Members of the Hsp70 family are very strongly upregulated by heat stress and toxic chemicals, particularly heavy metals such as arsenic, cadmium, copper, mercury, etc. Hsp70 was originally discovered by FM Ritossa in the 1960s when a lab worker accidentally boosted the incubation temperature of Drosophila (fruit flies).
A expresión dos membros da familia Hsp70 é fortemente regulada á alza polo estrés por calor e substancias tóxicas, especialmente metais pesados como o arsénico, cadmio, cobre, mercurio etc. A Hsp70 descubriuna FM Ritossa na década de 1960 cando un traballador de laboratorio aumentou accidentalmente a temperatura de incubación de moscas da froita Drosophila.