Amitriptyline, chlorpromazine, cimetidine, clomethiazole, clotrimazole, clozapine, disulfiram, diethylthiocarbamate, diallyl sulfide, econazole, methimazole, methoxsalen, 4-methylpyrazole, miconazole, modafinil, ritonavir, selegiline, sildenafil, sulconazole, ticlopidine, tioconazole
TABLE 4–2 Human liver P450s (CYPs), and some of the drugs metabolized (substrates), inducers, and selective inhibitors. Note: Some P450 substrates can be potent competitive inhibitors and/or mechanism-based inactivators. (Continued)
CYP Substrates Inducers Inhibitors 3A41 Aminoglutethimide, avasimibe, barbiturates, carbamazepine, efavirenz, glucocorticoids, nevirapine, pioglitazone, phenytoin, primidone, rifampin, rifa-pentine, St. John’s wort