dermatologic disorders
Acute Febrile Neutrophilic Dermatosis
Symptoms and Signs
Patients are febrile, with an elevated neutrophil count, and have painful, tender, and edematous red to violet plaques or papules, most often on the face, neck, and upper extremities, especially the dorsum of hands. Oral lesions can also occur. The lesions often develop in crops and may appear annular. Each crop is usually preceded by fever and persists for days to weeks. Rarely, bullous and pustular lesions are present as well. Less common variants include a bullous form that can ulcerate and resemble Pyoderma Gangrenosum and a subcutaneous form involving the subcutaneous fat that typically has 2- to 3-cm erythematous nodules, commonly affecting the extremities. When on the lower extremities, this form can resemble are rare and can involve the eyes (eg, Overview of Conjunctivitis , 