pediatrics
Chromosomal Deletion Syndromes
4p syndrome (4p minus syndrome or Wolf Hirschhorn syndrome)
Deletion of the short arm of chromosome 4 (4p) results in variable Intellectual Disability ; individuals with larger deletions are usually more severely affected. Manifestations also may include epilepsy, a broad or beaked nose, midline scalp defects, ptosis and Coloboma , Many affected children die during infancy; those who survive into their 20s often have severe disability. 