hematology and oncology
Prothrombin (Factor II) 20210 Gene Mutation
Introduction
A genetic mutation causes increased plasma levels of prothrombin (factor II), predisposing to venous thrombosis. (See also Overview of Thrombotic Disorders .) generation) and increases the risk of Deep Venous Thrombosis (DVT) (VTE). The prevalence of the mutation ranges from < 1% to 4%, depending on the population studied ( General reference ). The mutation is very rare in individuals of Asian or African descent ( The diagnosis is made by genetic analysis of the prothrombin 20210 gene using blood samples. 