Furthermore, genes are often flanked by several binding sites for distinct transcription factors, and efficient expression of each of these genes requires the cooperative action of several different transcription factors (see, for example, hepatocyte nuclear factors).
Štaviše, geni su često okruženi sa nekoliko veznih mesta za različite transkripcione faktore, i efikasna ekspresija tih gena zahteva združeno dejstvo nekoliko različitih faktora (vidi, na primer, hepatocitni nuklearni faktori).