The effects of dietary manipulation on arachidonic acid metabolism have been extensively studied. Dietary intake of linoleic and α-linolenic acids, which are, respectively, omega-6 and omega-3 essential fatty acids, can modify arachidonic acid metabolism and the nature of the eicosanoids produced. Two approaches have been used. The first adds corn, safflower, and sunflower oils, which contain linoleic acid (C18:2), to the diet, allowing for generation of 1-series prostaglandins via dihomo-γ-linoleic acid. The second approach adds oils from cold-water fish that contain the omega-3 fatty acids eicosapentaenoic (C20:5) and docosahexaenoic acids (C22:6). Diets high in fish oils have been shown to impact indices of platelet and leukocyte function, blood pressure, and triglycerides with different dose-response relationships. There is an abundance of epidemiologic data relating diets high in fatty fish to a reduction in the incidence of myocardial infarction and sudden cardiac death, although there is more ambiguity about stroke. However, such epidemiologic data may be confounded by concurrent reduction in saturated fats and inclusion of other elements of a “healthy” lifestyle, raising questions about the cardiovascular benefit of dietary omega-3 fatty acids. Nevertheless, data from prospective randomized trials suggest that such dietary interventions may reduce the incidence of sudden death while experiments in vitro suggest that fish oils protect against experimentally induced arrhythmogenesis, platelet aggregation, vasomotor spasm, and dyslipidemias.
NONSTEROIDAL ANTI-INFLAMMATORY DRUGS ARE LISTED IN CHAPTER 36.
Alprostadil Penile injection, mini-suppository Caverject, Edex, Muse Parenteral Generic, Prostin VR Pediatric Bimatoprost Lumigan, Latisse Carboprost tromethamine Hemabate Dinoprostone [prostaglandin E2] Prostin E2, Prepidil, Cervidil Epoprostenol [prostacyclin] Generic, Flolan, Veletri Iloprost Ventavis Latanoprost Generic, Xalatan Misoprostol Generic, Cytotec Montelukast Generic, Singulair Selexipag Uptravi Travoprost Generic, Travatan, Travatan-Z Treprostinil Remodulin, Tyvaso, Orenitram Zafirlukast Generic, Accolate Zileuton Zyflo, Zyflo CR
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