PrimePCR™ ddPCR™ Expression Probe Assay: HLA-DQA1, Human



Info:   HEX; Same primer pair and probe as used in qPCR assay qHsaCEP0039978; exonic

Fluorophore:   HEX
List Price:    $201.00
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Assay Information

Technology:   ddPCR
Assay Type:   Probe
Application:   Gene Expression
Unique Assay ID:   dHsaCPE5190524
Chromosome Location:   6:32609800-32609942question
Amplicon Length:   113

Gene Information

HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB) both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes dendritic cells macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide exons 2 and 3 encode the two extracellular domains and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq Jul 2008]

Gene Symbol:   HLA-DQA1
Gene Name:   major histocompatibility complex, class II, DQ alpha 1
Aliases:   CD, CELIAC1, DQ-A1, FLJ27088, FLJ27328, GSE, HLA-DQA, MGC149527
RefSeq:   NC_000006.11 NT_007592.15
Ensembl:   ENSG00000196735
Entrez:   3117
UniGene:   Hs.387679
Chromosome Mapping:   6p21.3

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