eye disorders
Inflammatory Orbital Disease
Treatment of Inflammatory Orbital Disease
Corticosteroids, radiation therapy, and/or immunomodulating drugs Some surgery Treatment for inflammatory orbital pseudotumor depends on the type of inflammatory response and may include oral corticosteroids, radiation therapy, and one of several immunomodulating drugs. In difficult cases of inflammatory orbital pseudotumor, particularly those with granulomatous inflammation, some initial success has occurred with monoclonal antibodies against tumor necrosis factor (TNF)-alpha or with lymphocyte depletion usingrituximab, if the inflammation is primarily vasculitis. -like growth factor 1 (IGF-1) receptor inhibitor, is effective therapy for moderate-to-severe ophthalmopathy ( Treatment reference ). Treatment of concomitant hyperthyroidism includes thionamides, radioiodine, or surgery, However, radioiodine therapy may accelerate progression of ophthalmopathy and is therefore contraindicated in the active phase, which is typically determined by clinical signs and symptoms as indicated by the clinical activity score. Surgical decompression for severe thyroid eye disease may be needed. Surgical thyroidectomy may help resolve or prevent progression of ophthalmopathy. 1.Smith TJ, Kahaly GJ, Ezra DG, et al:Teprotumumabfor thyroid-associated ophthalmopathy.N Engl J Med376:1748-1761, 2017. doi: 10.1056/NEJMoa1614949 