pediatrics
Neonatal Herpes Simplex Virus (HSV) Infection
Treatment of Neonatal HSV Infection
Parenteralacyclovir Supportive therapy Acyclovirshould be started immediately and presumptively in suspected cases while awaiting confirmatory diagnostic tests. Infants with disseminated and/or CNS disease are given 20 mg/kg IV every 8 hours for 21 days. After this regimen, infants with CNS disease are given oralacyclovir300 mg/m23 times a day for 6 months; this long-term regimen improves neurodevelopmental outcomes at 1 year of age but may cause neutropenia. Vigorous supportive therapy is required, including appropriate IV fluids, alimentation, respiratory support, correction of clotting abnormalities, and control of seizures. , iododeoxyuridine, or vidarabine (see Treatment ). 