question: Are Notch mutations related to T-cell Acute Lymphoblastic Leukemia (T-ALL)?
answer: Notch1 is a transmembrane receptor that is frequently mutated in human T-cell acute lymphoblastic leukemia (T-ALL). Activating mutations in NOTCH1, an essential regulator of T cell development, are frequently found in human T cell acute lymphoblastic leukemia (T-ALL). 