Upon binding of thrombopoietin, CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.
Unha vez que se une a trombopoetina ao CD110, este dimerízase e a familia JAK de tirosina quinases non receptoras, e a familia STAT, a familia MAPK, a proteína adaptadora Shc e os propios receptores son fosforiladas na tirosina.