hematology and oncology
Secondary Iron Overload
Symptoms and Signs of Secondary Iron Overload
The clinical consequences of iron overload are the same regardless of the etiology and pathophysiology of the overload. Historically, experts believed that symptoms did not develop until significant organ damage had occurred. However, organ damage is slow and subtle, and fatigue and nonspecific systemic symptoms often occur early. Glucose intolerance or Diabetes Mellitus (DM) is another common initial manifestation. Some patients present with Liver disease is the most common complication and may progress to Cirrhosis . Patients who develop cirrhosis are at increased risk of 