Vorinostat (Zolinza) and romidepsin (Istodax) are histone deacetylase inhibitors that are approved for the treatment of cutaneous T-cell lymphoma in patients with progressive, persistent, or recurrent disease after prior systemic therapy. Adverse effects include thrombocytopenia, anemia, and gastrointestinal disturbances. Pulmonary embolism, which has occurred with vorinostat, has not been reported to date with romidepsin.
Drugs used primarily for other conditions may also find use as oral therapeutic agents for dermatologic conditions. A few such preparations are listed in Table 61–7.
TABLE 61–7 Miscellaneous medications and the dermatologic conditions in which they are used.
Bronaughs R, Maibach HI: Percutaneous Penetration: Principles and Practices, 4th ed. Taylor & Francis, 2005.
Lebwohl MG et al: Treatment of Skin Disease, 4th ed. Elsevier-Saunders, 2014.
Maibach HI, Gorouhi F: Evidence-Based Dermatology, 2nd ed. Peoples Medical Publishing, 2012.
Wakelin S, Maibach HI, Archer CB: Systemic Drug Treatment in Dermatology, 2nd ed. CRC Press, 2015.
Wilhem, KP, Zhai H, Maibach HI: Marzulli & Maibach Dermatotoxicology, 8th ed. Informa Healthcare, 2012.
Wolverton S: Comprehensive Dermatologic Drug Therapy, 2nd ed. Saunders, 2007.
Antibacterial, Antifungal, & Antiviral Drugs
Baddour LM: Skin abscesses, furuncles, and carbuncles. UpToDate 2014; topic 7656.
James WD: Clinical practice. Acne. N Engl J Med 2005;352:1463.
Leone PA: Scabies and pediculosis pubis: An update of treatment regimens and general review. Clin Infect Dis 2007;44(Suppl 3):S153.
Levitt J: The safety of hydroquinone. J Am Acad Dermatol 2007;57:854.
Stolk LML, Siddiqui AH: Biopharmaceutics, pharmacokinetics, and pharmacology of psoralens. Gen Pharmacol 1988;19:649.
Shalita AR et al: Tazarotene gel is safe and effective in the treatment of acne vulgaris. A multicenter, double-blind, vehicle-controlled study. Cutis 1999;63:349.
Thami GP, Sarkar R: Coal tar: Past, present and future. Clin Exp Dermatol 2002;27:99.
Tzellos T et al: Topical retinoids for the treatment of acne vulgaris. Cochrane Database Syst Rev 2013;8:CD009470.
Brazzini B, Pimpinelli N: New and established topical corticosteroids in dermatology: Clinical pharmacology and therapeutic use. Am J Clin Dermatol 2002;3:47.
Williams JD, Griffiths CE: Cytokine blocking agents in dermatology. Clin Exp Dermatol 2002;27:585.
Bhutani T, Hong J, Koo J: Contemporary Diagnosis and Management of Psoriasis, 5th ed. Handbooks in Healthcare, 2011.
Samarasekera EJ et al: Topical therapies for the treatment of plaque psoriasis: Systematic review and network meta-analyses. Br J Dermatol 2013;168:954.