immunology allergic disorders
Leukocyte Adhesion Deficiency
Treatment of Leukocyte Adhesion Deficiency
Supportive care using prophylactic antibiotics and granulocyte transfusions Hematopoietic stem cell transplantation Treatment of leukocyte adhesion deficiency is with prophylactic antibiotics, often given continuously (usuallytrimethoprim/sulfamethoxazole). Granulocyte transfusions can also help. Hematopoietic Stem Cell Transplantation is the only effective treatment and can be curative. Gene therapy, which is under study, appears promising. For patients with type 2 leukocyte adhesion deficiency, correcting the underlying defect with fucose supplementation should be tried. Patients with mild or moderate disease can survive into young adulthood. Most patients with severe disease die by age 5 unless treated successfully with hematopoietic stem cell transplantation. 