eye disorders
Toxic and Nutritional Optic Neuropathies
Symptoms and Signs
In patients with toxic or nutritional optic neuropathy, vision blurring and dimness typically develop over days to weeks. An initially small central or pericentral scotoma slowly enlarges, typically involving both the fixation and the blind spot (centrocecal scotoma), and progressively interferes with vision. Color vision may be lost out of proportion to the loss of visual acuity. Total blindness may occur in methanol ingestion, but other nutritional causes typically cause significant central vision loss but not usually complete loss of vision. Retinal abnormalities do not usually occur, but temporal disk pallor may develop late. 