During the chronic phase, the consequences of generalized immune activation coupled with the gradual loss of the ability of the immune system to generate new T cells appear to account for the slow decline in CD4+ T cell numbers.
Durante a fase crónica, as consecuencias da activación inmune xeneralizada acoplada coa perda gradual da capacidade do sistema inmunitario de xerar novas células T parece explicar o lento declive do número de células T CD4+.