Regardless of these various nuances, the GPCR's preferred coupling partner is usually defined according to the G-protein most obviously activated by the endogenous ligand under most physiological or experimental conditions.
Pored svih tih nijansi, uobičajeni GPCR parter je obično definisan na osnovu G-proteina koji je najočevidnije aktiviran endogenim ligandom pod fiziološkim i/ili eksperimentalnim uslovima.