neurologic disorders
Fragile X–Associated Tremor Ataxia Syndrome (FXTAS)
Key Points
Fragile X–associated tremor/ataxia syndrome (FXTAS) affects about 1/3000 men > 50; Fragile X syndrome, the most common cause of intellectual disability in males, develops from a related gene mutation. Ask patients whether any of their grandchildren have intellectual disability and whether their daughters have had early menopause or infertility, and ask grandparents of patients with Fragile X syndrome whether they have symptoms suggesting FXTAS. Do genetic testing to confirm the diagnosis. Treat tremor withprimidone,propranolol,topiramate,gabapentin,pregabalin, benzodiazepines, and/or antiparkinsonian drugs. 