hormonal and metabolic disorders
Acidosis
Causes of Acidosis
Acidosis is categorized depending on its primary cause as Metabolic Respiratory Metabolic acidosis develops when the amount of acid in the body is increased through ingestion of a substance that is, or can be broken down (metabolized) to, an acid—such as wood alcohol (methanol), antifreeze (ethylene glycol), or large doses ofaspirin(acetylsalicylic acid). Many other medications and poisons can cause acidosis. Metabolic acidosis can also occur as a result of abnormal metabolism. The body produces excess acid in the advanced stages of Shock (lactic acidosis) and in poorly controlled type 1 diabetes mellitus ( Even the production of normal amounts of acid may lead to acidosis when the kidneys are not functioning normally ( Overview of Kidney Failure ) and are therefore not able to excrete sufficient amounts of acid in the urine. Metabolic acidosis also develops when the body loses too much base. For example, bicarbonate can be lost through the digestive tract due to diarrhea. Respiratory acidosis develops when the lungs do not expel carbon dioxide adequately (inadequate ventilation), a problem that can occur in disorders that severely affect the lungs (such as Chronic Obstructive Pulmonary Disease (COPD) [COPD], severe Respiratory acidosis can also develop when disorders of the brain or of the nerves or muscles of the chest (such as Guillain-Barré Syndrome (GBS) or Sleep-disordered breathing (for example, Sleep Apnea ) can repeatedly pause breathing long enough to cause temporary respiratory acidosis. 