neurologic disorders
Polyneuropathy
Key Points
Suspect polyneuropathy if patients have diffuse sensory deficits, weakness without hyperreflexia, or both. Use clinical findings, particularly time course and progression and distribution of sensory and/or motor deficits, to classify polyneuropathies and identify possible causes. Do electromyography and nerve conduction studies in all patients with polyneuropathy and tailor laboratory evaluation to possible causes. Treat the cause of polyneuropathy. Give immune–system modifying treatments (IVIG, plasma exchange, corticosteroids, antimetabolites) to treat myelin dysfunction polyneuropathies. Treat neuropathic pain with tricyclic antidepressants or antiseizure drugs; minimize disability by providing physical and occupational therapy. 