"Direct" creation of a humanized antibody can be accomplished by inserting the appropriate CDR coding segments (so-called 'donor', responsible for the desired binding properties) into a human antibody "scaffold" (so-called 'acceptor').
A creación "directa" dun anticorpo humanizado pode realizarse inserindo os segmentos codificantes CDR axeitados (responsables das propiedades de unión desexadas) nun "armazón" de anticorpo humano.