endocrine and metabolic disorders
POEMS Syndrome
Symptoms and Signs of POEMS Syndrome
Patients may have the following: Adrenal insufficiency ( Addison Disease ) Diabetes Mellitus (DM) type 2 Hepatomegaly Primary hyperparathyroidism None Hypogonadism Lymphadenopathy None Monoclonal gammopathy Osteoclastic bone lesions Polyneuropathy (peripheral motor and sensory manifestations) Primary Hypothyroidism None Skin abnormalities (eg, hyperpigmentation, dermal thickening, hirsutism, angiomas, hypertrichosis) Other symptoms and signs of POEMS syndrome may include edema, ascites, pleural effusion, papilledema, and fever. About 15% of patients with POEMS syndrome have associated Castleman disease (a lymphoproliferative disorder, some forms of which are associated with infection by HIV or human herpesvirus 8). 