special subjects
Cannabidiol (CBD)
What drug interactions occur with CBD?
CBD could speed up or slow down the body's breakdown of certain drugs and, therefore, decrease or increase levels of these drugs in the body. Examples of drugs that may increase blood levels of CBD include the following: Various drugs used to treat epilepsy (includingbrivaracetam,carbamazepine,clobazam, andtopiramate) Everolimusandtacrolimus, drugs used, for example, to prevent rejection after an organ transplant Methadone(used to treat opioid addiction) Other drugs, includingamitriptyline(a tricyclic antidepressant sometimes used for treatment of chronic pain),warfarin(a blood thinner),omeprazole(a type of drug called a proton pump inhibitor, used to decrease production of stomach acid),nicotine,lithium(a mood stabilizer), andketamine(an anesthetic occasionally used to treat depression) CBD could interact in other ways with other drugs, such as Sedatives, such as benzodiazepines,phenobarbital, andmorphine, as well as alcohol: CBD can cause sleepiness and drowsiness, so taking both CBD and sedatives might make people too drowsy. Phenytoinandrifampin: may lower the levels of CBD. Levothyroxine,warfarin, and some antiseizure drugs: CBD may increase serum concentrations of these drugs, thereby intensifying and increasing their effects. Valproic acid: Bothvalproic acidand CBD can cause liver injury, so the combination of CBD andvalproic acidmight increase the chance of liver injury. 