gastrointestinal disorders
Solitary Rectal Ulcer Syndrome
Diagnosis of Solitary Rectal Ulcer Syndrome
Clinical evaluation Flexible sigmoidoscopy Sometimes biopsy Diagnosis of solitary rectal ulcer syndrome is typically made by clinical history and flexible sigmoidoscopy, but biopsy is sometimes done for confirmation. Assessment for internal or full-thickness rectal prolapse should be done (see Diagnosis ). Histopathologic examination of the biopsy specimen shows a thickened mucosal layer with distortion of the crypt architecture and replacement of the lamina propria with smooth muscle and collagen, leading to hypertrophy and disorganization of the muscularis mucosa. 