question: Does mTOR regulate the translation of MAPKAPK2?
answer: Yes. mTOR regulates the translation of the MK2 (also known as MAPKAPK2) kinase through 4EBP1.  In turn, MAPKAPK2 phosphorylates the RNA-binding protein ZFP36L1 during senescence, inhibiting its ability to degrade the transcripts of numerous senescence-associated secretory phenotype (SASP) components. Consequently, mTOR inhibition or constitutive activation of ZFP36L1 impairs the non-cell-autonomous effects of senescent cells in both tumour-suppressive and tumour-promoting contexts.