Recently it has been shown that HMGA1 proteins, HMGA1a and HMGA1b, can cross-link DNA fibers in vitro and can induce chromatin clustering in vivo suggesting a structural role of HMGA1 proteins in heterochromatin organization.
Recentemente, as proteínas HMGA1, HMGA1a e HMGA1b, poden crear enlaces cruzados coas febras de ADN in vitro e poden inducir agrupamentos da cromatina in vivo, o que suxire un papel estrutural da proteína HMGA1 na organización da heterocromatina.