neurologic disorders
Neuropathic Pain
Symptoms and Signs of Neuropathic Pain
Dysesthesias (spontaneous or evoked burning pain, often with a superimposed lancinating component) are typical, but pain may also be deep and aching. Other sensations—eg, hyperesthesia, hyperalgesia, allodynia (pain due to a nonnoxious stimulus), and hyperpathia (particularly unpleasant, exaggerated pain response)—may also occur. Patients may be reluctant to move the painful part of their body, resulting in muscle atrophy, joint ankylosis, bone loss, and limited movement. Symptoms are long-lasting, typically persisting after resolution of the primary cause (if one was present) because the CNS has been sensitized and remodeled. 