Delavirdine NNRTI 400 mg tid Separate dosing from ddI or Rash, ↑ liver enzymes, head-See footnote 4. Avoid concurrent antacids by ≥1 h. ache, nausea, diarrhea fosamprenavir. Teratogenic in rats.
Didanosine NRTI1 Tablets, 400 mg qd or 200 mg bid3 Take on an empty stomach. Peripheral neuropathy, pan-Avoid concurrent neuropathic drugs (eg, (ddI) creatitis, diarrhea. stavudine, zalcitabine, isoniazid), ribavirin, or allopurinol. Chewable tablets contain
Buffered powder, 250 mg bid3 phenylalanine.
Dolutegravir INSTI INSTI-naïve: 50 mg qd Separate dosing from antac-Insomnia, headache, Avoid carbamazepine, dofetilide, nevirapine, ids and polyvalent cations hypersensitivity reaction, phenobarbital, phenytoin.
If co-administered with efavirenz, fosam by ≥2 h. ↑ liver enzymes prenavir/ritonavir, tipranavir/ritonavir, or rifampin or if certain INSTI mutations: 50 mg bid
Efavirenz NNRTI 600 mg qd Take on an empty stomach, Neuropsychiatric symptoms, See footnote 4. Avoid elvitegravir/ at bedtime. rash, ↑ liver enzymes, head-cobicistat, etravirine, indinavir, simeprevir. ache, nausea Teratogenic in primates.
Elvitegravir INSTI Treatment-naïve: 150 mg qd with cobici-Take with food. Separate dos-Diarrhea, rash, ↑ liver See footnote 4. Avoid efavirenz and stat 150, emtricitabine 200, and tenofovir ing from antacids by ≥2 h. enzymes nevirapine.
Treatment-experienced: 85 mg–150 mg qd with a protease inhibitor
Emtricitabine NRTI1 200 mg qd3 Headache, diarrhea, nausea, Avoid concurrent lamivudine. rash, hyperpigmentation
TABLE 49–3 Currently available antiretroviral agents. (Continued)
Etravirine NNRTI 200 mg bid Take with food. Rash, nausea, diarrhea
Fosamprenavir PI2 1400 mg bid or 700 mg bid with ritonavir Rash, diarrhea, nausea, head100 mg bid or 1400 mg daily with ritonavir ache, ↑ liver enzymes
Indinavir PI2 800 mg tid or 800 mg bid with ritonavir Best on an empty stomach. Nephrolithiasis, nausea, 100–200 mg bid; adjust dose in cirrhosis Drink at least 48 oz liquid indirect hyperbilirubinemia, daily. Separate dosing from headache, diarrhea; posddI by ≥1 h. sible increase in myocardial infarction
See footnote 4. Avoid atazanavir, efavirenz, elvitegravir/cobicistat, fosamprenavir, indinavir, tipranavir.