FISH probes are generally labelled with a variety of different fluorescent tags and can only be detected under a fluorescence microscope, whereas CISH probes are labelled with biotin or digoxigenin and can be detected using a bright-field microscope after other treatment steps have been applied.
As sondas para FISH son xeralente etiquetadas con diversas etiquetas fluorescentes e só pode detectarse con microscopio fluorescente, mentres que as sondas para CISH son etiquetadas con biotina ou digoxixenina e poden detectarse usando un microsocpio de campo brillante unha vez que se aplicaron outros pasos do tratamento.