endocrine and metabolic disorders
Multiple Endocrine Neoplasia, Type 2B (MEN 2B)
Diagnosis of MEN 2B
Serumcalcitoninlevels Plasma free metanephrines and urinary catecholamine levels Neck CT or MRI Pheochromocytoma localization with magnetic resonance imaging (MRI) or computed tomography (CT) Genetic testing MEN 2B is suspected in patients with a family history of MEN 2B, pheochromocytoma, multiple mucosal neuromas, or medullary thyroid carcinoma. Genetic testing is highly accurate and is done to confirm the disorder. Genetic screening also is done to screen 1st-degree relatives and any symptomatic family members of patients with MEN 2B, as in MEN 2A. Diagnosis may be suspected clinically and is confirmed by measuring plasma free metanephrines and urinary catecholamines. Medullary Thyroid Carcinoma with serum MRI or CT is used to search for pheochromocytomas and medullary thyroid carcinoma. 