Reprinted with permission from the CBD Awareness Project: www.cbdoil.org


If you’re familiar with marijuana, you’ve probably heard of THC. It stands for tetrahydrocannabinol, and it’s the chemical ingredient behind that “high” feeling marijuana is known for.

However, THC is just one of over a hundred chemical compounds found naturally in Cannabis. Another one of these compounds is cannabidiol (CBD). CBD has recently become popular, as more people become aware of the many health benefits it provides.

Because they both originate from the Cannabis plant, there’s a lot of confusion around CBD and THC. If THC gets you high, does CBD as well? How are they different? What are the benefits of CBD vs. THC?

In this guide, we break it all down. Keep reading to understand the difference between CBD and THC.

Cannabinoids and the endocannabinoid system

We mentioned above that both CBD and THC are chemical compounds naturally found in the cannabis plant. These chemical compounds are properly known as cannabinoids.

When you ingest cannabinoids, they interact with your body’s endocannabinoid system, which is made up of three parts. The first of these are the cannabinoids your body naturally produces. These are called endocannabinoids, with “endo” coming from the word “endogenous” to indicate they are created internally by your body.

The other two elements include the cannabinoid receptors that your body’s endocannabinoids (as well as cannabinoids you ingest) bond with, and the enzymes that break down both the endocannabinoids and cannabinoids.

All of these elements work together to help your body regulate various functions, such as your appetite, immune response, motor control, and feelings of pleasure and pain. Specifically, the endocannabinoid system communicates with your central and peripheral nervous systems to relay messages from your brain to the rest of your body.

Two main types of cannabinoid receptors are critical to this process. These include:

  • CB1 receptors: These reside in your central nervous system, including the nerve tissues of your brain and spinal cord.
  • CB2 receptors: These reside in your peripheral nervous system, which includes the nerve tissues everywhere else in your body, as well as your digestive and immune system.

Fun fact: The endocannabinoid system was actually named after cannabis, as cannabinoids were discovered before the cannabinoid receptors in our brains.

CBD vs. THC: Effects on the brain and body


Both CBD and THC have the same molecular formula: C21H30O2. They’re both comprised of 21 carbon atoms, 30 hydrogen atoms, and 2 oxygen atoms. However, they have a different chemical structure:

chemical structure of cbd vs thc

Because their atoms are arranged differently, THC and CBD interact differently with the CB1 and CB2 receptors in our endocannabinoid system—and as a result, they have different effects on the human body.


CBD, on the other hand, binds to both kinds of receptors—CB1 and CB2—which are located in your brain and throughout the body. Because it binds to both receptors equally, CBD doesn’t cause the same psychoactive effects of THC. Rather, the effects of CBD are distributed throughout the body, enabling it to benefit various other conditions, like muscle spasms, depression, pain, and inflammation.

Benefits of CBD vs. THC

Because they both bind to CB1 receptors, both CBD and THC can be used to treat many of the same conditions. However, they each have unique uses of their own due to the way they affect different parts of your nervous system.

Both CBD and THC can have some beneficial effects on our physical and mental wellbeing. Both cannabinoids interact with the endocannabinoid system, prompting the body to initiate a variety of biological responses. These interactions are still being studied, and the medical community does not yet fully understand the effects of CBD or THC. For the time being, the most common uses for CBD and THC include addressing pain and inflammation, sleep issues, and anxiety. As knowledge of cannabis’ effects on the body expands, we expect that both CBD and THC will be used for an even wider variety of health concerns.

CBD is more widely used for therapeutic purposes, because it is non-intoxicating. CBD’s main applications are in addressing sleep problems, chronic pain, inflammation, nausea, anxiety, depression, and certain seizure disorders.

THC is also widely used, but it’s more commonly used recreationally than medicinally. Despite its reputation as a recreational drug, THC does have some legitimate benefits. It’s most commonly used to manage pain, sleep troubles, glaucoma, insomnia, and low appetite.

The table below summarizes the different benefits of THC and CBD:

CannabinoidCommon Uses
THC (tetrahydrocannabinol)Glaucoma
Insomnia/sleep issues
Pain management
Low appetite
CBD (cannabidiol)Seizures & epilepsy
Pain management
Inflammatory bowel disease
Anxiety & depression

Is CBD or THC dangerous? A review of the side effects

Both CBD and THC can have some side effects, but neither are considered particularly dangerous. It is impossible to overdose on either cannabinoid, and there have been zero fatalities linked to CBD and THC. 

With that said, side effects are possible for both cannabinoids. Some of the most common are listed below.

THC Side Effects

  • Intoxication
  • Impaired reaction time and motor skills
  • Red eyes
  • Fatigue
  • Memory impairment
  • Increased heart rate
  • Dry mouth
  • Increased hunger
  • Anxiety/paranoia 

Due to its psychoactive properties, THC has more side effects overall. THC is the main cannabinoid responsible for the intoxicating effect of marijuana, so it can also impair motor skills, judgement and reaction time. Because of this, you should not drive or operate heavy machinery while under the influence of THC. 

