genitourinary disorders
Myeloma Related Kidney Disease
Glomerulopathies
Types of glomerular renal disorders in multiple myeloma include AL amyloidosis (primary amyloidosis) None Light chain deposition disease Heavy chain deposition, rarely AL amyloidosis results in glomerular deposition of AL amyloid in the mesangial, subepithelial, or subendothelial areas or a combination. Amyloid deposition is with randomly oriented, nonbranching fibrils composed of the variable regions of lambda light chains. Light chain deposition disease, which also can occur with lymphoma and macroglobulinemia, is glomerular deposition of nonpolymerized light chains (ie, without fibrils), generally the constant regions of kappa chains. Rarely, a nonproliferative, noninflammatory glomerulopathy that causes nephrotic-range proteinuria can develop in advanced myeloma-related renal disease. A proliferative glomerulonephritis occasionally develops as an early form of light chain deposition disease with progression to Membranoproliferative Glomerulonephritis and nodular glomerulopathy reminiscent of 