blood disorders
How Blood Clots
Blood clotting factors
Formation of a clot also involves activation of a sequence of blood clotting factors, which are proteins produced mainly by the liver. There are over a dozen blood clotting factors. They interact in a complicated series of chemical reactions that ultimately generatethrombin.Thrombinconverts fibrinogen, a blood clotting factor that is normally dissolved in blood, into long strands of fibrin that radiate from the clumped platelets and form a net that entraps more platelets and blood cells. The fibrin strands add bulk to the developing clot and help hold it in place to keep the vessel wall plugged. Severe liver disease (such as Cirrhosis of the Liver or 