neurologic disorders
Pure Autonomic Failure
Introduction
Pure autonomic failure results from neuronal loss in autonomic ganglia, causing orthostatic hypotension and other autonomic symptoms. (See also Overview of the Autonomic Nervous System .) Pure autonomic failure, previously called idiopathic orthostatic hypotension or Bradbury-Eggleston syndrome, denotes generalized autonomic failure without central nervous system (CNS) involvement. This disorder differs from Multiple System Atrophy (MSA) because it lacks central or preganglionic involvement. Pure autonomic failure affects women and men, tends to begin during a person’s 40s or 50s, and does not typically result in death. Pure autonomic failure is a Pathophysiology (due to synuclein deposition); alpha-synuclein can also accumulate in patients with 