pediatrics
Neonatal Sepsis
Etiology of Neonatal Sepsis
Onset of neonatal sepsiscan be Early (≤ 3 days of birth) Late (after 3 days) Early-onset neonatal sepsis usually results from organisms acquired intrapartum. Most infants have symptoms within 6 hours of birth. are caused by Streptococcal Infections (GBS) and gram-negative enteric organisms (predominantly tend to be caused by gram-negative enteric bacilli (eg, Klebsiella, Enterobacter, and Serratia Infections species) and certain gram-positive organisms ( Late-onset neonatal sepsis is usually acquired from the environment ( see Neonatal Hospital-Acquired Infection ). Although universal screening and intrapartum antibiotic prophylaxis for group B streptococcus have significantly decreased the rate of early-onset disease due to this organism, the rate of late-onset GBS sepsis has remained unchanged, which is consistent with the hypothesis that late-onset disease is usually acquired from the environment. The role of Overview of Anaerobic Bacteria (particularly Candidiasis species are increasingly important causes of late-onset sepsis, occurring in 12 to 18% of extremely LBW infants. Certain viral infections (eg, Neonatal Herpes Simplex Virus (HSV) Infection , 