PTPN11 (SHP2), Active(P38-21G)

PTPN11 (SHP2), Active(P38-21G)

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Description :Recombinant human PTPN11 (246-593) was expressed in E.coli cells using a N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:E.coli

Sequence :246-593

Genbank Number :NM_002834




Applications :Phosphatase Assay, Western Blot

Molecular Weight :~69 kDa

Gene Aliases :SHP2, CFC, NS1, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP3, MGC14433

Scientific Background :Mammalian PTPases can be subdivided into 1 of 2 broad categories: transmembrane receptor PTPases and intracellular PTPases. PTPN11 is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain (1). This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration (2)

References :
1. Dechert, U. et al: Protein-tyrosine phosphatase SH-PTP2 (PTPN11) is localized to 12q24.1-24.3. Hum. Genet. 96: 609-615, 1995.

2. Ahmad, S. et al: A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains. Proc. Nat. Acad. Sci. 90: 2197-2201, 1993.

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Research Areas :Cancer, Neurobiology, Inflammation, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Phosphatases, Cancer, Inflammation, Metabolic Disorder, JAK/STAT Pathway, WNT Signaling, Invasion/Metastasis, Phosphatases