hematology and oncology
Hodgkin Lymphoma
Key Points
Hodgkin lymphoma is of B cell origin. Patients usually present with painless lymphadenopathy or with incidental cervical or mediastinal adenopathy discovered on chest x-ray or physical examination. Biopsy shows pathognomonic, binucleated Reed-Sternberg cells. Most patients are cured using combination chemotherapy and sometimes additional systemic therapies or radiation therapy. Subsequent therapeutic options include high-dose chemotherapy, autologous stem cell transplantation, orbrentuximab vedotinand the checkpoint inhibitorsnivolumabandpembrolizumab. 