



#1082 HAMAP:MF_03115 mappings

Valerie Wood

O74821, an iron sulphur cluster asssembly protein has IEA annotations

GO:0010421 hydrogen peroxide-mediated programmed cell death IEA HAMAP:MF_03115
GO:0043066 negative regulation of apoptotic process IEA HAMAP:MF_03115

which does not seem to be correct for yeast?

I don't think this process exists in yeast?
GO:0010421 hydrogen peroxide-mediated programmed cell death


  • ivo

    Hi, sorry for the late comment, the issue finally find its way to me:

    The GO term is actually assigned based on data in yeast from PubMed:19194512. I agree that it is still a matter of debate whether programmed cell death really exists in unicellular organisms (also a matter of definition, I believe), but the authors are in favor of it.

    I could also replace the GO term by something more generic, e.g.
    GO:0070301 cellular response to hydrogen peroxide

    Would you prefer this?

  • Valerie Wood
    Valerie Wood

    I don't know. We tend not to use
    GO:0070301 cellular response to hydrogen peroxide, hydrogen hydrogen peroxide is usually a condition used to activate the "oxidative stress-response".

    I think I would stick with the "iron sulphur cluster assembly" mapping until more is known. SGD have not made a stress response annotation, although they have noted it expression is increased in response to replication stress.

    I don't think there is enough info to make a mapping which will be transferred between species.