Until the discovery of factor V, coagulation was regarded as a product of four factors: calcium (IV) and thrombokinase (III) together acting on prothrombin (II) to produce fibrinogen (I); this model had been outlined by Paul Morawitz in 1905.
Ata o descubrimento do factor V, considerábase que a coagulación era causada por catro factores: calcio (IV) e tromboquinase (III) actuando xunto coa protrombina (II) para producir fibrinóxeno (I); este modelo fora ideado por Paul Morawitz en 1905.