hematology and oncology
Sideroblastic Anemias
Acquired sideroblastic anemia
Most often,acquired sideroblastic anemias are part of a Myelodysplastic Syndrome (MDS) None Somatic mutations in genes involved in RNA splicing, most frequentlySF3B1(splicing factor 3b subunit 1), commonly occur. Acquired sideroblastic anemia occurs in adulthood. Less common causesinclude Deficiency of vitamin B6 (pyridoxine) orcopper(possibly caused by zinc ingestion, which prevents absorption ofcopperin the gastrointestinal tract) Medications (eg,chloramphenicol,cycloserine,isoniazid,linezolid,pyrazinamide) Toxins (includingethanoland lead) Deficient reticulocyte production, intramedullary death of red blood cells (RBCs), and bone marrow erythroid hyperplasia (and dysplasia) occur. Although hypochromic RBCs are produced, other RBCs may be large, producing normocytic or macrocytic indices; if so, variation in RBC size (dimorphism) usually produces a high RBC distribution width (RDW). 