endocrine and metabolic disorders
ArginineVasopressin Deficiency (Central Diabetes Insipidus)
Treatment of ArginineVasopressin Deficiency
Prostaglandin inhibitors (eg, indomethacin 0.5 to 1.0 mg/kg orally 3 times a day, although most nonsteroidal anti-inflammatory drugs [NSAIDs] are effective) are modestly effective. They may reduce urine volume, but generally by no more than 10 to 25%, perhaps by decreasing renal blood flow and glomerular filtration rate (GFR). Together with indomethacin, restriction of sodium intake and a thiazide diuretic help further reduce urine volume in argininevasopressin resistance.