bone, joint, and muscle disorders
Joint Tumors
Tenosynovial giant cell tumor
Tenosynovial giant cell tumor (also known as pigmented villonodular synovitis [PVNS]) causes the lining of the joint to become swollen and grow. This growth harms the cartilage and bone around the joint. The lining also produces extra fluid that can cause pain and swelling. The process often causes bloody fluid in the joint. Tenosynovial giant cell tumor usually affects one joint. The treatment is usually surgical, but recurrences are not infrequent.Pexidartinib, a drug taken by mouth, is used to diminish the tumor's growth, but only if symptoms are severe and not relieved by surgery.Pexidartinibis available in the United States only in cancer centers through the manufacturer's Risk Evaluation and Mitigation Strategy Program. The drug can cause serious and potentially fatal liver injury in some people. A total joint replacement may be needed if the condition returns after treatment. On rare occasions after several synovectomies, Radiation Therapy for Cancer is sometimes given. 