Although ergot alkaloids are mostly nonspecific 5-HT receptor antagonists, a few ergot derivatives such as metergoline bind preferentially to members of the 5-HT2 receptor family.
Mada su ergot alkaloidi uglavnom nespecifični antagonisti 5-HT receptora, nekoliko ergot derivata kao što je metergolin se vezuju preferentno za članove 5-HT2 receptorske familije.