hormonal and metabolic disorders
Polyglandular Deficiency Syndromes
Introduction
Polyglandular deficiency syndromes are hereditary disorders in which several endocrine (hormone-producing) glands malfunction. Endocrine Glands are organs that secrete one or more specific hormones. The actual cause of the endocrine gland malfunctioning may be related to an Type 1 is also called autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED). In this type, which develops in children, the Overview of Parathyroid Function and Type 2 is also called Schmidt syndrome. In this type, which develops in adults (particularly women), the adrenal and thyroid glands are underactive, although the thyroid gland sometimes becomes overactive. People with type 2 polyglandular deficiency may also develop Diabetes Mellitus (DM) . Type 3:This type is very similar to type 2, except that the adrenal glands remain normal. In people with polyglandular deficiency syndromes, symptoms depend on which endocrine organs are affected. The hormone deficiencies do not always appear at the same time and may require a period of years to develop. The deficiencies do not occur in a particular sequence, and not every person will have all of the deficiencies associated with each type. 