lung and airway disorders
Goodpasture Syndrome
Treatment of Goodpasture Syndrome
Procedure to remove unwanted antibodies from the blood (plasma exchange) Corticosteroids (such asmethylprednisolone) andcyclophosphamidegiven by vein (intravenously) Sometimes dialysis or kidney transplantation Goodpasture syndrome may very rapidly lead to severe loss of lung function, a complete loss of kidney function, and death. The person undergoes Plasma exchange —a procedure in which the unwanted antibodies are removed from the blood. High doses of corticosteroids andcyclophosphamideare given intravenously to suppress the activity of the immune system.Rituximab, another medication that suppresses the immune system, is sometimes used in people who have severe side effects as a result ofcyclophosphamideuse. The early use of this combination of treatments may help preserve lung and kidney function. Once damage occurs to the kidneys, it is usually permanent, and people may need Dialysis or Many people may need supportive care until the disease runs its course. For example, people may be given oxygen or may need help to breathe (using a Mechanical Ventilation ) for a time. Blood or blood product transfusions may also be needed. 