Mycobacterium leprae was sensitive to dapsone (diaminodiphenylsulfone, the first effective treatment which was discovered for leprosy in the 1940s), but resistance against this antibiotic has developed over time.
M. leprae byla citlivá na lék Dapson (tzn. diaminodiphenylsulfone, první účinná léčba, která byla v roce 1940 objevena pro léčbu lepry), ale v průběhu času se stala vůči tomuto antibiotiku rezistentní.