infectious diseases
Ebola Vaccine
Contraindications and Precautions for Ebola Vaccine
Themain contraindication for all three Ebola vaccinesis Severe allergic reaction (eg, Anaphylaxis ) to any component of the vaccine Precautions for all 3 Ebola vaccinesare Anaphylaxis Thrombocytopenia or any coagulation disorder Anaphylaxis has occurred after administration of these vaccines. After vaccination, people should be observed for at least 15 minutes for early signs of anaphylaxis or anaphylactoid reactions. Appropriate medical treatment and supervision must be available in the event anaphylaxis occurs. The vaccines should be given with caution to people with Thrombocytopenia or any coagulation disorder because bleeding or bruising may occur after the vaccines are given. Themain precaution for rVSV-ZEBOVis Immunocompromise The safety and effectiveness of rVSV-ZEBOV have not been assessed in immunocompromised people. The effectiveness of this vaccine may be diminished in immunocompromised people. The risk of vaccination with rVSV-ZEBOV, a live-virus vaccine, in immunocompromised people should be weighed against the risk of disease due toZaire ebolavirus. Precautions for Ad26.ZEBOV/MVA-BN-Filoare Immunocompromise Acute severe febrile illness or acute infection The safety and immunogenicity of the Ad26.ZEBOV/MVA-BN-Filo vaccine regimen have not been assessed in immunocompromised people, including those receiving immunosuppressive therapy. Immunocompromised people may not respond as well as immunocompetent people to the vaccine regimen. Vaccination with Ad26.ZEBOV/MVA-BN-Filo should be postponed in people who have an acute severe febrile illness or acute infection, unless the benefit of immediate vaccination outweighs the potential risks. The presence of a minor infection, a low-grade fever, or both should not delay vaccination. 