pediatrics
Tuberous Sclerosis Complex (TSC)
Key Points
Tuberous sclerosis complex is a dominantly inherited genetic disorder in which tumors (usually hamartomas) develop in multiple organs. Manifestations vary greatly; skin lesions are typically present. Diagnose using clinical criteria, identification of characteristic skin lesions, imaging of affected organs, and molecular genetic testing. Treat symptomatically and specifically for the multiple complications. Considereverolimusorsirolimusfor malignant tumors and some of the benign tumors. 