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BINDINGDB Benchmark Summary:

Model         Encoding RMSE ±               MAE ±               
-----------------------------------------------------------------
gat           ecfp     2.6672 ± 0.4774     1.9156 ± 0.1894
gat           selfies  1.8164 ± 0.2667     1.3696 ± 0.1159
gat           smiles   1.7932 ± 0.2338     1.3722 ± 0.1176
gcn           ecfp     2.1744 ± 0.3132     1.5856 ± 0.1452
gcn           selfies  1.7671 ± 0.2332     1.3612 ± 0.1056
gcn           smiles   1.8313 ± 0.2654     1.3773 ± 0.1171
gin           ecfp     2.0116 ± 0.3040     1.4942 ± 0.1247
gin           selfies  1.7480 ± 0.2425     1.3502 ± 0.1123
gin           smiles   1.7566 ± 0.2513     1.3585 ± 0.1048
gp+tanimoto   ecfp     1.6921 ± 0.2544     1.2645 ± 0.1051
gp+tanimoto   selfies  1.8034 ± 0.2504     1.3793 ± 0.1135
gp+tanimoto   smiles   1.6945 ± 0.2640     1.2650 ± 0.1057
sage          ecfp     2.1945 ± 0.3115     1.6303 ± 0.1384
sage          selfies  1.9251 ± 0.3445     1.4001 ± 0.1262
sage          smiles   1.8614 ± 0.3434     1.3816 ± 0.1282

BOILINGPOINT Benchmark Summary:

Model         Encoding RMSE ±               MAE ±               
-----------------------------------------------------------------
gat           ecfp     73.1437 ± 6.6197     53.9304 ± 4.6799
gat           selfies  60.0938 ± 4.9932     44.2603 ± 3.9387
gat           smiles   60.0681 ± 4.7094     45.0223 ± 3.8590
gcn           ecfp     63.2157 ± 5.0890     48.2488 ± 3.9244
gcn           selfies  66.5821 ± 5.0110     50.7737 ± 4.1893
gcn           smiles   68.6942 ± 5.0914     52.5543 ± 4.2683
gin           ecfp     59.5471 ± 5.0798     44.7224 ± 3.9753
gin           selfies  72.0029 ± 5.4545     54.6066 ± 4.6104
gin           smiles   70.0021 ± 4.9849     55.1386 ± 4.2748
gp            ecfp     51.6225 ± 4.9579     37.8647 ± 3.4987
gp            selfies  79.3254 ± 5.8622     63.3404 ± 4.5846
gp            smiles   51.5120 ± 5.3235     37.8171 ± 3.5411
sage          ecfp     64.4034 ± 5.4008     47.8241 ± 4.1397
sage          selfies  59.2558 ± 4.7487     44.8262 ± 3.8195
sage          smiles   62.0991 ± 4.6785     46.6419 ± 4.0569

ESOL Benchmark Summary:

Model         Encoding RMSE ±               MAE ±               
-----------------------------------------------------------------
gat           ecfp     1.2483 ± 0.1534     0.9410 ± 0.1059
gat           selfies  1.5646 ± 0.1858     1.1441 ± 0.1370
gat           smiles   1.5192 ± 0.1740     1.1516 ± 0.1287
gcn           ecfp     1.1634 ± 0.1252     0.8822 ± 0.0988
gcn           selfies  1.6861 ± 0.1825     1.3087 ± 0.1381
gcn           smiles   1.7133 ± 0.1825     1.3146 ± 0.1394
gin           ecfp     1.1526 ± 0.1277     0.8507 ± 0.1042
gin           selfies  1.6538 ± 0.1885     1.2690 ± 0.1427
gin           smiles   1.6409 ± 0.1715     1.2461 ± 0.1419
gp+tanimoto   ecfp     1.0513 ± 0.1187     0.7792 ± 0.0866
gp+tanimoto   selfies  2.1744 ± 0.1980     1.7338 ± 0.1715
gp+tanimoto   smiles   1.0503 ± 0.1235     0.7798 ± 0.1002
sage          ecfp     1.1407 ± 0.1321     0.8713 ± 0.0983
sage          selfies  1.6127 ± 0.1710     1.2302 ± 0.1312
sage          smiles   1.5419 ± 0.1694     1.1597 ± 0.1326

FREESOLV Benchmark Summary:

Model         Encoding RMSE ±               MAE ±               
-----------------------------------------------------------------
gat           ecfp     2.5469 ± 0.5988     1.7310 ± 0.3236
gat           selfies  3.7543 ± 0.7218     2.8503 ± 0.3962
gat           smiles   3.5968 ± 0.7350     2.6242 ± 0.4419
gcn           ecfp     2.5038 ± 0.6450     1.6743 ± 0.3326
gcn           selfies  3.8168 ± 0.8156     2.7834 ± 0.4549
gcn           smiles   3.8458 ± 0.8551     2.8537 ± 0.4530
gin           ecfp     2.3410 ± 0.5840     1.5615 ± 0.3094
gin           selfies  3.7603 ± 0.8412     2.7327 ± 0.4461
gin           smiles   3.7822 ± 0.8187     2.7178 ± 0.4620
gp+tanimoto   ecfp     2.0696 ± 0.6732     1.3354 ± 0.2849
gp+tanimoto   selfies  4.1141 ± 0.8004     3.0900 ± 0.4399
gp+tanimoto   smiles   2.0787 ± 0.7082     1.3375 ± 0.2831
sage          ecfp     2.5430 ± 0.6463     1.7124 ± 0.3320
sage          selfies  3.8307 ± 0.8413     2.7317 ± 0.4656
sage          smiles   3.7483 ± 0.8613     2.6734 ± 0.4676

IC50 Benchmark Summary:

