Oncolytic adenovirus vectors (OAdVs) are genetically modified adenoviruses engineered to infect and lyse specifically cancer cells.
Oncolytic adenovirus vectors (OAdVs) are genetically modified adenoviruses engineered to infect and lyse specifically cancer cells. We study several approaches to increase their specificity and therapeutic efficiency. Bispecific adaptors and tumor-specific promoters can ensure OAdV specificity by making them able to infect (resp. express their gene) only cancer cells. We also screen large collections of natural human adenoviruses, as well as chimeric vectors pseudotyped with the fiber protein or knob domain of other types, in order to identify which vectors present the best oncolytic features in various cancer models. These models include triple-negative breast cancer and head-and-neck cancer primary cultures.