The airport is the major hub for the SATA Group of airlines, which includes both inter-island SATA Air Açores and international Azores Airlines, and since April 2015 as a base for Ryanair.
É o principal centro de conexións para o grupo de aeroliñas SATA Group, ao que pertencen SATA Air Açores e Azores Airlines, e dende abril de 2015 é unha base para Ryanair.