hematology and oncology
Excessive Bleeding
Etiology of Excessive Bleeding
Excessive bleeding can result from several mechanisms (see table), including the following: Overview of Platelet Disorders None Overview of Coagulation Disorders None Overview of Vascular Bleeding Disorders None Platelet disorders may involve an abnormal number of platelets (typically too few platelets, although an extremely elevated platelet count may be associated with excessive bleeding because platelets can metabolize high molecular weightvon Willebrand factormultimers), defective platelet function, often due to drugs such asaspirin, P2Y12 inhibitors (eg,clopidogrel,cangrelor,prasugrel,ticagrelor), or nonsteroidal anti-inflammatory drugs (NSAIDs), or both an abnormal number and defective function of platelets. Coagulation disorders may be acquired or hereditary. Overall, the most common causes of excessive bleeding include Severe Overview of Platelet Disorders None Excessive anticoagulation, as withwarfarin,heparin, or a direct oral anticoagulant (eg,apixaban,edoxaban,rivaroxaban) Liver disease (inadequate production of coagulation factors) 