hematology and oncology
Overview of Thrombotic Disorders
Etiology of Thrombotic Disorders
Genetic defectsthat increase the propensity for venous thromboembolism include Factor V Leiden mutation, which causes Factor V Resistance to Activated Protein C (APC) (APC) Prothrombin (Factor II) 20210 Gene Mutation None Protein C Deficiency None Protein S Deficiency None Protein Z Deficiency None Antithrombin Deficiency None Elevated Factor VIII, IX, and XI Levels None . Protein Z Deficiency predisposes to venous thrombosis (mainly in patients who also have other clotting abnormalities). However, measurement of its activity is not available in most laboratories. Acquired defectsalso predispose to venous and arterial thrombosis (see table). Other disorders and environmental factors can increase the risk of thrombosis, especially if a genetic abnormality is also present. 