Most cancers of the oral cavity, oropharynx, nasopharynx, larynx, sinuses, and salivary glands arise from the epithelial cells that line them, resulting in squamous cell carcinoma. The majority of these are related to cell damage caused by smoking and alcohol use. Certain viruses are also related to cancers in the head and neck, including human papillomavirus (HPV) and Epstein-Barr virus (EBV).