musculoskeletal and connective tissue disorders
Overview of Bone and Joint Tumors
Introduction
Bone tumors may be benign or malignant. Malignant tumors may be primary or metastatic. most bone tumors are primary and benign; some are Primary Malignant Bone Tumors (eg, especially those over age 40, metastatic tumors are about 100 times more common than primary malignant tumors. Excluding marrow cell tumors (eg, Multiple myeloma ), there are only about 3900 cases of primary malignant bone tumors in the US each year among children and adults ( Synovial tumors are extremely rare in both children and adults. Tenosynovial giant cell tumors ( Tenosynovial giant cell tumor [PVNS]) are benign but at times contain destructive synovial cells. Synovial sarcoma is a malignant soft tissue tumor that arises in different types of soft tissue but is not of synovial origin and seldom occurs inside of a joint. It is a monomorphic blue spindle cell soft tissue cancer with variable degree of epithelial differentiation characterized by the specific SS18-SSX/1/2/4 fusion gene but is often biphasic with both spindle cell and glandular–like components. is often considered a marrow cell tumor within the bone rather than a Primary Malignant Bone Tumors because it is of hematopoietic derivation (see also 