cardiovascular disorders
Aortic Dissection
Pathophysiology of Aortic Dissection
The pathophysiologic sequence of aortic dissections involves Aortic wall inflammation Apoptosis of vascular smooth muscle cells Degeneration of aortic media Elastin disruption Vessel dissection Dissections may communicate back with the true aortic lumen through intimal rupture at a distal site, maintaining systemic blood flow. Serious consequencesof aortic dissection are common and include Compromise of the blood supply of arteries that branch off the aorta (including coronary arteries) Aortic valvular dilation and Aortic Regurgitation None Heart Failure (HF) None Fatal rupture of the aorta through the adventitia into the pericardium, right atrium, or left pleural space Acute dissections and those present<2 weeks are most likely to cause these complications. Risk decreases at≥2 weeks if evidence indicates thrombosis of the false lumen and loss of communication between the true and false lumina. Variants of dissection are thought to be precursors of classic aortic dissection. Variants of aortic dissection include Separation of the intima and media by intramural hematoma without a clear intimal tear or flap Intimal tear and bulge without hematoma or false lumen Dissection or hematoma caused by ulceration of atherosclerotic plaque Aortic Dissection (https://www.youtube.com/watch?v=vrbsxsadiwI) by Osmosis (https://open.osmosis.org/) is licensed under CC-BY-SA 4.0 (https://creativecommons.org/licenses/by-sa/4.0/). 