infectious diseases
Daptomycin
Indications forDaptomycin
Daptomycinhas activity against the following: Gram-positive bacteria (broad-spectrum activity) Multidrug-resistant gram-positive bacteria Daptomycinis used mainly for infections caused by - and methicillin-resistant Staphylococcal Infections None -resistant Enterococcal Infections None However, methicillin-resistantS. aureusandvancomycin-resistant enterococci may become resistant duringdaptomycintherapy, resulting in relapsing or persistent infection. Daptomycinis inferior toceftriaxonefor pneumonia, presumably becausedaptomycincan bind to pulmonary surfactant, reducingdaptomycin’s activity in the alveolar epithelial lining fluid. 