neurologic disorders
Isaacs Syndrome
Key Points
The sine qua non of Isaac syndrome is myokymia—continuous muscle twitching described as bag-of-worms movements, typically in the limbs. Diagnose based on clinical findings, results of nerve conduction and EMG studies, and laboratory testing for specific antibody markers. Treat with drugs to relieve symptoms (eg,carbamazepine,phenytoin,gabapentin), plasma exchange, and sometimes IVIG. 