pediatrics
Septo Optic Dysplasia
Introduction
Septo-optic dysplasia is a malformation of the front of the brain that occurs toward the end of the first month of gestation and includes optic nerve hypoplasia, absence or abnormality of the septum pellucidum (the membrane that separates the front of the 2 lateral ventricles), and pituitary hypoplasia and hypopituitarism. Although the causes may be multiple, abnormalities of one particular gene,HESX1, have been found in some children with septo-optic dysplasia. 