The characters in Pokémon Puzzle Challenge are based on those in the Gold and Silver games, while those in Pokémon Puzzle League—its Nintendo 64 equivalent—were based more on the anime characters.
As personaxes de Pokémon Puzzle Challenge están baseadas nos xogos de Gold e Silver, mentres que os de Pokémon Puzzle League —o seu equivalente de Nintendo 64— estaban baseados nas personaxes do anime.