pediatrics
Wilms Tumor
Prognosis for Wilms Tumor
Prognosis for Wilms tumor depends on Histology (favorable or unfavorable) Stage at diagnosis Patient’s age (older age is associated with a worse prognosis) Molecular findings (loss of heterozygosity at 1p, 11p15, and 16q, and 1q gain are associated with increased relapse) The outcome for children with Wilms tumor is excellent. Cure rates for lower-stage disease (localized to the kidney) range from 85% to 95%. Even children with more advanced disease fare well; cure rates range from 60% (unfavorable histology) to 90% (favorable histology). The cancer may recur, typically within 2 years of diagnosis. Cure is possible in children with recurrent cancer. Outcome after recurrence is better for children who present initially with lower-stage disease, whose tumors recur at a site that has not been irradiated, who relapse>1 year after presentation, and who receive less intensive treatment initially. 