bone, joint, and muscle disorders
Granulomatosis with Polyangiitis
Symptoms of Granulomatosis with Polyangiitis
Granulomatosis with polyangiitis may begin suddenly or gradually. Usually, the first symptoms involve the upper respiratory tract—the nose, sinuses, ears, and windpipe (trachea). They may include the following: Nasal congestion with crusting in and around the nose, sometimes with bloody discharge Collapse of the bridge of the nose, causing it to sag ( Fractures of the Nose ) A hole in the nasal cartilage that separates one side of the nose from the other (nasal septum) Sinusitis and sinus pain Hoarseness Inflammation in the middle ear (otitis media), typically with ear pain and sometimes loss of hearing Difficulty breathing Coughing (sometimes with blood) Pain in the voice box (larynx), wheezing, and rarely a loud squeaking noise when breathing in (stridor) Sometimes only the upper respiratory tract is affected for many years. People may also have a fever, feel generally unwell, and lose their appetite. Inflammation can affect the eyes, which may become swollen, red, and painful. The disorder may progress to affect other areas of the body or may affect several organs from the beginning: Lungs:The lungs are usually affected at some point. People may feel short of breath and cough, sometimes cough up blood. Difficulty breathing may result from bleeding in the lungs, which requires immediate medical attention. Joints:Joints and muscles often ache. Arthritis may develop. Nerves:A limb may feel numb, tingly, or weak, or vision may be impaired. Nerves may be damaged. People may see double and, without treatment, may become blind. The eyes may bulge and be painful because inflammation causes tissues to swell and press on other structures in the orbit. Skin:A rash or sores may appear on the skin. The kidneys are often affected. Kidney function may be slightly or severely impaired. Severe kidney damage causes and swelling due to fluid retention (edema). Life-threatening Blood clots ( Deep Vein Thrombosis (DVT) ) can develop in the legs. Overview of Anemia is common and can be severe. 