hepatic and biliary disorders
Primary Sclerosing Cholangitis (PSC)
Treatment of Primary Sclerosing Cholangitis
Supportive care Endoscopic retrograde cholangiopancreatography (ERCP) dilation for major (dominant) strictures Transplantation for recurrent bacterial cholangitis or complications of liver failure Asymptomatic patients usually require only monitoring (eg, physical examination and liver tests twice/year) and, if adults, periodic imaging and measurement of CA 19-9 for gallbladder cancer and Tumors of the Gallbladder and Bile Ducts screening. Liver Transplantation is the only treatment that improves life expectancy in patients with primary sclerosing cholangitis and that offers a cure. Recurrent bacterial cholangitis, complications of end-stage liver disease (eg, intractable 1.Aabakken L, Karlsen TH, Albert J, et al: Role of endoscopy in primary sclerosing cholangitis: European Society of Gastrointestinal Endoscopy (ESGE) and European Association for the Study of the Liver (EASL) Clinical Guideline.Endoscopy49(6):588-608, 2017. doi: 10.1055/s-0043-107029 2.Bowlus CL, Arrivé L, Bergquist A, et al: AASLD practice guidance on primary sclerosing cholangitis and cholangiocarcinoma.Hepatology77(2):659-702, 2023. doi: 10.1002/hep.32771 