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gen_155a63b1445e395f177d9381bbeba950 | Biography, Belief and Communities: Non-Conformist Religious Narratives in Ireland, 1649-1700 | Irish Research Council | Maynooth University | Not available | Early Career / Postdoctoral Fellowship Programme | 1fellowships_scholarships | |
gen_f461821d97623287b734041de35006f4 | Dual DNA barcoding to allow multiplexed single cell spatial transcriptomics | Irish Research Council | University of Limerick | Not available | Early Career / Enterprise Partnership Scheme (Postgraduate) | 1fellowships_scholarships | |
gen_67dab343962f76f991ed3f3395741a66 | Dante's "Divine Comedy" and the "Queste del Saint Graal" | Irish Research Council | Trinity College Dublin | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_2d7666f9f004aa10a7dedc701a8ce6c3 | Local voices, worldwide conversations: generating a meaningful assessment for the online dissemination of cultural heritage projects | Irish Research Council | University College Cork | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_495e373b045a70e23374ef765bc251b6 | Investigation of the therapeutic potential of Mesenchymal Stem Cells in preclinical models of systemic sepsis | Irish Research Council | University of Galway | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_3c4a0055e8dc3b5c3e0b1e5d3b22d2b4 | The Promise of Multiculturalism': An Analysis of the Feasibility and Desirability of an EU Policy on Immigration and Multiculturalism. | Irish Research Council | University College Dublin | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_27654930298856688b94f1ff4e9013ba | The Place of Esfir Shub in the Evolution of Fiction and non-Fiction Editing Techniques. | Irish Research Council | University College Dublin | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_70918aa55a3f5ec47dad428049f73227 | The Regulation of Shadow Banking and its Implications for Systemic Risk | Irish Research Council | University of Limerick | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_3514ab831fd617b8084f8e3bd3d91447 | Polycrates, Tyrant of Samos: Friendship and Power in the Archaic Mediterranean. | Irish Research Council | University College Dublin | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_82f089133ddb311a4abc549c4f4eb3b8 | Thinking broadly: Participation, plurality, and solidarity in the phenomenology of Hannah Arendt | Irish Research Council | Mary Immaculate College, Limerick | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_73c4f6c7332c7426849529bcf1535b2d | Tackling antimicrobial resistance using small molecule disruptors of bacterial communication | Irish Research Council | University College Cork | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_02143fb14bbe2a452da843cc815e4b4d | THE EMERGENCE OF FINANCIAL TECHNOLOGY (FINTECH) AND FINANCING OF SMALL AND MEDIUM ENTERPRISES (SMEs) IN GAUTENG PROVINCE OF SOUTH AFRICA | Irish Research Council | Technological University Dublin | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_98c31d0ccfb6846295024dd563e00768 | Electrochemical investigations into latent fingerprint enhancement on metallic surfaces using electrodeposited films and electrochromic materials. | Irish Research Council | Maynooth University | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_73de2b34726d94638909e48c3a8dab03 | Identifying a heritability profile of cognitive and sensory deficits in adult attention deficit hyperactivity disorder (ADHD): Multi-domain approach | Irish Research Council | Trinity College Dublin | Not available | Early Career / Postdoctoral Fellowship Programme | 1fellowships_scholarships | |
gen_c638e64b66ddeeffb241319f07886767 | Re-shaping narratives: An analysis of life and culture as dramatised by Irish women playwrights following the Irish War of Independence, (1922-1959). | Irish Research Council | Waterford Institute of Technology | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_b7c1c4b5d15d9c3e6aa8c1eedb3d9b70 | The Language of Caribbean Poetry | Irish Research Council | University College Cork | Not available | Principal Investigator-led / Research Fellowship Scheme | 1fellowships_scholarships | |
gen_efaf3a13a8ad0e8dba68f02e0e02d6e0 | A Critical Edition of the Zoilomastix of Philip O'Sullivan Beare c.1626. | Irish Research Council | University College Cork | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_538eda21aa0102b56e82ce7317069bee | Control of endogenous analgesia by midbrain peroxisome proliferator-activated receptors | Irish Research Council | University of Galway | Not available | Early Career / Postdoctoral Fellowship Programme | 1fellowships_scholarships | |
gen_67be4633ae39ec0e2e5fe961a9d6ea2e | A Poetic Heteroglossia Re-Articulating 1930s Irish Women's Poetry: Weighted Silences | Irish Research Council | University College Cork | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_30c7a2a0f2990ed8fe70ffc032f1bdf8 | On the factorization of p-adic L-functions | Irish Research Council | University College Dublin | Not available | Early Career / Postdoctoral Fellowship Programme | 1fellowships_scholarships | |
gen_e014aa57cd27e7b56f6b7465b8f9656f | Villains, Vagabonds or Victims? Criminal Justice Responses to Deviance, 1955-1985 | Irish Research Council | University College Dublin | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_f7fd84b0e90280ab02672107bfde0d40 | Fundamental In-Situ Investigation of Kinetics, Stress and Morphology of Fe Deposition in Iron Flow Batteries | Irish Research Council | University of Limerick | Not available | Early Career / Postdoctoral Fellowship Programme | 1fellowships_scholarships | |
gen_4b0c4b66db17b4c87fdec4d6aa7d780e | Functional Genomics on the Targets of a Novel Transcriptional Regulator that Determines Host Specificity in Bacterial-Host Interactions | Irish Research Council | University College Cork | Not available | Early Career / Postdoctoral Fellowship Programme | 1fellowships_scholarships | |
gen_403dd79d444f98ce2e4b0f5ef52e2400 | Dialogues in Opposition – political violence and peacemaking in post-settlement ethno-nationalist divided societies | Irish Research Council | University College Dublin | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_51587faa08ccdbfdede637e02090e851 | A process of learning? Reassessing the impact of the "big bang" enlargement on EU policy outcomes. | Irish Research Council | Trinity College Dublin | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_2f9edca90370484a5f1cb4d4ac8d8652 | From the pen to the public domain: a critical analysis of mainstream media coverage of agriculture and food; the factors that influence editorial decisions on farm and food production news, and audience impact | Irish Research Council | University College Dublin | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_1f24a23575699ab29e324073d6c5fdeb | Secure East/West-Bound Communication for 5G Networks (SECURER) | Irish Research Council | University College Dublin | Not available | Early Career / Postdoctoral Fellowship Programme | 1fellowships_scholarships | |
gen_253414415edf92a3a63fa458aacf740e | Growing your Own AND Growing Social Cohesion: A Study of the Social Impact of Urban Agriculture Initiatives in Dublin, Belfast and London | Irish Research Council | Maynooth University | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_12ea7f0e4bde91b06cf14b21f5ad5aa0 | Modernity and Modernism: Interpreting the Roots of Religious Crisis | Irish Research Council | Trinity College Dublin | Not available | Principal Investigator-led / Senior Research Fellowship Scheme | 1fellowships_scholarships | |
gen_3092933881adb9684813eeda02ee7cb0 | Climate Change and Natura 2000: The Future of EU Nature Conservation | Irish Research Council | Trinity College Dublin | Not available | Early Career / EMBARK | 1fellowships_scholarships | |
gen_ff51296d816db5828bc2d7d552ee1214 | Building a Coherent Approach to Peace Building | Irish Research Council | Dublin City University | Not available | Early Career / Postdoctoral Fellowship Programme | 1fellowships_scholarships | |
gen_48eb42cb0dc78a08ce39bf4b0c176016 | Civilian experiences of the Irish revolution 1917-1923 | Irish Research Council | Trinity College Dublin | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_329d2122560101216e2d5e812329d956 | Electoral Participation in the Republic of Ireland: Political disengagement and Spaces of Neglect in the Current Political System. | Irish Research Council | Maynooth University | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_03e543443b06e1ffa278bb710476b8b3 | User-Controllable Physics-Based Quadrupedal Animation | Irish Research Council | University College Dublin | Not available | Early Career / Enterprise Partnership Scheme (Postgraduate) | 1fellowships_scholarships | |
gen_3e08427c47eacd89b60d915f8c3f8335 | Assessment of SIRT4 in pancreatic beta cell metabolism and insulin secretion | Irish Research Council | University College Dublin | Not available | Early Career / Enterprise Partnership Scheme (Postgraduate) | 1fellowships_scholarships | |
gen_cef00fc5a143f5889406f3f05ba94f8f | Enantioselective carbolithiation initiated cascade reaction | Irish Research Council | University College Dublin | Not available | Early Career / Enterprise Partnership Scheme (Postdoctoral) | 1fellowships_scholarships | |
gen_1bcd588fa99d364764d6795e28102a78 | How Does a Spinning Secondary Influence EMRI Waveforms? | Irish Research Council | University College Dublin | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_c022acbab76473fbfd0750f6dc7bfd48 | Hardware and Software Development of Real-Time Functional Imaging | Irish Research Council | Trinity College Dublin | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_225843210063a0522c975c2f41e0dc12 | A Novel Plasma Source for the efficient production of Plasma Activated Water | Irish Research Council | Dublin City University | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_5f34436a39c043a6535c4cf1af8dbe1b | Going native: Culture, identity and counterinsurgency in Iraq | Irish Research Council | Trinity College Dublin | Not available | Early Career / Postgraduate Scholarship Programme | 1fellowships_scholarships | |
gen_610d8eb779cf7334b72266f572c2d3ca | A Study of the Amazon-Myth in Medieval German Literature | Irish Research Council | Trinity College Dublin | Not available | Early Career / Postdoctoral Fellowship Programme | 1fellowships_scholarships | |
gen_68bf0b0a7f96014499a867b849fb45e5 | An evaluation of dosage profiling and genomic analysis to predict the optimum racing distance for thoroughbred horses and determination of the ancestral origin of the speed allele | Irish Research Council | University College Dublin | Not available | Early Career / Enterprise Partnership Scheme (Postgraduate) | 1fellowships_scholarships | |
gen_f894ee1f2bab217737908f052b3c0271 | Research stay at Princeton University | Carlsberg Foundation | University of Copenhagen | CF18-0471 | Not available | Research / Field Trips / Research Stays >100,000 / Award | 1fellowships_scholarships |
gen_5a9a495a258af73432268268b0bf719f | Queer(y)ing Pleasure: Nydelsens rolle i queerfeministisk kunstpraksis imellem det intime og det politiske | Novo Nordisk Foundation | University of Copenhagen | NNF21OC0068621 | What’s your pleasure? From a queer-feminist perspective a lot is at stake in this question, quivering enticingly and challengingly between the intimate and the political. The project will focus on the ambivalent role of pleasure in queer-feminist art practice from the 1970s and onward, aiming at contributing to a further definition of the specificities of queer feminist art histories. | Research Education (PhD) / Fellowships / Award | 1fellowships_scholarships |
gen_d6af9f03f2edfed96e46a755cc6231a1 | Assessing the influence of cosmic rays on clouds | Carlsberg Foundation | University of Oxford | CF20-0433 | What? This project sets out to gauge the atmospheric relevance of a potential cloud production mechanism that has recently been demonstrated in the laboratory. If important, this mechanism links galactic cosmic rays, originating from supernova explosions in the Milky Way, to Earth's climate. Correlations between cosmic rays and clouds have been observed, but scientific convergence on their implications has been missing, as no direct microphysical mechanism linking cosmic rays to clouds was known. This has recently changed as laboratory experiments uncovered a physical mechanism, that ties ionization from cosmic rays to cloud formation: Ions have been shown to accelerate the production and growth of nanometer size aerosols towards sizes that allow them to act as seed particles for cloud droplets. Why? The largest uncertainty in estimates of Earth's energy budget stems from clouds and aerosols. Clouds regulate the albedo of our planet, and any systematic modulation of atmospheric aerosol and clouds must be taken into account for us to build a complete picture of climate variability. If cosmic rays affect aerosols through ion production, then that is completely unaccounted for in our current climate models. The atmospheric relevance of this new ion-based aerosol growth mechanism should therefore be quantified. My project aims precisely to investigate wether the ion induced aerosol production and growth mechanism observed in the laboratory can function in the real atmosphere. How? The most practical way to conduct experiments on a global scale is through atmospheric computer models. I will implement the newly found aerosol growth mechanism into ECHAM-HAM, a global circulation aerosol model developed at University of Oxford, and investigate wether it is able to affect aerosol concentrations on a global scale. Cosmic rays and thus atmospheric ionization exhibits natural variation on a range of time scales. These variations may be imposed upon the model, and their consequences for aerosol concentrations monitored. We plan to target weeklong Forbush decreases of the cosmic ray flux, the 11-year solar cycle and millennial scale variations, and describe the response in global and local aerosol concentrations. | Postdoc / Visiting Fellowships at University of Oxford / Award | 1fellowships_scholarships |
