neurologic disorders
Progressive Supranuclear Palsy (PSP)
Introduction
Progressive supranuclear palsy is a rare, degenerative central nervous system disorder that progressively impairs voluntary eye movements and causes bradykinesia, muscular rigidity with progressive axial dystonia, pseudobulbar palsy, and dementia. Diagnosis is clinical. Treatment focuses on relieving symptoms. (See also Overview of Movement and Cerebellar Disorders .) The cause of progressive supranuclear palsy is unknown. Neurons in the basal ganglia and brain stem degenerate; neurofibrillary tangles containing an abnormally phosphorylated tau protein are also present. 