infectious diseases
Fluoroquinolones
Contraindications to Fluoroquinolones
Contraindications include Previous allergic reaction to the drugs Certain disorders that predispose to arrhythmias (eg, QT-interval prolongation, uncorrected hypokalemia or hypomagnesemia, significant bradycardia) Use of drugs known to prolong the QT interval or to cause bradycardia (eg,metoclopramide,cisapride,erythromycin,clarithromycin, classes Ia and III antiarrhythmics, tricyclic antidepressants) Delafloxacindoes not appear to cause significant prolongation of the QT interval. Fluoroquinolones have traditionally been considered to be contraindicated in children because they may cause cartilage lesions if growth plates are open. However, some experts, who challenge this view because evidence is weak, have recommended prescribing fluoroquinolones as a 2nd-line antibiotic and restricting use to a few specific situations, includingP. aeruginosainfections in patients with cystic fibrosis, prophylaxis and treatment of bacterial infections in immunocompromised patients, life-threatening multiresistant bacterial infections in neonates and infants, andSalmonellaorShigellagastrointestinal tract infections. 