musculoskeletal and connective tissue disorders
Eosinophilic Fasciitis
Diagnosis of Eosinophilic Fasciitis
Biopsy Eosinophilic fasciitis should be suspected in patients with typical symptoms. The cutaneous manifestations may suggest Diagnosis ; however, patients with systemic sclerosis usually also have distal skin involvement often with telangiectasia, Diagnosis of eosinophilic fasciitis is confirmed by biopsy, which should be deep enough to include fascia and adjacent muscle fibers. Characteristic findings are inflammation of the fascia, with or without eosinophils. Blood tests are not diagnostic, but a complete blood count (CBC) usually shows Eosinophilia (in early active disease), and serum protein electrophoresis shows polyclonal hypergammaglobulinemia in about one third of patients. However, most of these patients have low risk 1.Mazori DR, Kassamali B, Min MS, et al: Characteristics and outcomes of eosinophilic fasciitis-associated monoclonal gammopathy.JAMA Dermatol157(12):1508-1509, 2021. doi:10.1001/jamadermatol.2021.4302 