immune disorders
Mastocytosis
Symptoms of Mastocytosis
A single mastocytoma may not cause symptoms. Spots and bumps may itch, particularly if they are rubbed or scratched. Itching may be worsened by the following: Changes in temperature Contact with clothing or other materials Use of some drugs, including nonsteroidal anti-inflammatory drugs (NSAIDs) Consumption of hot beverages, spicy foods, or alcohol Exercise Rubbing or scratching the spots may result in Hives and make the skin turn red. Flushing is common. Peptic Ulcer Disease may develop because too much histamine is produced, stimulating secretion of excess stomach acid. Ulcers can cause stomach pain. Nausea, vomiting, and chronic diarrhea may also occur. Mast cells may accumulate in the liver and spleen, causing them to malfunction. As a result, fluid may accumulate in the abdomen, causing it to enlarge. If bone marrow is affected, bone pain and anemia can result. People with mastocytosis may become irritable, depressed, or moody. Widespread reactions may occur. With systemic mastocytosis, the widespread reactions tend to be severe. They include Anaphylactic Reactions , which cause fainting and a life-threatening drop in blood pressure ( Systemic mastocytosis may affect bone marrow, and up to 30% of adults with systemic mastocytosis develop cancers, particularly Acute Myeloid Leukemia (AML) . In these people, life expectancy may be shortened. 