HMG-CoA reductase is anchored in the membrane of the endoplasmic reticulum, and was long regarded as having seven transmembrane domains, with the active site located in a long carboxyl terminal domain in the cytosol.
A HMG-CoA redutase está ancorada na membrana do retículo endoplasmático, e durante moito tempo se pensou que tiña sete dominios transmembrana, co sitio activo localizado nun longo dominio carboxilo terminal no citosol.