infectious diseases
Daptomycin
Adverse Effects ofDaptomycin
Adverse effects ofdaptomycininclude Acute Eosinophilic Pneumonia None Myopathy Chronic use may cause reversible organizing pneumonia with eosinophilic pulmonary infiltrates, presumably becausedaptomycinbinds to pulmonary surfactant and thus accumulates in the alveolar spaces. Skeletal myopathy due todaptomycinis often reversible but seldom occurs with once-a-day dosing. Nevertheless, rhabdomyolysis has been reported, and coadministration ofdaptomycinwith other drugs associated with myopathy, such as hydroxymethylglutaryl CoA reductase inhibitors (statins), may increase risk. 