infectious diseases
Fluoroquinolones
Pharmacokinetics
Oral absorption is diminished by coadministration of polyvalent cations (aluminum, magnesium, calcium, zinc, and iron preparations). After oral and parenteral administration, fluoroquinolones are widely distributed in most extracellular and intracellular fluids and are concentrated in the prostate, lungs, and bile. Most fluoroquinolones are metabolized in the liver and excreted in urine, reaching high levels in urine.Moxifloxacinis eliminated primarily in bile. 