Although an RNase H domain was tentatively identified in the retron ORF, it was later found that the RNase H activity required for msDNA synthesis is actually supplied by the host.
Aínda que se identificou provisionalmente un dominio RNase H no ORF retron, posteriormente viuse que a actividade de RNase H necesaria para a síntese de msDNA é subministrada en realidade polo hóspede.