dermatologic disorders
Skin Manifestations of Internal Disease
Internal Cancer
Patients with Autoimmune Myositis who are over age 40 have an increased risk of breast, lung, ovarian, and gastrointestinal cancers. Acute onset of multiple Seborrheic Keratoses (Leser-Trélat sign) may indicate underlying internal cancer, particularly adenocarcinoma. However, because of the high prevalence of seborrheic keratoses in healthy adults, this sign may be overdiagnosed. Acute Febrile Neutrophilic Dermatosis (Sweet syndrome) is sometimes associated with hematologic cancer. Acanthosis nigricansthat is associated with cancer can be of rapid onset and particularly widespread. Acquired ichthyosis or pruritus without a clearly associated dermatitis may indicate occult cancer, often lymphoma. Paraneoplastic pemphigusis a relatively rare autoimmune blistering disease that has been associated with various cancers, including leukemias. Carcinoid Syndrome (flushing and erythema of the neck) is associated with carcinoid tumor. Erythema gyratum repensis a rare eruption consisting of concentric erythematous lesions, resembling wood grain, which has been associated with various cancers. 