pediatrics
Overview of Hereditary Periodic Fever Syndromes
Introduction
Hereditary periodic fever syndromes are a subset of hereditary autoinflammatory disorders characterized by recurrent fever and other symptoms that are not explained by other causes. Most patients develop symptoms during childhood;<10% develop symptoms after age 18. Disorders include Familial Mediterranean Fever None Hyper-IgD Syndrome None TNF Receptor–Associated Periodic Syndrome (TRAPS) None PFAPA Syndrome (periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis) syndrome (which may not be hereditary) The Hereditary Cryopyrin-Associated Periodic Syndromes (Cryopyrinopathies) : Familial cold autoinflammatory syndrome, Muckle-Wells syndrome, and neonatal-onset multisystem inflammatory disease (NOMID) PAPA Syndrome (pyogenic arthritis, pyoderma gangrenosum, and acne) syndrome 