In mammals it has been found that snoRNAs can also regulate the alternative splicing of mRNA, for example snoRNA HBII-52 regulates the splicing of serotonin receptor 2C.
Nos mamíferos atopouse que os snoRNAs poden tamén regular o splicing alternativo do ARNm; por exemplo o snoRNA HBII-52 regula o splicing do receptor 2C da serotonina.