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Monoamine reuptake inhibitor

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Main article: Neurotansmitter uptake inhibitors
File:Serotonin (5-HT).svg
Norepinephrine structure





The majority of currently approved antidepressants act as MRIs including the selective serotonin reuptake inhibitors (SSRIs) and most of the tricyclic antidepressants (TCAs).[2] Many psychostimulants used either as anorectics or in the treatment of ADHD also behave as MRIs.[3] Additionally, psychostimulants acting as MRIs that affect dopamine such as cocaine and methylphenidate are often abused as recreational drugs.[4] As a result, many of them have become controlled substances, which in turn has resulted in the clandestine synthesis of a vast array of designer drugs for the purpose of bypassing drug laws, a prime example of such is the mixed monoamine reuptake inhibitor and releasing agent mephedrone.[5]

Types of MRIsEdit

There are a variety of different kinds of MRIs, of which include the following:

Refer to the above articles for more information on MRIs.

See alsoEdit


  1. Axel AM, Mikkelsen JD, Hansen HH (June 2010). Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 35 (7): 1464–76.
  2. (16 July 2008) Lippincott's Illustrated Reviews: Pharmacology, Lippincott Williams & Wilkins. URL accessed 12 May 2012.
  3. (2008) Encyclopedia of Molecular Pharmacology, Springer. URL accessed 12 May 2012.
  4. (15 April 2011) Lowinson and Ruiz's Substance Abuse: A Comprehensive Textbook, Lippincott Williams & Wilkins. URL accessed 12 May 2012.
  5. Hadlock GC, Webb KM, McFadden LM, et al. (November 2011). 4-Methylmethcathinone (mephedrone): neuropharmacological effects of a designer stimulant of abuse. The Journal of Pharmacology and Experimental Therapeutics 339 (2): 530–6.

Antidepressants (ATC N06A) edit
Reversible inhibitor of monoamine oxidase A (RIMA) Brofaromine, Moclobemide
Norepinephrine-dopamine reuptake inhibitors Bupropion
Selective serotonin reuptake enhancer (SSRE) Tianeptine
Tetracyclic antidepressants Maprotiline, Mianserin, Nefazodone, Trazodone
Noradrenergic and specific serotonergic antidepressant (NaSSA) Mirtazapine

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