disorders of nutrition
Niacin Excess
Introduction
Niacin(nicotinic acid but not nicotinamide) in high doses may be prescribed to improve cholesterol and triglyceride (lipid) levels in the blood. , a B Overview of Vitamins , is essential for the processing (metabolism) of carbohydrates, fats, and many other substances in the body and for the normal functioning of cells. Good sources of The term "niacin" is used in two ways: as a synonym fornicotinic acidand as a broader term that includes nicotinamide andnicotinic acid, two forms of this B vitamin. High doses of nicotinic acid can have the following beneficial effects: Decrease Overview of Cholesterol and Lipid Disorders None Increase high-density lipoprotein (HDL—the good) Overview of Cholesterol and Lipid Disorders levels Moderately decrease low-density lipoprotein (LDL—the bad) cholesterol levels However, whether taking nicotinic acid supplements reduces the risk of Overview of Coronary Artery Disease (CAD) and Such high doses of nicotinic acid can cause flushing, itching, Gout , and liver damage (rarely) and increase the level of sugar (glucose) in the blood. Flushing may be worse after drinking alcohol, being physically active, being in the sun, and eating spicy foods. Most side effects can be minimized by starting with a relatively low dose and gradually increasing the dose. Takingaspirinbefore taking nicotinic acid and taking nicotinic acid after meals also help. If the side effects of nicotinic acid are intolerable, the dose may be decreased, other (especially extended-release) formulations may be tried, or nicotinic acid may be stopped and another Lipid-Lowering Drugs substituted. 