brain, spinal cord, and nerve disorders
Overview of Prion Diseases
Sporadic prion diseases
Sporadic prion diseases are the most common of all human prion diseases, accounting for 85 to 90% of all cases. There are three types of sporadic prion disease: Creutzfeldt-Jakob Disease (CJD) None Fatal Insomnia None Variably Protease-Sensitive Prionopathy (VPSPr) None Sporadic Creutzfeldt-Jakob disease is the most common type of the sporadic prion diseases. Worldwide, sporadic Creutzfeldt-Jakob disease occurs at a rate of about 1 or 2 new cases per million people each year. In sporadic prion diseases, how the first prion forms is unknown. But it is suspected that an error occurs in a cell's processes (cell metabolism), and this error causes PrPCto spontaneously change its shape. 