By the mid to late 1980s, with advances in cryofixation and freeze substitution methods for electron microscopy, it was generally concluded that mesosomes do not exist in living cells.
A mediados da década 1980, cos avances en crioxenia, e en xeral, a substitución dos métodos de microscopía electrónica, chegouse á conclusión de que os mesosomas non existen nas células vivas.