dermatologic disorders
Psoriasis
Etiology of Psoriasis
 locus on chromosome 6p21 plays the greatest role in determining a patient's susceptibility of developing psoriasis. An environmental trigger is thought to evoke an inflammatory response and subsequent hyperproliferation of keratinocytes ( Etiology reference ). Well-identified triggers include Injury (Koebner phenomenon) Sunburn HIV infection Beta-hemolytic streptococcal infection (leading to guttate psoriasis) Medications (especially beta-blockers,chloroquine,lithium, angiotensin-converting enzyme inhibitors,indomethacin,terbinafine, interferon-alfa, immune checkpoint inhibitors, and tumor necrosis factor inhibitors) Emotional stress Alcohol consumption Tobacco smoking Obesity 1.Zhou X, Chen Y, Cui L, et al: Advances in the pathogenesis of psoriasis: From keratinocyte perspective.Cell Death Dis13(1):81, 2022. doi: 10.1038/s41419-022-04523-3 