musculoskeletal and connective tissue disorders
Immunoglobulin A–Associated Vasculitis (IgAV)
Treatment of IgAV
For adults, primarily symptomatic measures and corticosteroids with or without an immunosuppressant For children, symptomatic treatment for pain control as needed If the cause is a drug, it has to be stopped. Otherwise, treatment is primarily symptomatic. For adults, corticosteroids (eg,prednisone2 mg/kg up to a total of 50 mg orally once a day) may help control abdominal pain and are occasionally needed to treat severe joint pain or renal disease. Pulse IVmethylprednisolonefollowed by oralprednisoneand an immunosuppressant (mycophenolatemofetil,azathioprine,rituximab, orcyclophosphamide) can be given to attempt to control inflammation when the kidneys are severely affected. However, the beneficial effects of corticosteroids on renal manifestations are not clear. Corticosteroids or other immunosuppressants are usually not necessary for children. 