musculoskeletal and connective tissue disorders
Paget Disease of Bone
Introduction
Paget disease of bone is a chronic disorder of the adult skeleton in which bone turnover is accelerated in localized areas. Normal matrix is replaced with softened and enlarged bone. The disease may be asymptomatic or cause gradual onset of bone pain or deformity. Diagnosis is by x-ray. Treatment includes symptomatic measures and often medications, usually bisphosphonates. 55 years old in the United States have Paget disease, with a slight male predominance ( General references ). Prevalence increases with age; however, overall prevalence seems to be decreasing. The disease is most common in the United Kingdom and European countries including Spain, France, and Italy, as well as in countries settled by European immigrants (eg, Australia, New Zealand, the United States, and Canada) ( 