 serious, sometimes fatal infections, cancers including lymphoma and lung, blood clots, serious heart-related events, tears in the stomach or intestines, and allergic reactions have happened. People 50 and older with heart disease risk factors have an increased risk of death. Tell your doctor if you've had hepatitis B or C, have flu-like symptoms, are prone to infections, or have ever had a heart attack, stroke, clot, or other heart problems, or swelling of lips, tongue, throat, or hives.