immunology allergic disorders
Chronic Mucocutaneous Candidiasis
Introduction
Chronic mucocutaneous candidiasis is persistent or recurrent candidal infection due to inherited T-cell defects. Autoimmune and endocrine disorders may develop in its recessive form. Diagnosis is based on recurrent, unexplained candida infections. Treatment includes antifungal drugs and treatment of any endocrine and autoimmune disorders. (See also Overview of Immunodeficiency Disorders and Chronic mucocutaneous candidiasis is a Primary Immunodeficiencies that involves Inheritance may be Autosomal dominant: Involving a mutation in the signal transducer and activator of transcription 1 gene (STAT1) Autosomal recessive: Involving a mutation in the autoimmune regulator gene (AIRE) (autoimmune polyendocrinopathy–candidosis-ectodermal dystrophy), autoimmune manifestations typically develop; they include endocrine disorders (eg, Hypoparathyroidism , PTPN22(protein tyrosine phosphatase, non-receptor type 22 [also calledLYP, or lymphoid tyrosine phosphatase], which is involved in T-cell–receptor signalling) Dectin-1 (an innate pattern recognition receptor essential for the control of fungal infections) CARD9 (caspase recruitment domain-containing protein 9, which is an adaptor molecule important in the production of interleukin (IL)-17 and for protection against fungal invasion) and other antigens. Candidiasis (Mucocutaneous) recurs or persists, usually beginning during infancy but sometimes during early adulthood. Life span is not affected. 