pediatrics
PFAPA Syndrome
Diagnosis of PFAPA Syndrome
Clinical evaluation Diagnosis of PFAPA syndrome is based on clinical findings, which include the following ( Treatment ): ≥3 febrile episodes, lasting up to 5 days and occurring at regular intervals Pharyngitis plus adenopathy or aphthous ulcers Good health between episodes and normal growth Acute-phase reactants (eg, C-reactive protein, erythrocyte sedimentation rate) are elevated during a febrile episode but not between episodes. Neutropenia or other symptoms (eg, diarrhea, rash, cough) are not present; their presence suggests a different disorder. Specifically, Diagnosis needs to be ruled out. 1.Cantarini L, Vitale A, Sicignano LL, et al: Diagnostic criteria for adult-onset periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome.Front Immunol8:1018, 2017. doi: 10.3389/fimmu.2017.01018 