hematology and oncology
Acquired Platelet Dysfunction
Drugs
Aspirin, other NSAIDs, inhibitors of the platelet P2Y12adenosinediphosphate (ADP) receptor (eg,clopidogrel,prasugrel,ticagrelor), and glycoprotein IIb/IIIa receptor inhibitors (eg,abciximab,eptifibatide,tirofiban) may induce platelet dysfunction. Sometimes this effect is incidental (eg, when the drugs are used to relieve pain and inflammation) and sometimes therapeutic (eg, whenaspirinor the P2Y12 inhibitors are used for prevention of stroke or coronary thrombosis). , patients with severe Hemophilia ). A number of other drugs can also cause platelet dysfunction ( General reference ). 