infectious diseases
Granuloma Inguinale
Introduction
Granuloma inguinale is a progressive infection of genital and perineal skin caused byKlebsiella(formerlyCalymmatobacterium) granulomatis. The disease is characterized by slowly progressive skin lesions that are beefy red, raised, painless, and often ulcerated; regional lymphadenopathy is uncommon. Diagnosis is by clinical criteria and microscopy. Treatment is with antibiotics, usually tetracyclines, macrolides, ortrimethoprim/sulfamethoxazole. (See also Overview of Sexually Transmitted Infections .) Infections withKlebsiella granulomatisare extremely rare in high-resource countries but have been reported in areas such as Papua New Guinea, Australia, southern Africa, the Caribbean, and parts of Brazil and India. 