See footnote 4. Avoid elvitegravir/ cobicistat, etravirine, lopinavir/ritonavir, nevirapine. Avoid in patients with sulfa allergy or severe hepatic insufficiency. Avoid cimetidine, disulfiram, metronidazole, vitamin E, ritonavir oral solution, and alcohol with the oral solution.
See footnote 4. Avoid efavirenz and etravirine.
Lamivudine NRTI1 150 mg bid or 300 mg qd3 Nausea, headache, dizziness, Do not administer with emtricitabine or fatigue zalcitabine.
Lopinavir/ PI/PI2 400/100 mg bid or 800/200 mg qd Separate dosing from ddI Diarrhea, nausea, hyper-See footnote 4. Avoid darunavir, elvitegravir/ ritonavir by 1 h. triglyceridemia, ↑ liver cobicistat, fosamprenavir, tipranavir. Avoid enzymes; possible increase in disulfiram and metronidazole with oral myocardial infarction solution.
Maraviroc CCR5 inhibitor 300 mg bid; 150 bid with CYP3A inhibitors;
Cough, muscle pain, diarrhea, See footnote 4. Do not administer in 600 mg bid with CYP3A inducers sleep disturbance, ↑ liver patients with severe renal dysfunction. enzymes; possible increase in myocardial infarction
Nelfinavir PI2 750 mg tid or 1250 mg bid Take with food. Diarrhea, nausea, flatulence See footnote 4. The oral powder contains phenylalanine.
Nevirapine NNRTI 200 mg bid Dose-escalate from 200 mg Rash, hepatitis (occasionally See footnote 4. Avoid atazanavir, dolutedaily over 14 days. fulminant), nausea, headache gravir, elvitegravir/cobicistat, fosamprenavir. Contraindicated with moderate or severe hepatic impairment.
Raltegravir INSTI 400 mg bid Nausea, headache, fatigue, The chewable tablets contain muscle aches, ↑ amylase phenylalanine. levels, ↑ liver enzymes
Rilpivirine NNRTI 25 mg qd Take with food. Separate Headache, insomnia, depres-See footnote 4. dosing from antacids or H2 sion, rash, ↑ liver enzymes blockers by ≥4 h.
Rilpivirine PI2 1000 mg bid with ritonavir 100 mg bid Take within 2 h of a full meal. Nausea, diarrhea, abdominal See footnote 4. Avoid darunavir, garlic pain, dyspepsia, rash capsules, tipranavir and drugs that increase the QT interval. Avoid in severe hepatic insufficiency.
Stavudine NRTI1 30–40 mg bid, depending on weight3
Peripheral neuropathy, pan-Avoid zidovudine and neuropathic drugs creatitis, rapidly progressive (eg, ddI, zalcitabine, isoniazid). ascending neuromuscular weakness (rare)
Tenofovir NRTI1 10 mg qd with emtricitabine plus