infectious diseases
Melioidosis
Treatment of Melioidosis
For symptomatic patients, several weeks of IV antibiotics followed by a prolonged course of an oral drug Asymptomatic melioidosis needs no treatment. Symptomatic patients are givenceftazidime30 mg/kg IV every 6 hours for 2 to 4 weeks (imipenem,meropenem, and piperacillin are acceptable substitutes), then oral antibiotics (one double-strength tablet oftrimethoprim/sulfamethoxazole [TMP/SMX] 2 times a day ordoxycycline100 mg 2 times a day) for 3 to 6 months. In children < 8 years and pregnant women,amoxicillin/clavulanate 25/5 mg/kg 3 times a day is used instead ofdoxycycline. 