gastrointestinal disorders
Peutz Jeghers Syndrome
Introduction
Peutz-Jeghers syndrome is an autosomal dominant disease with multiple hamartomatous polyps in the stomach, small bowel, and colon along with distinctive pigmented skin lesions. (serine/threonine kinase 11) tumor suppressor gene. Patients are at a significantly increased risk of gastrointestinal (GI) and non-GI cancers. GI cancers include those of the Pancreatic Cancer , The skin lesions are melanotic macules of the skin and mucous membranes, especially of the perioral region, lips and gums, hands, and feet. All but the buccal lesions tend to fade by puberty. Polyps may bleed and often cause obstruction or intussusception. 