infectious diseases
Fosfomycin
Pharmacokinetics
 salt is low (about 40%), and, consequently, serum levels are low relative to the minimum inhibitory concentrations (MICs). For this reason, the drug is used to treat uncomplicated lower Introduction to Urinary Tract Infections (UTIs) , not Fosfomycindoes not bind to plasma proteins and distributes widely into tissues.Fosfomycinis excreted in urine mainly by glomerular filtration without biotransformation. After oral dosing, urinary levels exceed the MICs of susceptible pathogens for over 24 hours. An IV formulation offosfomycinis available in some countries and can be useful for more serious infections, including central nervous system infections, osteomyelitis, and pneumonia; when used to treat these infections, it is often used with other antibiotics such as beta-lactams. 