hematology and oncology
Immunotherapy of Cancer
Nonspecific Immunotherapy
 (IFN-alpha, IFN-beta, IFN-gamma) are glycoproteins that have antitumor and antiviral activity. Depending on dose, interferons may either enhance or decrease Host Response to Tumors . Interferons also inhibit cell division and certain synthetic processes in a variety of cells, including hematopoietic stem cells. Interferons have antitumor activity in various cancers, including hairy cell leukemia, Chronic Myeloid Leukemia (CML) , ) have tumoricidal properties. They have been used with or without added tumor antigen to treat a variety of cancers, usually along with intensive chemotherapy or radiation therapy. For example, direct injection of BCG into cancerous tissues has resulted in regression of Melanoma and prolongation of disease-free intervals in 1.Arico E, Castiello L, Capone I, et al: Type I interferons and cancer: An evolving story demanding novel clinical applications.Cancers(Basel) 11(12):1943, 2019. doi:10.3390/cancers11121943 2.Gupta P, Chen C, Chaluvally-Raghavan P, Pradeep S: B Cells as an immune-regulatory signature in ovarian cancer.Cancers(Basel) 11(7):894, 2019. doi:10.3390/cancers11070894 