 Twisters came in number one at the box office over the weekend in a big way. It earned $80 million. That's about $30 million more than analysts expected initially for that sequel to the 1996 hit. It makes for the biggest opening of a live-action movie yet this summer. Despicable Me came in second with $23 million. And Inside Out 2 wrapped up the top three with more than $12 million in ticket sales.