hormonal and metabolic disorders
ArginineVasopressin Deficiency (Central Diabetes Insipidus)
Treatment ofArginineVasopressinDeficiency
Desmopressin Desmopressin(a longer acting form ofvasopressin) may be taken as a nasal spray twice a day or sometimes as a tablet or as an injection under the skin or into a vein (intravenously). The dose is adjusted to maintain the body's water balance and a normal urine output. Taking too muchvasopressincan lead to fluid retention, swelling, and other problems. People with central diabetes insipidus who are undergoing surgery or are unconscious are generally given injections ofvasopressin. Sometimesargininevasopressindeficiency can be controlled with medications that stimulate production ofvasopressin, such as chlorpropamide,carbamazepine, clofibrate, and thiazide diuretics. These medications are unlikely to relieve symptoms completely in people whoseargininevasopressindeficiency is severe. 