genitourinary disorders
Postinfectious Glomerulonephritis (PIGN)
Etiology of Postinfectious Glomerulonephritis
Postinfectious glomerulonephritis (PIGN), a Overview of Nephritic Syndrome , is the most common cause of a glomerular disorder in children between 5 and 15 years; it is rare in children Most cases are caused by nephritogenic strains of group A beta-hemolytic streptococci, most notably type 12 (which causes Tonsillopharyngitis ) and type 49 (which causes ). Infective Endocarditis and The mechanism is unknown, but microbial antigens are thought to bind to the glomerular basement membrane and activate primarily the alternate complement pathway both directly and via interaction with circulating antibodies, causing glomerular damage, which may be focal or diffuse. Alternatively, circulating immune complexes could precipitate on the glomerular basement membrane. 