which disease was exported from america to europe
Columbian exchange The history of syphilis has been well-studied, but the exact origin of the disease is unknown and remains a subject of debate.[25] There are two primary hypotheses: one proposes that syphilis was carried to Europe from the Americas by the crew of Christopher Columbus in the early 1490s, while the other proposes that syphilis previously existed in Europe but went unrecognized.[26] These are referred to as the "Columbian" and "pre-Columbian" hypotheses.[26] The first written descriptions of the disease in the Old World came in 1493.[27] The first large outbreak of syphilis in Europe occurred in 1494/1495 in Naples, Italy, among the army of Charles VIII, during their invasion of Naples.[26][28][29][30]