hematology and oncology
Hemoglobin S C Disease
Introduction
Hemoglobin S-C disease is a Overview of Hemoglobinopathies that causes symptoms similar to those of sickle cell disease, but usually less severe. (See also Overview of Hemolytic Anemia .) The heterozygous S-C combination is more common than homozygous Hemoglobin C Disease . This is because of the high prevalence of hemoglobin (Hb) S trait (which is responsible for Symptoms are similar to the Symptoms and Signs , but are usually less frequent and less severe. However, gross hematuria, retinal hemorrhages, and aseptic necrosis of the femoral head are common. Splenomegaly may be present. Hemoglobin S-C disease is suspected in patients whose clinical features suggest sickle cell disease or whose red blood cells demonstrate sickling. Stained blood smears show target cells, spherocytes, and rarely sickle cells or oat-shaped cells. Sickling is identified in a sickling preparation, and hemoglobin electrophoresis establishes the diagnosis. Treatment can be similar to the Treatment but is determined by the severity of the symptoms. 