pediatrics
Purine Nucleotide Synthesis Disorders
Introduction
Purines are key components of cellular energy systems (eg, ATP, NAD), signaling (eg, GTP, cAMP, cGMP), and, along with pyrimidines, RNA and DNA production. Purines may be synthesized de novo or recycled by a salvage pathway from normal catabolism. The end product of complete catabolism of purines is uric acid. In addition to purine nucleotide synthesis disorders, purine metabolism disorders (see also table Purine Metabolism Disorders ) include Purine Catabolism Disorders None Purine Salvage Disorders None Also see Approach to the Patient With a Suspected Inherited Disorder of Metabolism and 