In the current era of repurposing established drugs that are well tolerated, unexpected benefits can emerge. Infantile hemangiomas are the most common vascular tumors of infancy, which can disfigure or impair vital functions. Propranolol at 2 mg/kg/d has been found to reduce the volume, color, and elevation of infantile hemangioma in infants younger than 6 months and children up to 5 years of age, perhaps displacing more toxic drugs such as systemic glucocorticoids, vincristine, and interferon-alfa.
Propranolol is the standard against which newer β antagonists for systemic use have been compared. In many years of very wide use, propranolol has been found to be a safe and effective drug for many indications. Since it is possible that some actions of a β-receptor antagonist may relate to some other effect of the drug, these drugs should not be considered interchangeable for all applications. For example, only β antagonists known to be effective in stable heart failure or in prophylactic therapy after myocardial infarction should be used for those indications. It is possible that the beneficial effects of one drug in these settings might not be shared by another drug in the same class. The possible advantages and disadvantages of β-receptor partial agonists have not been clearly defined in clinical settings, although current evidence suggests that they are probably less efficacious in secondary prevention after a myocardial infarction compared with pure antagonists.
Many adverse effects have been reported for propranolol but most are minor. Bradycardia is the most common adverse cardiac effect of β-blocking drugs. Sometimes patients note coolness of hands and feet in winter. CNS effects include mild sedation, vivid dreams, and rarely, depression. Discontinuing the use of β blockers in any patient who develops psychiatric depression should be seriously considered if clinically feasible. It has been claimed that β-receptor antagonist drugs with low lipid solubility are associated with a lower incidence of CNS adverse effects than compounds with higher lipid solubility (Table 10–2). Further studies designed to compare the CNS adverse effects of various drugs are required before specific recommendations can be made, although it seems reasonable to try the hydrophilic drugs nadolol or atenolol in a patient who experiences unpleasant CNS effects with other β blockers.
The major adverse effects of β-receptor antagonist drugs relate to the predictable consequences of β blockade. Beta2-receptor blockade associated with the use of nonselective agents commonly causes worsening of preexisting asthma and other forms of airway obstruction without having these consequences in normal individuals. Indeed, relatively trivial asthma may become severe after β blockade. However, because of their lifesaving potential in cardiovascular disease, strong consideration should be given to individualized therapeutic trials in some classes of patients, eg, those with chronic obstructive pulmonary disease who have appropriate indications for β blockers. While β1-selective drugs may have less effect on airways than nonselective β antagonists, they must be used very cautiously in patients with reactive airway disease. Beta1-selective antagonists are generally well tolerated in patients with mild to moderate peripheral vascular disease, but caution is required in patients with severe peripheral vascular disease or vasospastic disorders.