children s health issues
Limb Girdle Dystrophy
Introduction
Limb-girdle dystrophy encompasses a group of muscular dystrophies that can be inherited in various ways. The muscles of the shoulder or pelvis are affected. Muscular dystrophies are a group of inherited muscle disorders in which one or more Genes needed for normal muscle structure and function are defective, leading to muscle As a group, limb-girdle dystrophies are the fourth most common inherited muscle disorder. These dystrophies affect 2 to 10 of 100,000 people. Males and females are affected equally. Forms of limb-girdle dystrophy can be inherited in various ways because different genes may be involved. Sometimes only one defective gene is needed, which can be inherited from either parent ( Dominant disorders ). Sometimes a defective gene must be inherited from both parents ( Limb-girdle dystrophy causes weakness in the muscles of either the pelvis (Leyden-Möbius muscular dystrophy) or the shoulder (Erb muscular dystrophy). These inherited disorders often begin in early childhood but may not begin until adulthood. They rarely cause serious weakness. 