where is the nucleolus and what does it do
Nucleolus The nucleolus (/njuːˈkliːələs/ or /ˌnjuːkliˈoʊləs/, plural nucleoli /njuːˈkliːəˌlaɪ/ or /ˌnjuːkliˈoʊlaɪ/) is the largest structure in the nucleus of eukaryotic cells.[1] It is best known as the site of ribosome biogenesis. Nucleoli also participate in the formation of signal recognition particles and play a role in the cell's response to stress.[2] Nucleoli are made of proteins, DNA and RNA and form around specific chromosomal regions called nucleolar organizing regions. Malfunction of nucleoli can be the cause of several human conditions called "nucleolopathies"[3] and the nucleolus is being investigated as a target for cancer chemotherapy.[4][5]