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Kramell, R.; Miersch, O.; Schneider, G.; Wasternack, C. Liquid chromatography of jasmonic acid amine conjugates Chromatographia 49, 42-46, (1999)


Wasternack, C.; Xie, D. The genuine ligand of a jasmonic acid receptor: Improved analysis of jasmonates is now required. Plant Signal Behav 5, 337-340, (2010) DOI: 10.4161/psb.5.4.11574

Jasmonic acid (JA), its metabolites, such as the methyl ester or amino acid conjugates as well as its precursor 12-oxophytodienoic acid (OPDA) are lipid-derived signals. JA, OPDA and JA-amino acid conjugates are known to function as signals in plant stress responses and development. More recently, formation of JA-amino acid conjugates and high biological activity of JA-Isoleucine (JA-Ile) were found to be essential in JA signaling. A breakthrough was the identification of JAZ proteins which interact with the F-box protein COI1 if JA-Ile is bound. This interaction leads to proteasomal degradation of JAZs being negative regulators of JA-induced transcription. Surprisingly, a distinct stereoisomer of JA-Ile, the (+)-7-iso-JA-Ile [(3R,7S) form] is most active. Coronatine, a bacterial phytotoxine with an identical stereochemistry at the cyclopentanone ring, has a similar bioactivity. This was explained by the recent identification of COI1 as the JA receptor and accords well with molecular modeling studies. Whereas over the last two decades JA was quantified to describe any JA dependent process, now we have to take into account a distinct stereoisomer of JA-Ile. Until recently a quantitative analysis of (+)-7-iso-JA-Ile was missing presumable due to its equilibration to (−)-JA-Ile. Now such an analysis was achieved. These aspects will be discussed based on our new knowledge on JA perception and signaling.

Wasternack, C.; Goetz, S.; Hellwege, A.; Forner, S.; Strnad, M.; Hause, B. Another JA/COI1-independent role of OPDA detected in tomato embryo development. Plant Signal Behav 7, 1349-1353, (2012) DOI: 10.4161/psb.21551


Song, S.; Qi, T.; Wasternack, C.; Xie, D. Jasmonate signaling and crosstalk with gibberellin and ethylene Curr Opin Plant Biol. 21 , 112-119, (2014) DOI: 10.1016/j.pbi.2014.07.005

The phytohormone jasmonate (JA) plays essential roles in plant growth, development and defense. In response to the JA signal, the CORONATINE INSENSITIVE 1 (COI1)-based SCF complexes recruit JASMONATE ZIM-domain (JAZ) repressors for ubiquitination and degradation, and subsequently regulate their downstream signaling components essential for various JA responses. Tremendous progress has been made in understanding the JA signaling pathway and its crosstalk with other phytohormone pathways during the past two decades. Recent studies have revealed that a variety of positive and negative regulators act as targets of JAZs to control distinctive JA responses, and that JAZs and these regulators function as crucial interfaces to mediate synergy and antagonism between JA and other phytohormones. Owing to different regulatory players in JA perception and JA signaling, a fine-tuning of JA-dependent processes in plant growth, development and defense is achieved. In this review, we will summarize the latest progresses in JA signaling and its crosstalk with gibberellin and ethylene.

Wasternack, C.; Hause, B. OPDA-Ile – a new JA-Ile-independent signal? Plant Signal Behav 11, e125364600, (2016) DOI: 10.1080/15592324.2016.1253646

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