gen_8c43c3b2f4061bb4ef2dc987d659fbcf | Single Molecule Tracking of the Dopamine Transporter: Surface Dynamics as a Novel Key Player in Shaping Dopaminergic Neurotransmission? | Independent Research Fund Denmark | Københavns Universitet | 6110-00292A | Dopamin er et af hjernens vigtigste signalstoffer og især betydningsfuld for kontrol af bevægelser og for hjernens belønningssystem. Dopamintransporteren (DAT) regulerer dopaminbalancen ved at transportere frisat dopamin tilbage ind i dopamin-producerende nerveceller. DAT er mål for psykostimulatoriske stoffer som kokain og amfetamin, foruden at ændringer i DATs funktion bidrager til parkinsonisme og psykiatriske sygdom. I dette projekt vil vi teste hypotesen, at DAT er lokaliseret til diskrete kolesterol-afhængige ’nanodomæner’ i nervecellernes cellemembran, og at den dynamiske lokalisering til disse domæner er afgørende for at kunne tilpasse DATs lokalisering til nervecellernes øjeblikkelige behov. For at kunne studere dette vil vi bl.a. bruge helt nyudviklede fluorescerende kokainanaloger, der for første gang gør det muligt at undersøge DATs bevægelser i dopaminerge nervecellers cellemembran på enkeltmolekyleniveau. Vi vil ikke bare undersøge bevægelsernes afhængighed af kolesterol men også undersøge, hvorvidt de reguleres af substrat (dopamin/amfetamin) og G protein koblede signaleringskaskader. Endelig vil vi bestemme om mutationer i DAT, der er associeret med parkinsonisme og psykiatrisk sygdom, udviser ændringer i deres membranbevægelsesmønstre. Projektet introducerer ved muliggørelse af enkeltmolekylestudier en helt ny dimension i vores forståelse af, hvorledes DAT kontrollerer dopaminsignalering og hvordan denne ændres ved dopamin-relaterede sygdomme. | Postdoc / DFF-Individuel Postdoc / fellowship | 1fellowships_scholarships |
gen_85d5df44afe06c02f6b0fd717796bca2 | A TIME OF ONE'S OWN / SIN EGEN TID | Novo Nordisk Foundation | Kunstmuseum Brandts | NNF21OC0067445 | ”A woman must have money and a room of her own if she is to write fiction,” Virginia Woolf famously states in A Room of One’s Own. But what about the necessity of having a time of one’s own, this project asks with a focus on three women artists from Funen: Alhed Larsen, Anna Syberg and Christine Swane. As housewives and mothers working from home, lack of time for artistic production connects the women. Through theories of feminism, phenomenology and Hannah Arendt’s concept of modernity and human activity, this project examines the importance of time in their artistic production; time both as an objectively measurable amount of hours per day and as subjective experiences. It aims to show how the artists visualise ‘a time of one’s own': how they process their lack of time in their art through choices of self-referential subjects such as flowers, cultivated gardens, decorated spaces, and their own art, but also through sensuously capturing moments of creation and of aesthetic experience. | Research Education (PhD) / Fellowships / Award | 1fellowships_scholarships |
gen_a4eeac89fcbc81a52f13036c2fb70380 | The freest port? Slavery and literature in St. Thomas. | Carlsberg Foundation | Aarhus University | CF19-0682 | What? The book studies different kinds of texts and narratives connected to the former Danish colony St. Thomas in the Caribbean over a 400-year period from the settlement of the island in 1666 to today. St. Thomas is particularly interesting because it in 1764 was declared a free port, making it a central hub for Caribbean trade and the town of Chalotte Amalie became a small metropolis of people from all colonial spheres. Studying diverse texts from this microcosm the book charts the importance of trade in the colonial world with special emphasis on the ways in which slavery and slave trade undergirded this world and the imprint of this reality in different narrative genres. Why? By reading a diverse set of text the book will show how slavery and the slave trade was perceived and reflected in different ways in the colonial world thus adding to our understanding of the structures upholding the system of slavery and, in particular, its relation to early forms of liberalism and capitalism and the afterlives of these forms up until today. How? The book is based on archive studies in St. Thomas, USA and Europe. These studies has unearthed a large corpus of diverse writings on and from St. Thomas that forms the basis for the study. | Research / Monograph Fellowships / Award | 1fellowships_scholarships |
gen_8a94ce873878098fa2a6bb92711e449e | Peace and Power in the Roman Principate (PePo) | Carlsberg Foundation | University of Copenhagen | CF18-1093 | What? PePo explores the deployment in early imperial Roman literature of the ideology that makes one-man rule a necessary condition for peace in the Roman Empire. With the establishment of the Principate, the power structures of Roman society changed radically, a change accompanied by a move from a republican to an imperial 'regime of truth': as the meaning of key political and moral terms changed, so did the premises whereon one reasoned. I will 1) explore how the claim that one-man rule was necessary for peace functions within the imperial 'regime of truth': how it is deployed, negotiated, and played with by imperial writers. 2) analyse the reception of the claim in modern scholarship: how it has come to be accepted and used to explain the establishment of one-man rule in ancient Rome. Why? Firstly, PePo offers a new way to think about a crucial, transformative period of Roman history: a philological close reading of early imperial literary texts facilitates a deconstruction of the rhetoric through which imperial ideology was promoted and an exploration of the 'regime of truth' on which it rested. Secondly, it also deals with questions of sustained importance for broader, more interdisciplinary, and increasingly relevant debates on governmental legitimacy, the connection between political system and peace, and the power of discourse to invent and sustain perceptions of reality. Of special importance in this regard is the relation of 'regimes of truth' to contemporary debates on fake news and the post-truth era. How? Through philological analyses of imperial literary texts carried out at Bristol University, I will explore the emerging imperial 'regime of truth' and investigate the claim around which changes in politics, morality, and rhetorical strategies during this period revolve: that one-man rule was necessary for the maintenance of peace. Key texts are Seneca's philosophical treatise "On Mercy", Lucan's epic poem on the civil wars, Pliny's panegyric to the emperor Trajan, and the historical works of Tacitus and Velleius Paterculus. The close attention bestowed upon a text through philological analysis makes it a powerful tool for the exploration of the imperial 'regime of truth' as well as of modern scholarship which uncritically accepts the link between peace and one-man rule as true. | Postdoc / Internationalisation Fellowships / Award | 1fellowships_scholarships |
gen_e7d5a191aeef7863d1e29ee822083958 | Trust and the Social Dimension of Rationality | Carlsberg Foundation | Unknown | CF18-0791 | What? We know from recent research that when people trust each other less, they start to think and behave differently. Many of us would not be surprised to hear this, because it seems to us rational to change the way one interacts with other people if one ceases to trust them. This project is about explaining this relation between trust and rationality. The overarching explanation comprises two elements. The first is that what it is rational for us to do is determined by our knowledge. The second is that whether or not we trust other people can help determine what we can know about them. Together, these two elements can explain why trust affects people's attitudes and behaviour in the way that empirical research suggests they do. Why? The project is important for two reasons. First, we know that people's behaviour tends to change for the worse when they become less trusting. Low-trust societies tend to engender corruption, political polarisation, a perceived lack of institutional authority, and the list goes on. Second, we know that in much of the developed world, levels of trust in both people and institutions are falling, and have been for at least 15-20 years. We have clear interest in bucking that trend, To do so, however, we need to understand why trust affects people's behaviour in the way that it does, and part of this project is to understand the relation of trust to rationality. That is what this project is about. How? A central methodological aspect of the project is to further explore a phenomenon known as "pragmatic encroachment" which has been much discussed in philosophy recently. Roughly, the idea is that non-truth related factors like risk or practical interests can affect what one knows. For instance, if the possible side-effect of vaccine A is death and the possible side-effect of vaccine B is a rash, some have argue that it will be much harder to know that vaccine A is safe than that B is. The project will explore the extent to which trust can be said to have a similar effect on knowledge, how such account should be spelled out in further detail, and how it coheres with existing empirical data on how people make ascriptions of trust, knowledge, and rationality. | Postdoc / Reintegration Fellowships / Award | 1fellowships_scholarships |
gen_c52168563674779a99aa06055d16952d | Grief trajectories and patterns of health-care use in family caregivers: a nationwide prospective cohort study | Novo Nordisk Foundation | University of Aarhus | NNF17OC0024410 | Not available | Postdoc / Fellowships / Award | 1fellowships_scholarships |
gen_e365a242ea0fa5ba70431e96bbc5a43f | New media technologies and the remediation of the Israeli-Palestinian conflict | Carlsberg Foundation | University of Copenhagen | CF18-1015 | What? The project examines the role of new media technologies, such as social media platforms and mobile devices, in the remediation of the Israeli-Palestinian conflict. Why? Increasing the power of civil society, while at the same time providing new tools for surveillance and disinformation practices, new media technologies are transforming international relations. This is particularly evident in the Israeli-Palestinian conflict, where the Web and social media platforms have enabled a variety of new actors to coordinate global advocacy campaigns, engage in new diplomatic dialogues, while at the same time also becoming an instrument for inciting violence and contributing to radicalization. The ambition of this project is to study empirically the role of new media technologies in this conflict and to better understand whether and how new media technologies may advance the promotion of peace and reconciliation rather than conflict and violence. How? Drawing on insights from Science and Technology Studies (STS), the project will pursue a two-fold research strategy, combining qualitative and quantitative methods. First, I will trace how new media technologies have come to play a role in the Israeli-Palestinian conflict, mapping the predominant discourses, practices, and material settings through which the digital remediation of the conflict takes place. Then, using the digital methods approach, the project will explore the concrete role of specific new media platforms and devices in the remediation of central political events. | Postdoc / Reintegration Fellowships / Award | 1fellowships_scholarships |
