pediatrics
Osteogenesis Imperfecta
Treatment of Osteogenesis Imperfecta
Growth hormone Bisphosphonates Sometimesdenosumab Sometimesvitamin D Growth hormone helps growth-responsive children (types I and IV). Treatment with bisphosphonates is aimed at increasing bone density and decreasing bone pain and fracture risk ( Treatment references ). IV is a potent inhibitor of osteoclastic bone resorption and is typically given as an injection. Studies have shown that this drug is beneficial in some patients with OI ( Treatment references ). Vitamin Dsupplementation should be provided to people who are deficient in this hormone. Orthopedic surgery, physical therapy, and occupational therapy help prevent fractures and improve function. Cochlear implantation is indicated in selected cases of hearing loss. 1.Dwan K, Phillipi CA, Steiner RD, Basel D: Bisphosphonate therapy for osteogenesis imperfecta.Cochrane Database Syst RevCD005088, 2016. doi: 10.1002/14651858.CD005088.pub4 2.Li G, Jin Y, Levine MAH, et al: Systematic review of the effect ofdenosumabon children with osteogenesis imperfecta showed inconsistent findings.Acta Paediatr107(3):534–537, 2018. doi: 10.1111/apa.14154 