Wortmannin is a PI3K-specific inhibitor, and treatment of cells with Wortmannin in combination with PDGF resulted in enhanced osteoblast differentiation compared to just PDGF alone, as well as compared to EGF.
A wortmannina é un inhibidor específico de PI3K, e o tratamento de células con wortmannina en combinación con PDGF ten como resultado o aumento da diferenciación de osteoblastos en comparación co uso de PDGF só, e tamén comparado con EGF.