In addition, VEGF-A production and VEGFR-2 activation on the surface of breast cancer cells indicates the presence of a distinct autocrine signaling loop that enables breast cancer cells to promote their own growth and survival by phosphorylation and activation of VEGFR-2.
Ademais, a produción de VEGF-A e a activación de VEGFR-2 na superficie de células de cancro de mama indican a presenza dun bucle de sinalización autócrina que permite que as células de cancro de mama promovan o seu crecemento e supervivencia por fosforilación e activación de VEGFR-2.