neurologic disorders
COVID Related Neuropsychiatric Manifestations
Key Points
Patients hospitalized with COVID-19 are likely to have neuropsychiatric symptoms during the acute phase and the recovery period. During the acute phase of COVID-19, critically ill patients may have delirium and agitation or somnolence. After recovery from COVID-19, many patients report persistent neuropsychiatric symptoms (long COVID); these symptoms may include sleep disturbances, fatigue, impaired memory and cognition, headache, numbness and tingling, or anosmia. Neuropsychologic testing may be useful in defining cognitive deficits and measuring their severity. In patients who have acute neuropsychiatric symptoms or who have recovered from COVID-19, exclude alternative diagnoses with appropriate imaging and laboratory testing. Treat patients with supportive care and antidepressants as needed, and use a comprehensive, multidisciplinary approach to manage comorbid conditions in patients with long COVID. 