As with many weight-bearing joints, degenerative changes may occur with the sacro-iliac joints and cause pain and discomfort in the region. In addition, disorders associated with the major histocompatibility complex antigen HLA-B27, such as ankylosing spondylitis, psoriatic arthritis, inflammatory arthritis associated with inflammatory bowel disease, and reactive arthritis (the group referred to as seronegative spondyloarthropathies), can produce specific inflammatory changes within these joints.