This site was not sensitive to the same inhibitors as those at the AMP allosteric site, and most success has been had synthesizing new inhibitors that mimic the structure of glucose, since glucose-6-phosphate is a known inhibitor of HLGP and stabilizes the less active T-state.
Este sitio non era sensible aos mesmos inhibidores ca o sitio alostérico para o AMP, e o maior éxito na inhibición conseguiuse sintetizando novos inhibidores que imitan a estrutura da glicosa, xa que a glicosa 6-fosfato é un inhibidor coñecido da HLPG e estabiliza o estado T, que é menos activo.