It has been used to investigate the mechanism of action of caffeine, which is a mixed A1 / A2A antagonist, and has shown that the A2A receptor is primarily responsible for the stimulant effects of caffeine, but blockade of both A1 and A2A receptors is required to accurately replicate caffeine's effects in animals.
On je korišten za istraživanje mehanizma dejstva kofeina, koji je mešoviti A1 / A2A antagonist, i pokazano je da je A2A receptor prvenstveno odgovoran za stimulantno dejstvo kofeina, dok je blokada oba, A1 i A2A, receptora potrebna za precizno reprodukovanje dejstva kofeina kod životinja.