;) CRISPR fusion proteins and new nucleases are being investigated for their ability to facilitate site-specific integrations of large genetic sequences.
Expanding gene editing technology. There is growing interest in expanding gene-editing technologies to facilitate larger-scale genomic edits than is currently possible with CRISPR-based technologies such as base editing and prime editing.10Base editing and primer editing approaches are built on CRISPR-Cas9 technology and are generally limited to single nucleotide edits or small insertions in the genome.;) CRISPR fusion proteins and new nucleases are being investigated for their ability to facilitate site-specific integrations of large genetic sequences. Rather than repairing individual mutations, which may differ among patients with the same diseases, these approaches seek to fully replace larger faulty genomic sequences with corrected versions, potentially expanding the impact of gene editing to more diseases. Companies pursuing these technologies received $240 million in VC support in 2022.