pediatrics
Rhabdomyosarcoma
Histology
There are 2 major histologic subtypes of rhabdomyosarcoma: Embryonal: Characterized by loss of heterozygosity on chromosome 11p15.5 Alveolar: Associated with translocation t(2;13), which fuses thePAX3gene with theFOXO1(FKHR) gene, and t(1;13), which fuses thePAX7gene with theFOXO1(FKHR) gene 