nutritional disorders
Chromium Toxicity
Introduction
 should be considered an essential (required) trace element ( Reference ). picolinate supplementation is beneficial in Diabetes Mellitus (DM) . Patients with diabetes should not take High doses of trivalentchromiumgiven parenterally cause skin irritation, but lower doses given orally are not toxic. Exposure to hexavalentchromium(CrO3) in the workplace (eg, welding plants, steel mills) may irritate the skin, lungs, and gastrointestinal tract and may cause perforation of the nasal septum and lung carcinoma. (See also Overview of Minerals .) 