Thus, cytoplasmic vacuolation induced by the dominant-negative PIKfyveK1831E mutant is suppressed upon co-expression of a Sac3 phosphatase-inactive point-mutant along with ArPIKfyve.
Así, a vacuolización citoplasmática inducida polo mutante dominante negativo PIKfyveK1831E é suprimida pola coexpresión dun mutante puntual de fosfatase Sac3 inactiva xunto con ArPIKfyve.