This CXCL12-CXCR4 interaction used to be considered exclusive (unlike for other chemokines and their receptors), but recently, it was suggested that CXCL12 may also bind the CXCR7 receptor (now called ACKR3).
CXCL12-CXCR4 interakcija je nekad bila smatrana eksluzivnom (za razliku od drugih hemokina i njihovih receptora), ali je nedavno bilo predloženo da se CXCL12 možda takođe vezuje za CXCR7 receptor.