Cortisol is also metabolized into 5-alpha tetrahydrocortisol (5-alpha THF) and 5-beta tetrahydrocortisol (5-beta THF), reactions for which 5-alpha reductase and 5-beta-reductase are the rate-limiting factors, respectively.
O cortisol tamén se metaboliza a 5-alfa tetrahidrocortisol (5-alfa THF) ed 5-beta tetrahidrocortisol (5-beta THF), reaccións nas que os factores limitantes son, respectivamente, a 5-alfa redutase e a 5-beta redutase.