Tuberculosis (TB) may invade the central nervous system, including the brain, spinal cord, and meninges (Fig. 8.51). Symptoms of brain TB include headache, neck stiffness, weight loss, and fever. Symptoms of spinal cord TB include leg weakness and fecal and urinary incontinence. Meningitis can cause altered mental status, fever, and seizures. Treatment usually requires a cocktail of drugs for 1 year, but treatment for brain TB can require 2 years.