One of the bottlenecks in currently approved autologous cell therapies is the expensive and time-consuming production of treatments derived from patient cells.
Scalable allogeneic therapies. One of the bottlenecks in currently approved autologous cell therapies is the expensive and time-consuming production of treatments derived from patient cells. Biotechs are addressing these challenges by exploring diverse cell types with limited immunogenic profiles that may be more suitable for off-the-shelf treatments. Emerging approaches include virus-specific T cells, NK cells, and macrophages. Alongside new cell types, start-ups are increasingly focused on optimizing and automating in-house manufacturing processes. This strategy may help with scaling the production of approved cell therapies in the future and avoiding manufacturing delays that affect CAR T-cells. Efforts to create scalable allogeneic cell therapy solutions pulled in more than $400 million in VC support in 2022.