hematology and oncology
Megaloblastic Macrocytic Anemias
Symptoms and Signs of Megaloblastic Macrocytic Anemias
Megaloblastic anemia develops insidiously and may not cause symptoms until anemia is severe. Gastrointestinal manifestations are common, including diarrhea, glossitis, and anorexia. Neurologic manifestations, including peripheral neuropathy and gait instability, are unique to vitamin B12 deficiency and can be permanent if prolonged. Paresthesias can be the presenting manifestation of B12 deficiency, even before (or in the absence of) anemia. 