immune disorders
Wiskott Aldrich Syndrome
Introduction
Wiskott-Aldrich syndrome is a hereditary immunodeficiency disorder characterized by abnormal antibody (immunoglobulin) production, T-cell (lymphocyte) malfunction, a low platelet count, and eczema. People with Wiskott-Aldrich syndrome tend to bleed easily, and the first symptom is usually bloody diarrhea. The diagnosis is based on results of blood tests and sometimes genetic testing. Stem cell transplantation is necessary to preserve life. (See also Overview of Immunodeficiency Disorders .) Antibodies (immunoglobulins) are substances produced by the immune system to help defend the body against infection, cancer, and foreign substances. Antibodies are produced by a type of white blood cell called Wiskott-Aldrich syndrome is a Primary immunodeficiency . It usually affects only boys. It results from a mutation in a gene on the X (sex) chromosome (called an Platelets (cell particles that help blood clot) are small and malformed. The spleen removes and destroys them, causing the platelet count to be low ( 