immunology allergic disorders
Chédiak Higashi Syndrome
Introduction
Chédiak-Higashi syndrome is a rare, autosomal recessive immunodeficiency disorder characterized by impaired lysis of phagocytized bacteria, resulting in recurrent bacterial respiratory and other infections and oculocutaneous albinism. Genetic testing forLYSTmutations can confirm the diagnosis. Treatment includes prophylactic antibiotics, interferon gamma, and sometimes corticosteroids. Sometimes stem cell transplantation is curative. (See also Overview of Immunodeficiency Disorders and Chédiak-Higashi syndrome is a rare, autosomal recessive Primary Immunodeficiencies that involves 