infectious diseases
Nitrofurantoin
Adverse Effects ofNitrofurantoin
Adverse effects ofnitrofurantoininclude Gastrointestinal disturbances Pulmonary toxicity Peripheral neuropathy Hemolytic anemia Hepatic toxicity Common adverse effects are nausea and vomiting, which are less likely with the macrocrystalline form. Fever, rash, acute hypersensitivity pneumonitis (accompanied by fever and eosinophilia), and chronic progressive pulmonary interstitial fibrosis may occur. Paresthesias may result and may be followed by a severe ascending motor and sensory polyneuropathy if the drug is continued, especially in patients with renal failure. Leukopenia and hepatic toxicity (acute cholestatic or chronic active hepatitis) have been reported, and hemolytic anemia can occur in patients with G6PD deficiency and in infants<1 month of age. Chronic pulmonary and hepatic reactions occur when the drug is used for>6 months. 