The concept of "programmed cell-death" was used by Lockshin & Williams in 1964 in relation to insect tissue development, around eight years before "apoptosis" was coined.
O concepto de "morte celular programada" foi usado por Lockshin e Williams en 1964 en relación co desenvolvemento de tecidos de insectos, uns oito anos antes de que se acuñase o termo "apoptose".