Prebiotics from seaweeds: An ocean of opportunity?

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dc.contributor.author Cherry, Paul
dc.contributor.author Yadav, Supriya
dc.contributor.author Strain, Conall R.
dc.contributor.author Allsopp, Philip J.
dc.contributor.author McSorley, Emeir M.
dc.contributor.author Ross, R. Paul
dc.contributor.author Stanton, Catherine
dc.date.accessioned 2019-11-20T05:46:49Z
dc.date.available 2019-11-20T05:46:49Z
dc.date.issued 2019-06-01
dc.identifier.citation Cherry, P., Yadav, S., Strain, C.R., Allsopp, P.J., McSorley, E.M., Ross, R.P. and Stanton, C., 2019. Prebiotics from Seaweeds: An Ocean of Opportunity?. Marine drugs, 17(6), (327). DOI:10.3390/md17060327 en
dc.identifier.volume 17 en
dc.identifier.issued 6 en
dc.identifier.startpage 1 en
dc.identifier.endpage 42 en
dc.identifier.issn 1660-3397
dc.identifier.uri http://hdl.handle.net/10468/9134
dc.identifier.doi 10.3390/md17060327 en
dc.description.abstract Seaweeds are an underexploited and potentially sustainable crop which offer a rich source of bioactive compounds, including novel complex polysaccharides, polyphenols, fatty acids, and carotenoids. The purported efficacies of these phytochemicals have led to potential functional food and nutraceutical applications which aim to protect against cardiometabolic and inflammatory risk factors associated with non-communicable diseases, such as obesity, type 2 diabetes, metabolic syndrome, cardiovascular disease, inflammatory bowel disease, and some cancers. Concurrent understanding that perturbations of gut microbial composition and metabolic function manifest throughout health and disease has led to dietary strategies, such as prebiotics, which exploit the diet-host-microbe paradigm to modulate the gut microbiota, such that host health is maintained or improved. The prebiotic definition was recently updated to “a substrate that is selectively utilised by host microorganisms conferring a health benefit”, which, given that previous discussion regarding seaweed prebiotics has focused upon saccharolytic fermentation, an opportunity is presented to explore how non-complex polysaccharide components from seaweeds may be metabolised by host microbial populations to benefit host health. Thus, this review provides an innovative approach to consider how the gut microbiota may utilise seaweed phytochemicals, such as polyphenols, polyunsaturated fatty acids, and carotenoids, and provides an updated discussion regarding the catabolism of seaweed-derived complex polysaccharides with potential prebiotic activity. Additional in vitro screening studies and in vivo animal studies are needed to identify potential prebiotics from seaweeds, alongside untargeted metabolomics to decipher microbial-derived metabolites from seaweeds. Furthermore, controlled human intervention studies with health-related end points to elucidate prebiotic efficacy are required. en
dc.description.sponsorship PREMARA en
dc.format.mimetype application/pdf en
dc.language.iso en en
dc.publisher MDPI en
dc.relation.uri https://www.mdpi.com/1660-3397/17/6/327
dc.rights © 2019 by the authors. Licensee MDPI, Basel, Switzerland. en
dc.rights.uri https://creativecommons.org/licenses/by/4.0/ en
dc.subject Seaweed en
dc.subject Gut microbiota en
dc.subject Prebiotics en
dc.subject Dietary fibre en
dc.subject Complex polysaccharides en
dc.subject Polyphenols en
dc.subject Polyunsaturated fatty acids en
dc.subject Carotenoids en
dc.subject Phytochemicals en
dc.title Prebiotics from seaweeds: An ocean of opportunity? en
dc.type Article (peer-reviewed) en
dc.internal.authorcontactother Catherine Stanton, APC Microbiome Ireland, University College Cork, Cork, Ireland. +353-21-490-3000 Email: catherine.stanton@ucc.ie en
dc.internal.availability Full text available en
dc.description.version Published Version en
dc.contributor.funder Science Foundation Ireland en
dc.contributor.funder APC Microbiome institute en
dc.contributor.funder Department of Agriculture, Food and the Marine en
dc.description.status Peer reviewed en
dc.identifier.journaltitle Marine Drugs en
dc.internal.IRISemailaddress catherine.stanton@ucc.ie en
dc.identifier.articleid 327 en

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© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Except where otherwise noted, this item's license is described as © 2019 by the authors. Licensee MDPI, Basel, Switzerland.