blood disorders
Chronic Myeloid Leukemia (CML)
Treatment of CML
A tyrosine kinase inhibitor, sometimes with older chemotherapy drugs Sometimes stem cell transplantation The drugsimatinib,nilotinib,dasatinib,bosutinib, andponatinibare called tyrosine kinase inhibitors (TKIs). These drugs block the abnormal protein tyrosine kinase produced by the Philadelphia chromosome and have changed the treatment and prognosis of CML. TKIs are effective and usually cause only minor side effects. How long treatment with TKIs needs to continue and whether stopping treatment during a remission is safe is not yet known. TKIs combined with chemotherapy drugs are now showing success in treating people during the blast phase, which previously resulted in death within a few months. Stem Cell Transplantation combined with high-dose chemotherapy may result in a cure in people who do not respond to other therapy. 