The presence of an FxFP motif in the KSR1 scaffold protein also serves to make it an ERK1/2 substrate, providing a negative feedback mechanism to set the correct strength of ERK1/2 activation.
A presenza dun motivo FxFP na proteína armazón KSR1 tamén serve para facer dela un substrato de ERK1/2, proporcionando un mecanismo de retroalimentación negativa para establecer o nivel correcto de activación de ERK1/2.