The only problem with this equation in its present form is that it assumes absolute inhibition of the enzyme with inhibitor binding, when in fact there can be a wide range of effects anywhere from 100% inhibition of substrate turn over to just >0%.
Jedini problem sa ovom jednačinom u njenoj trenutnoj formi je što podrazumeva apsolutnu inhibiciju enzima vezivanjem inhibitora, dok se u stvarnosti može javiti širok opseg uticaja: od 100 % inhibicije supstrata do samo izvesnog procenta, > 0 %.