dermatologic disorders
Albinism
Symptoms and Signs of Albinism
The different genetic forms of oculocutaneous albinism have a variety of phenotypes. OCA type I (OCA1A) is classic tyrosinase-negative albinism; skin and hair are milky white, and eyes are blue-gray (decrease in visual acuity is the most severe in this form of oculocutaneous albinism). Pigmentary dilution in OCA1B ranges from obvious to subtle. OCA type II has phenotypes with pigmentary dilution that ranges from minimal to moderate. Pigmented nevi and lentigines may develop if skin is exposed to the sun; some lentigines become large and dark. Eye color varies greatly. In OCA type III, skin is brown, hair is rufous (reddish), and eye color can be blue or brown. In OCA type IV, the phenotype is similar to that for type II. In OCA type V, skin is white, and hair is golden-colored. In OCA type VI, skin can be white, and hair can be light at birth and may darken with age. In OCA type VII, skin pigment is decreased, and hair can range from white to brown. In OCA type VIII, skin and hair are mildly hypopigmented. Patients with ocular involvement may have decreased retinal pigmentation, leading to sensitivity to light and light avoidance. In addition, Nystagmus , 