Model         Encoding RMSE ±               MAE ±               
-----------------------------------------------------------------
gat           ecfp     1.1000 ± 0.0907     0.8420 ± 0.0685
gat           selfies  0.7474 ± 0.0619     0.6026 ± 0.0412
gat           smiles   0.7569 ± 0.0620     0.6190 ± 0.0446
gcn           ecfp     1.0079 ± 0.0862     0.7721 ± 0.0615
gcn           selfies  0.7475 ± 0.0764     0.5828 ± 0.0459
gcn           smiles   0.7451 ± 0.0747     0.5863 ± 0.0470
gin           ecfp     0.9375 ± 0.0819     0.7075 ± 0.0634
gin           selfies  0.7501 ± 0.0693     0.5891 ± 0.0450
gin           smiles   0.7487 ± 0.0718     0.5905 ± 0.0436
gp+tanimoto   ecfp     0.7660 ± 0.0707     0.5961 ± 0.0485
gp+tanimoto   selfies  0.7833 ± 0.0769     0.6129 ± 0.0476
gp+tanimoto   smiles   0.7647 ± 0.0698     0.5965 ± 0.0480
sage          ecfp     1.0252 ± 0.0872     0.7877 ± 0.0658
sage          selfies  0.7415 ± 0.0736     0.5863 ± 0.0426
sage          smiles   0.7418 ± 0.0683     0.5868 ± 0.0440

LIPOPHIL Benchmark Summary:

Model         Encoding RMSE ±               MAE ±               
-----------------------------------------------------------------
gat           ecfp     0.9952 ± 0.0666     0.7434 ± 0.0423
gat           selfies  1.1282 ± 0.0480     0.9185 ± 0.0418
gat           smiles   1.1348 ± 0.0519     0.9200 ± 0.0441
gcn           ecfp     0.8879 ± 0.0524     0.6652 ± 0.0397
gcn           selfies  1.1611 ± 0.0534     0.9350 ± 0.0464
gcn           smiles   1.1608 ± 0.0494     0.9434 ± 0.0482
gin           ecfp     0.8650 ± 0.0551     0.6453 ± 0.0374
gin           selfies  1.1683 ± 0.0516     0.9407 ± 0.0470
gin           smiles   1.1698 ± 0.0581     0.9380 ± 0.0485
gp+tanimoto   ecfp     0.7498 ± 0.0454     0.5594 ± 0.0341
gp+tanimoto   selfies  1.1848 ± 0.0545     0.9536 ± 0.0448
gp+tanimoto   smiles   0.7494 ± 0.0456     0.5600 ± 0.0316
sage          ecfp     0.9368 ± 0.0571     0.7010 ± 0.0418
sage          selfies  1.1439 ± 0.0534     0.9102 ± 0.0435
sage          smiles   1.1332 ± 0.0455     0.9405 ± 0.0445

POLYATOMIC Benchmark Summary:

Model         Encoding RMSE ±               MAE ±               
-----------------------------------------------------------------
polyatomic    unknown  1.5655 ± 0.1263     1.2717 ± 0.0984
polyatomic    unknown  1.0860 ± 0.1354     0.8171 ± 0.0812
polyatomic    unknown  1.5153 ± 0.3395     1.0409 ± 0.2181
polyatomic    unknown  0.6975 ± 0.0551     0.5724 ± 0.0436
polyatomic    unknown  0.7913 ± 0.0575     0.5953 ± 0.0382
polyatomic    unknown  0.7043 ± 0.1095     0.5150 ± 0.0722
polyatomic    unknown  48.1815 ± 5.4987     33.3759 ± 3.7307

POLYATOMICBASIC Benchmark Summary:

Model         Encoding RMSE ±               MAE ±               
-----------------------------------------------------------------
polyatomicbasic unknown  1.5608 ± 0.1286     1.2846 ± 0.0970
polyatomicbasic unknown  1.6139 ± 0.3575     1.1024 ± 0.2127
polyatomicbasic unknown  0.8041 ± 0.0534     0.6136 ± 0.0394
polyatomicbasic unknown  48.0145 ± 5.1040     34.3959 ± 3.6937
polyatomicbasic unknown  1.2799 ± 0.1198     0.9838 ± 0.0891
polyatomicbasic unknown  0.7214 ± 0.0589     0.5949 ± 0.0452
polyatomicbasic unknown  0.6955 ± 0.1043     0.5174 ± 0.0707

QM9 Benchmark Summary:

Model         Encoding RMSE ±               MAE ±               
-----------------------------------------------------------------
gat           ecfp     3.4215 ± 0.2718     2.6676 ± 0.2061
gat           selfies  2.0540 ± 0.1546     1.6340 ± 0.1216
gat           smiles   2.0858 ± 0.1508     1.6694 ± 0.1175
gcn           ecfp     3.0271 ± 0.2273     2.3643 ± 0.1876
gcn           selfies  2.8783 ± 0.1980     2.3116 ± 0.1699
gcn           smiles   2.8837 ± 0.2133     2.3072 ± 0.1694
gin           ecfp     2.8340 ± 0.2436     2.1962 ± 0.1761
gin           selfies  2.8427 ± 0.2038     2.2164 ± 0.1699
gin           smiles   3.2328 ± 0.2544     2.5469 ± 0.1975
gp+tanimoto   ecfp     2.2497 ± 0.2188     1.6977 ± 0.1431
gp+tanimoto   selfies  3.9735 ± 0.3086     3.1156 ± 0.2450
gp+tanimoto   smiles   2.2494 ± 0.2074     1.7009 ± 0.1444
sage          ecfp     3.2668 ± 0.2386     2.6014 ± 0.1890
sage          selfies  2.1091 ± 0.1556     1.6486 ± 0.1295
sage          smiles   2.0653 ± 0.1655     1.6209 ± 0.1244