question: In which way does DNA hydroxymethylation affect patients with Systemic Lupus Erythematosus?
answer: DNA hydroxymethylation contributes to the aberrant regulation of genes transcription in the pathogenesis of SLE.  A combined analysis of differential DNA hydroxymethylation profile and gene expression profile in SLE CD4(+) T cells, shows 131 genes with increased 5-hmC in promoter regions and up-regulated expression in SLE CD4(+) T cells compared with healthy controls, including selected immune-related genes, i.e. SOCS1, NR2F6 and IL15RA.