musculoskeletal and connective tissue disorders
Paget Disease of Bone
Key Points
Paget disease of bone is an often asymptomatic abnormality of bone metabolism, particularly among older adults. Complications can include osteoarthritis, fractures, neural compression, osteosarcoma, and rarely hypercalcemia. Confirmation is usually by x-rays showing findings such as bone sclerosis, coarse cortical trabeculation or cortical thickening, and bone bowing or enlargement. First-line treatment is with bisphosphonates, preferablyzoledronic acid. 