gastrointestinal disorders
Anal Cancer
Treatment of Anal Cancer
Combination chemotherapy and radiation therapy (chemoradiation) Sometimes surgical resection for treatment of refractory disease or recurrence Chemoradiation is the initial therapy in most cases and results in a high rate of cure when used for anal squamous and cloacogenic tumors. Tumor regression continues for up to 6 months after completion of chemoradiation ( Treatment reference ). Observation for a complete response during this time period is acceptable before considering surgery. Abdominoperineal resection is indicated when radiation and chemotherapy do not result in complete regression of the tumor or there is recurrent disease. 1.James RD, Glynne-Jones R, Meadows HM, et al:Mitomycinorcisplatinchemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT II): A randomised, phase 3, open-label, 2 × 2 factorial trial.Lancet Oncol14(6):516–524, 2013. doi: 10.1016/S1470-2045(13)70086-X 