special subjects
Melatonin
Drug Interactions
Evidence suggests thatmelatoninmay increase the effects ofwarfarin, increasing the risk of bleeding. Melatoninmay decrease the effects of antiseizure medications and increase the risk of seizures. Melatoninmay enhance the sedative effects of drugs such as benzodiazepines. Melatoninmay increase adverse effects ofmethamphetamine. Fluvoxamine, estrogens, and quinolone antibiotics may increasemelatoninlevels.Carbamazepineandrifampinmay decreasemelatoninlevels. (See also table.) 