neurologic disorders
Disorders of Neuromuscular Transmission
Introduction
Disorders of neuromuscular transmission affect the neuromuscular junction; they commonly cause fluctuating muscle weakness with no sensory deficits. (See also Overview of Peripheral Nervous System Disorders .) Disorders of neuromuscular transmission may involve Postsynaptic receptors (eg, in Myasthenia Gravis ) Presynaptic release of acetylcholine (eg, in Botulism ) Breakdown of acetylcholine within the synapse (eg, due to drugs or neurotoxic chemicals) The most common disorder that affects neuromuscular transmission is myasthenia gravis. Some disorders that affect other areas of the body primarily (eg, Stiff-Person Syndrome , 