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Outpatient digestive system diseases are as follows: antacids, H2 receptor antagonists, proton pump inhibitors, gastric mucosal protective agents, gastrointestinal antispasmodics, digestive aids, gastrointestinal motility drugs, laxatives, antidiarrheals , micro-ecological drugs, antibacterial and antibacterial drugs.

Below we will explain in detail the best time to take all kinds of digestive diseases.



Representative drugs include sodium bicarbonate tablets, magnesium aluminum carbonate tablets, compound aluminum hydroxide tablets, aluminum phosphate gels, and the like.

Sodium bicarbonate tablets, aluminum magnesium carbonate tablets can directly neutralize gastric acid, and quickly relieve symptoms such as acid reflux, stomach burns, stomach pain, etc. Generally, gastric acid secretion is more than 1 to 2 hours after a meal, so take it 1 to 2 hours after meals. 3 times a day. Due to the active digestive system at night, gastric acid secretion has increased. Some patients feel a burning pain in the stomach at night, and can also take it before going to bed. Since the effect of neutralizing gastric acid in acid-suppressing drugs is good and fast, it can be taken immediately according to the doctor’s advice.

In addition to neutralizing gastric acid, the compound aluminum hydroxide tablet can form a protective film on the ulcer surface. In order to avoid the influence of food, it is recommended to take it one hour before the meal or before going to bed.

Similarly, aluminum phosphate gel has the dual role of acid resistance and gastric mucosal protection. Different dosage periods should be chosen according to different indications: esophageal disease after meal, esophageal hiatus, gastric-esophageal reflux, esophagitis after meal And taken before going to bed at night, mainly used to inhibit stomach acid. Gastritis and gastric ulcers are taken half an hour before the meal, and it is easier to form a protective layer of the gastric mucosa. Duodenal ulcers are taken 3 hours after a meal and when pain is present. At this time, the stomach has been emptied and the drug is more likely to enter the duodenum.


H2 receptor antagonist

Representative drugs include cimetidine tablets, ranitidine tablets, famotidine tablets, nizatidine dispersible tablets, and the like.

Such drugs act to reduce gastric acid secretion by inhibiting H2 receptors on gastric parietal cells. Cimetidine has more adverse reactions, and the actual application of gastrointestinal ulcers is rare. Several other factors are determined according to their respective pharmacokinetic characteristics, ranitidine 2 times a day, morning and evening, or a day before bedtime. Famotidine was taken twice a day for half an hour after a meal. Nizatidine was given a daily dose before going to bed.


Proton pump inhibitor

Representative drugs are omeprazole enteric-coated tablets, lansoprazole enteric-coated tablets, rabeprazole sodium enteric-coated capsules, pantoprazole enteric-coated capsules, iprazol enteric-coated tablets, and the like.

The proton pump inhibitor inhibits the final step of gastric acid production by binding to the H+-K+ ATPase of the parietal cells. Most of the proton pump inhibitors used in clinical practice are weakly basic drugs. The original drug activity is extremely small, and it is transported to the gastric mucosal wall cells after being absorbed into the bloodstream in the intestine, and finally reaches the secretory tube and the acidic cavity to play a role. Therefore, taking it after meals can delay the time of reaching the intestines, delaying the peak time, and not controlling the stomach acid after meals. Therefore, these drugs should be taken about half an hour before meals, most of them are taken once a day, taken in the morning. If the doctor’s order indicates twice daily, take it before breakfast and before dinner.


Gastric mucosal protective agent

Representative drugs include colloidal tartaric acid capsules, sucralfate suspensions, glutamine granules, isoladine maleate tablets, rebamipide tablets, and teprenone capsules.

There are many types of gastric mucosal protective agents, and the mechanism of action is also different. The time of taking different drugs is also different. Drugs such as tinctures, sucralfate suspensions, glutamine granules, etc. can form protective films for gastrointestinal mucosal ulcer wounds or have direct repair effects on gastrointestinal mucosa. 3 to 4 times a day, half an hour before meals. Take it 1 hour and when you are sleeping.

Isoladine maleate enhances the adhesion of gastric mucosal epithelial cells, enhances the stability of gastric mucosa, increases the gastric mucosal blood flow and acts as an anti-ulcer. It is recommended to take 3 times a day for half an hour before meals.

Rebate tablets have a variety of pharmacological mechanisms of action on the gastrointestinal mucosa. It can be used for the improvement of gastric mucosal lesions (erosive, hemorrhagic, hyperemic, edema) in acute exacerbation of acute gastritis and chronic gastritis. The instructions for the drug indicate that it is taken 3 times a day, taken early, late and before going to bed. The pharmacokinetic information is still available. It is not clear that clinicians usually take half an hour before meals.

Teprenone capsule can improve gastric mucosal lesions, inhibit the action of certain active factors associated with gastric mucosal damage, increase gastric mucus and gastric mucosal blood flow, and its pharmacokinetics show blood taken from half an hour to one hour after meal. The area under the drug concentration-time curve (AUC) is the largest, so it is recommended to take it from half an hour to one hour after the meal.


Gastrointestinal expectorant

Representative drugs include trimebutin tablets, pitavirin tablets, quetiavir hydrochloride tablets and the like.

Trimebutine tablets have a two-way regulation of gastrointestinal smooth muscles, 3 times a day, and the physician usually takes them before meals.