gen_33ef92394ef631d9021aee06ddb4e372 | NO3 Chemistry at Night and at Sunrise - From Alkenes to Aerosols | Carlsberg Foundation | University of Copenhagen | CF19-0114 | What? Atmospheric particles contribute to air pollution and has an impact on Earth’s climate. Up to 90 % of the particles are of organic origin with a large fraction formed in atmospheric gas phase reactions. Of great interest is the formation of organic nitrates that lead to formation of secondary particles. The organic nitrates are formed in the reactions with nitrate radicals that dominate the chemistry at night and may have impact at sunrise. These reactions are associated with uncertainty and the changing conditions at sunrise has not been studied to a great extent. To understand the chemistry at the transition, I aim to characterise the atmospheric chemistry of nitrate reactions with different species under night and sunrise conditions using both experimental and theoretical methods. Why? The composition of atmospheric particles is a big uncertainty in understanding climate change and crucial to know in order to assess their health impacts. Understanding the drivers of the atmospheric chemistry will lead to a greater knowledge of climate change and air pollution. In this project I will investigate the reactions of nitrate radicals with different species relevant in the atmosphere, that could lead to particle formation. The impact of changing the conditions at sunrise are of interest as day and night chemistry influence each other, but previously have been studied separately. The project will add knowledge to gas phase atmospheric chemistry and particle formation as well as expand the predictive capabilities of models to be used and extended with experimental results. How? I will be using two atmospheric simulation chambers to investigate the gas phase nitrate reactions to study the reactions in different chemical regimes: making it possible to study the reaction mechanisms, intermediate species, and products at molecular level up to the initial particle formation. Different instruments will be used for analysis of the data and lamps will be used to simulate sunrise in some experiments. The theoretical part of the project will be focussed on two things: simulating the experiments, describing the mechanisms of the reactions and using the experimental results to update and correct the regional and global chemical models to include the results from this study, improving predictions of particle formation used in climate predictions and air pollution forecasts. | Postdoc / Internationalisation Fellowships / Award | 1fellowships_scholarships |
gen_a709ea5dae9e544200c712c100601638 | Breaking the weakest link: Broad-spectrum drugs against RNA viruses | Carlsberg Foundation | Stanford | CF23-0123 | What? Discovery of pan-corona antivirals and characterization of the structure-function relation between antiviral compounds and viral proteases Why? Viruses have crossed from animals to humans with high mortality rates in recent years and we can expect further crossings to happen over the next few decades. To avoid future pandemics as experienced during the SARS-CoV2 breakout, we must develop preemptive pan-coronavirus orally available drugs for a wide range of viral protection. This can only be done if we better understand how small molecules can inhibit viral autoproteases, such that we can create compounds used as an initial response to viral breakouts. How? We will investigate the power of a pre-existing small molecule library for their effect on viral proteases from all beta-corona lineages. To achieve this I will engineer a luminescence-based multi-protease reporter system, that allows for direct comparison of pan-corona protease inhibition. Then by collaboration, we will use structure-based, AI-assisted screens, to enhance inhibition, efficacy, and potency toward multiple targets. | Postdoc / Internationalisation Fellowships / Award | 1fellowships_scholarships |
gen_0da9011c47995acd411e817dd5c806f0 | The implications of using freelancers for coordination, cooperation, and performance | Carlsberg Foundation | Institute for Strategy, Technology, and Organization - Ludwig Maximilian University of Munich | CF23-0170 | What? Freelancing is the fastest growing form of employment in the western world. Many high-skilled workers are choosing a freelance career to take more control of their time, projects, and pay. Organizations are increasingly using freelancers as well, not only because of the flexibility, expertise, and experience freelancers provide, but also because of an unmet need for high-skilled talent in nearly all industries. Online labour markets (platforms like Worksome or Upwork) are making it easier for both freelancers and employers to find and work with each other. While this paints a rosy picture of freelancing, the reality is more complex: how do freelancers adapt to new clients (organizations) and projects? And how do organizations that want to use freelancers ensure that they will work well together with permanent employees and contribute to organizational goals and performance? The aim of this project is to answer these questions by studying how firms integrate freelancers and permanent employees through online labour markets or inside the firm. Why? We know little about why some organizations are better at integrating freelancers than others, or whether organizations are integrating freelancers optimally. Over half of Google's workforce are contract workers, but how does Google get their freelancers to work well with the other half that are Googlers? In theory, firms use freelancers for different tasks than full-time employees - tasks that are not very depedendent on full-time employees. But this is changing, meaning freelancers and employees are becoming more dependent on each other. Understanding how firms successfully integrate freelancers and permanent employees is important to reduce coordination failures (mistakes, misunderstandings, delays, etc.) and cooperation failures (stonewalling, witholding information, early departures, etc.). It also has implications for how firms successfully integrate new employees, new partners, new suppliers, or new acquisitions into their organization. How? To understand how firms integrate freelancers and employees successfully, we need to know how they do so, both inside the firm and by using online labour markets providing workforce management systems. To understand how integration takes place inside the firm, the project studies organizational practices that reduce coordination and cooperation failures and increase firm performance. To understand how online labor markets improve coordination, cooperation, and performance, the project studies tasks performed through online platforms and how platforms can help to reduce frictions when the work of freelancers and permanent employees is interdependent. | Postdoc / Internationalisation Fellowships / Award | 1fellowships_scholarships |
gen_8f00fcef025401aa4ddeee8a02edb86b | Queer to Queer Humanitarianism: Identity, activism and transnational benevolence among LGBT+ refugees and asylum seekers in Rome and Copenhagen | Independent Research Fund Denmark | Dansk Institut for Internationale Studier (DIIS) | 2058-00015A | Hver år fordrives tusindvis af mennesker på grund af homofobi og transfobi. En progressiv LGBT+ og menneskerettighedsdagsorden får nogen til at søge beskyttelse i Europa. Her støder en universalistisk rettighedskultur dog sammen med en stadigt stigende anti-immigrationsdagsorden, der har skabt et hul i beskyttelsessystemet. Det har skabt grobund for en ny type civilsamfundsorganisationer (CSOer) i det humanitære arbejde. Dette projekt undersøger to CSOer der arbejder med ’queer’ migranter og asylansøgeres særlige sårbarheder i Europa (i Italien og Danmark). Med en stor variation blandt deres medlemmer, en iboende politisk natur og et transnationalt udsyn, udgør disse CSOer velegnede cases til en undersøgelse af nye former for humanitær intervention. Projektet fokuserer på de udfordringer medlemmer af organisationerne konfronteres med og undersøger, hvordan de anvender LGBT+ kategorier til at skabe mening, relatere sig til hinanden og operationalisere konkrete humanitære aktioner, sidstnævnte både i forhold til at yde konkret humanitær bistand og bidrage til mere langsigtede ændringer for LGBT+ personers rettigheder i og udenfor Europa. På et mere teoretisk niveau reflekterer projektet over det humanitære arbejdes muligheder i en på samme tid globaliseret og grænsedragende verden. | Research Education (PhD) / Forskeruddannelse uden for universiteterne / grant | 1fellowships_scholarships |
gen_2e4622031ff311bed46d6d54d6e4faca | Preferences for universal health care coverage: the mechanisms of altruistic preferences in a welfare state | Independent Research Fund Denmark | KORA, Det Nationale Institut for Kommuners og Regioners Analyse og Forskning | 6119-00024A | Danmark står, som mange andre lande med offentligt finansierede sundhedssystemer, over for store udfordringer i prioriteringen af offentlige ressourcer. Sundhedsbeslutningstagere må nødvendigvis tage beslutning om hvilke sundhedsydelser, der skal finansieres og hvilke, der ikke skal. Ph.d.-projektet fokuserer på at afdække borgeres præferencer for universal sundhedsdækning og på at afdække underliggende motiver for at finansiere bestemte sundhedsydelser i et offentligt sundhedssystem. For at forstå hvorfor adgang til nogle sundhedsydelser foretrækkes frem for andre, er det afgørende at skelne imellem selviske og altruistiske motiver. For private forsikringer er valget af sundhedsydelser drevet af individets risikoaversion og individets behov for at sikre adgang til dyr behandling. Valget af sundhedsydelser i offentlige forsikringer kan yderligere være drevet af et altruistisk motiv grundet bekymring for andre individer. Ingen har tidligere undersøgt om et sådant socialt hensyn er forskelligt for forskellige typer sundhedsbehandlinger. Derfor undersøger dette ph.d.-projekt det sociale hensyn i valget af adgang til sundhedsydelser og hvad der driver det sociale hensyn. Det undersøges endvidere, om det sociale hensyn påvirkes af, om individers behov for sundhedsbehandling er opstået ved et uheld eller ved at f.eks. livstil har været afgørende for behandlingsbehovet. | Research Education (PhD) / Forskeruddannelse uden for universiteterne / grant | 1fellowships_scholarships |
gen_e07499b4e67db7d21a9211e0e2303a51 | Communicating Vessels: Re-defining Agency through Sounding | Novo Nordisk Foundation | Det Kongelige Danske Kunstakademi (Billedkunstskolerne) | NNF19OC0054542 | Heard and unheard sounds are a vehicle for communication that establishes a web of interdependencies within our environment offering a potential re-framing of notions of agency. Communicating Vessels: Re-defining Agency Through Sounding proposes Sounding as a practice and medium for apprehending new forms of agency, ones that will be explored in an experiment with conventional narrative film form. This research focuses on the body's ability to apprehend sound through a spectrum of interdependent senses and actors, phenomena that will be researched through a theoretical framework, field research into non-Western perspectives on sound and subjectivity, and collaborative exchanges and interviews with sound artists and scholars. Drawing from fields of disparate fields of study, the research expands upon the corporeal anthropology of sound, existing concepts of sonic agency, and practices of Deep Listening developed by composer Pauline Oliveros. | Research Education (PhD) / Fellowships / Award | 1fellowships_scholarships |
gen_495af736b2877647960ffae285e15b24 | Pregraduate scholarship for investigating lipid handling in chronic kidney disease | Independent Research Fund Denmark | Aarhus Universitet | 3188-00012A | Kronisk nyresygdom er et stigende problem som berører omkring 10% af befolkningen. Med sygdommen følger øget risiko for hjerte-kar-sygdomme og dette er også den hyppigste dødsårsag blandt nyresyge patienter. Omkring en tredjedel af patienterne har ændret fedtsammensætning i blodet, hvilket menes at være medvirkende til den øgede risiko for hjerte-kar-sygdomme og at nyresygdommen udvikler sig. Ved kronisk nyresygdom begynder nyren at oplagre fedt i nogle af cellerne og omsætningen af fedtet ændres også. De præcise mekanismer der ligger til grund herfor er ikke helt afklarede. Dog menes at øget fedtsyre optagelse via proteinerne, FATP2 og CD36, bidrager. Vi har i mange år studeret nogle proteiner i nyren, megalin og cubilin, som vi ved også kan mediere fedtsyre optagelse, hvilket stiger under nyresygdom. Vores nye data viser også, at denne stigende optagelse er associeret med ny-udtryk af et protein, der i andre celler er koblet til fedtomsætning. Vores hypotese er: megalin og cubilin har betydning for fedtoplagring i nyren og det nye protein påvirker fedt frigivelsen fra nyren til blodet. Vi vil teste vores hypotese og dermed afklare, hvilken rolle megalin og cubilin medieret optagelse af fedtsyrer spiller i forhold til CD36 og FATP2 for fedtoplagring, og undersøge det nye proteins rolle for fedt frigivelsen fra nyrerne. Vores mål er at nå ny indsigt i de mekanismer der bidrager til den øgede risiko for hjerte-kar-sygdomme hos nyresyge patienter. | Research Projects (Max 10 MDKK) / Skolarstipendier | Sundhed og Sygdom / grant | 1fellowships_scholarships |
gen_1890b78eb97473eef2fae9e777874c1e | Pre-graduate Scholarship Programme | Novo Nordisk Foundation | University of Aarhus | NNF21SA0069371 | Not available | Research Projects (Max 10 MDKK) / Fellowships / Award | 1fellowships_scholarships |
gen_a220aa1954efe3dc606f7494d8fe939d | Political Systems and Time: Timekeeping in Lebanon | Carlsberg Foundation | Aalborg University | CF22-0814 | Political systems have an uneasy relationship with time. They develop a lifecycle of their own. They also have an intriguing effect on people’s time. Clock time can be hostage to policy inaction. I propose to take the reader on a time travel through Lebanon’s political system. This century-old sectarian model has been time-resilient at the expense of people’s time. With the financial meltdown, people spend countless hours piling up rice and lentils and queueing in front of banks. Policy timelines have had dire consequences. Consider the Beirut Blasts that resulted from deliberate inaction or the case of Palestinian camps frozen in time. By exploring how political time and human time intersect, I hope to offer a real-life appraisal of how political systems cut to the core of our lifetime.What? Why? How? | Research / Monograph Fellowships / Award | 1fellowships_scholarships |
