Proximally, most major structures pass between the thigh and leg through or in relation to the popliteal fossa behind the knee.
Distally, structures pass between the leg and foot mainly through the tarsal tunnel on the posteromedial side of the ankle, the exceptions being the anterior tibial artery and the ends of the deep and superficial fibular nerves, which enter the foot anterior to the ankle.
The bony framework of the leg consists of two bones, the tibia and fibula, arranged in parallel.