cardiovascular disorders
Restrictive Cardiomyopathy
Pathophysiology of Restrictive Cardiomyopathy
Endocardial thickening or myocardial infiltration (sometimes with death of myocytes, papillary muscle infiltration, compensatory myocardial hypertrophy, and fibrosis) may occur in one, typically the left, or both ventricles. As a result, the mitral or tricuspid valves may malfunction, leading to regurgitation. If nodal and conduction tissues are affected, the sinoatrial (SA) and atrioventricular node malfunction, sometimes causing various grades of Sinus Node Dysfunction and The main hemodynamic consequence is Heart failure with preserved ejection fraction (HFpEF) with a rigid, noncompliant ventricle, impaired diastolic filling, and high filling pressure, leading to pulmonary venous hypertension. Systolic function may deteriorate if compensatory hypertrophy of infiltrated or fibrosed ventricles is inadequate. Mural thrombi can form, resulting in systemic emboli. 