The major regulator of enzyme activity, acetyl-CoA, stimulates the cleavage of ATP in the first partial reaction and also it has been shown to induce a conformational change in the tetrameric structure of the enzyme.
O principal regulador da actividade encimática, o acetil-CoA, estimula a clivaxe do ATP na primeira reacción parcial e tamén induce un cambio conformacional na estrutura tetramérica do encima.