hematology and oncology
Pure Red Blood Cell Aplasia
Etiology of Pure Red Blood Cell Aplasia
Pure red blood cell (RBC) aplasia is most often due to an inappropriate immune response causing suppression of erythropoiesis. Well-known causes include ABO-mismatched Hematopoietic Stem Cell Transplantation None Autoimmune Disorders /collagen vascular diseases ( Medications (eg, tranquilizers, antiseizure medications, recombinant erythropoietin, immune checkpoint inhibitors) Human Immunodeficiency Virus (HIV) Infection None Lymphoproliferative diseases ( Chronic Lymphocytic Leukemia (CLL) , large granular lymphocyte leukemia, Erythema Infectiosum (Parvovirus B19 Infection) , particularly in immunocompromised patients such as those with HIV infection or chronic hemolytic anemias (the parvovirus binds to the blood group P antigen on erythroid precursors and is directly cytotoxic to the cells) Pregnancy Riboflavin Deficiency None Solid tumors Thymomas Toxins (organic phosphates) 