hematology and oncology
Overview of Platelet Disorders
Treatment of Platelet Disorders
Stopping drugs that impair platelet function Rarely platelet transfusions Rarely antifibrinolytic drugs In patients with thrombocytopenia or platelet dysfunction, drugs that further impair platelet function, particularlyaspirinand other nonsteroidal anti-inflammatory drugs (NSAIDs), should not be given. Patients who are already taking such drugs should consider alternative drugs, such asacetaminophen, or simply stop using them. Patients may require Platelets , but transfusions are given only in limited situations. Prophylactic transfusions are used sparingly because they may lose their effectiveness with repeated use due to the development of platelet alloantibodies. In platelet dysfunction or thrombocytopenia caused by decreased production, transfusions, thrombopoietin (TPO)-receptor agonists (eg,romiplostim,eltrombopag,avatrombopag), or antifibrinolytic drugs (eg,aminocaproic acid,tranexamic acid) are reserved for patients with Active bleeding Severe thrombocytopenia (eg, platelet count<10,000/mcL [< 10 × 109/L) A need for an invasive procedure In thrombocytopenia caused by platelet destruction, transfusions are reserved for life-threatening,central nervous system or ocular bleeding. 