genitourinary disorders
Membranoproliferative Glomerulonephritis
Complement mediated MPGN
Complement-mediated MPGN is less common than immunuglobulin/immune complex–mediated MPGN. It is caused by dysregulation and persistent activation of the alternative complement pathway, and there is deposition of complement products along the capillary walls and in the mesangium. Complement-mediated MPGN can be further categorized based on features observed on immunofluorescence and electron microscopy as C3 or C4 glomerulonephritis or dense deposition disease (DDD). 