Poly(A)polymerase was first identified in 1960 as an enzymatic activity in extracts made from cell nuclei that could polymerise ATP, but not ADP, into polyadenine.
A poliadenilación identificouse en 1960 como unha actividade encimática en extractos feitos de núcleos celulares que podían polimerizar ATP, pero non ADP, formando poliadenina.