Following activation by the contact factor or tissue factor pathways, the coagulation cascade is maintained in a prothrombotic state by the continued activation of FVIII and FIX to form the tenase complex, until it is down-regulated by the anticoagulant pathways.
Despois da activación polo factor de contacto ou pola vía do factor tisular, a fervenza de coagulación mantense en estado protrombótico pola activación continuada de FVIII e FIX para formar o complexo tenase, ata que sexa regulado á baixa polas vías anticoagulantes.