Indications for: CAPASTAT

Adjunct in susceptible tuberculosis when first-line agents (INH, rifampin, ethambutol, aminosalicylic acid, streptomycin) are inappropriate.

Adult Dosage:

Give by IV infusion over 1 hour or deep IM inj. 1g (max 20mg/kg) daily for 60–120 days, then 1g (max 20mg/kg) 2–3 times per week; max 20mg/kg per day. Treat for 12–24 months. Renal dysfunction: reduce dose (see full labeling).

Children Dosage:

Not established.

Boxed Warning:

Use with extreme caution in patients with renal insufficiency or preexisting auditory impairment. Usage in pregnancy or pediatric.

CAPASTAT Warnings/Precautions:

Renal or auditory impairment. Monitor vestibular and auditory function at baseline and during therapy. Monitor renal function at baseline and during therapy; reduce dose or discontinue if BUN>30mg/dL or if renal function decreases. Monitor hepatic function and serum potassium. Elderly. Pregnancy (Cat.C; teratogenic; see full labeling). Nursing mothers.

CAPASTAT Classification:


CAPASTAT Interactions:

Concomitant streptomycin, other parenteral antituberculars: not recommended. Increased toxicity with other neuro/ototoxic drugs (eg, aminoglycosides).

Adverse Reactions:

Neurotoxicity (esp. ototoxicity), renal toxicity, leukocytosis, leukopenia, abnormal liver function tests, inj site reactions (eg, pain, induration, bleeding), rash.

How Supplied:

Vial (10mL)—1