infectious diseases
Monobactams
Introduction
Monobactams are parenteral Beta-Lactams bactericidal Aztreonamis currently the only available monobactam.Aztreonamhas activity similar to that ofceftazidimeagainst Enterobacterales that do not produce AmpC beta-lactamase, extended-spectrum beta-lactamase (ESBL), orKlebsiella pneumoniaecarbapenemase (KPC) Pseudomonas and Related Infections None (in contrast to Cephalosporins ). is used mainly for severe aerobic gram-negative bacillary infections (including Acute Bacterial Meningitis ) in patients who have a serious beta-lactam allergy but who nevertheless require beta-lactam therapy. Other antibiotics are added to cover any suspected gram-positive species or anaerobes. The dose ofaztreonamis reduced in renal failure. 