Harbury et al. performed a landmark study using an archetypal coiled coil, GCN4, in which rules that govern the way that peptide sequence affects the oligomeric state (that is, the number of alpha-helices in the final assembly) were established.
Harbury et al. realizaron o estudo do arquetipo de hélice superenrollada, GCN4, no que estableceron as normas que determinan a forma en que a secuencia peptídica afecta ao estado oligomérico (é dicir, o número de hélices alfa na ensamblaxe final).