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San Angelo, Texas San Angelo /sæn ˈændʒəloʊ/[3] is a city in and the county seat of Tom Green County, Texas, United States.[4] Its location is in the Concho Valley, a region of West Texas between the Permian Basin to the northwest, Chihuahuan Desert to the southwest, Osage Plains to the northeast, and Central Texas to the southeast. According to a 2014 Census estimate, San Angelo has a total population of 100,450.[5] It is the principal city and center of the San Angelo metropolitan area, which has a population of 118,182.[6]