hematology and oncology
Langerhans Cell Histiocytosis
Key Points
Langerhans cell histiocytosis (LCH) involves a proliferation of dendritic mononuclear cells that infiltrate one or more organs. Manifestations vary significantly depending on the organ(s) affected. Bone lesions cause pain; lesions at the skull base may affect vision, hearing, and pituitary function (particularly causing diabetes insipidus). Liver, spleen, lymph nodes, and bone marrow may be affected, resulting in a worse prognosis. Use surgery or curettage with or without corticosteroid injection for single bone lesions. Use chemotherapy for multisystem, multifocal and skull-based site involvement. 