dermatologic disorders
Basal Cell Carcinoma
Treatment of Basal Cell Carcinoma
Usually with local methods Treatment of basal cell carcinoma should be done by a specialist. The clinical appearance, size, site, and histologic subtype determine choice of treatment—curettage and electrodesiccation, surgical excision, cryosurgery, topical chemotherapy (imiquimodor 5-fluorouracil) and photodynamic therapy, or, occasionally, radiation therapy. Recurrent or incompletely treated cancers, large cancers, cancers at high-risk or recurrence-prone sites (eg, head and neck), and morphea-like cancers with vague borders are often treated with Mohs microscopically controlled surgery, in which tissue borders are progressively excised until specimens are tumor-free (as determined by microscopic examination during surgery). may be given ( Treatment references , 1.Basset-Séguin N, Hauschild A, Kunstfeld R, et al:Vismodegibin patients with advanced basal cell carcinoma: Primary analysis of STEVIE, an international, open-label trial.Eur J Cancer86:334-348, 2017. doi: 10.1016/j.ejca.2017.08.022 2.Lear JT, Migden MR, Lewis KD, et al: Long-term efficacy and safety ofsonidegibin patients with locally advanced and metastatic basal cell carcinoma: 30-month analysis of the randomized phase 2 BOLT study.J Eur Acad Dermatol Venereol32(3):372-381, 2018. doi: 10.1111/jdv.14542 3.Stratigos AJ, Sekulic A, Peris K, et al:Cemiplimabin locally advanced basal cell carcinoma after hedgehog inhibitor therapy: An open-label, multi-centre, single-arm, phase 2 trial.Lancet Oncol22(6):848–857, 2021. doi: 10.1016/S1470-2045(21)00126-1 