bone, joint, and muscle disorders
Immunoglobulin A–Associated Vasculitis
Introduction
Immunoglobulin A–associated vasculitis (formerly called Henoch-Schönlein purpura) is inflammation of mainly small blood vessels that most often occurs in children. A rash of reddish purple bumps and spots on the lower legs is usually the first symptom, followed by fever, joint aches, digestive upset, and kidney malfunction. Biopsy of the affected skin can confirm the diagnosis. For adults and children, drugs that relieve pain are given as needed. For adults, corticosteroids are sometimes needed to relieve joint aches and digestive upset, but, occasionally, other drugs that suppress the immune system are also needed. (See also Overview of Vasculitis .) Immunoglobulin A–associated vasculitis usually affects children but can occur at any age. It may develop when the Overview of the Immune System responds abnormally to an infection or something else. It may be triggered by viruses that cause upper respiratory infections, drugs, foods, immunizations, or insect bites. The inflammation typically occurs in blood vessels in the skin, but blood vessels in the intestine and kidney may also become inflamed. 