hematology and oncology
Paraneoplastic Syndromes
Gastrointestinal paraneoplastic syndromes
Watery diarrhea with subsequent dehydration and electrolyte imbalances may result from tumor-related secretion of prostaglandins or vasoactive intestinal peptide. Implicated tumors include pancreatic islet cell tumors ( Gastrinoma ) and others. Overview of Carcinoid Tumors produce serotonin degradation products that lead to flushing, diarrhea, and breathing difficulty. Protein-losing enteropathies may result from tumor mass inflammation, particularly with lymphomas. 