hematology and oncology
Overview of Platelet Disorders
Etiology of Platelet Disorders
 Essential Thrombocythemia None Reactive Thrombocytosis (Secondary Thrombocythemia) None Causes of thrombocytopenia can be classified by mechanism (see table Classification of Thrombocytopenia ) and include Decreased platelet production Increased splenic sequestration of platelets with normal platelet survival Increased platelet destruction or consumption (both immunologic and nonimmunologic causes) Dilution of platelets A large number of Drug-induced immunologic platelet destruction , typically by triggering immunologic destruction. Overall, themost common specific causesof thrombocytopenia include Pregnancy ( Pregnancy ; Drugs that cause immune-mediated platelet destruction (commonly,heparin,trimethoprim/sulfamethoxazole, rarelyquinine[cocktail purpura] orabciximab), and rarely vaccinations (eg, influenza, shingles, measles, mumps, and rubella, A COVID-19) Drugs that cause dose-dependent bone marrow suppression (eg, chemotherapeutic agents,ethanol) Systemic infection Immune disorders (eg, Immune Thrombocytopenia (ITP) , Platelet dysfunction may stem from an intrinsic platelet defect or from an extrinsic factor that alters the function of normal platelets. Dysfunction may be hereditary or acquired. Hereditary disorders of platelet function consist of Von Willebrand Disease , the most common hereditary hemorrhagic disease, and 