gastrointestinal disorders
Autoimmune Metaplastic Atrophic Gastritis
Complications of AMAG
Complications of AMAG include Vitamin B12 deficiency Gastric adenocarcinoma Carcinoid tumor The lack of intrinsic factor leads to Vitamin B12 Deficiency that can result in a The areas of atrophic gastritis in the body and fundus may manifest as metaplasia. Patients with AMAG have a 3-fold increased relative risk of developing Stomach Cancer . Patients with gland atrophy and/or intestinal metaplasia distributed multifocally, including to the lesser curvature of the corpus and fundus, have a phenotype called multifocal atrophic gastritis. Multifocal involvement is considered "extensive", in contrast to "marked," which refers to severity at a specific site. Risk of gastric adenocarcinoma is higher among patients who have multifocal atrophic gastritis. 1000 pg/mL [> 481 pmol/L]). Elevated gastrin levels lead to enterochromaffin-like cell hyperplasia, which occasionally undergoes transformation to a Overview of Carcinoid Tumors . 