dermatologic disorders
Epidermolysis Bullosa Acquisita
Introduction
Epidermolysis bullosa acquisita is a rare, acquired, chronic condition characterized by subepidermal blistering. Diagnosis is by skin biopsy and direct immunofluorescence. Treatment is with corticosteroids,dapsone, and meticulous skin care. Bullae are elevated, fluid-filled blisters ≥ 10 mm in diameter. Epidermolysis bullosa acquisita can occur in all ages. The exact etiology of epidermolysis bullosa acquisita is not known, but data suggest it involves autoimmune antibodies directed against type VII collagen, a key component of the anchoring fibrils within the dermal-epithelial junction. Multiple Myeloma , Epidermolysis bullosa acquisita is distinct from the inherited disorder Epidermolysis Bullosa , which involves various genetic mutations. 