musculoskeletal and connective tissue disorders
IgG4 Related Disease
Etiology of IgG4 Related Disease
The cause of IgG4-RD is unknown, but is thought to involve autoimmunity because of its chronic, insidious nature, the targeting of self-proteins by antibodies, and responsiveness to immunosuppression ( Etiology reference ). Perugino CA, Stone JH: IgG4-related disease: an update on pathophysiology and implications for clinical care.Nat Rev Rheumatol16(12):702-714, 2020. doi: 10.1038/s41584-020-0500-7 