Due to its position on chromosome 18 close to the bcl-2 protooncogene and several other serpins, PAI-2's role in apoptosis has been investigated, but current evidence remains inconclusive.
Debido á súa posición no cromosoma 18 preto do protooncoxene bcl-2 e outras varias serpinas, investigouse o papel do PAI-2 na apoptose, pero as evidencias actuais non son concluíntes.