Many patients throughout the world require renal dialysis for kidney failure. The patient’s blood is filtered and cleaned by the dialysis machine. Blood therefore has to be taken from patients into the filtering device and then returned to them. This process of dialysis occurs over many hours and requires considerable flow rates of 250–500 mL per minute. To enable such large volumes of blood to be removed from and returned to the body, the blood is taken from vessels that have a high flow. As no veins in the peripheral limbs have such high flow, a surgical procedure is necessary to create such a system. In most patients, the radial artery is anastomosed (joined) to the cephalic vein (Fig. 7.78) at the wrist, or the brachial artery is anastomosed to the cephalic vein at the elbow. Some surgeons place an arterial graft between these vessels.