drugs
Drug Elimination
Introduction
Drug elimination is the removal of drugs from the body. (See also Introduction to Administration and Kinetics of Drugs .) All drugs are eventually eliminated from the body. They may be eliminated after being chemically altered ( Drug Metabolism ), or they may be eliminated intact. Most drugs, particularly water-soluble drugs and their metabolites, are eliminated largely by the kidneys in urine. Therefore, drug dosing depends largely on kidney function. Some drugs are eliminated by excretion in the bile (a greenish yellow fluid secreted by the liver and stored in the gallbladder). 