infectious diseases
Acinetobacter Infections
Treatment ofAcinetobacterInfections
Typically empiric multidrug therapy for serious infections In patients with localized cellulitis or phlebitis associated with a foreign body (eg, IV catheter, suture), removal of the foreign body plus local care is usually sufficient. Tracheobronchitis after endotracheal intubation may resolve with pulmonary hygiene alone. Patients with more extensive infections should be treated with antibiotics and with debridement if necessary. ( Treatment reference ). Mild to moderate infections may respond to monotherapy. Traumatic wound infections caused by susceptible strains can be treated withminocycline. Serious AB infections are treated with combination therapy—typically, carbapenems (imipenemormeropenem) orampicillin/sulbactamplus an aminoglycoside; when drug resistance is extreme,tigecycline,cefiderocol, or the combination of colistin plusminocyclinemay be the only available options. To prevent spread, health care practitioners should use contact precautions (hand washing, barrier precautions) and appropriate ventilator care and cleaning for patients colonized or infected with MDR-AB. 1.Munier AL, Biard L, Rousseau C, et al: Incidence, risk factors, and outcome of multidrug-resistantAcinetobacter baumanniiacquisition during an outbreak in a burns unit.J Hosp Infect97(3):226–233, 2017. doi: 10.1016/j.jhin.2017.07.020 