Several residues, such as Gln165 (TM4), His197 (TM5), His265 (TM6) and Tyr287 (TM7) are involved in the binding of many non-peptide antagonists of the NK1 receptors.
Nekoliko ostataka, kao što su Gln165 (TM4), His197 (TM5), His265 (TM6) i Tyr287 (TM7) učestvuju u vezivanju mnogih ne-peptidnih antagonista NK1 receptora.