hematology and oncology
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Introduction
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired disorder characterized by intravascular hemolysis and hemoglobinuria. Leukopenia, thrombocytopenia, arterial and venous thromboses, and episodic crises are common. Diagnosis requires flow cytometry. Treatment is with a terminal complement inhibitor such aseculizumab. (See also Overview of Hemolytic Anemia .) Paroxysmal nocturnal hemoglobinuria is most common among men in their 20s, but it occurs in both sexes and at any age. Hemolysis occurs throughout the day not just at night. 