Simeons, while studying pregnant women in India on a calorie-deficient diet, and "fat boys" with pituitary problems (Frölich's syndrome) treated with low-dose HCG, observed that both lost fat rather than lean (muscle) tissue.
Simeons, mentres estudaba mulleres embarazadas en India con dietas deficientes en calorías, e "nenos gordos" con problemas hipofisarios (síndrome de Frölich), tratados con doses baixas de hCG, afirmou que ambos os grupos estudados perderon graxa en vez de tecido magro (masa muscular).