These structures elaborate the molecular mechanisms for DNA recognition, catalysis and the unique synapsis underlying the 12/23 rule, provide new insights into the RAG-associated human diseases, and represent a most complete set of complexes in the catalytic pathways of any DDE family recombinases, transposases or integrases.
Estas estruturas elaboran os mecanismos moleculares para o recoñecemento do ADN, a catálise e a singular sinapse baseada na regra do 12/23, e proporcionan novas ideas sobre as enfermidades humanas asociadas coa RAG, e representa un conxunto moi completo de complexos nas vías catalíticas de calquera familia DDE de recombinases, transposases ou integrases.