gen_9098313119fa33e40470d8d0e0333991 | Spaces, Borders, Bodies. A Postcolonial Inquiry into Danish Politics on Forced Migration | Independent Research Fund Denmark | Københavns Universitet | 6107-00393A | I dagens Danmark og Europa diskuteres tvungne migrations-kriser oftest som værende uden fortilfælde, og politiske løsninger om eksternaliseringen af flygtningekontrol og -beskyttelse til tidligere koloniale territorier i Nordafrika præsenteres som noget nyt. Med udgangspunkt i at staters politik både kan reagere på, og selv skabe, tvungen migration, undersøger dette projekt ligheder og forskelle mellem EU's eksport af grænsekontrol siden 2000, som Danmark også deltager i, og dansk kolonipolitik angående tvungen migration på Guldkysten (1754-1850) og de Vestindiske Øer (1754-1917). På tværfaglig vis spørger projektet ind til forskelle og ligheder mellem disse danske politikker gennem en genealogisk undersøgelse af diskurser om tvungen migration. Til dette formål foretages der data-indsamling fra arkiver om dansk kolonialisme, samt fra databaser med EU politik dokumenter om eksternaliseringen af grænsekontrol. Analyserne fokuserer på styringslogikkerne bag den koloniale og nutidige re-territorialisering af ikke-europæiske rum, samt de implikationer den har for de kroppe der bevæger sig gennem rummene - før som nu. Endelig foretager projektet også en normativ analyse af diskursernes argumentation for og imod disse praksisser. Dette knyttes til diskussioner af universel liberalisme’s scope, eksklusion af ikke-medlemmer og legitimiteten af tvang udført af liberale demokratier, og leder mod en immanent kritisk stillingstagen til liberal teori og dens historie. | Postdoc / DFF-Individuel Postdoc / fellowship | 1fellowships_scholarships |
gen_6af507908d40248640d18c3730fadcaf | The Lunatic Future for the Depressed Planet and the Flanet: Learning from the late work of artists who figured out how on earth to keep going. | Novo Nordisk Foundation | National Gallery of Denmark | NNF21OC0067470 | Why is late work often deemed oblique compared to the early work by an artist? Why aren’t ageism and the stereotyping surrounding the idea of generations in the arts discussed more? How do some artists find the incentive to continue their work in spite of numerous obstacles? And is there hope to find for all generations in the late work of artists who had worked out how not to give up? We live in a world where climate crisis is real and where there is a growing sentiment of hopelessness and exhaustion among us. Perhaps precedent lies in the precarious lives of artists who have come before; those who have continued in their work in spite of crisis and resistance, or a lack of almost every apparent sign of encouragement, including recognition. From a starting point of the ´late work’ of visual artists, this artistic research will take place between a perceived lack of future that’s intergenerational, and those artists who continued working in spite of a lack of energy and prospect. | Postdoc / Fellowships / Award | 1fellowships_scholarships |
gen_17e26740cf7d4a5e02bf9f88236d85e4 | Biosolutions Master’s programme in Kalundborg | Novo Nordisk Foundation | University of Copenhagen | NNF23SA0088538 | Not available | Research / Projects / Award | 1fellowships_scholarships |
gen_0369942b8a14b6c1a2cd8e15801125fc | Warming waters: Mapping fossil fishes to forecast climate change impacts | Carlsberg Foundation | Department of Earth Sciences, University of Turin, Italy | CF23-1059 | What? Among modern vertebrate species, the teleost fishes are by far the most diverse and abundant, currently represented by ~33,000 living species, constituting 96% of all recent fish species. They form a fundamental part of food webs in the world's oceans, and are concurrently an important economic resource for fisheries, human nutrition and global food supply. Why? The Paleocene–Eocene Thermal Maximum (PETM) is commonly considered the best ancient analogue of modern climate changes. Understanding the diversification and evolution of fossil fish lineages on Earth during this warming period, and the time following, including the Early Eocene Climatic optimum (EECO), is vital to predict and understand present and future hazards today’s oceans are facing. How? This study will be the first of its kind to conduct a comprehensive, comparative study across Eocene fish faunas based on the world’s largest µXRF-dataset and fossil archives from geological formations in Denmark and Italy, to assess the responses of past fish assemblages to Eocene climate changes, in order to understand how present and future climate changes will affect modern fish species. | Postdoc / Internationalisation Fellowships / Award | 1fellowships_scholarships |
gen_960258b6e620be1e1101360b1976e958 | The Northern and the Southern Enlargement in Historical Perspective: Scandinavian and Greek Responses to European Integration, 1960s–1970s. | Carlsberg Foundation | Danish Institute at Athens (housing commitment) | CF18-0271 | What? This project will explore the European integration dynamics from a business history perspective through a comparative analysis of the first and the second enlargement of the European Community (EC). The specific focus of the study is on the Danish, Greek and abortive Norwegian applications in the 1960s and 1970s. Adopting a business-centered approach, my research enquires into societal actors and transnational networks as analytical tools in order to question progressive interpretations of enlargement and illustrate how European integration impacted upon diverse environments. The research, by addressing direct and indirect business interactions, will examine both their impact on the respective European policies of each country and their potential bearing on the EC level. Why? This project aims to offer new insights into the emergence of the present-day EU, by adding to recent scholarship that challenges teleological accounts of European integration. Such accounts have largely overlooked the complex interplay between core and periphery and between insiders and outsiders in European integration. Yet these are central issues that are crucial not only to understanding why certain countries opted for joining or abstaining from the EC/EU in the first place, but also necessary in order to conceptualize the dynamics and limits of the Europeanization process. How? Based on archival research in multiple countries, this project makes use of a wide range of available sources at the national and the EU level. The project will bring transnational history methods, and business history insights to bear on debates over the North-South divide in Europe. My research views European integration as an inherently complex process, in which conflict among national economic strategies, organized business interests and sectoral or firm preferences may result in individual interests overriding general interests. In this respect, my research agenda includes investigation of both the contributing and counteracting causes of EC/EU enlargement and lays the groundwork for a non-teleological account. | Postdoc / Postdoctoral Fellowship at the Danish Institute at Athens / Award | 1fellowships_scholarships |
gen_ddfa08f1b58f07406fa0b4a1424d7a21 | Novel microfluidic platform for investigation of virus-biofilm interactions | Carlsberg Foundation | Université Côte d Azur | CF21-0394 | What? This research project aims to establish a physiological in vitro cell model to study the interactions between human herpes viruses (HHVs) and pathogenic bacteria involved in the progression of periodontal disease (PD), and use it to propose new treatment strategies. As a major novelty, we will use a compact platform (tabletop, laptop-sized format), based on centrifugal microfluidics or Lab-on-a-Disc (LoD), for cell culturing in flow (perfusion). The microfluidic disc, where the cells are cultured, has the size and shape of a CD, is compatible with conventional microscopy techniques, and can be combined with a custom-designed, miniaturized microscope for real-time, online monitoring. Why? PD is the most common chronic inflammatory disease in humans. In PD, bacterial inflammations in the structures supporting the teeth (gingiva, periodontal ligament and alveolar bone) can lead to tooth loss and contribute to systemic inflammation. The disease is difficult to treat with antibiotics, and often complex and expensive surgeries are needed. Traditionally, PD has been ascribed to the overgrowth of pathogenic bacteria, but the bacteria alone do not adequately explain the clinical characteristics of the disease. Recently, HHVs have been suggested as a possible trigger for oral dysbiosis resulting in progression of PD. However, there is an urgent need for in vitro platforms that can facilitate studies of the interactions between bacteria and viruses, to propose new treatments. How? We will design, optimize and realize a user-friendly, pump- and tubing-free LoD platform to study the cross-talk between HHVs and periodontal bacteria (e.g. Enterococcus faecalis and Streptococcus salivarius). To do so, we will grow virus-infected oral cells under flow in the presence of bacteria, and observe the cellular response by PCR-based detection of viral markers, release of cytokines and oxidative stress. Additionally, we will use the LoD platform to screen the effect of antiviral drugs, with and without co-delivery of antibiotics, as a novel treatment strategy for PD. | Postdoc / Internationalisation Fellowships / Award | 1fellowships_scholarships |
gen_97e841dfb858470fdd19feb2f5561edb | Iraqi Cinema beyond the Screen | Carlsberg Foundation | Oxford University Linacre College Faculty of Oriental Studies | CF21-0381 | What? In the beginning of the 20th century, Iraqi cities changed rapidly and new public spheres and forms of work and leisure emerged. In the process, modern leisure and entertainment began moving from the private realm into the public and increasingly came to be organized on a commercial scale. One index of these changes was cinema. My project explores the history of the Iraqi cinema industry and investigates the historical intertwinement of capital, culture, and leisure. My project interrogates networks, connections, and the circulation of cultural products and material objects, including films, equipment, and technology and asks how these came together at a particular historical moment with capital, actors, and people with technical skills to establish a film industry in Iraq. Why? My project will be the first to ask questions about how 20th century trade routes and flows of capital, distribution, production, and circulation networks brought cinema to Iraq. Moving beyond the screen and away from the analysis of individual films, my project pushes cinema history forward through the innovative conception of studying cinema with attention to its transnational, cultural, and material aspects and histories. Challenging the study cinema within purely national contexts, my project focuses on the mobility of the film medium through the movement of technology and film canisters, labor, and cinema stars across vast distances. This enhances our understanding not just of Iraq and its many global connections, but also of early cinema outside of the global centers of gravity. How? The intricacies and obstacles related to the writing of Iraqi history are many. Decades of authoritarian rule, instability, sanctions, and three destructive wars have for years made archival research difficult. The loss of sources and the present state of violence in Iraq pose serious challenges to historians. As a result, my project creatively uses previously unconsidered primary materials, including Arabic and Hebrew archival records, fiction and poetry, photography, popular song and music, periodicals, cinema magazines memoirs, and personal accounts by Iraqis involved in the industry. To capture the moral tensions, anxieties, and forms of policing that surrounded cinemas, my project combines historical analysis with close and critical readings of Iraqi literary texts and police records. | Postdoc / Visiting Fellowships at University of Oxford / Award | 1fellowships_scholarships |
gen_456558e0d18e5a2e66b385ad16b66b51 | Epigenetic regulation of tumor maintenance in acute myeloid leukemia | Independent Research Fund Denmark | Københavns Universitet | 6110-00115A | Akut Myeloid Leukæmi (AML) er en aggressiv form for blodkræft som er karakteriseret ved en overproduktion af umodne hvide blodlegemer. AML kan opstå hos mennesker i alle aldre dog hyppigst blandt ældre. Prognosen for AML er meget dårlig og kun ca. ¼ del af patienterne er i live 5 år efter at diagnosen er stillet. På trods af at vi ved mere og mere om biologien for AML har behandlingsmetoderne, herunder specielt kemoterapi, kun ændret sig i relativ begrænset grad over de sidste 30-40 år og der er således et stort behov for at udvikle nye strategier til målrettet at ramme leukæmi celler. Med dette for øje har vi karakteriseret betydningen af 370 proteiner for leukæmi cellers vækst i mus. Disse 370 proteiner er alle involveret i epigenetisk kontrol af gen ekspression og det er derfor sandsynligt at de spiller en rolle i AML. Et af de mest interessante fund i denne analyse er MLL5, som er nødvendigt for væksten af leukæmi celler i mus, hvorimod normale celler fint kan undvære dette protein. Funktionen og betydningen af MLL5 i kræftceller, herunder AML, er stort set ukarakteriseret og formålet med nærværende projekt er derfor at udføre en detaljeret analyse af MLL5´s rolle i AML og teste hvorvidt vores fund også er relevante i leukæmi celler fra mennesker. Projektet vil kunne bringe os nærmere en forståelse af hvordan AML udvikles og vil afgøre hvorvidt MLL5 udgør et muligt terapeutisk mål for fortidens AML behandling som på sigt kan kommer AML patienter til gode. | Postdoc / DFF-Individuel Postdoc / fellowship | 1fellowships_scholarships |
