dermatologic disorders
Vitiligo
Diagnosis of Vitiligo
Clinical evaluation Depigmented skin is typically obvious on examination, especially in darker-skinned people. Subtle hypopigmented or depigmented lesions are accentuated under a Wood Light (365 nm), which shows the chalk-white appearance of depigmented skin. Differential diagnosis includes postinflammatory hypopigmentation, piebaldism (a rare autosomal dominant disorder in which depigmented patches surrounded by hyperpigmented areas occur most often on the forehead, neck, anterior trunk, and mid-extremities), morphea (localized scleroderma, in which skin is usually sclerotic), Leprosy (in which lesions are usually hypoesthetic), Although there are no evidence-based guidelines, it is reasonable for physicians to test for complete blood count, fasting blood glucose, thyroid function, and antithyroid peroxidase antibodies (frequently present in Hashimoto thyroiditis) as clinically indicated by review of systems. 