neurologic disorders
Parkinson Disease
Pathophysiology of Parkinson Disease
Synuclein is a neuronal and glial cell protein that can aggregate into insoluble fibrils and form Lewy bodies. Thepathologic hallmark of sporadic or idiopathic Parkinson diseaseis Synuclein-filled Lewy bodies in the nigrostriatal system However, synuclein can accumulate in many other parts of the nervous system, including the dorsal motor nucleus of the vagus nerve, basal nucleus of Meynert, hypothalamus, neocortex, olfactory bulb, sympathetic ganglia, and myenteric plexus of the gastrointestinal tract. Lewy bodies appear in a temporal sequence, and many experts believe that Parkinson disease is a relatively late development in a systemic synucleinopathy. Other synucleinopathies (synuclein deposition disorders) include Dementia with Lewy Bodies and Parkinson Disease Dementia and Rarely, Parkinson disease occurs without Lewy bodies (eg, in a form due to a mutation in thePARK 2gene). in the dorsal aspect of the putamen (part of the basal ganglia) and causes many of the motor manifestations of Parkinson disease (see figure Basal ganglia ). 