endocrine and metabolic disorders
Hyperphosphatemia
Etiology of Hyperphosphatemia
Theusual cause of hyperphosphatemiais Decrease in renal excretion of phosphate 30 mL/minute) reduces excretion sufficiently to increase serum phosphate. Defects in renal excretion of phosphate in the absence of Chronic Kidney Disease also occur in Hyperphosphatemia occasionally results from a transcellular shift of phosphate into the extracellular space that is so large that the renal excretory capacity is overwhelmed. This transcellular shift occurs most frequently in Diabetic Ketoacidosis (DKA) (despite total body phosphate depletion) Crush injuries Nontraumatic Rhabdomyolysis None Overwhelming systemic infections Tumor Lysis and Cytokine Release Syndromes None Hyperphosphatemia can also occur with excessive oral phosphate administration and occasionally with overzealous use of enemas containing phosphate. Hyperphosphatemia can be spurious in cases of hyperproteinemia (eg, in Multiple Myeloma or 