hepatic and biliary disorders
Hepatic Granulomas
Etiology of Hepatic Granulomas
); medications and systemic disorders (often infections) are more common causes than primary liver disorders. Infections must be identified because they require specific treatments. Tuberculosis and Schistosomiasis are the most common infectious causes worldwide; fungal and viral causes are less common. Granulomas are much less common in primary liver disorders; Primary Biliary Cholangitis (PBC) (PBC, previously primary biliary cirrhosis) is the only important cause. Small granulomas occasionally occur in other liver disorders but are not clinically significant. Idiopathic granulomatous hepatitisis a rare syndrome of hepatic granulomas with recurrent fever, myalgias, fatigue, and other systemic symptoms, which often occur intermittently for years. Some experts believe it is a variant of sarcoidosis. 