Until 1982, it was widely accepted that phospholipids and membrane proteins were randomly distributed in cell membranes, according to the Singer-Nicolson fluid mosaic model, published in 1972.
Ata 1982 aceptábase xeneralizadamente que os fosfolípidos e as proteínas de membrana estaban distribuídas aleatoriamente nas membranas celulares, de acordo co modelo de mosaico fluído de Singer e Nicolson, publicado en 1972.