In December 1985, a freighter model, the 757-200PF, was announced following a launch order for 20 aircraft from UPS Airlines, and in February 1986, a freighter-passenger combi model, the 757-200M, was launched with an order for one aircraft from Royal Nepal Airlines.
En decembro de 1985, anunciouse un modelo de carga, o 757-200PF, tras un pedido de lanzamento de 20 unidades de UPS Airlines, e en febreiro de 1986 lanzouse un modelo combinado, o 757-200M, cun pedido dun avión por parte de Royal Nepal Airlines.