when do secondary ossification centers appear in the epiphysis
Ossification The secondary centers generally appear at the epiphysis. Secondary ossification mostly occurs after birth (except for distal femur and proximal tibia which occurs during 9th month of fetal development). The epiphyseal arteries and osteogenic cells invade the epiphysis, depositing osteoblasts and osteoclasts which erode the cartilage and build bone. This occurs at both ends of long bones but only one end of digits and ribs.