Exploring m6A RNA methylation in mosquitoes in response to infection


Supervisor – Professor Sassan Asgaris.asgari@uq.edu.au

Mosquitoes transmit a variety of viruses to humans and animals through blood feeding. This project aims to investigate one of the most common modifications of RNA molecules, known as N6-methyladenosine (m6A), in an important mosquito vector, Aedes aegypti, and its alterations upon infection by viruses and symbionts. The project involves various techniques including methylated RNA immunoprecipitation sequencing (MeRIP-Seq), bioinformatics analyses of the MeRIP-Seq data to determine differentially methylated RNAs, cell culture, PCR, and a number of other molecular biology techniques. Expected outcomes of this project include fundamental understanding of RNA methylation in mosquitoes and their role in mosquito biology and infection.

Preferred educational background

Applications will be judged on a competitive basis taking into account the applicant's previous academic record, publication record, honours and awards, and employment history.

A working knowledge of molecular biology would be of benefit to someone working on this project.

The applicant will demonstrate academic achievement in the field(s) of molecular biology or genetics and the potential for scholastic success.

A background or knowledge of RNA-Seq data analysis is highly desirable.

*The successful candidate must commence by Research Quarter 1, 2022. You should apply at least 3 months prior to the research quarter commencement date. International applicants may need to apply much earlier for visa reasons.

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