After returning to Switzerland, Wüthrich collaborated with, among others, Nobel laureate Richard R. Ernst on developing the first two-dimensional NMR experiments, and established the nuclear Overhauser effect as a convenient way of measuring distances within proteins.
Logo de volver a Suíza, Wüthrich colaborou co premio Nobel Richard R. Ernst en desenvolver os primeiros experimentos de RMN en dúas dimensións, e estableceu o efecto nuclear Overhauser como un xeito conveniente de medir distancias dentro das proteínas.