Originally thought to clamp onto their substrate protein (also known as a client protein) upon binding ATP, the recently published structures by Vaughan et al. and Ali et al. indicate that client proteins may bind externally to both the N-terminal and middle domains of Hsp90.
Críase inicialmente que abrazaban a súa proteína substrato (tamén coñecida como proteína cliente) ao unirse o ATP, pero as estruturas publicadas recentemente por Vaughan et al. e Ali et al. indican que as proteínas clientes poden unirse externamente aos dominios N-terminal e medio da Hsp90.