eye disorders
Interstitial Keratitis
Diagnosis of Interstitial Keratitis
Corneal opacification and other typical findings on slit-lamp examination Serologic testing to determine etiology The specific etiology must be determined. The stigmas of congenital syphilis, vestibuloauditory symptoms, history of an expanding rash, and tick exposure support specific etiologies. However, all patients should have serologic testing, including all of the following: Fluorescent treponemal antibody absorption test or the microhemagglutination assay forTreponema pallidumare the usual syphilis screening tests Lyme titer Epstein-Barr virus panel New tests such asTreponema pallidumparticle agglutination assay,Treponema pallidumenzyme immunoassay, chemiluminescence immunoassay, and nucleic acid amplification tests (NAAT) may also be useful in diagnosing ocular syphilis. Patients with negative serologic test results may have Cogan Syndrome , an idiopathic syndrome consisting of interstitial keratitis and vestibular and auditory deficits. To prevent permanent vestibuloauditory damage, symptoms of hearing loss, tinnitus, or vertigo require urgent referral to an otolaryngologist. 