genitourinary disorders
Membranous Nephropathy
Key Points
Membranous nephropathy is usually idiopathic; however, patients may have treatable associated disorders, such as cancers, autoimmune disorders, or infections. Initial manifestations are typically those of nephrotic syndrome (eg, edema, nephrotic-range proteinuria, occasionally microscopic hematuria and hypertension). Confirm the diagnosis with renal biopsy and consider associated disorders and causes. Treat symptoms of nephrotic syndrome and treat hypertension initially with angiotensin inhibition. Consider immunosuppressive therapy only for patients with idiopathic membranous nephropathy who are at risk for progression. 