nutritional disorders
Thiamin Deficiency
Etiology of Thiamin Deficiency
Primary thiamin deficiencyis caused by Inadequate intake of thiamin It is commonly due to a diet of highly refined carbohydrates (eg, polished rice, white flour, white sugar) in countries with high rates of food insecurity. It also develops when intake of other nutrients is inadequate, as may occur in young adults with severe Anorexia Nervosa ; it often occurs with other B vitamin deficiencies. Secondary thiamin deficiencyis caused by Increased demand (eg, due to Hyperthyroidism , pregnancy, lactation, strenuous exercise, or fever) Impaired absorption (eg, due to prolonged diarrhea) Impaired metabolism (eg, due to hepatic insufficiency) In people with Alcohol Use Disorder and Rehabilitation , many mechanisms contribute to thiamin deficiency; they include decreased intake, impaired absorption and use, increased demand, and possibly an apoenzyme defect. 