bone, joint, and muscle disorders
Medication Related Osteonecrosis of the Jaw (MRONJ)
Introduction
Medication-related osteonecrosis of the jaw (MRONJ) is a rare and potentially debilitating condition that involves exposure of the bone of the jaws. MRONJ occurs in some people who have taken or are taking high doses of bisphosphonate medications intravenously or the drugdenosumab, particularly if they have cancer or undergo oral surgery. MRONJ can occur after tooth extraction, injury, radiation therapy, or for no apparent reason. Treatment is best done by an experienced oral surgeon. To help prevent MRONJ, any necessary oral surgery should be done whenever possible before a person takes bisphosphonates. are medications that limit the loss of bone density in people with conditions such as osteoporosis and bone cancer. Most people with MRONJ have had cancer treated with high doses of bisphosphonates by vein. Very rarely, MRONJ has been noticed in people receiving bisphosphonates by mouth for postmenopausal Osteoporosis . People who do not have cancer or who have not taken bisphosphonates or MRONJ may occur any time or after Osteonecrosis of the jaw or trauma. ( The risk of MRONJ in people who have osteoporosis and are taking bisphosphonates by mouth is extremely low. People should still use bisphosphonates taken by mouth as prescribed. However, when possible, any necessary oral surgery should be done before use of bisphosphonates is begun. People should also continue good oral hygiene while taking bisphosphonates. 