genitourinary disorders
Renal Tubular Acidosis
Type 1 (distal) RTA
15 mEq/L (15 mmol/L), and Hypokalemia , hypercalciuria, and decreased citrate excretion are often present. Hypercalciuria is the primary abnormality in some familial cases, with calcium-induced tubulointerstitial damage causing distal RTA. Nephrocalcinosis and This syndrome is rare. Sporadic cases occur most often in adults and may be primary (nearly always in women) or secondary. Familial cases usually first manifest in childhood and are most often autosomal dominant. Secondary type 1 RTA may result from drugs, Kidney Transplantation , or various disorders: Autoimmune disease with hypergammaglobulinemia, particularly Sjögren Syndrome or Kidney Transplantation None Nephrocalcinosis Medullary Sponge Kidney None Chronic Obstructive Uropathy None Drugs (mainlyamphotericin B,ifosfamide, andlithium) Cirrhosis None Sickle Cell Disease None Potassium level may be high in patients with chronic obstructive uropathy or sickle cell anemia. 