Y-320 (0.3-3 mg/kg pp. o.) ameliorates collagen-induced arthritis (CIA) in Mice with a reduction of IL-17 mRNA in arthritic joints, and also shows therapeutic effects on CIA in cynomolgus monkeys.
Y-320 (0.3-3 mg/kg pp. o.) ublažava posledice kolagenom indukovanog artritisa (CIA) kod miševa putem redukcije IL-17 mRNA u artritičkim zglobovima, a isto tako pokazuje terapeutsko dejstvo na CIA kod cinomolgsnih majmuna.