hematology and oncology
Hemolytic Uremic Syndrome (HUS)
Treatment of HUS
Supportive care, often including hemodialysis For cases involving complement dysregulation, sometimeseculizumaborravulizumab Typical diarrhea-associated hemolytic-uremic syndrome in children caused by enterohemorrhagic infection usually spontaneously remits and is treated with supportive care; antibiotics are not used. Over half of patients require renal dialysis. Unlike with thrombotic thrombocytopenic purpura, plasma exchange and corticosteroids are not used. In patients with HUS caused by complement dysregulation, complement inhibition witheculizumaborravulizumabcan sometimes reverse the kidney failure. Children with known or presumed hereditary deficiency in complement regulatory proteins such as factor H are particularly likely to respond toeculizumaborravulizumab. 