infectious diseases
Diphtheria Tetanus Pertussis Vaccine
Contraindications and Precautions for Diphtheria Tetanus Pertussis Vaccine
Contraindicationsfor DTaP and Tdap are A severe allergic reaction (eg, Anaphylaxis ) after a previous dose or to a vaccine component For the pertussis component: Encephalopathy (eg, coma, decreased level of consciousness, prolonged seizures) that occurred within 7 days of a previous dose of DTaP or Tdap and that is not attributable to another identifiable cause Because tetanus vaccination is important, people who have had an anaphylactic reaction to components in DTaP or Tdap should be referred to an allergist to determine whether they are allergic to tetanus toxoid. If not, they can be vaccinated with tetanus toxoid (TT) vaccine. Adults with a history of encephalopathy can be vaccinated with tetanus-diphtheria, and children can be given diphtheria-tetanus (DT) instead of Tdap. Precautionsvary depending on the formulation. For DTaP and Tdap, they include Moderate or severe acute illness with or without fever (vaccination is postponed until illness resolves if possible) Guillain-Barré Syndrome (GBS) within 6 weeks after a previous dose to a vaccine containing tetanus toxoid For the pertussis component only: A progressive or unstable neurologic disorder, uncontrolled seizures, or progressive encephalopathy (vaccination is postponed until a treatment regimen is established and the disorder is stabilized) For DTaP only, precautions include A seizure, with or without fever, within 3 days after a previous dose of DTaP ≥ 3 hours of persistent, severe, inconsolable screaming or crying within 48 hours after a previous dose of DTaP Collapse or shock-like state (hypotonic hyporesponsive episode) within 48 hours after a previous dose of DTaP Temperature of ≥ 40.5° C, unexplained by another cause, within 48 hours after a previous dose of DTaP For Tdap only, precautions include History of Type III after a previous dose of a vaccine containing tetanus or diphtheria toxoid (vaccination is postponed ≥ 10 years since the last dose of tetanus toxoid-containing vaccine) 