bone, joint, and muscle disorders
IgG4 Related Disease
Treatment of IgG4 Related Disease
Corticosteroids Rituximab Sometimes, surgery Treatment of IgG4-RD aims to reduce inflammation and stop the effects of the disorder. Initial treatment is often with an oral corticosteroid (for example,prednisone), which is given for 2 to 4 weeks then tapered over the course of 2 to 3 months.Rituximab, a medication that modifies the immune system's activity, is often used when corticosteroids are not appropriate (for example, in people with uncontrolled diabetes) or if the disease recurs when tapering or stopping corticosteroids.Rituximabis nearly universally effective in treating active IgG4-RD. Typically, organ function returns to normal after treatment. However, if a lot of scar tissue had already formed in an organ, function may not fully return to normal. Some people require surgical procedures, such as stenting, to relieve blockages of the ureters (the tubes that carry urine from the kidneys to the bladder) or bile ducts. 