endocrine and metabolic disorders
Cushing Syndrome
Symptoms and Signs of Cushing Syndrome
Clinical manifestations of Cushing syndrome include Moon face with a plethoric appearance Truncal obesity with prominent supraclavicular and dorsal cervical fat pads (buffalo hump) Violaceous striae (stretch marks) Usually, very slender distal extremities and fingers This photo shows characteristic moon facies in a patient with Cushing syndrome. © Springer Science+Business Media This patient with Cushing syndrome has characteristic buffalo hump and red striae. © Springer Science+Business Media Purple linear stretch marks (striae) are visible on the abdomen of this patient with Cushing syndrome. SCIENCE PHOTO LIBRARY In this patient with Cushing syndrome, findings shown include facial rounding, plethora of the cheeks, supraclavicular fat, and striae. By permission of the publisher. From Biller B. InAtlas of Clinical Endocrinology: Neuroendocrinology and Pituitary Disease. Edited by SG Korenman (series editor) and ME Molitch. Philadelphia, Current Medicine, 2000. Muscle wasting and weakness are present. The skin is thin and atrophic, with poor wound healing and easy bruising. Purple striae may appear on the abdomen. Hypertension, renal calculi, osteoporosis, glucose intolerance, reduced resistance to infection, and mental disturbances are common. Cessation of linear growth is characteristic in children. Females usually have menstrual irregularities. In females with adrenal tumors, increased production of androgens may lead to hirsutism, temporal balding, and other signs of virilism. 