genitourinary disorders
Analgesic Nephropathy
Introduction
Analgesic nephropathy is chronic tubulointerstitial nephritis caused by cumulative lifetime use of large amounts (eg,≥2 kg) of certain analgesics. Patients present with kidney injury and usually non-nephrotic proteinuria and bland urinary sediment or sterile pyuria. Hypertension, anemia, and impaired urinary concentration occur as renal insufficiency develops. Papillary necrosis occurs late. Diagnosis is based on a history of analgesic use and results of noncontrast CT. Treatment is stopping the causative analgesic. (See also Overview of Tubulointerstitial Diseases .) Analgesic nephropathy, a type of Chronic tubulointerstitial nephritis , was originally described in conjunction with overuse of combination analgesics containing phenacetin (typically with 