Eventually, the FSH level becomes so high that downregulation of FSH receptors occurs and by postmenopause any remaining small secondary follicles no longer have FSH nor LH receptors.
Finalmente, o nivel de FSH chega a ser tan alto que ten lugar a regulación á baixa dos receptores de FSH e na menopausa o resto de folículos pequenos que queden xa non ten receptores de FSH.