Multiple human trials using HMG-CoA reductase inhibitors, known as statins, have repeatedly confirmed that changing lipoprotein transport patterns from unhealthy to healthier patterns significantly lowers cardiovascular disease event rates, even for people with cholesterol values currently considered low for adults.
Moitos ensaios clínicos en humanos nos que se usaron inhibidores da HMG-CoA redutase, chamados estatinas, confirmaron repeticamente que o cambio nos patróns de transporte de lipoproteínas de patróns pouco saudables a patróns saudables fan diminuír significativamente as taxas de episodios cardiovasculares, mesmo en persoas con valores de colesterol actualmente considerados baixos para adultos.