psychiatric disorders
Medications for Treatment of Depression
SerotoninModulators (5 HT2Blockers)
These medications block primarily the 5-HT2receptor and inhibit reuptake of 5-HT andnorepinephrine.Serotoninmodulators include Trazodone Mirtazapine Serotoninmodulators have antidepressant and anxiolytic effects but do not cause sexual dysfunction. has caused Priapism (in 1/1000) and, as an alpha-1 noradrenergic blocker, may cause Mirtazapineis a 5-HT antagonist and blocks alpha-2 adrenergic autoreceptors, as well as 5-HT2and 5-HT3receptors. The result is increased serotonergic function and increased noradrenergic function without sexual dysfunction or nausea. It has no cardiac adverse effects, has minimal interaction with drug-metabolizing liver enzymes, and is generally well-tolerated, although it does cause sedation and weight gain, mediated by H1(histamine) blockade. 