pulmonary disorders
Alpha 1 Antitrypsin Deficiency
Symptoms and Signs of Alpha 1 Antitrypsin Deficiency
Neonates with hepatic involvement present with cholestatic jaundice and hepatomegaly during the first week of life; jaundice usually resolves by 2 to 4 months of age. Cirrhosis may develop in childhood or adulthood (symptoms and signs of Symptoms and Signs and Severity of pulmonary disease varies greatly depending on phenotype, smoking status, and other factors. Pulmonary function is well preserved in some PI*ZZ smokers and can be severely impaired in some PI*ZZ nonsmokers. PI*ZZ people identified in population surveys (ie, those without symptoms or pulmonary disease) tend to have better pulmonary function, whether they smoke or not, than do index people (those identified because they have pulmonary disease). Airflow obstruction occurs more frequently in men and in people with Asthma , recurrent respiratory infections, occupational dust exposure, and a family history of pulmonary disease. Panniculitis , an inflammatory disorder of subcutaneous soft tissue, manifests as indurated, tender, discolored plaques or nodules, typically on the lower abdomen, buttocks, and thighs. 