Clinical studies showed that atherosclerotic cardiovascular disease (ASCVD) and cancer often coexist in the same individual.
Clinical studies showed that atherosclerotic cardiovascular disease (ASCVD) and cancer often coexist in the same individual. The study first showed that obesity could promote atherosclerosis burden as well as promote tumorigenesis and metastasis of lung cancer in the same individual mice. The results showed that obesity could contribute to the coexistence of atherosclerosis and lung cancer; so, screening both ASCVD and lung cancer would be significant in obese patients. LOX-1-related pathway likely was a significant contributor to the coexistence of atherosclerosis and lung cancer in the same individual. LOX-1 could be a target for the management of ASCVD and lung cancer in obese patients.