What is the difference between Zoloft and Wellbutrin?

  • Q: What is the difference between Zoloft and Wellbutrin?
  • A: Zoloft is a selective serotonin reuptake inhibitor (SSRI) Zoloft stops the body from breaking down serotonin, therefore increasing serotonin levels. Serotonin is a chemical in the body that helps with mood. Zoloft can be used for depression, obsessive compulsive disorder, panic disorder, post-traumatic stress disorder, social anxiety disorder, and premenstrual dysphoric disorder. Wellbutrin is considered a dopamine reuptake inhibitor. It increases the amount of dopamine available in the body. Dopamine is also a chemical that plays a role in mood. Wellbutrin can be used for depression, seasonal affective disorder and smoking cessation. Both medications may also be used for purposes other than those listed. This information is solely informational. It's important to consult with your physician or healthcare provider about any specific questions regarding your medical conditions or medications; particularly before taking any action. Kristen Dore, PharmD
This question was answered on September 08, 2010.


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