injuries poisoning
Organophosphate Poisoning and Carbamate Poisoning
Pathophysiology
Organophosphates and carbamates are absorbed through the gastrointestinal tract, lungs, and skin. They inhibit plasma and red blood cell (RBC) cholinesterase, preventing breakdown of acetylcholine, which then accumulates in synapses. Carbamates are cleared spontaneously within about 48 hours after exposure. Organophosphates, however, can irreversibly bind to cholinesterase. 