BRD3 Protein(B17-30G)

BRD3 Protein(B17-30G)

  • $314.00


Description :Recombinant full-length human BRD3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full length

Genbank Number :NM_007371



Applications :Western Blot

Molecular Weight :115 kDa

Gene Aliases :KIAA0043; ORFX; RING3L

Scientific Background :As the best characterized binding motif for lysine acetylation, Bromodomains (BRDs) are 110 amino acid highly conserved modules found in transcriptional co-regulators, chromatin modifying enzymes and nuclear scaffold proteins. Initially identified in the protein encoded by the D. melanogaster brahama gene. Along with BRD2, BRD4 and BRDT, Bromodomain-containing protein 3 (BRD3) lacks intrinsic chromatin modifying potential and primarily function as scaffolds for transcription factors or other chromatin regulating factors. It is characterized by the presence of two distinct BRDs at the N-terminal end of the protein. BRD3 is involved in the pathognomonic chromosomal translocations seen in NUT midline carcinoma (NMC).

References :
1. French CA, et al: BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 63(2):304-7, 2003.

2. Barbieri I, et al: Bromodomains as therapeutic targets in cancer. Brief Funct Genomics. 12(3):219-30, 2013.

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Research Areas :Cancer, Cardiovascular Disease, Cell Cycle, Inflammation, Neurobiology