Although numerous classification schemes have been proposed, the superfamily was classically divided into three main classes (A, B, and C) with no detectable shared sequence homology between classes.
Kuigi välja on pakutud paljusid klassifitseerimise skeeme, jagatakse G-valguga seotud retseptorite perekond klassikaliselt kolme põhiklassi (A, B ja C), kus klasside järjestuste vahel pole tuvastatavat homoloogiat.