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amoxicillin, clarithromycin, and lansoprazole

Pronunciation: a MOX i SIL in, kla RITH roe MYE sin, LAN soe PRA zole

Brand: Prevpac

What is the most important information I should know about amoxicillin, clarithromycin, and lansoprazole?

You should not take this medicine if you've ever had a severe allergic reaction to certain antibiotics, if you've had certain heart rhythm disorders, or if you've had liver problems caused by taking clarithromycin.

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

What is amoxicillin, clarithromycin, and lansoprazole?

Amoxicillin is a penicillin antibiotic. Clarithromycin is a macrolide antibiotic. These antibiotics fight bacteria in the body.

Lansoprazole decreases the amount of acid produced in the stomach.

Amoxicillin, clarithromycin, and lansoprazole is a combination medicine used in people with Helicobacter pylori (H. pylori) infection and stomach ulcers. Treating H. pylori infection can help prevent future stomach ulcers.

Amoxicillin, clarithromycin, and lansoprazole may also be used for purposes not listed in this medication guide.


You should not take this medicine if you are allergic to amoxicillin (Amoxil), clarithromycin (Biaxin), or lansoprazole (Prevacid), or if:

  • you have a history of long QT syndrome or certain heart rhythm disorders;
  • you have ever had liver problems or jaundice caused by taking clarithromycin;

Some medicines can cause unwanted or dangerous effects when used with amoxicillin, clarithromycin, and lansoprazole. Your doctor may change your treatment plan if you also use:

  • cisapride;
  • colchicine (if you also have liver or kidney disease);
  • dihydroergotamine or ergotamine;
  • lovastatin (Advicor, Altoprev, Mevacor) or simvastatin (Zocor, Simcor, Vytorin, Juvisync); or
  • pimozide.

Tell your doctor if you have ever had:

  • liver disease;
  • kidney disease;
  • allergies;
  • myasthenia gravis;
  • osteoporosis or low bone mineral density (osteopenia); or
  • an electrolyte imbalance or metabolic disorder.


This medicine may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.


You should not breast-feed while using this medicine.

This medicine is not approved for use by anyone younger than 18 years old.

How should I take amoxicillin, clarithromycin, and lansoprazole?


Take this medicine twice daily before you eat, unless your doctor tells you otherwise.


Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. This medicine will not treat a viral infection such as the flu or a common cold.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using amoxicillin, clarithromycin, and lansoprazole.


What happens if I miss a dose?


What happens if I overdose?


What should I avoid while taking amoxicillin, clarithromycin, and lansoprazole?


What are the possible side effects of amoxicillin, clarithromycin, and lansoprazole?



Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;

Serious side effects may be more likely in older adults.

Common side effects may include:

  • nausea, vomiting, diarrhea;
  • headache;
  • vaginal itching or discharge;
  • unusual or unpleasant taste in the mouth; or
  • black or "hairy" tongue.


What other drugs will affect amoxicillin, clarithromycin, and lansoprazole?

If you take any of the following medicines, take them separately:

  • Zidovudine: take this medicine at least 2 hours before or 2 hours after you take amoxicillin, clarithromycin, and lansoprazole.
  • Sucralfate (Carafate): take it at least 30 minutes after you take amoxicillin, clarithromycin, and lansoprazole.



Tell your doctor about all your current medicines. Many drugs can affect amoxicillin, clarithromycin, and lansoprazole, especially:

  • antiviral medication;
  • "statin" cholesterol medication;
  • insulin or oral diabetes medicine (especially nateglinide, pioglitazone, repaglinide, or rosiglitazone);
  • heart or blood pressure medication --amlodipine, diltiazem, verapamil; or
  • a Valium-type sedative --alprazolam, midazolam, triazolam.

This list is not complete and many other drugs may affect amoxicillin, clarithromycin, and lansoprazole. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about amoxicillin, clarithromycin, and lansoprazole.



Copyright 1996-2019 Cerner Multum, Inc. Version: 6.02. Revision date: 6/26/2018.
