infectious diseases
Metronidazole and Tinidazole
Dosing Considerations forMetronidazoleandTinidazole
Metronidazoleandtinidazoledoses are not decreased in patients with renal failure.Metronidazoledoses are usually decreased 50% in patients with significant liver disease;tinidazolehas not been studied in liver disease and should be used with caution if at all. Metronidazoleandtinidazoleinhibit metabolism ofwarfarinand may increase its anticoagulant effect. 