musculoskeletal and connective tissue disorders
Primary Malignant Bone Tumors
Introduction
Primary malignant bone tumors are much less common than metastatic bone tumors, particularly in adults. Primary malignant bone tumors include Multiple myeloma , The two most widely used systems for staging these tumors are The American Joint Committee on Cancer (AJCC) Cancer Staging Manual, 8th edition: For osteosarcoma, chondrosarcoma, and Ewing sarcoma, staging is based on distinct tumor category, histologic grade, size, nodal involvement, and metastases (TNM classification). The manual classifies tumors into 4 stages and is used for reporting cancer data. The Musculoskeletal Tumor Society (MSTS) staging system: Used by orthopedic oncology surgeons based on histologic grade (eg, Stage I-low-grade histology and Stage II-high-grade histology, whether the tumor is contained entirely within the bone (A) or has broken outside of the cortex into surrounding soft tissue (B), and metastases Stage III). The typical (conventional) osteosarcoma with an associated soft tissue mass without metastases is Stage IIB in the MSTS system. 