kidney and urinary tract disorders
Liddle Syndrome
Introduction
Liddle syndrome is a rare hereditary disorder in which the collecting tubules of the kidneys excrete potassium but retain too much sodium and water, leading to high blood pressure. (See also Introduction to Disorders of Kidney Tubules .) The gene that causes Liddle syndrome is dominant, meaning that children of a person with the disorder have a 50% chance of inheriting the defective gene. Liddle syndrome does not always cause symptoms. When it does, symptoms such as high blood pressure often begin during childhood or young adulthood. People also have low levels of potassium and high levels of bicarbonate in the blood. 