It is known that APC works on Factor VIIIa by cleaving at two sites, Arg336 and Arg562, either of which is sufficient to disable Factor VIIIa and convert it to Factor VIIIi.
Sábese que a APC funciona sobre o factor VIIIa clivándoo en dous sitios, Arg336 e Arg562, cada un dos cales en solitario é suficiente para desactivar o factor VIIIa e convertelo no factor VIIIi.