gen_b14a02d246c9950355c014be1088b422 | Hazards and risks from volcanic ash | Carlsberg Foundation | Not affiliated | CF18-1031 | What? Why does a volcano start to erupt violent plumes of volcanic ash and who will be affected? This question became vital for the inhabitants of the state and island of Hawaii, USA as a 10 km high ash plume rose from the summit of Kīlauea volcano on May 17th 2018 with explosions continuing for several weeks. The aim of this project is to provide an answer by studying the formation of ash plumes from Kīlauea. Furthermore the project aims to quantify the risk of future eruptions based on different eruption scenarios, which are defined by the historic behaviour of the volcano. The findings of the study will be integrated with new communication strategies at the Hawaiian Volcano Observatory to ensure local impact of the results, and to reach the people, whose lives and livelihoods are at risk. Why? Volcanic ash is the most widespread of all volcanic hazards. It can cause respiratory problems in humans and animals, cause jet engine damage/shutdown in airplanes, clog air filters, block and contaminate water supplies, and adversely affect the agriculture, ground transportation, and tourism industry. Basaltic volcanism dominates worldwide, but is typically percieved to generate little ash. Therefore it is often omitted in hazard and risk assessments. However, new studies show that basaltic eruptions generate much bigger ash plumes than previously thought. Therefore the risk potential of basaltic ash plumes need to be quantified. Kīlauea is the type locality of basaltic volcanism with a 300-year period of frequent explosive activity, making it the ideal natural laboratory for this study. How? The study is a combination of field studies, laboratory processing and computer modelling. The fieldwork is to be carried out on the rim of the active volcano Kīlauea in Hawaii, where meters of ash covers the summit area in several places. The deposits will be measured, sampled and mapped out. Subsequently, samples will be taken to the lab to measure the size of the ash grains, their shape, density and grain type. Then all information will be used in a number of integrated computer models to achieve mathematical parameters describing the size of the eruptions. Further modeling using these parameters will show, which areas could be affected by similar size and type of eruptions today. Finally maps of hazards and risks are produced to local authorities for emergency planning. | Postdoc / Internationalisation Fellowships / Award | 1fellowships_scholarships |
gen_7df4c0d986799cc05b68f0c9f20222bc | Metabolic drivers of cellular damage in low oxygen | Carlsberg Foundation | Aarhus University | CF19-0543 | What? All animals die when deprived of oxygen, but some animals, such as the African naked-mole rat, can survive oxygen deprivation much longer than others. Without oxygen, metabolism is reprogrammed, which leads to several negative consequences such as energy deprivation, acidosis and oxidative damage when oxygen returns. This project will investigate how the naked-mole rat is able to avoid these negative consequences to survive prolonged oxygen deprivation. Specifically, we will focus on the metabolic reprogramming during oxygen deprivation in the naked-mole rat heart and whether they have evolved specific biochemical tricks to survive oxygen deprivation. Why? Although oxygen is essential for life, the consequences of hypoxia for cells and organisms are not well understood from a biological perspective, but have been studied more intensively in recent years in pathological settings in medical research, including heart infarction, stroke, diabetes and cancer. My intention is to exploit the knowledge and methodological approaches from the biomedical research to determine the molecular basis for how animals differ in their tolerance to varying oxygen levels. How? To investigate how naked-mole rats regulate metabolism I will expose isolated hearts and whole animals to oxygen deprivation and measure how metabolic intermediate levels change using mass-spectrometric metabolomics. This will be coupled with mass-spectrometric proteomics and enzyme kinetics measurements to establish whether the activity of metabolic enzymes are modified post-translationally during oxygen deprivation. Together this will give a detailed overview of metabolic regulation in an extraordinarily hypoxia tolerant mammal. | Postdoc / Internationalisation Fellowships / Award | 1fellowships_scholarships |
gen_8703cbeb83e3153a6c6df0084e52be03 | Copenhagen Bioscience PhD Programme NNF costs 2018 | Novo Nordisk Foundation | Novo Nordisk Foundation | NNF18SA0033564 | Not available | Research Education (PhD) / Fellowships / Award | 1fellowships_scholarships |
gen_b59d577daba03c8bdc5d777e119d5cfe | Integrating microbiome and metabolite population data for discovery of novel antibiotics | Independent Research Fund Denmark | Unknown | 9058-00025A | Antibiotika-resisten er ved at blive et udbredt problem, uden simple løsninger og med store potentielle økonomiske og menneskelige omkostninger. En løsning kunne være at identificere nye antibiotika, som bakterier endnu ikke er resistente over for. Den klassiske strategi til at identifcere nye antibiotika er besværlig og kandidater har ofte problemer med bivirkninger. I dette projekt vil vi istedet drage fordel af de store mængder af data der er genereret fra menneskelige fæces prøver, da molekyler her må antages at have været til stede i kroppen uden at skade værten. Ved hjælp af medborgerforskning har university of San Diego lavet et datasæt med observationer af både bakterier og molekyler med en størrelse der gør man ved hjælp af statistiske metoder kan finde bakterier der aldrig optræder på samme tid, og hvilke molekyler der kunne mediere denne negative interaktion. Ved hjælp af dette kan man finde organismer der kan isoleres og producere et molekyle. | Postdoc / DFF-International Postdoc / fellowship | 1fellowships_scholarships |
gen_78b222b31623991740376418601e35ef | Regulated secretion and role of urinary nanovesicles | Independent Research Fund Denmark | Aarhus Universitet | 6110-00118A | Ekstracellulære nanovesikler, såkaldte "exosomer", er små membranafgrænsede vesikler, der udskilles af en række celletyper. Exosomer indeholder forskellige molekylære bestanddele fra deres oprindelsescelle bl.a. proteiner og genetisk materiale. For nyligt blev exosomer opdaget i normal human urin. De potentielle funktioner af urin-exosomer, og hvordan den regulerede udskillelse af disse foregår, er imidlertid uafklaret. Dette projekt sigter mod at anvende moderne “mass spectrometry-based proteomics” til at undersøge de underliggende mekanismer for urinexosomsekretion i normale og patofysiologiske modeller. | Postdoc / DFF-Individuel Postdoc / fellowship | 1fellowships_scholarships |
gen_6a27d1e4e2c3f99d819cb1c70c76b8a3 | On the effect of turbulence on anomalous power deposition in fusion plasmas | Carlsberg Foundation | University of Oxford, Theoretical Astrophysics and Plasma Physics group at Rudolf Peierls Centre for Theoretical Physics | CF23-0181 | What? A hot magnetized fusion plasma is a medium which can support a large number of waves and wave interactions. High power microwaves injected into a fusion plasma can interact with plasma waves which causes them to deposit power in unexpected regions of the plasma. Steep gradients in the edge of the plasma may further complicate this by giving rise to plasma turbulence which affects microwave propagation. Why? High power microwaves play an important role in starting and sustaining fusion plasmas through localized heating and current drive. Most current heating schemes are challenged in fusion plasmas with a high fuel density but newer advanced microwave schemes may work without at arbitrary densities and high efficiencies. Knowing where the power is deposited is important but wave interactions and turbulence can complicate this significantly. Efficient microwave heating is crucial to the design of the UK demonstration fusion power plant STEP. How? By developing analytical models and validating them against simulations run on supercomputers, a predictive capability can be developed. Experiments at the MAST-U fusion device in the UK will mature the models so that they may contribute to the empirical foundation of the design of the STEP device. | Postdoc / Visiting Fellowships at University of Oxford / Award | 1fellowships_scholarships |
gen_6045b69a5df517062eba4f5ec1d91f3e | PhD Technology Driven Sciences: Technologies for Cultural Heritage | European Commission | AKADEMIE DER BILDENDEN KUNSTE WIEN; Università degli Studi di Torino | CORDIS-754511 | T4C is a novel research and training doctoral programme in “Heritage Sciences” conceived by the University of Torino, (UNITO) with the financial support of the banking foundation Compagnia di San Paolo (CSP) and the scientific and training involvement of a 35 local, national and international partner organisations belonging to academic and non-academic sectors. Main aim of T4C is to build up the next generation of Cultural Heritage professionals, able to develop technological solutions and services for the restoration, the protection, the diagnostics and the valorization of cultural heritage and skilled with a complementary scientific training from socio-economic disciplines and humanities and soft skills. Target are early stage researchers with a scientific background in chemistry, physics, biotechnology, ICT, biology and related disciplines, undergoing a genuine mobility to Italy. T4C will last 60 months and will be implemented through 2 calls for applications, assigning a total of 18 transnational incoming fellowships. Fellows will be offered an independent and personalized scientific training choosing from two specific scientific domains: Digital Sciences and Conservation, within the specific panels of Digital Sciences, Physical Sciences, Basic and Natural Sciences, Environmental Sciences They will be enrolled in the T4C PhD programme and will be supervised by a joint supervision of academic and non-academic supervisors. Fellows will attend an exclusive traninig programme, encompassing basic traninig, scientific training through individual project implementation and interdisciplinary training, short term visits, secondment opportunities at non-academic premises, soft skills, dissemination and outreach activities. T4C intends also to capitalize on the experience of the already funded Cofund project (Train2Move) in managing international mobility programmes with national and international impact and in aligning national mechanisms to EU ones. | H2020-EU.1.3. / 1.3 Marie Skłodowska-Curie Actions (MSCA) | 1fellowships_scholarships |
gen_d0fe5ebca9e797bcf36486f68d7fd428 | Defining the role of NC1 domain assembly in collagen biosynthesis and collagen associated disorders | NIH | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | 5F31AR081704-02 | PROJECT SUMMARY/ABSTRACT Collagens are essential components of the extra-cellular matrix and basement membranes, where they serve to bolster tissue integrity, mediate cell migration, and organize signaling. Collagen proteins have three domains: the C-terminal trimerization domain (CTD/NC1), the collagen domain and the 7S N-terminal domain. Collagens undergo folding followed by trimerization and collagen triple helix formation in the ER prior to secretion to the extra-cellular environment. Trimerization of the NC1 domain is the first step in collagen folding and is required for formation of the collagen triple helix. Mutations in collagens result in severe diseases, such as Osteogenesis Imperfecta, Alport’s Disease and Cerebral Small Vessel Disease which impair the integrity of bones, kidneys and blood vessels in the brain and eye respectively. Although many disease-causing mutations in collagens have been identified, there still is an incomplete understanding of the mechanisms of pathogenesis. The goal of this proposal is to understand how perturbing the initial trimerization effects the maturation and biosynthesis of collagen IV. In my first aim, I will develop new cell-based assays to quantify the effect of NC1 domain perturbation on collagen assembly. Specifically, I have developed a split luciferase assay that measures NC1 domain interactions in isolation and have begun to quantify the effect of pathogenic mutations. Additionally, I will develop complementary cell lines that express full-length collagen IV, including the most interesting mutants identified in the split luciferase assays, to better understand the functional consequences of these perturbations. In my second aim, I have designed point mutations at the NC1 interface, and identified those that increase or decrease trimer stability. Excitingly, one of these mutations significantly increased NC1 association and secretion. Together, these studies will reveal the mechanisms of collagen-associated disease and suggest ways of circumventing them. The major innovation is the application of cutting-edge computational approaches to design point mutations that probe specific questions about collagen assembly and stability. Together, we expect these studies to suggest new avenues for the treatment of collagen associated disorders. Finally, these experiments serve as an exciting training opportunity, providing me with a mentored research experience in inter- disciplinary, translational studies. PROJECT NARRATIVE Collagens are essential components of the extra-cellular matrix and basement membranes and mutations in these proteins result in severe diseases. Here, we propose an integrated approach that combines chemical biology, computational protein design and biochemistry to elucidate the mechanistic details of how the efficiency of initial trimerization dictates overall collagen biosynthesis. These studies will reveal how disease-associated mutation damage the unique folding pathway of collagens and potentially elucidate therapeutic approaches to treat collagen associate disorders (CADs). | Training, Individual | 1fellowships_scholarships |
