TY - JOUR T1 - The Role of Estrogen on Cardiovascular Response Due to GABA and Glutamate Receptors in Rostral Ventromedial Medulla in Ovarictomized Rats TT - تأثیر استروژن بر پاسخ‌های قلبی ـ عروقی گابا و گلوتامات در هسته‌ی جلویی ـ شکمی ـ میانی بصل‌النخاع در موش‌های صحرایی ماده‌ی فاقد تخمدان JF - IJEM JO - IJEM VL - 10 IS - 2 UR - http://ijem.sbmu.ac.ir/article-1-511-en.html Y1 - 2008 SP - 107 EP - 114 KW - The rostral ventromedial medulla KW - Estrogen KW - GABA KW - Glutamate KW - Blood pressure KW - Heart rate N2 - Introduction: The Rostral Ventromedial Medulla (RVMM) is one of the nuclei controlling cardiovascular system. This study was performed to delermine the effects of 17β-estradiol (E), on the GABA and Glutamate cardiovascular responses of RVMM of female rats. Material and methods: Experiments were performed on 40 anaesthetized and paralyzed rats, divided into two groups of ovarictomized (OVX) and ovarictomized-estrogen treated (OVX+E) rats. Drugs (50 nl) bicuculline methiodide (BMI) an antagonist GABAA receptor (1 mM), phaclophen an antagonist GABAB receptor (5mM), and kynurenic acid a nonselective antagonist glutamate receptors (5 mM), were microinjected by micropipette into the RVMM using stereotaxic system. Blood pressure and heart rate were recorded before and throughout each experiment. The means of maximum changes of mean arterial pressure and heart rate were compared between groups of OVX and OVX+E and saline using ANOVA. Results: In the OVX+E group, estrogen decreased the mean arterial blood pressure (P M3 ER -