hepatic and biliary disorders
Sinusoidal Obstruction Syndrome
Treatment of Sinusoidal Obstruction Syndrome
Supportive care Treatment of cause For progressive disease, transjugular intrahepatic portosystemic shunting or transplantation helps prevent Complications in bone marrow or hematopoietic stem cell transplant recipients. , a sodium salt of single-stranded oligodeoxyribonucleotide, has been demonstrated to protect endothelial cells from further activation, and may be considered in patients with sinusoidal obstruction syndrome that complicates hematopoietic stem cell transplantation ( Treatment reference ). Most patients have mild to moderate disease and do quite well. Transjugular intrahepatic portosystemic shunting (TIPS) can be tried for relief of Treatment , but has not yet been shown to prolong survival, particularly when sinusoidal obstruction syndrome is severe. In 25%, sinusoidal obstruction syndrome is severe, accompanied by 1.Richardson PG, Riches ML, Kernan NA, et al: Phase 3 trial ofdefibrotidefor the treatment of severe veno-occlusive disease and multi-organ failure.Blood27(13):1656-1665, 2016. doi: 10.1182/blood-2015-10-676924 