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Sterilization and Filtration of Disinfectants

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The new version GMP requires that disinfectants entering Class A and Class B clean areas should be sterilized by sterile filtration or other appropriate methods. However, disinfectants often have certain oxidizing or corrosive properties. According to the GMP standard, the chemical compatibility between the disinfectant and the filter must be inspected. We Cobetter have completed a lot of similar validations and have abundant relevant experience.


Disinfectants containing chlorine:84 disinfectant solution, chlorine dioxide, sodium hypochlorite, etc.
Peroxide disinfectants: hydrogen peroxide, peroxyacetic acid, acetic acid, etc., hydrogen peroxide, reactive oxygen (solid), ozone.
Aldehydes disinfectants: formaldehyde, glutaraldehyde, sulfuric acid/hydrochloric acid acid fortified glutaraldehyde, etc.
Phenolic disinfectants: phenol, cresol soap, etc.
Alcohol-based disinfectants: ethanol, isopropyl alcohol, etc.
Quaternary ammonium salts disinfectants: new knots, ANIOS (A/B) of Ostar, MPD of Ostar, Sume QB (quaternary ammonium salts + biguanide), Ugil V80, etc.
Iodine disinfectants: Iodophor (2% iodine in aqueous solution), etc.
Biguanide disinfectants: chlorhexidine (chlorobenzene-guanidine hexane), etc.
Heterocyclic gas disinfectants: ethylene oxide, etc.
Other disinfectants: potassium permanganate, etc.

  • SteriPS Filter Cartridges Cobetter SteriPS® Filter Cartridges are specially designed to provide superior flow rates at an economical cost. The unique construction allows for optimal sterilization effect with low diffusion flow. Hydrophilic polyethersulfone membrane cartridges require no pre-wetting and are ready to use.This assures a cost effective device while maintaining excellent performance in the pharmaceutical application.
  • Super-Dura Filter Cartridges Cobetter Super-Dura® Filter Cartridges is designed for almost all pharmaceutical liquids, especially for the solvent-containing liquid and ophthalmic solution. Super-Dura filter cartridge is made of hydrophilic PTFE membrane which provides excellent chemical and heat tolerance.
  • TeflonFlow Filter Cartridges Cobetter TeflonFlow Filter Cartridges are composed of hydrophobic PTFE membrane. It’s features include exceptional organic & inorganic corrosion resistance and inherently hydrophobicity. They are highly recommended for the pre-filtration and sterile filtration of strong solvents, highly corrosive fluids, strong oxidant luids and critical air venting applications.