infectious diseases
Chloramphenicol
Adverse Effects of Chloramphenicol
The neonatal gray baby syndrome, which involves hypothermia, cyanosis, flaccidity, and circulatory collapse, is often fatal. The cause is high blood levels, which occur because the immature liver cannot metabolize and excrete chloramphenicol. To avoid the syndrome, clinicians should not give infants ≤ 1 month of age > 25 mg/kg/day initially, and doses should be adjusted based on blood levels of the drug.