 Better Life with Dr. Sanjay Gupta. Working weird hours can wreak havoc on your health. Not just when you're working those super early or super late or overnight shifts, but even years later, according to a new study out of NYU. Of course, a lot of people who work those hours don't have a choice. But aside from messing with your sleep, one expert told us non-standard schedules can make it difficult to maintain other lifestyle habits important for good health.