The thoraco-acromial artery is short and originates from the anterior surface of the second part of the axillary artery just posterior to the medial (superior) margin of the pectoralis minor muscle (Fig. 7.50). It curves around the superior margin of the muscle, penetrates the clavipectoral fascia, and immediately divides into four branches—the pectoral, deltoid, clavicular, and acromial branches, which supply the anterior axillary wall and related regions.