infectious diseases
Human Papillomavirus (HPV) Vaccine
Dose and Administration of HPV Vaccine
The HPV vaccine dose is 0.5 mL IM, given in a 3-dose or 2-dose series depending on age at initial HPV vaccination. Initial dose at age 9 to 14 years: A 2-dose series is given at 0 and 6 to 12 months. Minimum interval between doses is 5 months. If a dose is given too soon (in < 5 months), the dose should be repeated ≥ 12 weeks after the invalid dose and ≥ 5 months after the first dose. Initial dose at age ≥ 15 years: A 3-dose series is given at 0, 1 to 2 months, and 6 months. Minimum intervals are 4 weeks between the first and second dose, 12 weeks between the second and third doses, and 5 months between the first and third doses. If the second or third dose is administered too soon it should be repeated. Some adults aged 27 to 45 years: Based on a shared clinical decision-making discussion, adults in this age group may be given the 2- or 3-dose series as above. People with immunocompromising conditions, including HIV infection: People with immunocompromise are given the 3-dose series as above, regardless of age at initial vaccination. 