Children 1–8 yr of age: oral 5,000–10,000 U/kg/day for 5 days or until recovery. Children >8 yr of age and adults: oral 500,000 U/day for 3 days; then 50,000 U/day for 14 days; then 10,000–20,000 U/day for 2 mo.
Deficiency without Infants <1 yr of age: 100,000 U/day orally, q4–6mo. corneal changes
Children 1–8 yr of age: 200,000 U/day orally, q4–6mo. Children >8 yr and adults: 100,000 U/day for 3 days, followed by 50,000 U/day for 10 days.
Deficiency IM given only to those patients with malabsorption in whom oral dosing is not possible. Infants: 7,500–15,000 U/day for 10 days. Children 1–8 yr of age: 17,500–35,000 U/day for 10 days. Children >8 yr of age and adults: 100,000 U/day for 3 days, then 50,000 U/day for 14 days. Give follow-up oral multivitamin that contains vitamin A:
LBW infants: no dose established, children ≤8 years of age: 5,000–10,000 U/day, children >8 yr of age and adults: 10,000–20,000 U daily.
Malabsorption syndrome Children >8 yr of age and adults: oral 10,000–50,000 U/day of water-miscible product. (prophylaxis)
Cystic fibrosis 1,500–10,000 U/day prophylaxis (CF Foundation).
Measles WHO recommendations: single dose, repeating the dose next day and at 4 wk for children with eye findings: 6 mo to 1 yr of age: 100,000 U; >1 yr of age: 200,000 U.
Niacin Pellagra Children: 50–100 mg tid. Adults: 50–100 mg/day, max 100 mg/day.
Pyridoxine (B6) Seizures Neonates and infants: initial 50–100 mg/day orally, IM, IV, SC.
Drug-induced Children: 10–50 mg/day as treatment, 1–2 mg/kg/day as prophylaxis. deficiencies
Adults: 100–200 mg/day as treatment, 25–100 mg/day as prophylaxis.
Dietary deficiency Children: 5–25 mg/day for 3 wk, then 1.5–2.5 mg/day in a multivitamin product. Adults: 10–20 mg/day for 3 wk.
Riboflavin (B2) Children: 2.5–10 mg/day in divided doses. Adults: 5–30 mg/day in divided doses.
Ascorbic acid Scurvy Children: 100–300 mg/day in divided doses orally, IM, IV, or SC for several days. Adults: 100–250 mg/day one to two times/day.