special subjects
Glucosamine
Evidence
 sulfate from Rotta Research Laboratorium for treatment of mild-to-moderate osteoarthritis of the knee when given for at least 6 months ( References ). Other formulations still need to be rigorously evaluated. The role of hydrochloride (500 mg 3 times a day) did not reduce pain effectively in the all-patient group. However, an exploratory analysis found pain relief with combination therapy in a subgroup of patients with moderate-to-severe knee pain ( References ). Overall, although studies have reported that the combination of 