Another source for Ohno's theory was the observation that even closely related species can have widely (orders-of-magnitude) different genome sizes, which had been dubbed the C-value paradox in 1971.
Outra fonte para a teoría de Ohno foi a observación de que mesmo as especies que están estreitamente emparentadas poden ter tamaños de xenomas moi diferentes (en ordes de magnitude), o cal fora denominado paradoxo do valor C en 1971.