gastrointestinal disorders
Medications for the Treatment of Gastric Acidity
Sucralfate
This medication is a sucrose-aluminum complex that dissociates in stomach acid and forms a physical barrier over an inflamed area, protecting it from acid, pepsin, and bile salts. It also inhibits pepsin-substrate interaction, stimulates mucosal prostaglandin production, and binds bile salts. It has no effect on acid output or gastrin secretion.Sucralfateseems to have trophic effects on the ulcerated mucosa, possibly by binding growth factors and concentrating them at an ulcer site. Systemic absorption ofsucralfateis negligible. Constipation occurs in 3 to 5% of patients.Sucralfatemay bind to other medications and interfere with their absorption. 