what type of protein is affected in cells of individuals with tay-sachs
Tay–Sachs disease Tayâ€“Sachs disease is caused by a genetic mutation in the HEXA genes on chromosome 15.[1] It is inherited from a person's parents in an autosomal recessive manner.[1] The mutation results in problems with an enzyme called beta-hexosamidase A which results in the buildup of the molecule GM2 ganglioside within cells, leading to toxicity.[1] Diagnosis is by measuring the blood hexosaminidase A level or genetic testing.[2] It is a type of sphingolipidoses.[3]