pediatrics
Rett Syndrome
Treatment of Rett Syndrome
Management of symptoms Multidisciplinary team support Treatment of seizures and behavior disturbances with antiseizure and behavioral medications Possible use oftrofinetide There is no cure for Rett syndrome. Optimal treatment of Rett syndrome includes a multidisciplinary approach that addresses symptoms and signs. A program of occupational therapy, physical therapy, and communication therapy (with a speech and language therapist) should be provided to address self-help skills such as feeding and dressing, limited mobility, walking difficulty, and communication deficits. Medications may be needed to control seizures and behavior disturbances, for breathing dysfunction, or for motor difficulties. produced modest improvement in these areas in clinical trials ( Treatment reference ). Regular re-evaluation is needed for scoliosis progression and to monitor cardiac abnormalities. Nutrition support may be needed to help affected children maintain weight. Special education programs and social and support services are needed. 1.Neul JJL, Percy AK, Youakim JM:Trofinetidefor the treatment of Rett syndrome: A randomized phase 3 study.Nature Medicine2023. doi: 10.1038/s41591-023-02398-1 