endocrine and metabolic disorders
Polyglandular Deficiency Syndromes
Symptoms and Signs of Polyglandular Deficiency Syndromes
The clinical appearance of patients with polyglandular deficiency syndromes is the sum of the individual endocrine deficiencies and associated nonendocrine disorders; their symptoms and signs are discussed elsewhere in THE MANUAL. The deficiencies do not always appear at the same time and may require a period of years to manifest; in such cases they do not follow a particular sequence. 