gastrointestinal disorders
Gastrointestinal Stromal Tumors (GISTs)
Treatment of GISTs
Surgical removal Treatment of GISTs is surgical removal. Patients with metastatic disease (most commonly to the liver) may also be candidates for surgery depending on the degree of liver involvement, tumor size, and surgical resectability. can be used when tumors are positive for the KIT protein CD117; it is effective for patients with unresectable and/or metastatic malignant GISTs and also as adjuvant treatment following resection in adults ( Treatment reference ). Avapritinib, another tyrosine kinase inhibitor, should be used as first-line therapy for patients with a platelet-derived growth factor receptor alpha (PDGFRA) exon 18 mutation, including PDGFRA D842V mutations. 