psychiatric disorders
Medications for Treatment of Depression
Melatonergic Antidepressant
Agomelatine is a melatonergic (MT1/MT2) agonist and a 5-HT2Creceptor antagonist that is taken at bedtime. It is used for major depressive episodes. Agomelatine has fewer adverse effects than most antidepressants and does not cause daytime sedation, insomnia, weight gain, or sexual dysfunction. It is not addictive and does not cause withdrawal symptoms. It may cause headache, nausea, and diarrhea. It may also increase liver enzyme levels, and these levels should be measured before therapy is started and every 6 weeks thereafter. It is contraindicated in patients with hepatic dysfunction. 