1,074 results found
    1. Genetics and Genomics
    2. Neuroscience


    Eric Deneault et al.
    1. Cell Biology

    Erk regulation of actin capping and bundling by Eps8 promotes cortex tension and leader bleb-based migration

    Jeremy S Logue et al.
    Eps8, a specific effector of oncogenic signaling, organizes the cortical actin cytoskeleton of cancer cells to promote mechanical properties that favor a newly identified mode of confined, adhesion-independent cell migration.
    1. Genetics and Genomics


    David A Knowles et al.
    1. Cell Biology
    2. Neuroscience

    Quantitative mapping of transcriptome and proteome dynamics during polarization of human iPSC-derived neurons

    Feline W Lindhout et al.
    A dynamic qualitative and quantitative map of human iPSC-derived neuronal stem cells transitioning into polarized neurons with the identification and characterization of a previously unrecognized axon developmental stage.
    1. Evolutionary Biology


    Michelle C Ward, Yoav Gilad
    Evolutionarily conserved hypoxic stress response genes are depleted for association with expression quantitative trait loci.
    1. Developmental Biology
    2. Medicine


    Hironobu Okuno et al.
    1. Chromosomes and Gene Expression

    A promoter interaction map for cardiovascular disease genetics

    Lindsey E Montefiori et al.
    Promoter capture Hi-C in human iPSCs and iPSC-derived cardiomyocytes provides a platform to interrogate gene-regulatory dynamics of cardiomyocyte differentiation and directly links thousands of cardiovascular disease risk loci to hundreds of distal target genes.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    16p11.2 microdeletion imparts transcriptional alterations in human iPSC-derived models of early neural development

    Julien G Roth et al.
    A model of in vitro human corticogenesis identifies alterations in gene expression caused by loss of 16p11.2 CNV genes in hiPSC-derived progenitor cells.
    1. Genetics and Genomics
    2. Medicine


    Jeanne L Theis et al.
    1. Stem Cells and Regenerative Medicine
    2. Genetics and Genomics


    Irene Gallego Romero et al.
    A panel of chimpanzee induced pluripotent stem cells (iPSCs) will help realise the potential of iPSCs in primate studies, and in combination with genomic technologies, transform studies of comparative evolution.

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