The best-known case of imprinting in human disorders is that of Angelman syndrome and Prader-Willi syndrome – both can be produced by the same genetic mutation, chromosome 15q partial deletion, and the particular syndrome that will develop depends on whether the mutation is inherited from the child's mother or from their father.
Os casos mellor coñecidos de trastorno por improta en humanos son a síndrome de Angelman e a síndrome de Prader-Willi, que se poden producir ambas as dúas pola mesma mutación xenética, a deleción parcial do cromosoma 15q, e as características concretas da síndrome que se presenta na persoa afectada dependen de se a mutación se herdou do pai ou da nai.