Xenotransplantation is transplanting animal organs into humans. Researchers are concentrating on making pig hearts, lungs, and kidneys safe by genetically engineering their DNA to be accepted by human immune systems. Last year, the first such heart transplant took place, allowing a man with end-stage heart failure to live for an additional two months. The landmark surgery ignited hope that a future of widely available pig organs could be edging closer for the 100,000+ people in dire need of transplants in the U.S.
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Health — January 12, 2023

# 5 biotech trends to watch in 2023

From synthetic biology to xenotransplantation, biotech will continue to march forward in 2023, in part powered by data and AI.

biotech trends

Credit: andriano_cz / Adobe Stock

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2022 saw some incredible scientific and technological breakthroughs, as well as some major medical breakthroughs — and 2023 is poised to follow up with more paradigm-shifting advances in the making. As the Deputy Director of Communications for Leaps by Bayer, I surveyed a brain trust of scientists, investors, and CEOs to learn which areas of biotech they are most eagerly watching this year. Here’s what they said.

## Cell and gene therapies

Cell and gene therapies encompass a wide range of approaches that attempt to treat disease at the cellular and genetic level. With cell therapy, patients’ cells are extracted, reprogrammed, and then injected back into their bodies, often with the goal of leveraging their own immune system to fight diseases like cancer. Of the approved cell therapies in the U.S., most focus on blood cancers because they have not yet shown success in treating solid tumors. One of the next goals in cell therapy is to improve efficiency by reprogramming patients’ cells in vivo — that is, inside their own bodies.

In gene therapy, genetic material is delivered into patients’ bodies with the objective of replacing or correcting faulty DNA. Several gene therapies recently have been approved to treat a variety of disorders: a rare eye disease called Leber congenital amaurosis, spinal muscular atrophy in infants, and hemophilia B in adults. One limitation of current gene therapies is their delivery system. They are typically delivered to patients via a viral vector, a harmless virus that carries its genetic cargo into the body, but this approach typically only affects cells in the liver. Delivering precision genetic medicine to organs and cells beyond the liver represents one of the next frontiers in gene therapy. ReCode Therapeutics, a Leaps portfolio company, is on the forefront of that effort.

## Synthetic biology

Synthetic biology involves the wholesale redesign or construction of biological entities to carry out desirable biotechnological processes. It’s already revolutionized the treatment of diabetes, for example. Since 1982, insulin has been produced by inserting a human gene into a common bacterium. Today, through companies like Ginkgo BioWorks, a Bayer partner, many more opportunities are arising to use synthetic biology in everything from medicine to farming to manufacturing.

## Resilient and sustainable agriculture

As we grapple with a changing climate, the frequent occurrence of droughts and floods will pose a challenge to farmers. One way we can adapt is to tweak our crops to better withstand long-term environmental volatility. It is also critical that we keep up with the food demands of a growing population, which is set to reach almost ten billion people by 2050. Today, we already are facing a worsening global food insecurity crisis due to the war in Ukraine, which has been forced to severely limit its grain exports. We can hedge against future crises by making crops more nutrient dense and easier to grow.

Today, agriculture accounts for 25% of the world’s greenhouse gas emissions, in part due to farming’s reliance on nitrogen fertilizer. To be sure, chemical fertilizer has enabled billions of people to eat and live, and without it, the fabric of society would crumble. But moving forward, the ideal would be to achieve a new paradigm in which high-yielding crops are less reliant on fertilizer. New approaches currently in development encourage growth while also protecting the planet.

## Xenotransplantation

Xenotransplantation is transplanting animal organs into humans. Researchers are concentrating on making pig hearts, lungs, and kidneys safe by genetically engineering their DNA to be accepted by human immune systems. Last year, the first such heart transplant took place, allowing a man with end-stage heart failure to live for an additional two months. The landmark surgery ignited hope that a future of widely available pig organs could be edging closer for the 100,000+ people in dire need of transplants in the U.S.

## AI-enhanced precision medicine

As advances in machine learning (ML) and artificial intelligence (AI) rapidly leap forward, they are unlocking previously impossible opportunities in the life sciences, such as finding novel biological targets and designing better drugs. The confluence of tech and biotech holds the promise of faster, more personalized treatments for patients as well as for more resilient, nutritious foods.

Kira Peikoff is the Deputy Director of Communications at Leaps by Bayer, a unit of Bayer AG that leads impact investments into solutions to some of today's biggest challenges in health and agriculture.

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