hematology and oncology
Chronic Myeloid Leukemia (CML)
Prognosis for CML
With use of tyrosine kinase inhibitors, survival is now>90% at 5 years after diagnosis for chronic phase CML. Before tyrosine kinase inhibitors were used, even with treatment, 5 to 10% of patients died within 2 years of diagnosis; 10 to 15% died each year thereafter. Median survival was 4 to 7 years. Most (90%) deaths followed a blast phase or an accelerated phase of the disease. Median survival after blast crisis was about 3 to 6 months or longer if remission was achieved. 