special subjects
Kava
Drug Interactions
Kava may prolong the effect of other sedatives (eg, barbiturates, benzodiazepines), which could affect driving or other activities requiring alertness. Kava may interfere with the effects ofdopamine. As a result, it may decrease the benefit oflevodopa. Kava also has inhibited metabolism ofropinirole, a Parkinson disease medication, resulting in dopaminergic toxicity. Thus, patients with Parkinson disease should avoid using kava. Kava may intensify the effect of anesthetics. Kava may cause liver damage if taken with hepatotoxins. (See also table.) 