blood disorders
Myelofibrosis
Symptoms of Myelofibrosis
Often, myelofibrosis causes no symptoms for years. However, in some people, myelofibrosis rapidly leads to Overview of Anemia , low levels of platelets in the blood ( People with secondary myelofibrosis also have symptoms of whatever disorder caused the myelofibrosis. The liver and spleen enlarge as they try to take over some of the job of making blood cells, but blood cell production is ineffective in these organs and instead just contributes to the spleen enlargement. Enlargement of the liver and spleen may cause pain in the abdomen and may lead to abnormally high blood pressure in certain veins, such as a vein supplying blood to the liver ( Portal Hypertension ) and bleeding from varicose veins in the esophagus ( Malignant myelofibrosis (sometimes called acute myelofibrosis) is a rare type of myelofibrosis in which levels of red blood cells, white blood cells, and platelets are all decreased. The number of certain immature white blood cells (blast cells) in the bone marrow is increased. Malignant myelofibrosis is considered to be a type of Overview of Leukemia . 