If your protagonist lives in a rundown, ramshackle house, this house can represent his ramshackle life; a character that lives in a gentrified apartment building in an otherwise poor neighborhood might be equally ritzy and oblivious to the world around her.
Finally, setting can build symbolism. If your protagonist lives in a rundown, ramshackle house, this house can represent his ramshackle life; a character that lives in a gentrified apartment building in an otherwise poor neighborhood might be equally ritzy and oblivious to the world around her.