infectious diseases
Antifungal Medications
Introduction
Medications for systemic antifungal treatment include the following (see also table): Amphotericin B(and its lipid formulations) Various azole derivatives (fluconazole,isavuconazonium[also referred to as isavuconazole],itraconazole,posaconazole, andvoriconazole) Echinocandins (anidulafungin,caspofungin, andmicafungin) Flucytosine Amphotericin B, an effective but relatively toxic medication, has long been the mainstay of antifungal therapy for invasive and serious mycoses. However, newer potent and less toxic triazoles and echinocandins are now often recommended as first-line drugs for many invasive fungal infections. These drugs have markedly changed the approach to antifungal therapy, sometimes even allowing oral treatment of chronic mycoses. (See also Overview of Fungal Infections .) 