genitourinary disorders
Focal Segmental Glomerulosclerosis
Key Points
Suspect focal segmental glomerulosclerosis if patients have nephrotic syndrome, proteinuria, or renal dysfunction with no obvious cause, particularly patients who have disorders or use illicit drugs or medications associated with FSGS. When possible, confirm FSGS by renal biopsy with immunostaining and electron microscopy. Consider treatment with corticosteroids and possibly a calcineurin inhibitor (eg,cyclosporineortacrolimus) or alternatively,mycophenolatemofetil, if FSGS is idiopathic and proteinuria reaches the nephrotic range or renal function worsens. 