endocrine and metabolic disorders
Medications for Diabetes Mellitus Treatment
Disease Modifying Medications for Diabetes
, an anti-CD3 monoclonal antibody, is a disease-modifying medication for type 1 diabetes. It Prevention in at-risk individuals. It is only used in patients with confirmed type 1 stage 2 (dysglycemia without overt symptoms of hyperglycemia and at least 2 positive autoantibodies for type 1 diabetes). It is given as an intravenous infusion daily for 14 days and had been shown to delay the onset of symptomatic type 1 diabetes for an average of 2 years ( 1.Herold KC, Bundy BN, Long SA, et al. An Anti-CD3 Antibody,Teplizumab, in Relatives at Risk for Type 1 Diabetes [published correction appears inN Engl J Med2020 Feb 6;382(6):586].N Engl J Med2019;381(7):603-613. doi:10.1056/NEJMoa1902226 2.Sims EK, Bundy BN, Stier K, et al.Teplizumabimproves and stabilizes beta cell function in antibody-positive high-risk individuals.Sci Transl Med2021;13(583):eabc8980. doi:10.1126/scitranslmed.abc8980 