Type VI secretion systems were originally identified in 2006 by the group of John Mekalanos at the Harvard Medical School (Boston, USA) in two bacterial pathogens, Vibrio cholerae and Pseudomonas aeruginosa.
Os sistemas de secreción de tipo VI foron identificounos en 2006 o grupo de John Mekalanos na Escola Médica de Harvard (Boston, EEUU) en dous patóxenos bacterianos, Vibrio cholerae e Pseudomonas aeruginosa.