children s health issues
Cholestasis in the Newborn
Causes of Cholestasis in Newborns
Cholestasis in the newborn can be caused by Biliary atresia (blockage of the bile ducts) Biliary cysts Infection An immune disorder Metabolic disorders Genetic defects Toxic causes Biliary Atresia None ). Biliary cysts are more common among infants who have Polycystic Kidney Disease (PKD) (PKD). PKD is an inherited disorder that causes cysts to form in the kidneys. Infectionscan lead to cholestasis in the newborn. Some infecting organisms are Viruses: Including Cytomegalovirus (CMV) Infection , Bacteria: Most often Urinary Tract Infection (UTI) in Children and/or bloodstream infection ( Parasites: Including Toxoplasmosis None Gestational alloimmune liver diseaseis a disorder that begins before birth. In this disease, antibodies from the mother cross the placenta and attack the fetus's liver. Overview of Hereditary Metabolic Disorders None such as Alagille syndrome and Cystic Fibrosis (CF) , may cause cholestasis in the newborn. Genetic defects and other gene mutations can disrupt normal bile production and removal, which causes cholestasis. include the use of Intravenous Feeding (parenteral nutrition) in extremely premature newborns or in infants who have Neonatal hepatitis syndromeis the term used to describe inflammation in the newborn's liver for which there is no identified cause. This diagnosis is being made less frequently due to advances in tests that can determine an exact cause. 