user6307: I posted a comment on this question, which has mysteriously vanished. It wasn't exactly ground breaking, though it was certainly constructive. I'm curious why it's gone…

user3340: It was not unconstructive but it was not very informative too. Moreover, it is obsoleted in the presence of the answer. 

Q: How do DNA-binding proteins determine that they're binding to the
  correct DNA base pairs?
C: The major groove contains more information and can distinguish between
  C-G and G-C

If you disagree then I can undelete it. Comments are generally not used for answering (even if it is partial).

6307: <p>I posted a comment on <a href="https://biology.stackexchange.com/questions/38808/how-do-dna-binding-proteins-determine-that-theyre-binding-to-the-correct-dna-ba">this</a> question, which has mysteriously vanished. It wasn't exactly ground breaking, though it was certainly constructive. I'm curious why it's gone…</p>
 3340: <p>It was not unconstructive but it was not very informative too. Moreover, it is obsoleted in the presence of the answer. </p>

<blockquote>
  <p>Q: How do DNA-binding proteins determine that they're binding to the
  correct DNA base pairs?</p>
  
  <p>C: The major groove contains more information and can distinguish between
  C-G and G-C</p>
</blockquote>

<p>If you disagree then I can undelete it. Comments are generally not used for answering (even if it is partial).</p>
