blood disorders
Hemoglobin C, S C, and E Diseases
Hemoglobin C disease
Hemoglobin C disease occurs mostly in people with African or Black American ancestry. One copy of the gene that causes hemoglobin C disease is present in 2 to 3% of people with African or Black American ancestry in the United States. However, people must inherit two copies of the abnormal gene to develop the disease. In general, symptoms are few. Anemia varies in severity. People who have this disease, particularly children, may have episodes of abdominal and joint pain, an enlarged spleen, and mild jaundice, but they do not have severe crises, as occur in Sickle Cell Disease . Gallstones are a common complication of hemoglobin C disease. 