pediatrics
Kawasaki Disease
Prognosis for Kawasaki Disease
With adequate therapy, mortality in the United States is 0.17%. Long duration of fever increases cardiac risk. Deaths most commonly result from cardiac complications and can be sudden and unpredictable:>50% occur within 1 month of onset, 75% within 2 months, and 95% within 6 months but may occur as long as 10 years later. Effective therapy reduces acute symptoms and, more importantly, lowers the incidence of coronary artery aneurysms from 20% to<5%. In the absence of coronary artery disease, the prognosis for complete recovery is excellent. About two thirds of coronary aneurysms regress within 1 year, although it is unknown whether residual coronary stenosis remains. Giant coronary aneurysms are less likely to regress and require more intensive follow-up and therapy. 