special subjects
Zinc Supplements
Drug Interactions
The absorption and effect of certain antibiotics (eg,cephalexin, tetracyclines, quinolones) may be diminished by the oral zinc supplements; therefore, zinc should be taken at least 2 hours before or 4 to 6 hours after the antibiotic. Zinc may stimulate tumor cell production of metallothionein, which may inactivatecisplatin, chelate integrase inhibitors (dolutegravir), and also decreasepenicillaminelevels by forming an insoluble complex. 