infectious diseases
Leptospirosis
Treatment of Leptospirosis
Penicillin Doxycycline Antibiotic therapy is most effective when begun early in the infection. Insevere illness,one of the following is recommended: Penicillin G1.5 million units IV every 6 hours for 7 days Ampicillin500 to 1000 mg IV every 6 hours for 7 days Ceftriaxone1 g IV every 24 hours for 7 days In severe cases, supportive care, including fluid and electrolyte therapy and sometimes renal replacement therapy and/or blood transfusion, is also important. Inless severe cases,one of the following may be given: Doxycycline100 mg orally every 12 hours for 5 to 7 days Ampicillin500 to 750 mg orally every 6 hours for 5 to 7 days Amoxicillin500 mg orally every 6 hours for 5 to 7 days Patient isolation is not required, but urine must be handled and disposed of carefully. 