The sphenopalatine foramen opens onto the lateral wall of the nasal cavity and is in the medial wall.
The lateral aspect of the pterygopalatine fossa is continuous with the infratemporal fossa via a large gap (the pterygomaxillary fissure) between the posterior surface of the maxilla and pterygoid process of the sphenoid bone.
The superior aspect of the anterior wall of the fossa opens into the floor of the orbit via the inferior orbital fissure.