hepatic and biliary disorders
Budd Chiari Syndrome
Etiology of Budd Chiari Syndrome
In the Western world, the most common cause is a clot obstructing the hepatic veins and the adjacent inferior vena cava. Clots commonly result from the following: Thrombotic conditions (eg, protein C or S deficiency, antiphospholipid syndrome,antithrombin IIIdeficiency, factor V Leiden mutation, pregnancy, oral contraceptive use) Hematologic disorders (eg, Overview of Myeloproliferative Neoplasms such as Overview of Inflammatory Bowel Disease None Connective tissue disorders Trauma Infection (eg, hydatid cyst, amebiasis) Tumor invasion of the hepatic vein (eg, Hepatocellular Carcinoma or Sometimes Budd-Chiari syndrome begins during pregnancy and unmasks a previously asymptomatic hypercoagulability disorder. The cause of obstruction is often unknown. In Asia and South Africa, the basic defect is often a membranous obstruction (webs) of the inferior vena cava above the liver, likely representing recanalization of a prior thrombus in adults or a developmental flaw (eg, venous stenosis) in children. This type of obstruction is called obliterative hepatocavopathy. Budd-Chiari syndrome usually develops over weeks or months. When it does develop over a period of time, Cirrhosis and 