Pibecium bromide is an antispasmodic agent acting on the gastrointestinal tract. It is a calcium antagonist that acts to relax gastrointestinal smooth muscle by inhibiting the flow of calcium ions into intestinal smooth muscle cells. It should be swallowed with water when eating, but not in the lying position or before going to sleep. Because the gastrointestinal smooth muscle is in a relaxed state, the lying position may cause reflux of food and the risk of food entering the trachea.

The drotaverine hydrochloride tablet is a pro-muscle antispasmodic agent that directly acts on smooth muscle cells. It inhibits the smooth muscle relaxation by inhibiting the myosin light chain muscle enzyme, thereby relieving the sputum and sputum, regardless of the influence of food.


Digestive drug

Representative drugs include compound digestive enzyme capsules, compound azinamide enteric-coated tablets, and the like.

These drugs contain a variety of gastric enzymes, pancreatic enzymes and components secreted by digestive enzymes to help digestion. Postprandial administration can help patients with dyspepsia caused by digestive enzyme deficiency. If you take it before fasting, you may have stomach in your stomach. Intestinal ulcer risk, it is recommended to take after meals.


Gastrointestinal motility

Representative drugs include itopride hydrochloride dispersible tablets, metoclopramide tablets, mosapride citrate dispersible tablets, domperidone and the like.

The pharmacological mechanism of these drugs is to accelerate the gastric emptying by enhancing the contractile force of the stomach and intestine, and has the effect of inhibiting vomiting. It is recommended to take it 15 to 30 minutes before meals.



Representative drugs are magnesium sulfate solution, bisacodyl enteric-coated tablets, lactulose oral solution, polyethylene glycol 4000 and so on.

When the magnesium sulfate solution is used for catharsis, it is taken orally every morning on an empty stomach; it is used for gallbladder, 3 times a day, before meals or between meals.

The bisacodyl enteric-coated tablets are rarely absorbed after oral administration, directly acting on the large intestine, stimulating the sensory nerve endings, causing reflexive peristalsis of the rectum to cause defecation, and having no effect on the taking effect before or after a meal, in order to make the patient form a second time. It is recommended to take it in the morning before going to bed at night. You should not take milk or antacids within 2 hours before and after taking the medicine.

Lactulose is converted into a low molecular weight organic acid in the colon by the digestive flora, resulting in a decrease in pH in the intestine, and by restoring moisture, increasing the volume of the stool to stimulate colonic peristalsis and restoring the circadian rhythm of the colon. Since the digestive flora is the most active during meals, it is recommended to take it once at breakfast.

Polyethylene glycol 4000 is a linear long-chain polymer that fixes water molecules through hydrogen bonding to keep moisture in the colon, increasing the moisture content of the feces and softening the feces, thus improving constipation symptoms. After oral administration, it is neither absorbed by the digestive tract nor involved in biotransformation. It is effective 24 to 48 hours after taking the drug, so the taking time is not affected by food. However, other drugs before oral administration of this product may be washed away from the digestive tract. If other drugs are needed, it is recommended to be separated by more than 2 hours.



The representative drug is loperamide hydrochloride tablets.

Loperamide hydrochloride tablets act on opioid receptors in the intestinal wall, preventing the release of acetylcholine and prostaglandins, thereby inhibiting intestinal peristalsis and prolonging the retention time of intestinal contents. Take it when you have diarrhea, take it on a fasting or half an hour before a meal.

Representative drug has montmorillonite

The montmorillonite powder has a layered structure and a non-uniform charge distribution, which has a fixed and inhibitory effect on viruses, pathogens and toxins produced in the digestive tract; it has a covering ability to the digestive tract mucosa, and is combined with mucus glycoprotein. It repairs and improves the defense function of the mucosal barrier against attack factors from both quality and quantity. If you need to take other drugs, it is recommended to leave the product at a certain interval to avoid being adsorbed by montmorillonite. In order to avoid the effects of food, it is recommended to take an empty stomach between meals.


Microecological preparation

Representative drugs include compound Lactobacillus acidophilus tablets, Bacillus coagulans live bacteria tablets, and complex lactic acid bacteria capsules.

These drugs are used to treat intestinal dysfunction caused by intestinal flora imbalance. It should be noted that antacids and antibacterials combined with this product can reduce the efficacy of the drug, so it is taken separately (interval 3 hours), another tincture , citric acid, medicinal charcoal, tincture, etc. can inhibit, adsorb live bacteria, can not be combined. When taking it, choose the time to avoid the above-mentioned drugs that interact with each other. If no other drugs are affected, take it after meals.


Antibacterial and antibacterial drugs

Representative drugs include berberine hydrochloride tablets, montmorillonite powder, anti-Helicobacter pylori drugs such as clarithromycin tablets, amoxicillin capsules, metronidazole dispersible tablets and the like.

The berberine hydrochloride tablets are effective for intestinal infection caused by dysentery bacilli and Escherichia coli. Combined with enamel can reduce the effect, it is recommended to take it orally after meal.

Food has little effect on the pharmacokinetics of clarithromycin tablets and amoxicillin capsules. The treatment for ulcers in patients is recommended after meals. The metronidazole dispersible tablet drug instruction manual is taken 1 hour before the meal.

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