where does gluconeogenesis take place in eukaryotic cells
Gluconeogenesis In mammals, gluconeogenesis has been believed to be restricted to the liver,[19] the kidney,[19] the intestine,[20] and muscle,[citation needed] but recent evidence indicates gluconeogenesis occurring in astrocytes of the brain.[21] These organs use somewhat different gluconeogenic precursors. The liver preferentially uses lactate, alanine and glycerol (especially alanine) while the kidney preferentially uses lactate, glutamine and glycerol (especially glutamine).[22][7] Lactate from the Cori cycle is quantitatively the largest source of substrate for gluconeogenesis, especially for the kidney.[7] The liver uses both glycogenolysis and gluconeogenesis to produce glucose, whereas the kidney only uses gluconeogenesis.[7] After a meal, the liver shifts to glycogen synthesis, whereas the kidney increases gluconeogenesis.[10] The intestine uses mostly glutamine and glycerol.[20]