While serine/threonine kinases all phosphorylate serine or threonine residues in their substrates, they select specific residues to phosphorylate on the basis of residues that flank the phosphoacceptor site, which together comprise the consensus sequence.
Dok sve serin/treonin kinaze fosforilišu serin ili treonin ostatake u svojim supstratima, one biraju specifične ostataka na osnovu ostataka koji okružuju mesto fosfoakceptora, koji zajedno čine konsenzus sekvencu.