Within the lateral zone of the hypothalamus is a large bundle of axons forming the medial forebrain bundle (MFB) (eFig. 9.90). Theses fibers interconnect the hypothalamus with the septal nuclei rostrally and nuclear complexes within the brainstem. Axons arising from the large lateral nucleus in this zone enter the MFB and function in promoting feeding behavior. The other and smaller nuclear group in this zone is the tuberal group. Axons from the tuberal nuclei make connections with the anterior pituitary through the tuberoinfundibular tract to regulate release of hormones in the hypophysial portal system and to the cerebellum to regulate motor activity (eFig. 9.89).