pediatrics
Congenital and Perinatal Cytomegalovirus Infection (CMV)
Key Points
Cytomegalovirus (CMV) is the most common congenital viral infection and may be asymptomatic or symptomatic. Multiple organs can be affected, and risk of premature birth increases. Distinguish symptomatic congenital CMV infection from other congenital infections (eg, toxoplasmosis, rubella, lymphocytic choriomeningitis virus, syphilis) using polymerase chain reaction (PCR) testing or viral culture. IVgancicloviror oralvalganciclovirmay help prevent hearing loss and developmental delay in infants with symptomatic infection. 