The protein sequences of antibodies produced in this way are partially distinct from homologous antibodies occurring naturally in humans, and are therefore potentially immunogenic when administered to human patients (see also Human anti-mouse antibody).
As secuencias proteicas dos anticorpos producidos deste xeito son parcialmente distintas das dos anticorpos homólogos que producirían de forma natural os humanos, e, por tanto, son potencialmente inmunoxénicos cando se administran a pacientes humanos (ver tamén anticorpo anti-rato humano).