infectious diseases
Metronidazole and Tinidazole
Indications forMetronidazoleandTinidazole
Metronidazoleis active against All obligate Overview of Anaerobic Bacteria (it is inactive against facultative anaerobic and aerobic bacteria) Certain protozoan parasites (eg, Trichomoniasis , is the drug of choice for Bacterial Vaginosis (BV) . The drug has other clinical uses (see table Tinidazoleis used primarily for the protozoan parasites mentioned above. It is not used for systemic anaerobic bacterial infections. Indication Indication Comments Comments Infections due to obligate Overview of Anaerobic Bacteria (eg, intra-abdominal, pelvic, soft-tissue, periodontal, and odontogenic infections; lung abscess) Often used with other antimicrobials Bacterial Vaginosis (BV) None Drug of choice Crohn Disease None — Central nervous system infections ( Acute Bacterial Meningitis , — Infective Endocarditis None — Septicemia — Prophylaxis before intestinal surgery — Clostridioides (formerly Clostridium) difficile–Induced Diarrhea (pseudomembranous colitis) No longer recommended as a first-line drug Should be considered only for mild cases whenvancomycinorfidaxomicinare unavailable or for severe systemic cases given in combination withvancomycin Peptic ulcers due to Helicobacter pylori Infection None For treatment and prevention of relapses Used with other drugs Rosacea None Topical or oral use 