gen_a6787dd3e19c6c30fdacceda24437047 | Regulation of Steady-State Hematopoiesis by Microbiota-Driven IFN-I Signaling | NIH | BAYLOR COLLEGE OF MEDICINE | 5F31HL168921-02 | Abstract/Project Summary Over 200 million courses of antibiotics were prescribed in the U.S. in 2020, raising a significant clinical concern as antibiotic courses of two weeks or longer result in hematological complications, the most serious of which is neutropenia. Neutropenia, if left untreated, is a risk factor for subsequent infections, sepsis, and death. Elucidating the molecular mechanisms of antibiotic-associated bone marrow suppression will allow us to develop therapies to prevent or treat bone marrow suppression in patients who require prolonged antibiotics. Our lab has developed a mouse model of antibiotic-associated bone marrow suppression that showed that depletion of the microbiome on prolonged antibiotics results in anemia, leukopenia, and other cytopenias. However, the precise stage in differentiation at which antibiotics disrupt hematopoiesis remains unknown. We further demonstrated that the microbiome promotes a basal level of type I interferon (IFN-I) signaling, which is required to maintain steady-state hematopoiesis in a STAT1-dependent manner. Although prior studies showed that activation of NOD1 and TLR-MYD88 pathways can support myelopoiesis, I observed normal numbers of hematopoietic progenitors and granulocytes at baseline in Nod1 and Myd88-deficient mice, suggesting that these pathways are dispensable for normal blood production. Several independent studies have shown that the microbiome can induce tonic IFN-I signaling through TLR-TRIF, cGAS-STING, and RIG-I-MAVS pathways, though their contribution to hematopoietic maintenance is not well understood. In an untargeted metabolomics screening, we identified 29 microbial metabolites that were enriched in stool and serum samples from non- leukopenic mice compared to those that were leukopenic two weeks post-antibiotics. Whether these metabolites can support hematopoiesis in vivo remains unexplored. This proposal will test the hypothesis that the microbiome utilizes immune-related signaling pathways such as TLR-TRIF, cGAS-STING, and RIG-I-MAVS pathways to support IFN-I mediated steady-state hematopoiesis at the level of the hematopoietic stem cell (HSC). A major limitation of our prior work is that a shift in Sca-1 expression caused by IFN-I suppression could have skewed the enumeration of HSPCs in antibiotic-treated mice. To address this, we will first perform a limiting dilution transplant to quantify functional HSCs in antibiotics and mock-treated mice. We will also trace the fate of HSPCs and granulocyte populations by tracking their proliferation, differentiation, and turnover in Krt18- CreERT2:Rosa26-lox-STOP-lox-TdTomato mice treated with or without antibiotics. To elucidate the mechanism of microbiome-dependent hematopoiesis, we will characterize the hematopoietic defects in Trif-/-, Sting-/-, and Mavs-/- mice treated with or without antibiotics. We will validate our results by assessing the sufficiency of TLR, STING, and RIG-I agonists to rescue antibiotic-associated hematopoietic defects. We will also use IfnbΔβ-luc/Δβ-luc reporter mice to evaluate the ability of microbial metabolites to sustain basal IFN-I production. These studies will define the mechanisms by which the microbiome promotes IFN-I production to regulate hematopoiesis. Project Narrative Prolonged use of antibiotics impairs normal blood production by depleting the microbiome. Here, we propose to investigate the effects of prolonged antibiotics on hematopoietic progenitors and granulocyte populations and identify the microbiome-driven immune signaling pathways and metabolites that promote normal hematopoiesis. | Training, Individual | 1fellowships_scholarships |
gen_cb33d1486144e2ef0f49bd56618cf650 | Functionalizing a T1D/T2D-associated locus within an intron of GLIS3. | NIH | UNIVERSITY OF WISCONSIN-MADISON | 1F31DK137447-01 | PROJECT SUMMARY Diabetes mellitus has been characterized since antiquity, with the first documentation of this group of disorders dating back to 1500 BC1. While many advances have been made in the field in terms of treatment, there remains no cure for diabetes. This has become increasingly problematic for both the individuals and the entire healthcare system as rates of diabetes continue to rise. It is estimated that healthcare for individuals with diabetes costs over $200 billion per year in the United States alone2. Diminishing these costs and improving treatment options for patients are just a couple of the many reasons why diabetes-related research is so critical. I will use a genetic approach to more fully understand the initiation and progression of diabetes. In this application, I highlight a method that integrates human and mouse datasets to examine the role of intragenic and intronic regions of the genome in diabetes susceptibility. One such locus of interest resides in the first intron of the GLIS3 gene and has highly significant SNPs associated with both type 1 diabetes (T1D) and type 2 diabetes (T2D). To study this Glis3T1D/T2D locus, we determined the syntenic region in mouse and deleted 1729bp to create a novel mouse model (Glis31729 mouse). I found that these mice exhibit hyperglycemia, despite increased insulin secretion and glucose-evoked Ca2+ oscillations. My overall objective for this proposal is to functionalize this locus in an effort to elucidate its role in driving diabetes. My central hypothesis for the function of this locus is that it acts as an enhancer for Glis3 in islets, and that T1D/T2D-related SNPs within the locus alter its activity. I will test this hypothesis, and thus accomplish the goals of this proposal, by pursuing the following aims: 1) evaluate the enhancer activity of the Glis3T1D/T2D locus, 2) identify the influence of T1D/T2D-associated SNPs on transcription factor binding at the Glis3T1D/T2D locus, and 3) evaluate differentially expressed (DE) genes in the Glis3 1729 mice to reveal the role of the Glis3T1D/T2D locus on altering T1D and T2D risk. With the completion of these aims, I anticipate a more complete understanding of this non-coding locus, including how it regulates gene expression and affects both type 1 and type 2 diabetes susceptibility. Additionally, I believe this proposal will provide the necessary training for me to progress as an islet biologist and prepare me for a tenure-track position at a research institution. PROJECT NARRATIVE Diabetes is a complex chronic disease that is largely driven by genetic factors. This proposal aims to determine the function of a T1D and T2D – associated locus located in an intronic region of GLIS3. Further characterizing this locus will help elucidate its role in altering diabetes susceptibility and may provide a mechanism for a novel shared pathophysiology at the genetic level for T1D and T2D. | Training, Individual | 1fellowships_scholarships |
gen_1975414ebe12c9cfc7ad963ada415f58 | Investigating the impact of hyperglycemia on modulating T cell populations in breast cancer | NIH | UNIVERSITY OF ALABAMA AT BIRMINGHAM | 5F31CA284611-02 | PROJECT ABSTRACT This grant application is for the F31-Diversity support of Courtney Swain during her MD-PhD training. The research focus of this proposal is to establish a mechanism in which hyperglycemia and Hedgehog (Hh) signaling conspire to modulate CD8+ T cell exhaustion and regulatory T cell (Treg) immunosuppression in triple-negative breast cancer (TNBC). Breast cancer continues to threaten the lives of many women in the U.S. and worldwide as it accounts for more than 30% of all female cancer cases. Additionally, type 2 diabetes mellitus (T2D) is a highly prevalent morbidity and about a quarter of breast cancer patients are diabetic, which can increase treatment complications and limit therapy options. TNBC tumors are immunologically “cold,” characterized by the limited infiltration of cytotoxic populations and increased abundance of immunosuppressive constituents in the primary tumor. Hyperglycemia in T2D pathogenesis has been implicated to impair CD8+ T cells, lymphocytes critical in tumor killing and immunotherapy response, and their exhaustion process. Upon tumor challenge, subsets of immunologically reactive TCF1+ stem-like and TCF1- transitory effector CD8+ T cells are generated. These CD8+ T cell subsets have been found to be highly essential in tumor control despite their phenotype and nomenclature of early exhaustion. Notably, hyperglycemia exacerbates dysregulated Hh signaling in breast cancer. Initial investigations have revealed that hyperglycemia and Hh signaling may be cooperatively driving dysfunctional CD8+ T cell exhaustion in the mammary tumor milieu. Additionally, the presence of Tregs during mammary tumorigenesis correlates with poorer prognoses in TNBC. Supporting evidence in this proposal underscores that both, Hh signaling and hyperglycemia, impair CD8+ T cell exhaustion and promote Treg immunosuppression. However, the mechanisms by which these factors influence these key T cell populations are unknown. Therefore, this proposal will apply unique model systems of Hh signaling and hyperglycemia to delineate their roles in CD8+ T cell and Treg activity in TNBC. Findings will provide more relevance for combination TNBC therapies, especially for the distinct patient population of diabetic breast cancer patients. The proposed training plan for the PI is sponsored by her PhD mentor, Dr. Lalita Shevde-Samant. The goals of the training plan are to provide the PI with: (i) a rigorous research project using distinctive pre-clinical models of diabetes-associated breast cancer, novel genetically engineered mice, and tumor-immune crosstalk; (ii) opportunities in developing immunologic and bioinformatic techniques and in expanding training in responsible conduct of research, rigor, reproducibility, and principles of scientific integrity; and (iii) a scientifically enriching and equipped environment essential for developing a successful career as an oncologist-scientist. Given this project’s focus on the interaction of two major disease challenges of the U.S., breast cancer and diabetes, the PI will have exemplary guidance and a solid foundation to develop into a very competent physician-scientist. PROJECT NARRATIVE Type 2 diabetes-associated breast cancer supports an immunosuppressive microenvironment that impairs CD8+ T cell anti-tumor response and promotes regulatory T cell immunosuppression via dysregulated Hedgehog signaling, precipitating into poorer overall and disease-free outcomes in this distinct, but highly prevalent, patient subset. More studies are required in understanding the modulation of CD8+ and regulatory T cell activity by Hedgehog signaling and hyperglycemia during mammary tumorigenesis. This proposal will elucidate the roles of hyperglycemia and Hedgehog signaling in breast cancer progression and control, as well as support the initiative of developing effective combination therapies for highly-aggressive, diabetes- associated breast cancer. | Training, Individual | 1fellowships_scholarships |