CBD Side Effects

  • Fatigue
  • Appetite changes
  • Diarrhea
  • Interactions with medications
  • Dry mouth
  • Blood pressure changes

CBD has significantly fewer and less intense side effects than THC. It also does not provide the “high” or euphoric feeling of THC, so individuals can experience the health benefits without it interfering with their mental capacity. In fact, CBD can temper some of THC’s potential side effects, such as anxiety and the intoxication associated with THC. In general, CBD is considered to have a favorable side effect profile, particularly when compared to medications often used to address the same issues that CBD is used for.

Typically, when side effects occur, it is due to other medications the individual is taking and their interaction with the CBD. This is an important consideration, however: If you are taking any medications, it’s important to speak to your doctor before using CBD products

Keep in mind that other side effects are always possible. While most people do not experience significant side effects from CBD or THC, everyone reacts differently. Speak with your doctor if you have questions or concerns.

How can you use CBD vs. THC?

CBD and THC can both be consumed by the body in a variety of ways, including:

  • Orally, either added to food or through a standalone edible, supplement, gel, tincture, or liquid
  • Topically, through an oil, lotion, or extract massaged into the skin
  • Inhaled through smoke, vapor, or spray

Different strains of Cannabis contain varying amounts of CBD vs. THC.  When you purchase a product that contains CBD or THC, it comes from some sort of Cannabis source. Typically, this is either marijuana or hemp.

Marijuana vs. hemp

Marijuana and hemp are two varieties of the Cannabis Sativa plant. While there are more complexities to the differences between marijuana and hemp, essentially it comes down to this:

  • Marijuana contains higher amounts of THC, up to 30%, although the average potency is about 12%.
  • Industrial hemp contains 0.3% THC or less. Instead, it contains higher amounts of CBD.

THC products are almost exclusively sourced from marijuana. These products are available for purchase only in states where marijuana is legal for recreational or medicinal use (which may require a prescription).

The majority of CBD products are sourced from hemp. It is possible, however, that a CBD product can be sourced from marijuana. Those products tend to have higher amounts of THC, which can be a concern for individuals who either don’t want the psychoactive effects of THC, live in a state where THC isn’t legal, or are providing the product to their child (THC is illegal for anyone under 21). Also, it’s important to note that CBD products sourced from marijuana may cause you to test positive for marijuana use.

When you purchase a CBD product, the label will indicate whether it is sourced from marijuana or hemp. The label will also state whether it is an isolate or full-spectrum CBD product.

  • CBD isolates contain no THC whatsoever. CBD isolates are pure CBD which has been extracted in isolation (hence the name) from other cannabinoids in the plant. Due to their concentration of CBD, isolates can have a more pronounced effect on specific bodily systems.
  • Full-spectrum CBD, conversely, does contain other cannabinoids from the Cannabis plant, including up to 3% THC. Because they contain more cannabinoids, full-spectrum CBD products tend to enhance the benefits of CBD across the body, rather than targeting a particular system.

Legality of CBD vs. THC

The legality of CBD and THC is complex, and regulations often change. As a result, there is a lot of confusion surrounding the legality of both cannabinoids. This section will break it down as simply as possible. Keep in mind that this section refers to laws in the United States. If you live outside of the US, be sure to check your local regulations. 

THC Laws

THC is federally illegal, and considered a recreational narcotic drug. Under federal law, it is not lawful to possess or use THC or marijuana products. However, most states now have separate laws relating to cannabis, and many of these laws conflict with federal regulations.

The majority of US states (33) now have medical marijuana laws that allow for the use of THC products with a prescription. As of January 1, 2020 11 states also have recreational marijuana laws, which allow anyone over 21 to purchase and use marijuana and THC products without a prescription. Again, remember that even in these states, THC is still technically illegal under federal law – although federal law enforcement agencies rarely take action against individual users.

CBD Laws

CBD regulations are also complex, but generally more favorable than laws concerning THC. Under the 2018 US Farm Billcertain CBD products are now federally legal, so long as they meet certain requirements. Essentially, the CBD must be derived from industrial hemp plants, which are grown under the strict regulations of the Farm Bill. Primarily, this law dictates that THC content in the hemp plants – as well as the finished CBD products – must be kept to under 0.3% total.

In other words, CBD products derived from legal hemp are federally legal. However, CBD products derived from marijuana, or any that contain more than 0.3% THC, remain illegal on a federal level.

To add to the confusion, certain states have laws specifically restricting – or allowing – the use of CBD products. Just like with THC laws, these state-specific laws often conflict with federal regulations. For more information, see this CBD laws by state guide.

Bottom Line: 

THC is federally illegal, but is allowed under state law in certain states. CBD is federally legal, as long as it is produced from industrial hemp grown following specific regulations. 

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