This protection is particularly salient in brain metastases, which tend to express high levels of PAI-2 and neuroserpin, and whose growth may be partially inhibited by knockout of PAI-2.
Esta protección é especialmente salientable nas metástases cerebrais, que adoitan expresar altos niveis do PAI-2 e neuroserpina, e cuxo crecemento pode ser parcialmente inhibido polo knockout de PAI-2.