First, the Heart-pace group participates to an international consortium aiming at expressing various ion channels in patient’s hearts to restore healthy cardiac pace-making activity.
Several gene therapy specific applications are developed using adenovirus vectors. First, the Heart-pace group participates to an international consortium aiming at expressing various ion channels in patient’s hearts to restore healthy cardiac pace-making activity. Second, large collections of adenovirus vectors are screened on various blood leukocyte populations including hematopoietic stem and NK cells in order to improve therapies targeted at these still hard to durably modify cell types. Third, adenovirus vectors expressing von-Willebrand factor are constructed for the treatment of coagulation disorders.