immunology allergic disorders
Leukocyte Adhesion Deficiency
Symptoms and Signs of Leukocyte Adhesion Deficiency
Manifestations of leukocyte adhesion deficiency usually begin in infancy. Severely affected infants have recurrent or progressive necrotic soft-tissue infections with staphylococcal and gram-negative bacteria, periodontitis, poor wound healing, no pus formation, leukocytosis, and delayed (>3 weeks) umbilical cord detachment. WBC counts remain high even between infections. Infections become increasingly difficult to control. Less severely affected infants have few serious infections and mild alterations in blood counts. Developmental delay is common in type 2. 