infectious diseases
Macrolides
Dosing Considerations for Macrolides
Forazithromycin, no dosage adjustment is required for renal insufficiency. Erythromycinand, to some extent,clarithromycininteract with numerous drugs because they inhibit hepatic metabolism via the cytochrome P-450 (CYP450) system.Azithromycinis the least likely to interact with other drugs. Interactions may occur whenerythromycinorclarithromycinis taken with the following: Warfarin: Further elevation of the prothrombin time/international normalized ratio (PT/INR) Lovastatinandsimvastatin: Rhabdomyolysis Midazolamandtriazolam: Somnolence Theophylline: Nausea, vomiting, and seizures Tacrolimus,cyclosporine, and ergot alkaloids: Elevated serum levels of these drugs 