gynecology and obstetrics
Intraamniotic Infection
Key Points
Intraamniotic infection is infection of the chorion, amnion, amniotic fluid, placenta, or a combination that increases risk of obstetric complications and problems in the fetus and neonate. Consider the diagnosis when women have the classic symptoms of infection (eg, fever, purulent cervical discharge, uterine pain or tenderness) or when fetal or maternal tachycardia or refractory preterm labor is present. Determine the white blood cell count, and consider analyzing and culturing amniotic fluid if women have refractory preterm labor or preterm PROM. Treat suspected or confirmed intraamniotic infection with broad-spectrum antibiotics, antipyretics, and delivery. Also treat women in labor if they have an isolated temperature of ≥ 39° C and no other clinical risk factors for fever. 