musculoskeletal and connective tissue disorders
Paget Disease of Bone
Etiology of Paget Disease of Bone
 (sequestosome-1) gene, resulting in increased nuclear factor kappa-B activity, which increases osteoclast activity ( Etiology references , A viral etiology, such as measles, has been proposed because nuclear inclusions in diseased osteoclasts that are similar to those seen in paramyxovirus-infected cells have been seen on electron microscopy. Although a viral cause remains controversial, it is hypothesized that in genetically predisposed patients an as yet unidentified virus triggers abnormal osteoclast activity. 1.Laurin N, Brown JP, Morissette J, Raymond V: Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone.Am J Hum Genet70:1582–1588, 2002. doi: 10.1086/340731 2.Rea SL, Walsh JP, Layfield R, et al: New insights into the role of sequestosome 1/p62 mutant proteins in the pathogenesis of Paget's disease of bone.Endocr Rev34(4):501-24, 2013. doi: 10.1210/er.2012-1034 