TY - JOUR T1 - MUltiple myeloma with new bone formation AU - KRAININ P AU - D'ANGIO CJ AU - SMELIN A Y1 - 1949/12/01 N1 - 10.1001/archinte.1949.00230060133010 JO - Archives of Internal Medicine SP - 976 EP - 982 VL - 84 IS - 6 N2 - THERE that the typical and characteristic lesion of bone in multiple myeloma is a discrete osteolytic involvement. The roentgenographic appearance is usually that of a punched-out area with sharp margination and without evidence of surrounding productive reaction. In a description of multiple myeloma Boyd1 stated, "It is a pure rarefying lesion with no formation of new bone." To quote Geschichter2: "The widespread occurrence of small, sharply demarcated defects in the marrow cavity, unaccompanied by bending deformity or the formation of new bone, are the cardinal features in the diagnosis of multiple myeloma." Snapper3 affirmed that in multiple myeloma "no new formation of bone takes place." Shanks, Kerley and Twining4 declared categorically concerning the osseous lesions of multiple myeloma that "they are entirely osteolytic, and never give rise to new bone formation."The case to be presented is of unusual interest because it has been possible to SN - 0730-188X M3 - doi: 10.1001/archinte.1949.00230060133010 UR - http://dx.doi.org/10.1001/archinte.1949.00230060133010 ER -