cardiovascular disorders
Lamin A C Cardiomyopathy (Cardiolaminopathy)
Key Points
Lamin A/C cardiomyopathies are genetic disorders that cause tachyarrhythmias, heart blocks, and heart failure. Some of the mutations also affect skeletal muscle. Diagnosis is based on clinical and electrocardiographic factors, cardiac imaging, and genetic testing. First-degree family members have a significant risk of disease and require screening. Treatment requires usually requires an implantable cardioverter-defibrillator and a beta-blocker. 