Because of its importance in clotting, Factor VIII is also known as anti-haemophilic factor, and deficiencies of Factor VIII cause haemophilia A. APC inactivates Factor Va by making three cleavages (Arg306, Arg506, Arg679).
Debido a esta importancia na coagulación, o factor VIII coñécese tamén como factor antihemofílico e as deficiencias do factor VIII causan hemofilia A. A APC inactiva o factor Va ao realizar tres clivaxes (en Arg306, Arg506, Arg679).