gastrointestinal disorders
Helicobacter pylori Infection
Pathophysiology ofH. pyloriInfection
Effects ofH. pyloriinfection vary depending on the location within the stomach. results in increased gastrin production, probably via local impairment of somatostatin release. Resultant hypersecretion of acid predisposes to prepyloric and Peptic Ulcer Disease . acid production, possibly via increased local production of interleukin-1 beta. Patients with body-predominant infection are predisposed to Peptic Ulcer Disease and Some patients have mixed infection of both antrum and body with varying clinical effects. Many patients withH. pyloriinfection have no noticeable clinical effects. Ammonia produced byH. pylorienables the organism to survive in the acidic environment of the stomach and may erode the mucus barrier. Cytotoxins and mucolytic enzymes (eg, bacterial protease, lipase) produced byH. pylorimay play a role in mucosal damage and subsequent ulcerogenesis. is a group 1 carcinogen ( Pathophysiology reference ). 1.American Cancer Society: Known and probable human carcinogens. 2022. Accessed 1/20/23. 