There are eight hydrogen bonds directly made to residues in the binding site (the so-called 'first shell' of hydrogen bonding), involving residues Asn23, Tyr43, Ser27, Ser45, Asn49, Ser88, Thr90 and Asp128.
Hai oito enlaces de hidróxeno feitos directamente con residuos situados no sitio de unión (a denominada 'primeira capa' de enlaces de hidróeno), nos que están implicados os residuos Asn23, Tyr43, Ser27, Ser45, Asn49, Ser88, Thr90 e Asp128.