genitourinary disorders
Immunoglobulin A Nephropathy
Key Points
IgA nephropathy is the most common cause of glomerulonephritis worldwide and is common among young adults and White and Asian people. Consider the diagnosis in patients with unexplained signs of glomerulonephritis, particularly when it occurs within 2 days of a febrile mucosal illness or with flank pain. Treat patients who have creatinine>1.2 mg/dL (106.08 micromol/L) or proteinuria>300 mg/day with ACE inhibitors or ARBs, and subsequently SGLT2 inhibitors if proteinuria persists. Reserve corticosteroids for patients with worsening renal function or proteinuria (>1 g/day) despite treatment with an ACE inhibitor or ARB plus an SGLT2 inhibitor. Treat patients who have proliferative injury or rapidly progressive glomerulonephritis with corticosteroids andcyclophosphamide. 