In the first method (hemodialysis), blood is taken from the circulation, dialyzed through a complex artificial membrane, and returned to the body. A high rate of blood flow is required to remove excess body fluid, exchange electrolytes, and remove noxious metabolites. To accomplish this, either an arteriovenous fistula is established surgically (by connecting an artery to a vein, usually in the upper limb, and requiring approximately six weeks to “mature”) and is cannulated each time the patient returns for dialysis, or a large-bore cannula is placed into the right atrium, through which blood can be aspirated and returned.