dermatologic disorders
Skin Manifestations of Internal Disease
Endocrinopathies
Many skin findings are associated with endocrinopathies but are not specific. Patients with diabetes mellitus may have acanthosis nigricans, necrobiosis lipoidica, perforating disorders, and scleredema (hard, thick skin, typically on the upper back, neck, and shoulders). Thyroid disease, both Hypothyroidism and Cushing Syndrome causes striae distensae, moon facies, and skin fragility. Addison Disease is characterized by hyperpigmentation that is accentuated in skin creases and areas of trauma. 