eye disorders
Hereditary Optic Neuropathies
Leber hereditary optic neuropathy
Leber hereditary optic neuropathy involves a Mitochondrial Oxidative Phosphorylation Disorders that affects cellular respiration. Although mitochondrial DNA throughout the body is affected, vision loss is the primary manifestation. Most cases (80 to 90%) occur in males. The disease is inherited with a maternal inheritance pattern, meaning that all offspring of a woman with the abnormality inherit the abnormality, but only females can pass on the abnormality because the zygote receives mitochondria only from the mother. 