gastrointestinal disorders
Colonic Diverticulosis
Etiology of Colonic Diverticulosis
, corticosteroids, and opioids. Other possible risk factors include heritable factors and alterations in the colonic wall structure and motility ( Diverticular bleeding reference , The etiology of giant diverticula is unclear. One theory is that a narrow neck-opening leads to a ball-valve effect with intermittent obstruction of the opening causing the diverticulum to enlarge. A very large giant diverticulum is often a true perforation of a smaller diverticulum that was contained and walled off and became lined mostly by granulation tissue. 