dermatologic disorders
Epidermolysis Bullosa
Introduction
Epidermolysis bullosa is a group of 4 very rare genetic diseases and their subtypes. Epithelial fragility and easy blistering of skin and mucous membranes usually manifest at birth or in infancy. Disease phenotypes vary from mild to life-threatening. Diagnosis is by skin biopsy with immunofluorescence testing or transmission electron microscopy, and gene analysis. Treatment is supportive, and specialized multidisciplinary participation is required for severe cases. Epidermolysis bullosa occurs in 20/million live births. There is no gender predilection. Occasionally, epidermolysis bullosa is not recognized until adolescence or early adulthood. Epidermolysis bullosa is a group of inherited disorders that involve various genetic mutations. Autoantibodies contribute. This group of disorders is distinct from Epidermolysis Bullosa Acquisita , which is thought to be an autoimmune disease but is not inherited. 