special subjects
Radiographic Contrast Agents
Paramagnetic Contrast Agents
Paramagnetic contrast agents change the magnetic properties of particles in a way that increases the contrast between different tissues, making MRI images clearer. These agents usually contain gadolinium. Usually, no side effects occur. However, in a few people who have severe kidney disease or who are undergoing dialysis, these agents may cause a life-threatening disorder called Nephrogenic systemic fibrosis In nephrogenic systemic fibrosis, the skin, connective tissue, and organs thicken. Red or dark patches may develop on the skin. The skin may feel tight, movement is difficult and limited, and organs may malfunction. This disorder is now very rare because doctors use gadolinium paramagnetic contrast agents in people with kidney problems only when necessary, and they use the lowest dose and safest agent possible. Doctors also consider using other imaging tests in people with severe kidney problems. 