pediatrics
Growth Hormone Deficiency in Children
Etiology of Growth Hormone Deficiency
Growth hormone (GH) deficiency can occur in isolation or in association with generalized hypopituitarism. In both instances, growth hormone deficiency may be acquired or congenital (including hereditary genetic causes). Rarely, GH is not deficient, but the GH receptors are abnormal (GH insensitivity). gene and certain central nervous system (CNS) malformations. Acquired causes include therapeutic radiation of the CNS (high-dose radiation can cause generalized hypopituitarism), Overview of Meningitis , may have genetic causes, involving hereditary or sporadic mutations that affect cells of the pituitary. In such cases, there also may be anomalies of other organ systems, particularly midline defects, such as Cleft Lip and Cleft Palate or 