Vaccination was made compulsory in England and Wales by the 1853 Vaccination Act, and parents could be fined £1 if their children were not vaccinated before they were three months of age.
Vaktsineerimisseadusega tehti vaktsineerimine 1853. aastaks Inglismaal ja Walesis kohustuslikuks ning vanematele võis teha ühe naela trahvi, kui nende laps polnud enne kolmandat elukuud vaktsineeritud.