immunology allergic disorders
Common Variable Immunodeficiency (CVID)
Treatment of CVID
Prophylactic immune globulin (IgG) replacement therapy Antibiotics for infections Disease-specific treatment for comorbid immunodeficiency disorders such as granulomatous lung disease or associated autoimmune disease Treatment of CVID consists of Replacement of missing immune components and antibiotics as needed to treat infection. Rituximab,vedolizumab, tumor necrosis factor (TNF)-alpha inhibitors (eg,etanercept,infliximab), corticosteroids, and/or other treatments may be required to treat complications such as autoimmune disorders, immune enteropathy, lymphoid interstitial pneumonia, and granulomatous inflammation. Recent trials have confirmed the benefit of prophylactic antibiotics in select patients with antibody deficiency ( Treatment reference ). 1.Milito C, Pulvirenti F, Cinetto F, et al: Double-blind, placebo-controlled, randomized trial on low-doseazithromycinprophylaxis in patients with primary antibody deficiencies.J Allergy Clin Immunol144:584–593. e7, 2019. doi: 10.1016/j.jaci.2019.01.051 