psychiatric disorders
Borderline Personality Disorder (BPD)
Etiology of Borderline Personality Disorder
Stresses during early childhood may contribute to the development of borderline personality disorder. A childhood history of physical and sexual abuse, neglect, separation from caregivers, and/or loss of a parent is common among patients with borderline personality disorder. Certain people may have a genetic tendency to have pathologic responses to environmental life stresses, and borderline personality disorder clearly appears to have a heritable component. First-degree relatives of patients with borderline personality disorder are 5 times more likely to have the disorder than the general population ( Etiology references ). Disturbances in regulatory functions of the brain and neuropeptide systems may also contribute but are not present in all patients with borderline personality disorder ( Etiology references ). 1. American Psychiatric Association:Diagnostic and Statistical Manual of Mental Disorders, 5th ed, Text Revision (DSM-5-TR). Washington, DC, American Psychiatric Association, 2022, pp 755. 2.Stanley B, Siever LJ: The interpersonal dimension of borderline personality disorder: Toward a neuropeptide model.Am J Psychiatry167(1):24-39, 2010. doi: 10.1176/appi.ajp.2009.09050744 