infectious diseases
Macrolides
Contraindications to Macrolides
Macrolides are contraindicated in patients who have had an allergic reaction to them. Concomitant administration of macrolides with astemizole,cisapride,pimozide, or terfenadine is contraindicated because potentially fatal cardiac arrhythmias (eg, QT prolongation, ventricular tachycardia, ventricular fibrillation, torsades de pointes) may occur whenclarithromycinorerythromycinis given with these drugs. This effect is most likely due to inhibition of metabolism of these drugs byerythromycinandclarithromycin. 