Characteristic motifs indicate that three of the five GRAFS families, Rhodopsin, Adhesion, and Frizzled, evolved from the Dictyostelium discoideum cAMP receptors before the split of Opisthokonts.
Os motivos característicos indican que tres das cinco familias GRAFS, Rodopsina, Adhesión, e Crepitado (Frizzled), evolucionaron a partir de receptores de AMPc de Dictyostelium discoideum antes da separación dos Opisthokonta.