bone, joint, and muscle disorders
Mixed Connective Tissue Disease (MCTD)
Introduction
Mixed connective tissue disease is a term used by some doctors to describe a disorder characterized by features of Systemic Lupus Erythematosus (SLE) , Raynaud syndrome, joint pains, various skin abnormalities, muscle weakness, and problems with internal organs can develop. The diagnosis is based on symptoms and the results of blood tests to detect levels of characteristic antibodies. Treatment varies depending on the severity of symptoms and may include nonsteroidal anti-inflammatory drugs,hydroxychloroquine, corticosteroids, immunosuppressive drugs, or a combination. (See also Overview of Autoimmune Disorders of Connective Tissue .) Mixed connective tissue disease is more common among women than men. Mixed connective tissue disease occurs worldwide and affects people of all ages, often peaking in incidence during adolescence and the 20s. The cause of mixed connective tissue disease is unknown, but it is an autoimmune disease. 