gynecology and obstetrics
Gestational Trophoblastic Disease
Prognosis for Gestational Trophoblastic Disease
In metastatic disease, the World Health Organization (WHO) prognostic scoring system for metastatic gestational trophoblastic disease can help predict prognosis, including risk of death (see table). A WHO risk score of ≤ 6 is classified as low risk, and scores > 6 are classified as high risk. Poor prognosis is also suggested by the following (National Institutes of Health [NIH] criteria): Urinary hCG excretion>100,000 IU in 24 hours Duration of disease>4 months (interval since prior pregnancy) Brain or liver metastases Disease after full-term pregnancy Serum hCG>40,000 mIU/mL Unsuccessful prior chemotherapy WHO score > 6 