cardiovascular disorders
Medications for Hypertension
Direct Vasodilators for Hypertension
Direct vasodilators, includingminoxidilandhydralazine(see table), work directly on blood vessels, independently of the autonomic nervous system.Minoxidilis more potent thanhydralazinebut has more adverse effects, including sodium and water retention and hypertrichosis, which is poorly tolerated by women.Minoxidilshould be reserved for severe, refractory hypertension. may be used during pregnancy (eg, for Preeclampsia and Eclampsia ) and as an adjunct antihypertensive. 1.Handler J.Hydralazine-induced lupus erythematosis.J Clin Hypertens(Greenwich) 2012;14(2):133-136. doi:10.1111/j.1751-7176.2011.00573.x 2.Santoriello D, Bomback AS, Kudose S, et al. Anti-neutrophil cytoplasmic antibody associated glomerulonephritis complicating treatment withhydralazine.Kidney Int2021;100(2):440-446. doi:10.1016/j.kint.2021.03.029 