This is achieved by maintaining a pool of immensely large (about 109) clones of B cells, each of which reacts against a specific epitope by recognizing and producing antibodies against it.
Isto conséguese mantendo un conxunto enormemente grande (uns 109) de clons de células B, cada un dos cales reacciona contra un epítopo específico recoñecéndoo e producindo anticorpos contra el.