 This staggering number means a majority of American adults need to lose weight and improve their metabolic health. The good news? Prolon can help. Three decades ago, research began at the University of Southern California Longevity Institute to create a nutritional system to support healthy longevity. Today, that research is known as Prolon. Prolon is a patented, structured, plant-based nutrition program that helps support a healthy lifespan through cellular rejuvenation.