Cancer cells also have incredibly high mutation rates, which results in dysfunctional cellular machinery and damaged DNA.
We can also now create medicines that exploit the body’s multiple ways of detecting and repairing DNA damage, known as DNA damage response (DDR) mechanisms. Many cancers have lost one of these DDR mechanisms, which make them vulnerable to targeting other parts of these pathways2.Cancer cells also have incredibly high mutation rates, which results in dysfunctional cellular machinery and damaged DNA. While these cells can survive with a certain level of damage, there is a limit. Our goal is to develop innovative, targeted, and biomarker-driven treatments that exploit these vulnerabilities in the cancer cells.