However, testing the relative importance of the genomic and nongenomic mechanisms in vivo has been prevented by the absence of specific molecular mechanisms for the nongenomic effects that could be blocked by mutation of the receptor without disrupting its direct effects on gene expression.
Međutim, testiranje relativne važnosti genomskih i negenomskih mehanizama in vivo je bilo onemogućeno odsustvom specifičnih molekulskih mehanizama za negenomske efekte koji bi mogli da budu blokirani mutacijama receptora bez poremećivanje njegovih direktnih dejstava na expresiju gena.