Studies suggest that the concentration and composition of the free fatty acid pool in the environment in which PGHS-2 functions in cells, also referred to as the FA tone, is a key factor regulating the activity of PGHS-2 and its response to PTGS (COX) inhibitors.
Os estudos suxiren que a concentración e composición do conxunto de ácidos graxos libres no ambiente no cal funciona a PGHS-2 nas células, tamén denominado ton de ácidos graxos, é un factor clave para regular a actividade da PGHS-2 e a súa resposta aos inhibidores de COX (PTGS).