kidney and urinary tract disorders
Nephrogenic Diabetes Insipidus
Causes of Nephrogenic Diabetes Insipidus
Normally, the kidneys adjust the concentration and amount of urine according to the body’s needs. The kidneys make this adjustment in response to the level ofvasopressinin the blood.Vasopressin, which is secreted by the pituitary gland, signals the kidneys to conserve water and concentrate the urine. In nephrogenic diabetes insipidus, the kidneys fail to respond to the signal. Nephrogenic diabetes insipidus may be Hereditary Acquired In hereditary nephrogenic diabetes insipidus, the gene that typically causes the disorder is recessive and carried on the X chromosome, one of the two sex chromosomes, so usually only males develop symptoms. However, females who carry the gene can transmit the disease to their sons. Rarely, another abnormal gene can cause nephrogenic insipidus in both males and females. In the acquired form, nephrogenic diabetes insipidus may be caused by certain drugs that block the action ofvasopressin, such aslithium. Nephrogenic diabetes insipidus can also occur if the kidney is affected by disorders such as Polycystic Kidney Disease (PKD) , Also, high levels of calcium or low levels of potassium in the blood, especially if they persist, partially block the action ofvasopressin. Sometimes the cause is unknown. 