genitourinary disorders
Membranous Nephropathy
Prognosis for Membranous Nephropathy
About 25% of patients undergo spontaneous remission, 25% develop persistent, non–nephrotic-range proteinuria, 25% develop persistent nephrotic syndrome, and 25% progress to Chronic Kidney Disease . Women, children, and young adults with non–nephrotic-range proteinuria and patients with persistently normal renal function 3 years after diagnosis tend to have little disease progression. More than 50% of patients with nephrotic-range proteinuria who are asymptomatic or who have edema that can be controlled with diuretics will have a partial or complete remission within 3 to 4 years. Risk of progression to renal failureis highest among patients with Persistent proteinuria≥8 g/day, particularly men age>50 years An elevated serum creatinine level at presentation or diagnosis Biopsy evidence of substantial interstitial inflammation 