The posterior tibial artery descends through the deep region of the posterior compartment of the leg on the superficial surfaces of the tibialis posterior and flexor digitorum longus muscles. It passes through the tarsal tunnel behind the medial malleolus and into the sole of the foot.
In the leg, the posterior tibial artery supplies adjacent muscles and bone and has two major branches, the circumflex fibular artery and the fibular artery: