In addition to this homeodomain proteins and other proteins involved in development, LIM domains have also been identified in non-homeodomain proteins with relevant roles in cellular differentiation, association with cytoskeleton and senescence.
Ademais destas proteínas homeodominio e outras proteínas implicadas no desenvolvemento, os dominios LIM tamén se identificaron en proteínas non homeodominio con funcións importantes na diferenciación celular, asociación co citoesqueleto e senescencia.