musculoskeletal and connective tissue disorders
Primary Malignant Bone Tumors
Malignant giant cell tumor
Malignant giant cell tumor, which is rare, is usually located at the extreme end of a long bone. X-ray reveals classic features of malignant destruction (predominantly lytic destruction, cortical destruction, soft tissue extension, and pathologic fracture). A malignant giant cell tumor that develops in a previously benign giant cell tumor is characteristically radioresistant. MRI and biopsy are done. Treatment of malignant giant cell tumor is similar to that of Osteosarcoma (osteogenic sarcoma) , but the cure rate is low. 