The eight interventions emerge from basic research on aging, from drugs used to treat diabetes, and from studies of the gut microbiome, and a schematic on their mechanisms of action is depicted in Figure 1.
The eight interventions emerge from basic research on aging, from drugs used to treat diabetes, and from studies of the gut microbiome, and a schematic on their mechanisms of action is depicted in Figure 1. Note that the interventions have important metabolic effects, which relate to caloric intake and its consequences. We first give a brief scientific history of each of the interventions, and then describe recent, published results in human studies.