clinical pharmacology
Adverse Drug Reactions
Treatment of Adverse Drug Reactions
Modification of dosage Discontinuation of drug or medication if necessary Switching to a different medication For dose-related adverse drug reactions to medications, modifying the dose or eliminating or reducing precipitating factors may suffice. Increasing the rate of drug elimination is rarely necessary. For allergic and idiosyncratic ADRs, the drug usually should be discontinued and not tried again. Switching to a different drug class is often required for allergic ADRs and sometimes required for dose-related ADRs. For example, opioid-induced constipation may be improved with the use of an opioid receptor antagonist such aslubiprostone. 