25
Below is an instruction that describes a task. Write a response that appropriately completes the request.

### Instruction:
Find the missing number in this sequence: 0, 1, 4, 9, 16, __

### Response:
25
assistant

The pattern of the sequence is obtained by squaring the natural numbers (0^2, 1^2, 2^2, 3^2,...). 

To find the next number in the sequence, we need to find the square of 4 (since 4 is the next natural number after 3). 

Therefore, the missing number in the sequence is 25.