A Nobel Prize was awarded to Earl Sutherland in 1971 for discovering the key role of AC-III in human liver, where adrenaline indirectly stimulates AC to mobilize stored energy in the "fight or flight" response.
Concedéuselle o premio Nobel a Earl Sutherland en 1971 polo descubrimento do papel clave da AC-III no fígado humano, onde a adrenalina estimula indirectamente a AC para que se mobilice a enerxía almacenada na resposta de "loita ou fuxida".