gen_a1926ebaa8f9b5faedb8d1e18b7fb365 | The Role of Sleep in the Relationships Among Adverse Childhood Experiences, Mental Health Symptoms, and Persistent/Recurrent Pain during Adolescence | NIH | UNIVERSITY OF MICHIGAN AT ANN ARBOR | 1F31NR020837-01 | PROJECT SUMMARY The goal of this fellowship is to prepare the applicant, Thea Senger-Carpenter, as a nurse-scientist studying relationships among adolescent sleep, adverse childhood experiences (ACEs), and associated symptoms and outcomes. To that end, the proposed fellowship consists of two complementary components: (1) a training plan comprising formal training, mentorship, hands-on research, manuscript publication, and professional development activities and (2) a research project that will further our understanding of how sleep affects the relationships among ACEs, mental health symptoms and persistent or recurrent pain (PRP) during adolescence. The applicant will be supported by a strong mentorship team with sponsors at the University of Michigan School of Nursing and Yale School of Nursing. Together, the mentorship team provides expertise in adolescent sleep, pain and associated symptoms, and ACE exposure. The training program will help the applicant develop: a) expertise in adolescent sleep, PRP, and the sequelae of ACE exposure, b) methodological skills in longitudinal, multivariate data analysis and c) engage in the dissemination of research findings and professional networking activities. Sleep deficiency affects up to two-thirds of American adolescents and is a risk factor for PRP, anxiety, and depression. ACE exposure is similarly prevalent, affecting around half of U.S. teens, and has been associated with both PRP and mental health symptoms. Importantly, sleep deficiency may moderate the effect of ACE exposure on other health outcomes. However, little is known about how sleep deficiency impacts the relationships among ACE exposure, mental health symptoms, and PRP across adolescence nor how these relationships differ by race, ethnicity, socioeconomic status (SES), and sex. Thus, the aims of the proposed project are 1) to determine whether and how sleep deficiency moderates the indirect effect of ACEs on PRP through mental health symptoms and 2) to describe how these relationships differ by race, ethnicity, SES, and sex. All aims will be investigated using the Adolescent Brain Cognitive Development Study, an ongoing NIH- funded longitudinal study of youth development in the United States. This proposed project integrates the research lenses of health equity and population and community health outlined in the National Institute of Nursing Research's strategic plan. By identifying sleep as a modifiable target for intervention, our findings have the potential to reduce the symptom burden of adolescents exposed to ACEs and mitigate racial, ethnic, socioeconomic, and sex-based inequities in health outcomes. PROJECT NARRATIVE Elucidating how modifiable factors such as sleep deficiency alter relationships among adverse childhood experiences (ACEs), mental and physical symptoms and outcomes during adolescence is of critical importance to maximizing well-being and functioning during adolescence and into young adulthood. The proposed project is the first to examine how sleep deficiency affects relationships among ACEs, mental health symptoms, and persistent or recurrent pain during early adolescence, and how these associations differ by race, ethnicity, socioeconomic status, and sex. Results will significantly contribute to the development of targeted sleep-based interventions aimed at preventing or mitigating ACE-related mental and physical health symptoms. | Training, Individual | 1fellowships_scholarships |
gen_3046e78dbf4992f7dab8c162cda94944 | Novel therapeutics for treatment of catheter-associated UTI and depletion of the vaginal reservoir | NIH | WASHINGTON UNIVERSITY | 5F30DK135390-02 | PROJECT SUMMARY / ABSTRACT Antimicrobial resistance (AMR) contributes to an estimated 5 million deaths worldwide each year and is directly responsible for over 1.2 million deaths. In the not-to-distant future, we may face a reality where infections resistant to all existing antibiotics are commonplace. Therefore, addressing antimicrobial resistance by developing antibiotic-sparing therapeutics is an urgent global health concern. Urinary tract infections (UTI) drive over 15% of all antibiotic prescriptions and directly contribute to the development of AMR bacteria. One potential antibiotic-sparing therapeutic for UTIs is monoclonal antibodies (mAbs), which have been successfully deployed for decades and have a strong history of safety and efficacy. The objective of this proposal is to develop mAbs to two types of UTIs that greatly contribute to global disease burden. The overall hypothesis is that mAbs to bacterial pilus adhesin proteins will block adhesin-ligand interactions and thus prevent bacterial adherence to host tissues. In Aim 1, mAbs will be explored as a treatment for catheter- associated UTI (CAUTI) caused by two pathogens that are frequently multi-drug resistant: Enterococcus faecalis and Acinetobacter baumannii. These bacteria cause CAUTI by using sticky adhesins to bind to fibrinogen deposited on the surface of urinary catheters. mAbs will block this interaction to prevent catheter colonization. In Aim 2, mAbs will be tested for their ability to block bacterial interaction with host tissue. Uropathogenic Escheriscia coli (UPEC) frequently causes highly recurrent UTI (rUTI) in part by establishing reservoirs in the gastrointestinal tract and vagina that serve as a source for UPEC’s continuous reintroduction into the bladder lumen. While the adhesins responsible for gut colonization have been characterized, the adhesin responsible for vaginal colonization is unknown. Based on existing data suggesting a role for the UPEC S pilus in the vagina, the contribution of this pilus to vaginal colonization will first be elucidated. mAbs will then be generated to the S pilus adhesin and tested for their ability to deplete UPEC from the vagina. The long-term goal of the proposed research is to generate mAbs that can treat human urinary tract infections. During the fellowship, the applicant will develop important skills for becoming an independent investigator of infectious diseases. The sponsor of this work, Dr. Scott Hultgren, has vast experience studying urinary tract infection pathogenesis and treatment, and the institutional environment provides supportive, collaborative experts in microbiology and immunology. Washington University School of Medicine has a long history of helping physician-scientists build successful careers. The proposed training plan will facilitate the applicant’s transition into becoming an independent physician-scientist, using research to improve women’s health. PROJECT NARRATIVE The proposed work will generate monoclonal antibodies to treat catheter-associated urinary tract infections (UTI) and deplete the vaginal reservoir that harbors bacteria and contributes to UTI recurrence. The success of monoclonal antibodies as treatments for other diseases as well as significant preliminary data demonstrating the protective effect of immunity to bacterial adhesins, which mediate UTIs, suggest that this will be a highly effective strategy. These studies have the potential to directly contribute to the arsenal of antibiotic-sparing therapeutics for UTIs. | Training, Individual | 1fellowships_scholarships |
gen_014875b757e2fe61e529d66f452181b5 | Probing Differences in Gene Essentiality Between Mycobacteroides abscessus Smooth and Rough Morphotypes During Infection | NIH | GEORGIA INSTITUTE OF TECHNOLOGY | 5F32AI172296-02 | PROJECT SUMMARY Several pathogens utilize morphological changes to improve their fitness in a particular environment, but these changes often coincide with broad physiological reprogramming. Mycobacteroides abscessus (MAB) is one such pathogen, presenting as a smooth colony (MABS) in the environment and host, which can transition to a rough (MABR) morphotype following an unknown stimulus during infection. MAB is an emerging pathogen among immunocompromised and immunocompetent individuals causing a wide variety of infections, including respiratory, skin abscesses, soft tissue infection, and bacteremia. Several groups have shown that these two colony morphotypes are phenotypically distinct in vitro and in the host, yet the underlying genetic components contributing to their behavioral differences are still unknown. We have found that MABS and MABR require unique genes for survival indicating that they are molecularly distinct despite having a nearly identical genome. There still remains a significant gap in knowledge in the molecular genetic mechanisms underlying physiology that controls the phenotypic differences. To address this, in Aim 1, I will use transposon insertion (Tn-seq) libraries in both MABS and MABR to examine genes required for survival in a murine abscess model and seven infection relevant conditions (e.g., low oxygen, nitric oxide, metal limitation, abscess infection). The data gathered from individual infection relevant conditions will then be leveraged to determine which antimicrobial mechanisms the two morphotypes face in the host and if they use similar pathways to respond. I have already generated an ordered transposon library which will allow us to confirm our findings of select mutants. In Aim 2, I will investigate uniquely essential genes, MAB_2726c (unique to MABS) and MAB_3329c (unique to MABR) by assaying survival following knocked down with CRISPRi. These genes are transcriptional regulators which likely have broad effects; therefore, I will define their regulome using CHiPSeq and confirm our findings using RNAseq following repression by CRISPRi and controlling for differences in growth using a chemostat. I hypothesize that M. abscessus MABS and MABR have different essential genes when exposed to stress, during infection, and differential essentiality of transcriptional regulators contribute to broad physiological changes that confer phenotypic differences. Due to the lack of effective therapies and a vaccine, this fellowship aims to build a research portfolio that will address the urgent need for further understanding of this pathogen. Tn-seq offers a method for quick and broad identification of genes essential for survival in various environments and public availability of the data generated not only benefits my study of MAB as a postdoc but also as an independent scientist and the field at large. PROJECT NARRATIVE Several species of bacteria adapt to the host environment by changing their morphotype which often coincides with broad changes in physiology that promotes their survival. Mycobacteroides abscessus is an emerging pathogen that presents as either a smooth or rough morphotypes which have very different behaviors in the host. This proposal aims to define the genes contributing to the difference between the two morphotypes behavior in vitro and during infection using a library of gene mutants. | Training, Individual | 1fellowships_scholarships |
gen_72625acc0cfb7afcd665cfb2dd42eb8c | Empirically Based Career Development Program for Historically Under-Represented Early Career Trainees Supported by NIDDK | NIH | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | 1UE5DK137286-01 | PROJECT ABSTRACT Despite increased awareness and provision of resources, there remain significant disparities in the demographics of the workforce in science, engineering, technology, and mathematics, medicine (STEMM). These disparities are the result of a “leaky pipeline” in which there is attrition of certain historically under- represented groups at each stage of training and career advancement. In 2019-2020, 71% of doctoral degrees in STEMM fields were awarded to individuals who were categorized as White race and ethnicity. In 2019, although a higher number of women obtained a doctoral degree in a STEMM field compared to men, more than twice as many people employed in management or higher positions in the same fields were male compared to female. Prior studies showed that diversity within teams has many benefits, including innovation and strong information processing. Several conceptual frameworks have identified social supports that are mediated by enhanced self-efficacy and scientific identity to improve persistence to pursue a career in a STEMM field. Career development programs that offer evidence-based interventions that are rooted in these empirical models may be an individual-level approach to increase representation of historically under-represented groups in biomedical sciences. The purpose of this project, in partnership with NIDDK, is to offer a career development program to early career trainees who are funded by NIDDK grants. We hypothesize that, over five years, program scholars will report a strong sense of belonging and self-efficacy in the field; sustain and advance in their current career trajectory; and obtain the next appropriate level of funding to establish their independent program of research. The potential impact of this project is increased representation of early- and mid-career researchers from historically under-represented groups conducting research relevant to the priority areas of NIDDK. Specifically, this project targets individuals who are at the transition from culmination of training or early career investigators to established researcher. The long-term potential implications include the potential to realize both direct benefits for program scholars as well as broader indirect effects for future researchers PROJECT NARRATIVE The proposed project will provide a career development program to early career investigators from historically under-represented groups who are supported by NIDDK. We will provide theory-driven and evidence-based interventions that target scientific self-efficacy and identity to increase perseverance. The goal of the program is for scholars to obtain the next appropriate level of funding to establish independent programs of research. | Other Research-Related | 1fellowships_scholarships |
