gynecology and obstetrics
Primary Ovarian Insufficiency
Symptoms and Signs of Primary Ovarian Insufficiency
In women with occult or biochemical primary ovarian insufficiency (see Classification , below), the only sign may be unexplained infertility. Women with overt primary ovarian insufficiency or premature ovarian failure typically have The ovaries are usually small and barely palpable but occasionally are enlarged, usually when the cause is an immune-mediated disorder. Women may also have symptoms and signs of the causative disorder (eg, dysmorphic features due to Turner syndrome; intellectual disability, dysmorphic features, and autism due to Fragile X syndrome; rarely, orthostatic hypotension, hyperpigmentation, and decreased axillary and pubic hair due to adrenal insufficiency). therapy until about age 51 (the average age for menopause), the risk of Osteoporosis , If primary ovarian insufficiency is caused by an autoimmune disorder, women are at risk of potentially life-threatening primary adrenal insufficiency ( Addison Disease ). 