genitourinary disorders
Rapidly Progressive Glomerulonephritis (RPGN)
Key Points
Consider rapidly progressive glomerulonephritis if patients have acute kidney injury with hematuria and dysmorphic RBCs or RBC casts, particularly with subacute constitutional or nonspecific symptoms (eg, fatigue, fever, anorexia, arthralgia, abdominal pain). Evaluate with serologic tests and early renal biopsy. Initiate treatment early, with corticosteroids,cyclophosphamide, and in some cases plasma exchange. Consider kidney transplantation after disease activity is controlled. 