infections
Trimethoprim and Sulfamethoxazole
Use During Pregnancy and Breastfeeding
/sulfamethoxazole should be avoided during the first trimester of pregnancy. Defects of the brain and spinal cord ( Neural Tube Defects and Spina Bifida ), such as during breastfeeding is generally considered acceptable. (See also Medication and Substance Use During Breastfeeding .) 