infectious diseases
Cephalosporins
Adverse Effects of Cephalosporins
Significant potential adverse effects of cephalosporins include Overview of Allergic and Atopic Disorders (most common) Clostridioides (formerly Clostridium) difficile–Induced Diarrhea (pseudomembranous colitis) Overview of Leukopenias None Overview of Platelet Disorders None Positive Coombs test (although hemolytic anemia is very uncommon) Hypersensitivity reactions are the most common systemic adverse effects; rash is common, but immediate IgE-mediated urticaria and anaphylaxis are rare. Cross-sensitivity between cephalosporins and penicillins is uncommon; cephalosporins can be given cautiously to patients with a history of delayed hypersensitivity to penicillin if necessary. Pain at the IM injection site and thrombophlebitis after IV use may occur. Cefotetanmay have adisulfiram-like effect whenethanolis ingested, causing nausea and vomiting.Cefotetanmay also elevate the prothrombin time/international normalized ratio (PT/INR) and partial thromboplastin time (PTT), an effect that is reversible with vitamin K. 