The Pan-Apple domain contains important determinants for maintaining plasminogen in the closed form, and the kringle domains are responsible for binding to lysine residues present in receptors and substrates.
O dominio Pan-Apple contén determinantes importantes para manter ao plasminóxeno na súa forma pechada, e os dominios kringle son responsables da unión a residuos de lisina presentes nos receptores e substratos.