Finally, the Institute for Virology focuses on improving the methods used to apply adenovirus vectors to all sorts of goals such as vaccination, oncolytic virotherapy and gene therapy, that are studied in the other projects.
Finally, the Institute for Virology focuses on improving the methods used to apply adenovirus vectors to all sorts of goals such as vaccination, oncolytic virotherapy and gene therapy, that are studied in the other projects. Here, we have established large adenovirus collection and rational design engineering methods that made the generation of new therapeutic vectors easier. We also characterized the receptor usage of a wide range of adenoviruses in order to better understand their biology and abilities. Moreover, we have invented and keep improving workflows for high-throughput directed evolution of adenovirus vectors that enable to generate hundreds of thousands of novel vector variants, and have so far used these methods to increase OAdV cancer cell killing activity.