Tregelles first became generally known through his Book of Revelation in Greek Edited from Ancient Authorities (1844), which contained the announcement of his intention to prepare the new Greek New Testament.
Tregelles stał się znany dzięki swemu dziełu Book of Revelation in Greek Edited from Ancient Authorities (1844), które zawiera jego oświadczenie, że ma zamiar przygotować grecki Nowy Testament.