endocrine and metabolic disorders
Addison Disease
Key Points
Addison disease is primary adrenal insufficiency. Weakness, fatigue, and hyperpigmentation (generalized tanning or focal black spots involving skin and mucous membranes) are typical. Low serum sodium, high serum potassium, and high BUN (bloodureanitrogen) occur. Usually, plasma ACTH is high and serum cortisol levels are low. Replacement doses ofhydrocortisoneandfludrocortisoneare given; doses should be increased during intercurrent illness. 