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Neuroleptic Malignant Syndrome
Key Points
Neuroleptic malignant syndrome develops infrequently in patients taking neuroleptic or other drugs that decrease dopaminergic transmission. Suspect the disorder if patients develop altered mental status, muscle rigidity or involuntary movements, hyperthermia, and autonomic hyperactivity. Stop the causative drug, initiate rapid cooling, and begin aggressive supportive care, usually in an ICU. 