My favorites are the Southwest (California and beyond) as well as Highway 395, one of the most scenic stretches of highway in the US.
If you want to head off the beaten path, Humboldt and the Lost Coast are beautiful and laid-back. There are also a bunch of road-trip routes to choose from. My favorites are the Southwest (California and beyond) as well as Highway 395, one of the most scenic stretches of highway in the US.