It is not recommended for use in dogs with bleeding disorders (such as Von Willebrand's disease), as safety has not been established in dogs with these disorders.
Samuti pole ravimit pole soovitatav kasutada koertel, kellel esineb veritsushäireid (nagu näiteks Von Willebrandi tõbi), sest nende häiretega koertel ei ole ohutust kindlaks tehtud.