In addition to its role in long-patch BER, FEN1 cleaves flaps with a similar structure during Okazaki fragment processing, an important step in lagging strand DNA replication.
Ademais do seu papel na BER de parche longo, a FEN1 cliva solapas cunha estrutura similar durante o procesamento de fragmentos de Okazaki, un importante paso na replicación da febra retardada do ADN.