dermatologic disorders
Erythema Multiforme
Key Points
Erythema multiforme is usually triggered by herpes simplex virus (HSV) but can be caused by a drug. Target lesions and lesions on the palms and soles can be relatively specific findings. Biopsy is rarely necessary. Treat erythema multiforme supportively and consider prophylactic antiviral drugs if HSV is the suspected cause and recurrences are frequent. 