infectious diseases
Mycetoma
Treatment of Mycetoma
Antibacterials or antifungals Surgery in refractory cases (See also Antifungal Medications .) Treatment of mycetoma may be required for>10 years. Death may result from bacterial superinfection and sepsis if treatment is neglected. Treatment depends on the causative agent and the extent of the disease. In infections caused by Treatment , sulfonamides and certain other antibacterials, sometimes in combination, are used. In infections caused by fungi, certain potential causative organisms may be at least partially susceptible toamphotericin Boritraconazole, but some are resistant to all antifungals. Relapses occur after antifungal therapy is stopped in most patients, and many patients do not improve and even worsen during treatment, indicating the often refractory nature of the infection. Surgical debridement is occasionally necessary. Repeated debridement of the diseased tissue, including bone, may be required. Limb amputation to prevent potentially fatal severe secondary bacterial infections may be needed in advanced cases. 