liver and gallbladder disorders
Primary Biliary Cholangitis (PBC)
Causes of PBC
The cause is not clear but is probably an Autoimmune Disorders (in which the immune system attacks the body’s own tissues). Primary biliary cholangitis often occurs in people with other autoimmune disorders, such as An autoimmune cause is also thought possible because more than 95% of people with PBC have certain abnormal antibodies in their blood. These antibodies attack mitochondria (tiny structures that produce energy in cells). However, these antibodies are not involved in the destruction of the bile ducts. Other immune cells attack the bile ducts. What triggers this attack is unknown, but it may be exposure to a virus or a toxic substance. 