eye disorders
Uveitis Caused by Connective Tissue Disease
Vogt Koyanagi Harada (VKH) disease
Vogt-Koyanagi-Harada disease is an uncommon systemic disorder characterized by uveitis accompanied by cutaneous and neurologic abnormalities. VKH disease is particularly common among people of Asian, Asian Indian, American Indian, and Hispanic descent. Women in their 20s and 30s are affected more often than men. The etiology is unknown, although an autoimmune reaction directed against melanin-containing cells in the uveal tract, skin, inner ear, and meninges is strongly suspected. Neurologic symptoms tend to occur early and include tinnitus, dysacusis (auditory agnosia), vertigo, headache, and meningismus. Cutaneous findings frequently occur later and include patchy vitiligo (especially common on the eyelids, low back, and buttocks), poliosis (a localized patch of white hair, which may involve the eyelashes), and alopecia, often involving the head and neck. Common findings include serous Retinal Detachment , optic disk edema, and choroiditis. Long-term complications include Early treatment includes local and systemic corticosteroids and a cycloplegic-mydriatic drug. Many patients also require noncorticosteroid immunosuppressive drugs (eg,methotrexate,mycophenolatemofetil). 