Although a common mechanism has been suggested, the order of substrate binding, nucleotide binding and hydrolysis, and conformational changes, as well as interactions between the domains is still debated.
Mada je predložen zajednički mehanizam, redosled vezivanja supstrata, nukleotida, hidrolize, i konformacionih promena, kao i interakcija između domena su još uvek predmet aktivne debate.