Several studies have indicated that the proteolytic activity of APC contributes to the observed cytoprotective properties of APC, but variants that are proteolytically inactive also are able to regulate formation of PAR-activators thrombin and factor Xa and express cytoprotective properties in vitro and in vivo.
Varios estudos indicaron que a actividade proteolítica da APC contribúe ás propiedades citoprotectoras observadas da APC, pero as variantes que son proteoliticamente inactivas tamén poden regular a formación de PAR-activadores de trombina e factor Xa e expresar propiedades citoprotectoras in vitro e in vivo.