hematology and oncology
Disseminated Intravascular Coagulation (DIC)
Pathophysiology of Disseminated Intravascular Coagulation
 primarily causes venous thromboembolic manifestations (eg, Deep Venous Thrombosis (DVT) , Severe, rapidly evolving DIC,in contrast, causes thrombocytopenia, depletion of plasma coagulation factors and fibrinogen, and bleeding. Bleeding into organs, along with microvascular thromboses, may cause dysfunction and failure in multiple organs. Delayed dissolution of fibrin polymers by fibrinolysis may result in the mechanical disruption of red blood cells, producing schistocytes and mild intravascular hemolysis. 