infectious diseases
Cephalosporins
Pharmacokinetics
Cephalosporins penetrate well into most body fluids and the extracellular fluid of most tissues, especially when inflammation (which enhances diffusion) is present. However, the only cephalosporins that reach cerebrospinal fluid levels high enough to treat meningitis are Ceftriaxone Cefotaxime Ceftazidime Cefepime All cephalosporins penetrate poorly into intracellular fluid and the vitreous humor. Most cephalosporins are excreted primarily in urine, so their doses must be adjusted in patients with renal insufficiency. Cefoperazone andceftriaxone, which have significant biliary excretion, do not require such dose adjustment. 