liver and gallbladder disorders
IgG4 Related Sclerosing Cholangitis
Introduction
IgG4-related sclerosing cholangitis (IgG4-SC) causes symptoms similar to those of primary sclerosing cholangitis: inflammation, fibrosis, and narrowing of the bile ducts within and outside the liver, then eventual blockage and destruction of those ducts. Cirrhosis and liver failure may develop. (See also Overview of Gallbladder and Bile Duct Disorders .) IgG4-related sclerosing cholangitis (IgG4-SC) resembles but is different from Primary Sclerosing Cholangitis (PSC) in that it is the result of an abnormally regulated immune system ( This rare disorder primarily affects males in their 60s and 70s. Most people with it also have another immune-mediated condition called autoimmune pancreatitis. 