infectious diseases
Tigecycline
Pharmacokinetics
Tigecyclineis given IV.Tigecyclinehas a large volume of distribution (>12 L/kg), penetrating well into bone, lung, liver, and kidney tissues. However, because of its extensive distribution into tissue, blood levels are low, sotigecyclineis probably not a good choice for patients with bacteremia especially those with intravascular sources of infection. Most of the drug is excreted in bile and feces. No dosing adjustment is required in patients who have renal insufficiency. 