Dapsone is used for treatment of bacterial and fungal infections as well as for immunomodulatory actions. What is mechanism of dapsone for these indication?
Inhibition of cell wall synthesis
Inhibition of ergosterol in cell membranes
Inhibition of protein synthesis
Competition with PABA in folic acid synthesis
Sulfonamides (including Dapsone and PAS) : Competitively inhibit folic acid synthase enzyme as these are PABA analogues. Trimethoprim, Pyrimethamine : Inhibit Dihydro folate reductase enzyme (DHFRase). Inhibition of ergosterol in cell membrane (in fungus and leishmania): Amphotericin B.