A second afferent pathway from the entorhinal cortex to the hippocampal formation is through the alvear pathway. Axons in the alvear pathway project directly on to CA1 and CA3 of the hippocampus (eFig. 9.104B). Similar to the perforant pathway, axons leaving the alvear pathway primarily originate from CA1 and CA3, which then project to the subiculum.