Finally, we found that Wnt7B exhibited significant upregulation in the majority of cancer cases，at the same time，Wnt7B affects cancer prognosis through regulating tumor microenvironment，immune infiltration, tumor stemness, and other aspects, which suggests that Wnt7B can be a new cancer prognostic indicator and therapeutic target, and also the pharmacosensitivity analysis related to Wnt7B and cancer therapy can provide some help for clinical precision treatment.
Previous studies have confirmed the important role of Wnt family member 7B (Wnt7B) in the formation of various cancers such as breast, pancreatic, and gastric cancers; however, studies on the specificity of Wnt7B in tumors are limited to certain specific cancers, and systematic pan-cancer studies are lacking, and whether it can be used as a potential biomarker for cancer diagnosis and prognosis remains to be determined. We used bioinformatics techniques and immunohistochemistry (IHC) to observe its expression and function in cancerous and paracancerous tissues of various tumors. Finally, we found that Wnt7B exhibited significant upregulation in the majority of cancer cases，at the same time，Wnt7B affects cancer prognosis through regulating tumor microenvironment，immune infiltration, tumor stemness, and other aspects, which suggests that Wnt7B can be a new cancer prognostic indicator and therapeutic target, and also the pharmacosensitivity analysis related to Wnt7B and cancer therapy can provide some help for clinical precision treatment.