Low apparent volume of distribution of a drug indicates That
Drug has low half life
Drug has low bioavailability
Drug has low efficacy
Drug is not extensively distribution to tissue
Vd means "the plasma volume that would accommodate all the drug in the body, if the concentration throughout was same as in plasma". Drugs with high volume of distribution are more distributed in body and vice-versa. Low volume of distribution tells that most of the drug is retained in plasma.