gen_f8ab07b8b8930fda5983827b7cadcc49 | AHA Hypertension Scientific Sessions 2023 | NIH | UNIVERSITY OF VIRGINIA | 1R13HL170700-01 | Project Summary More than fifty percent of adults and children in the United States suffer from high arterial pressure (hypertension). If untreated, hypertension can cause cardiovascular disease, kidney damage, and stroke. The purpose of this application is to request travel funds to support trainees who wish to attend and participate in the Hypertension Scientific Sessions 2023 to be held September 7–10, 2023 in Boston, Massachusetts. Hypertension Scientific Sessions is the preeminent conference on hypertension, and it is organized by two Councils of the American Heart Association: The Council on Hypertension and the Council on Kidney in Cardiovascular Disease. This meeting is considered one of the most important and prestigious meetings focused on hypertension. The conference includes oral and poster presentations selected from abstracts submitted by clinical and basic researchers, followed by discussions facilitated by leading experts in their respective fields. Attendees will have the opportunity to interact closely with experts from around the world involved in cross- disciplinary research in hypertension, cardiac and kidney disease, genetics, stroke, and obesity. This meeting will offer sessions specifically designed to benefit trainees and early career investigators. In addition, the meeting offers Clinical Practice topics focused on applying clinical science and improving patient outcomes for primary care providers. By supporting the travel, education, and development of promising early-career scientists, we hope to expand and diversify the current workforce, thereby ultimately increasing the innovation of hypertension research. The specific aims of 2023 Hypertension Scientific Sessions and this application are: 1) Provide early- career attendees with a forum to present their research and obtain constructive feedback from a knowledgeable international audience of scientists working in the field of hypertension; 2) Encourage trainees to enhance their current knowledge by attending state-of-the-art and cutting-edge symposia and lectures organized by the Planning Committee of the Hypertension Scientific Sessions; 3) Offer trainees an opportunity to network with their peers and senior scientists in the area of hypertension; and 4) To increase the participation of speakers and moderators from Historically Marginalized communities (HMCs). This award will multiply the participation of researchers from HMCs, trainees, and early career scientists, in a welcoming environment devoted to learning the latest advances in the field of hypertension at a time when institutions are still limiting expenditures on travel. Project Narrative More than fifty percent of adults and children in the United States suffer from have high arterial blood pressure (hypertension); if untreated, hypertension leads to cardiovascular and kidney disease and stroke. The purpose of this application is to request travel and caregiver funds to support trainees who wish to attend and participate in the Hypertension Scientific Sessions 2023 to be held in person on September 7–10, 2023 in Boston, Massachusetts. By supporting the travel, education, and development of these promising early-career scientists to this preeminent meeting, we hope to expand and diversify the current workforce, ultimately increasing innovation in hypertension research. | Other Research-Related | 1fellowships_scholarships |
gen_3533854dfda320e6fac4e9bac1c319ba | CTSA Predoctoral T32 at Albert Einstein College of Medicine | NIH | ALBERT EINSTEIN COLLEGE OF MEDICINE | 1T32TR004537-01 | ABSTRACT This application seeks to continue a longstanding CTSA-supported predoctoral program, the PhD in Clinical Investigation (PCI) at the Albert Einstein College of Medicine (Einstein). PCI combines specialized training to prepare biomedical scientists to understand and appreciate the methodologies of clinical and population science, to practice team science as both leaders and members of research teams, and to advance the discipline of translational science. PCI leverages Einstein's longstanding success in fundamental laboratory- based research. PCI's unique integration with our master's degree-granting Clinical Research Training Program (CRTP), along with our requirement that each student's research and mentoring team must “bridge a translational divide,” fosters multidisciplinary team science while teaching the methodologies to overcome barriers plaguing translational research. PCI has (1) conferred 18 PhDs, (2) 12 current trainees, (3) sustained enrollment of trainees from historically marginalized communities (HMCs), and (4) a dramatic increase in inquiries and applicants. Einstein is located in the Bronx, NY, the most diverse and poorest urban county in the United States, whose catchment area experiences racial and ethnic disparities in health outcomes related to cancer, cardiovascular disease, and infectious diseases. Since much of our trainees' research involves patient data and samples from our catchment area, PCI has essentially been training trainees to conduct clinical and translational science (TS) research that meaningfully contributes to our understanding and mitigation of disparities that disproportionately affect HMCs. Building from our program's success and increased demand, we seek to evolve PCI during the next funding period with formalized emphasis on integrating health equity (HE) into our training and ensuring program sustainability. We will integrate health disparities research with a focus on overcoming barriers to HE into our training though collaboration with the Community and Stakeholder Engagement Research Module of our companion CTSA UM1. We will improve training of the next generation of trainees, who have been unfavorably affected by the COVID-19 pandemic, by establishing the position of Associate Director for Student Support. We will improve sustainability by developing a PCI-specific F-award path to submission program. While the PCI is disease-agnostic, many of our trainees have undertaken research that is highly relevant to our catchment area, particularly in relation to infectious disease, cancer, and brain science. During the next funding period, we seek to leverage the non-categorical PCI and develop new Research Focus Areas in Infectious Disease, Cancer Outcomes, and Brain Sciences, to integrate highly funded mentors and provide the opportunity to bring additional disease-specific T32 grants into PCI, providing PCI trainees funding opportunities beyond the four disease-agnostic slots sought through this application. While our training approach will remain non-categorical, in the next project period we will seek to emphasize these focus areas per our institutional strengths, while applying TS and HE lenses to all trainees' projects. PROJECT NARRATIVE The PhD in Clinical Investigation (PCI) at the Albert Einstein College of Medicine combines specialized training to prepare biomedical scientists to understand and appreciate the methodologies of clinical and population science, to practice team science as both leaders and members of research teams, and to advance the discipline of translational science. Building from our program's success and increased demand, we seek to evolve PCI by incorporating formalized emphases on integrating TS and health equity (HE) into our training. During the next funding period, we seek to leverage the non-categorical PCI and develop new Research Focus Areas in Infectious Disease, Cancer Outcomes, and Brain Sciences, to provide PCI trainees with funding opportunities that go beyond the four disease-agnostic slots while emphasizing our institutional strengths and applying TS and HE lenses to all trainees' projects. | Training, Institutional | 1fellowships_scholarships |
gen_c11467a94f6813fa262b65ab95f8716a | Skills Developments Grant - Travel award - Advances in Ewing Ssarcoma Research conference 14 October 2022 | Bone Cancer Research Trust | University of Padua | HRCS22_11821 | Oral presentation: Autoantibody Profiling in Ewing Sarcoma Patients | 4.1 Discovery and preclinical testing of markers and technologies | 1fellowships_scholarships |
gen_55c53fc9813d4f982513e0607f9b4936 | Skills Developments Grant - Travel award - Advances in Ewing Ssarcoma Research conference 14 October 2022 | Bone Cancer Research Trust | German Cancer Research Center | HRCS22_11826 | Oral presentation: Neomorphic DNA-binding enables tumour-specific therapeutic gene expression in fusion-addicted childhood sarcoma | 5.2 Cellular and gene therapies | 1fellowships_scholarships |
gen_5bf93fe5b9c56dbeb4be699c15b9fc99 | Skills Developments Grant - Travel award - Advances in Ewing Ssarcoma Research conference 14 October 2022 | Bone Cancer Research Trust | Istituto Ortopedico Rizzoli | HRCS22_11852 | Oral presentation: Triggering CD99 impacts on the macrophage functions and favors their role in tumor cell eradication | 5.2 Cellular and gene therapies | 1fellowships_scholarships |
gen_0dded0ebb290654ad7ef38cf2347167a | Skills Developments Grant - Travel award - Advances in Ewing Ssarcoma Research conference 14 October 2022 | Bone Cancer Research Trust | CERCA Institution | HRCS22_11853 | Oral presentation: KDM6 demethylases of H3K27 residue regulate critical transcriptional programs induced by EWSR1-FLI1 in Ewing sarcoma | 2.1 Biological and endogenous factors | 1fellowships_scholarships |
gen_f03cecc8c0e0d0daad34c40b7a88f94a | Skills Developments Grant - Travel award - Advances in Ewing Ssarcoma Research conference 14 October 2022 | Bone Cancer Research Trust | Essen University Hospital | HRCS22_11866 | Poster presentation: Preclinical testing of lestaurtinib (CEP701) as a single and combination agent for the treatment of Ewing sarcoma | 5.1 Pharmaceuticals | 1fellowships_scholarships |
gen_206f9fda24d1a612dfb61e19192c458d | Drug Discovery and Team Science | Wellcome Trust | University of Nottingham | HRCS22_20837 | This programme focuses on the application of a multidisciplinary Team Science approach to develop novel approaches and technologies involving the physical, biological and medical sciences to study membrane receptors in the right cell type and tissue. The programme embraces colleagues from UoN, pharmaceutical companies, SMEs and learned societies to develop a training programme that has the student at its centre but which engenders a collaborative multidisciplinary approach within a cohort-based programme of research. Each entry of four students will study one of the following disease-related themes: (a) cancer angiogenesis; (b) pain and addition; (c) respiratory diseases; (d) immune-oncology and (e) inflammation. Each cohort will tackle their given disease theme as a multidisciplinary team, with each student working in one of four key experimental areas: (a) Target engagement; (b) cellular environment; (c) in vivo and ex vivo models and (d) mathematical modelling and systems biology. The key programme goals will address: (1) the major skills gaps identified by ABPI in complex in vivo experimental models and in vitro pharmacological analytical approaches; (2) the need for multidisciplinary programmes, industrial/transitional placements and the provision of training in ‘translational’ skills such as communication, leadership and entrepreneurship; and (3) the need for supportive training environments. | Studentships | 1fellowships_scholarships |
gen_48676bdd8e7a7d2b2edd906814a6f6e3 | How does Synaptic Plasticity support Memory? | Irish Research Council | Trinity College Dublin | Not available | Early Career / EMPOWER | 1fellowships_scholarships | |
gen_bfe386784967cc3d0a6638b17dc6d287 | A nanoparticle-loaded hydrogel for Epidermolysis Bullosa (reGENErate) | Irish Research Council | Dublin City University | Not available | Early Career / Enterprise Partnership Scheme (Postdoctoral) | 1fellowships_scholarships | |
gen_a39fb7e9c70b48c9b2cc67380a92e8ab | Content Management for User Generated Videos | Irish Research Council | Dublin City University | Not available | Early Career / Enterprise Partnership Scheme (Postdoctoral) | 1fellowships_scholarships | |
gen_d378c32d3e7f787092cc8df886728ec3 | Sources and Chemical Composition of Atmospheric Aerosols | Irish Research Council | University College Cork | Not available | Early Career / EMBARK | 1fellowships_scholarships | |
gen_c89ec7b3c89cb1daa120f8b2c16ddbd4 | Civil War and Francoism in the Spanish Media Since 2007 | Irish Research Council | University College Dublin | Not available | Early Career / CARA | 1fellowships_scholarships | |
gen_6f26c333e2f25fb56683a51478fc8a58 | Integrating eHealth, Fitness Apps, and the Autonomous Vehicle. | Irish Research Council | University of Galway | Not available | Early Career / Enterprise Partnership Scheme (Postgraduate) | 1fellowships_scholarships | |
gen_e77a0de03b8afda6410ac23e80ab3abe | Population dynamics, habitat use, philopatry and feeding behaviour of the Red Squirrel (Sciurus vulgaris) | Irish Research Council | University College Cork | Not available | Early Career / Enterprise Partnership Scheme (Postdoctoral) | 1fellowships_scholarships | |
gen_3d51814a2fd049d8aff3b6c817eed608 | Unsalaried health workers in Sierra Leone: What impact does their unpaid status have on their lives and on the health services they deliver to populations? | Irish Research Council | Dublin City University | Not available | Early Career / SFI-IRC Pathway Programme | 1fellowships_scholarships |
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