infectious diseases
Primary Amebic Meningoencephalitis
Treatment
Multiple drugs, includingmiltefosineplus antifungal drugs and antibiotics Optimal treatment is unclear, but it must be started as soon as possible. Consultation with experts at the CDC is recommended (call theCDC Emergency Operations Centerat 770-488-7100). A regimen should includemiltefosine, an antileishmanial drug, which has been used in combination with other drugs in the successful treatment of patients with primary amebic meningoencephalitis.Miltefosinehas also been used successfully to treat encephalitis due toBalamuthiaandAcanthamoeba.Miltefosineis now available commercially. Other antimicrobial agents that have been used in combination treatment regimens forNaegleriainclude Amphotericin B Rifampin An azole (fluconazole,voriconazole, orketoconazole) Azithromycin Antiseizure Medications and 