By establishing the presence of two distinct steps in the process the possibility of identifying the factors involved was established and led on to the identification of the importin family of NLS receptors and the GTPase Ran.
Establecer a existencia de dous pasos distintos neste proceso, permitiu a posibilidade de identificar os factores implicados e isto levou á identificación da familia de receptores do NLS da importina e a GTPase Ran.