pediatrics
TNF Receptor–Associated Periodic Syndrome (TRAPS)
Diagnosis of TRAPS
Clinical evaluation Genetic testing Diagnosis of TRAPS is based on history, examination, and genetic testing. Proposed diagnostic criteria include the presence of a positive family history, long-lasting fever episodes, periorbital edema, migratory rash, and myalgia and the absence of pharyngotonsillitis and aphthous ulcers. These criteria have a sensitivity of 87% and a specificity of 92% ( Diagnosis reference ). Nonspecific findings include neutrophilia, elevated acute-phase reactants, and polyclonal gammopathy during attacks. Patients should be screened regularly for proteinuria. 1.Gattorno M, Hofer M, Federici S, et al: Classification criteria for autoinflammatory recurrent fevers.Ann Rheum Dis78(8):1025-1032, 2019. doi: 10.1136/annrheumdis-2019-215048 