infectious diseases
Granuloma Inguinale
Treatment of Granuloma Inguinale
Antibiotics (various) Many oral antibiotics kill the bacteria, but tetracyclines, macrolides, andtrimethoprim/sulfamethoxazole (TMP/SMX) are most effective, followed byceftriaxone, aminoglycosides, fluoroquinolones, andchloramphenicol. Recommended oral regimen isazithromycin1 g once a week or 500 mg a day for at least 3 weeks and continued until all lesions have completely healed. Alternate oral regimens should be continued until all lesions have completely healed and include Doxycycline100 mg twice a day for at least 3 weeks or TMP/SMX 160/800 mg twice a day for at least 3 weeks or Erythromycin500 mg four times a day for at least 3 weeks IV or IM antibiotics (eg,ceftriaxone) are an alternative. Response to treatment should begin within 7 days, but healing of extensive disease may be slow and lesions may recur, requiring longer treatment. HIV-infected patients may also require prolonged or intensive treatment. After apparently successful treatment, follow-up should continue for 6 months. Current sex partners should be examined and, if infected, treated. 