PGK proceeds through a charge-stabilized transition state that is favored over the arrangement of the bound substrate in the closed enzyme because in the transition state, all three phosphate oxygens are stabilized by ligands, as opposed to only two stabilized oxygens in the initial bound state.
A PGK pasa por un estado de transición estabilizado na carga que está favorecido polo arranxo do substrato enlazado no encima pechado porque no estado de transición os tres oxíxenos do fosfato están estabilizados por ligandos, mentres que no estado enlazado inicial só o estaban dous oxíxenos.