hematology and oncology
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Key Points
Paroxysmal nocturnal hemoglobinuria (PNH) can cause hemolysis at any time of day not only at night. Common clinical features include hemoglobinuria, pancytopenia and arterial and venous thromboses. Venous thromboses occur in unusual locations (eg, in hepatic veins). Treat symptomatic patients with complement inhibitors. 