dermatologic disorders
Kaposi Sarcoma
Classification of Kaposi Sarcoma
This type occurs most often in older (>60 years) men of Mediterranean, Eastern European, or Ashkenazi Jewish ancestry. The course is indolent, and the disease is usually confined to a small number of lesions on the skin of the lower extremities; visceral involvement occurs in<10%. This type is usually not fatal. This type is the most common Cancers Common in Patients with HIV Infection and is more aggressive than classic Kaposi sarcoma. Multiple cutaneous lesions are typically present, often involving the face and trunk. Mucosal, lymph node, and gastrointestinal (GI) involvement is common. Sometimes Kaposi sarcoma is the first manifestation of AIDS. An additional type of Kaposi sarcoma that has been increasingly recognized occurs in men who are HIV-negative and who have sex with men ( Classification reference ). The reasons for increased prevalence in this group is uncertain and remains an area of ongoing investigation. This type occurs in Africa independent of HIV infection. There are 2 main forms: Prepubertal lymphadenopathic form: It predominantly affects children; primary tumors involve lymph nodes, with or without skin lesions. The course is usually fulminant and fatal. Adult form: This form resembles classic Kaposi sarcoma. This type typically develops several years after organ transplantation. The course is more or less fulminant, depending on the degree of immunosuppression. 1.Vangipuram R, Tyring SK: Epidemiology of Kaposi sarcoma: review and description of the nonepidemic variant.Int J Dermatol58(5):538-542, 2019. doi: 10.1111/ijd.14080 