Haloperidol: [P] Increased haloperidol metabolism. Isoniazid: [P] Decreased carbamazepine metabolism. Kinase inhibitors: [P] Decreased metabolism of carbamazepine with ceritinib, dasatinib, imatinib, idelalisib, and lapatinib. Increased metabolism of kinase inhibitors.
Macrolide antibiotics: [P] Clarithromycin and erythromycin inhibit the metabolism of carbamazepine. Nefazodone: [NE] Decreased carbamazepine metabolism. Opioid analgesics: [P] Increased elimination of alfentanil, fentanyl, methadone, oxycodone, and sufentanil. Rifampin: [P] Increased carbamazepine metabolism. Selective serotonin reuptake inhibitors (SSRIs): [NE] Fluoxetine and fluvoxamine decrease carbamazepine metabolism. Sirolimus: [P] Increased sirolimus metabolism. St. John’s wort: [P] Increased carbamazepine metabolism. Tacrolimus: [P] Increased tacrolimus metabolism. Theophylline: [NE] Increased theophylline metabolism. See also Anticoagulants, oral; Antidepressants, tricyclic; Azole antifungals; Calcium channel blockers. Antivirals: [P] Decreased metabolism of amprenavir, atazanavir, boceprevir, daclatasvir, darunavir, delavirdine, etravirine, fosamprenavir, indinavir, lopinavir, maraviroc, nelfinavir, rilpivirine, ritonavir, saquinavir, and tipranavir. Benzodiazepines: [P] Decreased metabolism of alprazolam, chlordiazepoxide, diazepam, halazepam, prazepam, and clorazepate but not oxazepam, lorazepam, or temazepam. Carmustine: [NE] Increased bone marrow suppression. Dofetilide: [NP] Decreased renal excretion of dofetilide. Lidocaine: [P] Decreased metabolism of lidocaine. Opioid analgesics: [P] Decreased elimination of alfentanil, fentanyl, methadone, oxycodone, and sufentanil. Phenytoin: [NE] Decreased phenytoin metabolism. Procainamide: [P] Decreased renal excretion of procainamide. Quinidine: [P] Decreased metabolism of quinidine. Theophylline: [P] Decreased theophylline metabolism.
See also Anticoagulants, oral; Antidepressants, tricyclic; Azole antifungals; β-Adrenoceptor blockers; Calcium channel blockers; Carbamazepine. Amiodarone: [NP] Decreased cisapride metabolism. Expect similar interaction with dronedarone. Antivirals: [P] Amprenavir, atazanavir, boceprevir, darunavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, simeprevir, and telaprevir inhibit the metabolism of cisapride. Cobicistat: [P] Decreased metabolism of cisapride. Conivaptan: [P] Decreased metabolism of cisapride. Cyclosporine: [NE] Decreased metabolism of cisapride. Kinase inhibitors: [P] Decreased metabolism of cisapride with ceritinib, dasatinib, imatinib, idelalisib, and lapatinib.