pediatrics
Antibiotics in Neonates
Introduction
 concentrations in Preterm Infants may reduce antibiotic protein binding. Drugs that displace bilirubin from Absence or deficiency of certain enzymes in neonates may prolong the half-life of certain antibiotics (eg,chloramphenicol) and increase the risk of toxicity. Changes in glomerular filtration rate and renal tubular secretion during the first month of life necessitate dosing changes for renally excreted drugs (eg, penicillins, aminoglycosides,vancomycin). (See also Overview of Neonatal Infections .) 