musculoskeletal and connective tissue disorders
IgG4 Related Disease
Symptoms and Signs of IgG4 Related Disease
 of IgG4-RD include Lymphadenopathy and weight loss. Weight loss is a particularly prominent symptom in patients with exocrine pancreatic insufficiency. Fever is highly uncommon in IgG4-RD and should prompt consideration of alternative diagnoses. Other manifestations are specific to the affected organs. may be painless, sometimes with jaundice if there is an obstructing pancreatic mass, or may cause abdominal pain and nausea if Acute Pancreatitis is present. Some patients, likely many more than reported, present with a more smoldering and insidious Retroperitoneal fibrosismost often manifests with flank or back pain but is often asymptomatic and identified incidentally on abdominal imaging. are usually asymptomatic and identified only incidentally by imaging or postoperatively after aortic resection done to correct an aneurysm. The thoracic aorta is more commonly involved than the abdominal aorta ( Symptoms and signs reference ). Salivary and lacrimal glandinvolvement usually causes painless, bilateral enlargement but may be asymmetric. Dry mouth and/or eyes is uncommon. may cause Proptosis , orbital pain, periorbital edema, or pain with extraocular movements. Pulmonary involvementmay be asymptomatic or cause cough, dyspnea, or pleurisy. 1.Nikiphorou E, Galloway J, Fragoulis GE: Overview of IgG4-related aortitis and periaortitis. A decade since their first description.Autoimmun Rev19(12):102694, 2020. doi:10.1016/j.autrev.2020.102694 