birth. Manifestations include the following: Intrauterine growth restriction Preterm Infants None Microcephaly None Neonatal Hyperbilirubinemia None Petechiae Hepatosplenomegaly Periventricular calcifications Chorioretinitis Hepatitis Pneumonitis Sensorineural Hearing Impairment in Children None Infants who acquire CMV during or after birth, especially if they are premature, may develop a sepsis-like syndrome, pneumonia, hepatosplenomegaly, hepatitis (which can lead to liver failure), thrombocytopenia, and atypical lymphocytosis. However, if transmission is via breast milk, the risk of severe symptomatic disease and long-term sequelae is low. 