Of the nine MRP proteins, four of them, MRP4, 5, 8, 9, (ABCC4, 5, 11, and 12), have a typical ABC structure with four domains, comprising two membrane spanning domains, with each spanning domain followed by a nucleotide binding domain.
Od devet MRP proteinda njih četiri, MRP4, 5, 8, 9, (ABCC4, 5, 11, and 12), imaju tipične ABC strukture sa četiri domena, što obuhvata dva domena koji premoštavaju membranu, pri čemu svakom od njih sledi domen vezivanja nukleotida.