However it has been observed that many effects of the application of nuclear hormones, such as changes in ion channel activity, occur within minutes which is inconsistent with the classical mechanism of nuclear receptor action.
Međutim uočeno je da se mnogi efekti primene nuklearnih hormona, poput promena aktivnosti jonskih kanala, javljaju nakon nekoliko minuta, što je inkonsistentno sa klasičnim mehanizmom dejstva nuklearnih receptora.