infectious diseases
Macrolides
Pharmacokinetics
Macrolides are relatively poorly absorbed orally.Fidaxomicinis minimally absorbed and active only locally in the gastrointestinal tract. Food has the following effects on macrolide absorption: For extended-releaseclarithromycin, increased absorption For immediate-releaseclarithromycintablet or suspension, no effect Forazithromycincapsules anderythromycin(including base and stearate formulations), decreased absorption Forfidaxomicin, minimal effects Once absorbed macrolides diffuse well into body fluids, except cerebrospinal fluid, and are concentrated in phagocytes. Excretion is mainly in bile. 