hematology and oncology
Macroglobulinemia
Symptoms and Signs of Macroglobulinemia
Most patients are asymptomatic, but some present with anemia or manifestations of hyperviscosity syndrome: fatigue, weakness, skin deposits, skin and mucosal bleeding, visual disturbances, headache, symptoms of peripheral neuropathy, and other changing neurologic manifestations. An increased plasma volume can precipitate Heart Failure (HF) . Cold sensitivity, Examination may disclose lymphadenopathy, hepatosplenomegaly, and purpura (which rarely can be the first manifestation). Marked engorgement and localized narrowing of retinal veins, which resemble sausage links, suggests a hyperviscosity syndrome. Retinal hemorrhages, exudates, microaneurysms, and papilledema occur in late stages. Marked engorgement and localized narrowing of retinal veins, which resemble sausage links, suggest a hyperviscosity syndrome. 