hematology and oncology
Stomatocytosis and Anemia Caused by Hypophosphatemia
Stomatocytosis
Stomatocytosis is a rare condition of red blood cells (RBCs) in which a mouthlike or slitlike pattern replaces the normal central zone of pallor. Stomatocytosis may be Congenital Acquired Both congenital and acquired stomatocytosis may be asymptomatic or cause hemolysis. Symptoms, if present, result mainly from the anemia. which shows autosomal dominant inheritance, is rare. It can cause a severe Overview of Hemolytic Anemia presenting very early in life. The RBC membrane is hyperpermeable to monovalent cations (sodium and potassium); movement of divalent cations and anions is normal. The percentage of stomatocytes varies and RBC fragility is increased, as is autohemolysis with inconstant correction with glucose. Splenectomy ameliorates anemia in some cases. Acquired stomatocytosiswith hemolytic anemia occurs primarily with recent excessive alcohol ingestion. Stomatocytes in the peripheral blood and hemolysis disappear within 2 weeks of alcohol withdrawal. 