hematology and oncology
Hemophagocytic Lymphohistiocytosis (HLH)
Key Points
Hemophagocytic lymphohistiocytosis (HLH) is an uncommon rare disorder and usually affects infants < 18 months. HLH can be familial (inherited) or acquired. Diagnose HLH if the patient has at least 5 of 8 published diagnostic criteria or if the patient has a known mutation associated with HLH. Treat with chemotherapy, cytokine inhibitors, immune suppression, and sometimes hematopoietic stem cell transplantation. 