Ran can diffuse freely within the cell, but because RCC1 and RanGAP are located in different places in the cell, the concentration of RanGTP and RanGDP differs locally as well, creating concentration gradients that act as signals for other cellular processes.
Ran pode difundir libremente dentro da célula, pero como RCC1 e RanGAP están localizados en diferentes lugares da célula, a concentración de RanGTP e RanGDP difire localmente tamén, creando gradientes de concentración que actúan como sinais para outros procesos celulares.