hematology and oncology
Glucose 6 Phosphate Dehydrogenase (G6PD) Deficiency
Key Points
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common inherited disorder of red blood cell metabolism and can cause hemolysis in the presence of triggers. Incidence is higher in certain ethnic groups (eg, people with African, Mediterranean, or Asian ancestry). Triggers include acute illnesses (eg, infections), drugs (eg, salicylates) and other substances (eg, fava beans) that cause oxidative stress. Diagnose using peripheral smear and G6PD assay; false negative G6PD assays are possible during acute hemolysis so repeat testing after several weeks if initial G6PD assay is negative. Avoid triggers to limit hemolytic episodes. 