immunology allergic disorders
Leukocyte Adhesion Deficiency
Diagnosis of Leukocyte Adhesion Deficiency
Testing for adhesive glycoproteins on the surface of WBCs Diagnosis of leukocyte adhesion deficiency is by detecting absence or severe deficiency of adhesive glycoproteins on the surface of WBCs using monoclonal antibodies (eg, anti-CD11, anti-CD18) and flow cytometry. Leukocytosis detected by complete blood count is common but nonspecific. Genetic testing is recommended for siblings. 