It is thought that many Hsp70s crowd around an unfolded substrate, stabilizing it and preventing aggregation until the unfolded molecule folds properly, at which time the Hsp70s lose affinity for the molecule and diffuse away.
Pénsase que se concentran moitas Hsp70s arredor do substrato non pregado, estabilizándoo e impedindo a súa agregación ata que a molécula non pregada se prega correctamente, momento no que a Hsp70s perde afinidade pola molécula e difunde lonxe de alí.