genitourinary disorders
Immunoglobulin A Nephropathy
Prognosis for IgA Nephropathy
IgA nephropathy usually progresses slowly; renal insufficiency and hypertension develop within 10 years in 15 to 20% of patients. Progression to Chronic Kidney Disease occurs in 25% of patients after 20 years. When IgA nephropathy is diagnosed in childhood, prognosis is usually good. However, persistent hematuria invariably leads to hypertension, proteinuria, and renal insufficiency. Risk factors for progressive deterioration in renal function include the following: Proteinuria>1 g/day Elevated serum creatinine level Uncontrolled hypertension Persistent microscopic hematuria Extensive fibrotic changes in the glomerulus or interstitium Crescents on biopsy 