genitourinary disorders
Renal Artery Stenosis and Occlusion
Etiology of Renal Artery Stenosis and Occlusion
Occlusion may be acute or chronic. Acute occlusion is usually unilateral. Chronic occlusion may be unilateral or bilateral. The most common cause is thromboembolism. Emboli may originate in the heart (due to Atrial Fibrillation , after Rapid, total occlusion of large renal arteries for 30 to 60 minutes results in infarction. The infarct is typically wedge-shaped, radiating outward from the affected vessel. About 90% of cases are due to Atherosclerosis , which is usually bilateral. Almost 10% of cases are due to 45 (more often men) and usually affects the aortic orifice or proximal segment of the renal artery. Chronic progressive stenosis tends to become clinically evident after about 10 years of atherosclerosis, causing renal atrophy and Chronic Kidney Disease . FMD is pathologic thickening of the arterial wall, most often of the distal main renal artery or the intrarenal branches. The thickening tends to be irregular and can involve any layer (but most often the media). This disorder develops primarily in younger adults, particularly in women aged 20 to 50. It is more common among 1st-degree relatives of patients with FMD and among people with theACE1gene. 