special subjects
Milk Thistle
Evidence
 in 915 patients with alcoholic and/or hepatitis B or C virus liver diseases ( References ). Data from this analysis determined that intervention had no significant effect on all-cause mortality, complications of liver disease, or liver histology. When all trials were included in the analysis, liver-related mortality was significantly reduced; however, in an analysis limited to high-quality studies, this reduction was not significant. for hepatitis C reported that, although well tolerated, it does not provide overall benefit ( References ). In vitro, silymarin increases levels of intrahepatic glutathione, an antioxidant important for detoxification ( significantly decreased fasting glucose by 37.9 mg/dL (2.1 mmol/L) and hemoglobin A1C by 1.4% ( References ). A 2020 meta-analysis of 16 studies (1358 subjects) reported that In case reports, 2 cases of Amanita mushroom ingestion poisoning ( References ) showed favorable results after treatment with silybin. 