hematology and oncology
Autoimmune Hemolytic Anemia
Introduction
Autoimmune hemolytic anemia is caused by autoantibodies that react with red blood cells at temperatures≥37°C (warm antibody hemolytic anemia) or<37°C (cold agglutinin disease). Hemolysis is extravascular. The direct antiglobulin (direct Coombs) test establishes the diagnosis and may suggest the cause. Treatment depends on the cause and may include corticosteroids, splenectomy, IV immune globulin, immunosuppressants, avoidance of triggers (eg, cold), and withdrawal of drugs. (See also Overview of Hemolytic Anemia .) 