infectious diseases
Tetracyclines
Use During Pregnancy and Breastfeeding
Tetracyclines cross the placenta, enter fetal circulation, accumulate in fetal bones, and, if used during the 2nd or 3rd trimester, may cause permanent discoloration of the fetus's teeth. Hepatotoxicity may occur in pregnant women, particularly after IV administration and in those with azotemia or pyelonephritis. Taking high doses during pregnancy can lead to fatty degeneration of the liver, which may be fatal. Tetracyclines enter breast milk, but usually in small amounts (particularlytetracycline). Use during breastfeeding is usually discouraged. 