immunology allergic disorders
Hyper IgE Syndrome
Diagnosis of Hyper IgE Syndrome
Serum IgE levels Diagnosis of hyper-IgE syndrome is suspected based on symptoms and confirmed by serum IgE levels>2000 IU/mL (>4800 mcg/L). Genetic testing can identify the gene mutations and is done mainly to confirm the diagnosis or to help predict inheritance patterns. Close family members of patients with clinical symptoms consistent with hyper-IgE syndrome should be screened with an IgE level and possibly evaluated further if IgE levels are positive. 