gastrointestinal disorders
Chronic Pancreatitis
Pathogenesis of Chronic Pancreatitis
The pathogenesis of chronic pancreatitis is not well understood. Several mechanisms have been proposed. Thestone and duct obstruction theoryproposes that disease is due to ductal obstruction caused by formation of protein-rich plugs as a result of protein–bicarbonate imbalance for unknown reasons. These plugs may calcify and eventually form stones within the pancreatic ducts. If obstruction is chronic, persistent inflammation leads to fibrosis, pancreatic ductal distortion, strictures, and atrophy. After several years, progressive fibrosis and atrophy lead to loss of exocrine and endocrine function. posits that repeated attacks of Acute Pancreatitis with necrosis are key to the pathogenesis of chronic pancreatitis. Over years, the healing process replaces the necrotic tissue with fibrotic tissue, leading to the development of chronic pancreatitis. Neuronal sheath hypertrophy and perineural inflammation occur and may contribute to chronic pain. 