pediatrics
Familial Mediterranean Fever
Treatment of Familial Mediterranean Fever
Dailycolchicine In patients who arecolchicine-resistant or -intolerant, interleukin-1 (IL-1) inhibitors should be initiated as soon as the diagnosis is made to prevent attacks as well as Amyloidosis ( Colchicinedoes not add to the increased risk of infertility or spontaneous abortion among affected women; when taken during pregnancy, it does not increase the risk of teratogenic events. Lack of response tocolchicineis often caused by poor adherence to the regimen. every 4 weeks) ( Treatment references , Nonsteroidal anti-inflammatory drugs (NSAIDs) andacetaminophenare sometimes needed for analgesia. 1.Ter Haar N, Lachmann H, Özen S, et al: Treatment of autoinflammatory diseases: results from the Eurofever Registry and a literature review.Ann Rheum Dis72(5):678-685, 2013. doi: 10.1136/annrheumdis-2011-201268 2.Goldberg O, Levinsky Y, Peled O, et al: Age dependent safety and efficacy ofcolchicinetreatment for familial mediterranean fever in children.Semin Arthritis Rheum49(3):459-463, 2019. doi: 10.1016/j.semarthrit.2019.05.011 2.Ozen S, Demirkaya E, Erer B, et al: EULAR recommendations for the management of familial Mediterranean fever.Ann Rheum Dis75(4):644–651, 2016. doi: 10.1136/annrheumdis-2015-208690 3.De Benedetti F, Gattorno M, Anton J, et al:Canakinumabfor the treatment of autoinflammatory recurrent fever syndromes.N Engl J Med378(20):1908–1919, 2018. doi: 10.1056/NEJMoa1706314 