musculoskeletal and connective tissue disorders
Sjögren Syndrome
Key Points
Suspect Sjögren syndrome if patients have gritty or dry eyes or dry mouth, enlarged salivary glands, peripheral neuropathy, purpura, or unexplained renal tubular acidosis. Confirm the diagnosis usually by specific clinical criteria. Treat sicca symptoms symptomatically (eg, with topical lubricants) and avoid drying factors, particularly drugs that decrease salivary gland function. If patients have severe disease (eg, severe vasculitis or visceral involvement), treat with corticosteroids and sometimes other immunosuppressants (eg,rituximab). 