infectious diseases
Fosfomycin
Indications forFosfomycin
Fosfomycinhas a broad spectrum of activity against both gram-positive and gram-negative organisms, including many antibiotic-resistant organisms such as Staphylococcal Infections , including methicillin-resistant Enterococcal Infections species, including Enterobacterales (formerly Enterobacteriaceae), including extended-spectrum beta-lactamase (ESBL)–producing and carbapenem-resistant Klebsiella, Enterobacter, and Serratia Infections None Escherichia coli Infections , including fluoroquinolone-resistant Pseudomonas and Related Infections , which has variable rates of resistance Oralfosfomycinshould be used only for uncomplicated (ie, lower) urinary tract infections caused by susceptible pathogens. However, because it has a broad spectrum of activity, IVfosfomycin(when available) is sometimes used to treat infections with multidrug-resistant organisms at other anatomic sites. 