The families A and B are distinguishable with family A Pol sharing 9 distinct consensus sequences and only two of them are convincingly homologous to sequence motif B of family B. The putative sequence motifs A, B, and C of the polymerase domain are located near the C-terminus in family A Pol and more central in family B Pol.
As familias A e B son distinguibles, xa que a familia A Pol comparte 9 secuencias consenso distintas e só dúas delas son convincentemente homólogas do motivo de secuencia B da familia B. Os supostos motivos de secuencia A, B, e C do dominio da polimerase están localizados preto do extremo C-terminal na familia A Pol e son máis centrais na familia B Pol.