 Glucosamine takes quite a while to kick in. MSM is a wonderful sulfur compound. And again, it's an anti-inflammatory, as are many things like fish oil. These are all wonderful, but they're not dealing with the origin of the problem. The origin of the problem is the loss of cushioning in the joint. And if we can just replace it, if we can find a way to get that cushioning back, that's what we call youthfulness. That's what we had when we were young. Here's David writing to me from New York, 25 years ago.