gynecology and obstetrics
Recurrent Pregnancy Loss
Diagnosis of Recurrent Pregnancy Loss
Clinical evaluation Tests to identify the cause The diagnosis of recurrent pregnancy loss is clinical, based on history of 2 or 3 prior spontaneous abortions. Evaluation for recurrent pregnancy loss should include the following to help determine the cause: Preconception or Prenatal Carrier Testing of Parents (karyotyping) of both parents and any products of conception as clinically indicated to exclude possible genetic causes Screening for acquired thrombotic disorders: Anticardiolipin antibodies (IgG and IgM), anti-beta2 glycoprotein I (IgG and IgM), and lupus anticoagulant Thyroid-stimulating hormone Diabetes testing Hysterosalpingography or sonohysterography to check for structural uterine abnormalities Cause cannot be determined in up to 50% of women. Screening for hereditary thrombotic disorders is not routinely recommended unless supervised by a maternal-fetal medicine specialist. 