TNF can bind two receptors, TNFR1 (TNF receptor type 1; CD120a; p55/60) and TNFR2 (TNF receptor type 2; CD120b; p75/80).
O TNFα pode unirse a dous receptores, o TNFR1 (receptor de TNF tipo 1; CD120a; p55/60) e o TNFR2 (receptor de TNF de tipo 2; CD120b; p75/80).