Frederick II's efforts to bring all of Italy under his control failed as signally as those of his grandfather, and his death in 1250 marked the effective end of the Kingdom of Italy as a genuine political unit.
Friedrich II kavatsused võtta kogu Itaalia oma kontrolli alla olid sama edutud kui tema vanaisa omad, ja tema surm aastal 1250 tähistas Itaalia kuningriigi tõhusat lõppu ehtsa poliitilise üksusena.