This article was conceived at a meeting of the Academy for Health and Lifespan Research.
We wish to thank Jim Kirkland and Tom Rando for critically reading and commenting on the manuscript. This article was conceived at a meeting of the Academy for Health and Lifespan Research. L.G. has been supported through the years by NIH and the Glenn Foundation for Medical Research. He is currently supported by the Jain Foundation. G.K. is supported by the Ligue Contre le Cancer (équipe labellisée); Agence National de la Recherche (ANR)—projets blancs; AMMICa US23/CNRSUMS3655; Association