genitourinary disorders
Myeloma Related Kidney Disease
Treatment of Myeloma Related Kidney Disease
Management of multiple myeloma Prevention of volume depletion and maintenance of a high urine flow rate Management of Treatment and prevention of Several measures are often recommended but are of unproved efficacy. Plasma exchange may be tried to remove light chains. Alkalinization of the urine to help change the net charge of the light chain and reduce charge interaction with Tamm-Horsfall mucoprotein may make the light chains more soluble. 1.Dimopoulos MA, Sonneveld P, Leung N, et al: International Myeloma Working Group Recommendations for the Diagnosis and Management of Myeloma-Related Renal Impairment.J Clin Oncol34(13):1544-1557, 2016. doi: 10.1200/JCO.2015.65.0044 