endocrine and metabolic disorders
ArginineVasopressin Deficiency (Central Diabetes Insipidus)
Symptoms and Signs ofArginineVasopressinDeficiency
Onset ofargininevasopressindeficiency may be insidious or abrupt, occurring at any age. The only symptoms in primaryargininevasopressindeficiency are polydipsia and polyuria. In secondaryargininevasopressindeficiency, symptoms and signs of the associated lesions are also present. Enormous quantities of fluid may be ingested, and large volumes (3 to 30 L/day) of very dilute urine (specific gravity usually<1.005 and osmolality<200 mOsm/kg [200 mmol/kg]) are excreted. Nocturia almost always occurs. Dehydration and hypovolemia may develop rapidly if urinary losses are not continuously replaced. Common causes of Polyuria include Diabetes Mellitus (DM) (most common) Argininevasopressindeficiency resistance ( Nephrogenic Diabetes Insipidus ) Compulsive or habitual water drinking ( Primary polydipsia ) 