hematology and oncology
Primary Myelofibrosis (PMF)
Introduction
Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, splenomegaly, and anemia with nucleated and teardrop-shaped red blood cells. Diagnosis requires bone marrow aspirate and biopsy and exclusion of other conditions that can cause myelofibrosis (secondary myelofibrosis). Treatment is often supportive, but Janus kinase 2 (JAK2) inhibitors, such asruxolitinib,fedratinib, pacritnib, ormomelotinibmay decrease symptoms, and stem cell transplantation may be curative. (See also Overview of Myeloproliferative Neoplasms .) 