pediatrics
Retinoblastoma
Prognosis for Retinoblastoma
 90% of patients can be cured. Prognosis for patients with metastatic disease is poor ( Prognosis reference ). In patients with hereditary retinoblastoma, incidence of second cancers is increased; about 50% arise within the irradiated area. These cancers can include sarcomas and malignant melanoma. About 70% of patients who will develop a second cancer develop it within 30 years of the primary retinoblastoma. 1.Dunkel IJ, Piao J, Chantada GL, et al: Intensive multimodality therapy for extraocular retinoblastoma: A Children's Oncology Group trial (ARET0321).J Clin Oncol40(33):3839–3847, 2022. doi: 10.1200/JCO.21.02337 