infectious diseases
Mucormycosis
Diagnosis of Mucormycosis
Examination of tissue samples for broad, ribbon-like, nonseptate hyphae Culture Diagnosis of mucormycosis requires a high index of suspicion and examination of tissue samples for large nonseptate hyphae with irregular diameters and right-angle branching patterns; the examination must be thorough because much of the necrotic debris contains no organisms. For unclear reasons, cultures may be negative, even when hyphae are clearly visible in tissues. Microbial cell-free DNA next-generation sequencing of blood samples may be useful in diagnosis. CT scans and x-rays often underestimate or miss significant bone destruction. 