injuries poisoning
Aspirin and Other Salicylate Poisoning
Key Points
Salicylate poisoning causes respiratory alkalosis and, by an independent mechanism, metabolic acidosis. Consider salicylate toxicity in patients with nonspecific findings (eg, alteration in mental status, metabolic acidosis, noncardiogenic pulmonary edema, fever), even when a history of ingestion is lacking. Estimate the severity of toxicity by the salicylate level and ABGs. Treat with activatedcharcoaland alkaline diuresis with extra KCl. Consider hemodialysis if poisoning is severe. 