infectious diseases
Antifungal Medications
Flucytosine
 is used primarily to treat Cryptococcosis but is also valuable for some cases of disseminated Majoradverse effectsofflucytosineare bone marrow suppression (thrombocytopenia and leukopenia), hepatotoxicity, and enterocolitis; the degree of bone marrow suppression is proportional to serum levels. Becauseflucytosineis cleared primarily by the kidneys, blood levels rise if nephrotoxicity develops during concomitant use withamphotericin B, particularly whenamphotericin Bis used in doses>0.4 mg/kg/day.Flucytosineserum levels should be monitored, and the dosage should be adjusted to keep levels between 40 and 90 mcg/mL. Complete blood count and renal and liver tests should be done twice/week. If blood levels are unavailable, therapy is begun at 25 mg/kg 4 times a day, and dosage is decreased if renal function deteriorates. 