infectious diseases
Linezolid and Tedizolid
Tedizolid
Tedizolidis an oxazolidinone antibiotic with a spectrum of activity similar to that oflinezolid, although it may have activity against somelinezolid-resistant gram-positive cocci. In clinical trials, risk of serotonin syndrome and thrombocytopenia was lower withtedizolidthan withlinezolid.Tedizolid, likelinezolid, can cause significant neutropenia, and the use of these oxazolidinone antibiotics is not recommended in patients with neutrophil counts of < 1000 cells/mcL (< 1 × 109/L) when acceptable alternatives exist. Animal reproduction studies withtedizolidshow some risk, and no adequate and well-controlled studies have been done in pregnant women.Tedizolidshould be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Whetherlinezolidis excreted in breast milk or is safe to use during breastfeeding is unknown. 