hormonal and metabolic disorders
Amyloidosis
Treatment of Amyloidosis
In AL amyloidosis, chemotherapy In AA amyloidosis, treatment of the underlying disease In amyloidosis caused by transthyretin protein deposits, medications that stabilize transthyretin Sometimes, organ transplantation Treatment to decrease or control symptoms and complications of amyloidosis can improve quality of life for people with all forms of amyloidosis. Specific treatments to slow or stop amyloid formation can help in certain forms of amyloidosis. , sometimes with a peripheral Stem Cell Transplantation , can arrest the disease in the bone marrow, and prevent progression of the amyloid deposits. Radiation therapy can be used in people whose AL amyloidosis is present in only one area (localized disease). ForAA (secondary) amyloidosis,treating the underlying disease can reduce amyloid deposits. For AA amyloidosis caused specifically by familial Mediterranean fever,colchicineis very effective. Foramyloidosis caused by transthyretin protein deposits,medications such asdiflunisalandtafamidiscan stabilize transthyretin protein (preventing it from forming amyloid fibrils) and thus slow progression of hereditary and wild type transthyretin amyloid disease. Gene therapies that reduce transthyretin production (such aspatisiran,inotersen, andvutrisiran) can improve nervous system effects of hereditary disease. Organ transplants (for example, a kidney or the heart) have extended the lives of some people with organ failure due to amyloidosis. Liver Transplantation may be used. Liver transplantation can slow progression of the disease because the liver is where the mutant protein is produced. Interestingly, because there is a shortage of donor organs, the liver removed from a person with familial transthyretin amyloidosis is sometimes transplanted into people with a fatal liver disease such as cirrhosis or liver cancer. Such a "domino transplant" is possible because a liver from a person with familial transthyretin amyloidosis is otherwise a normally functioning liver. Although people who receive a liver from a person with familial transthyretin amyloidosis may eventually develop amyloidosis themselves, the transplant can save their lives in the short term. 