The hypoglossal nerve [XII] carries GSE fibers to innervate all intrinsic muscles and most of the extrinsic muscles of the tongue. It arises as several rootlets from the anterior surface of the medulla (Fig. 8.54), passes laterally across the posterior cranial fossa, and exits through the hypoglossal canal (Fig. 8.53). This nerve innervates the hyoglossus, styloglossus, and genioglossus muscles and all intrinsic muscles of the tongue.