immunology allergic disorders
Wiskott Aldrich Syndrome
Diagnosis of Wiskott Aldrich Syndrome
Immunoglobulin levels Platelet count and volume assessment White blood cell function tests (eg, neutrophil chemotaxis, T-cell function) Diagnosis of Wiskott-Aldrich syndrome is based on the following: Decreased T-cell count and function Elevated IgE and IgA levels Low IgM levels Low or normal IgG levels Decreased natural killer cell cytotoxicity Impaired neutrophil chemotaxis ) is usually measured. Platelets are small and defective, and splenic destruction of platelets is increased, causing Overview of Platelet Disorders . Mutation analysis may be used to confirm the diagnosis if there is clinical and laboratory evidence of Wiskott-Aldrich syndrome. Genetic testing is recommended for 1st-degree relatives. Because risk of lymphoma and leukemia is increased, a complete blood count with differential is usually done every 6 months. Acute changes in symptoms related to B-cell dysfunction require more in-depth evaluations. 