gastrointestinal disorders
Small Intestinal Bacterial Overgrowth (SIBO)
Pathophysiology of SIBO
The most common species in SIBO include Streptococcal Infections , The excess bacteria consume nutrients, including carbohydrates and vitamin B12, leading to caloric deprivation and Vitamin B12 Deficiency . However, because the bacteria produce folate, this deficiency is rare. The bacteria deconjugate bile salts, causing failure of micelle formation and subsequent fat malabsorption. Severe bacterial overgrowth also damages the intestinal mucosa. Fat malabsorption and mucosal damage can cause diarrhea. 