The principle of macromolecular crowding is derived from the notion that in vivo cells reside in a highly crowded/dense extracellular space and therefore the conversion of the de novo synthesised procollagen to collagen I is rapid.
O principio do ateigamento macromolecular deriva da noción de que in vivo as células se encontran nun espazo extracelular moi ateigado/denso e, por tanto, a conversión do procoláxeno sintetizado de novo a coláxeno I é rápida.