dermatologic disorders
Pyoderma Gangrenosum
Pathophysiology of Pyoderma Gangrenosum
Pathophysiology of pyoderma gangrenosum is poorly understood but may involve problems with neutrophil chemotaxis. Interleukin-8 is overexpressed in lesions. Ulcerations of pyoderma gangrenosum occur after trauma or injury to the skin in about 30% of patients; this process is termed pathergy. 