task_categories:text-classification task_categories:summarization task_categories:feature-extraction language:en license:mit size_categories:1K<n<10K format:json modality:text library:datasets library:pandas library:mlcroissant library:polars doi:10.57967/hf/4466 region:us
---
license: mit
task_categories:
- text-classification
- summarization
- feature-extraction
language:
- en
pretty_name: Liposome-RBC Scoping Review Screening
---

![image](https://i.ibb.co/7tLfYq7C/screening-overview.png)

# Liposome-RBC Interaction Studies Screening Dataset

## Overview
This dataset contains 2,152 screened abstracts from a systematic scoping review examining liposome-red blood cell (RBC) interactions. The dataset includes detailed screening decisions, rationales, and metadata for studies published through October 2024, with 487 included and 1,665 excluded studies.

## Dataset Details

### Description
- **Task Type**: Abstract screening for systematic scoping review 
- **Modality**: Text (titles, abstracts, and structured annotations)
- **Language**: English
- **Time Period**: Literature through October 5, 2024
- **License**: MIT
- **Format**: JSON
- **Size**: 2,152 entries
- **Download**: [Dataset JSON File](https://huggingface.co/datasets/UtopiansRareTruth/Liposome-RBC_Scoping_Review_Screening/resolve/main/Liposome-RBC_Scoping_Review_Screening.json)

### Curation Process

#### Step 1: Initial Database Searches
- **PubMed** (October 5, 2024)
  - Search terms: (liposome*[Title/Abstract] OR "lipid vesicle*"[Title/Abstract]) AND ("red blood cell*"[Title/Abstract] OR erythrocyte*[Title/Abstract])
  - Results: 1,818
  
- **Web of Science** (October 5, 2024)
  - Search terms: (TI=((liposome* OR "lipid vesicle*") AND ("red blood cell*" OR erythrocyte*))) AND AB=(((liposome* OR "lipid vesicle*") AND ("red blood cell*" OR erythrocyte*)))
  - Results: 169 from Core Collection

- **Google Scholar** (October 5, 2024)
  - Search terms: ("liposome" OR "lipid vesicle") AND ("red blood cell" OR "erythrocyte") AND ("fusion" OR "interaction")
  - Results: Top 66 most relevant articles imported

- **Scopus** (October 5, 2024)
  - Search terms: ((TITLE(liposome*) OR ABS(liposome*)) OR (TITLE("lipid vesicle*") OR ABS("lipid vesicle*"))) AND ((TITLE("red blood cell*") OR ABS("red blood cell*")) OR (TITLE(erythrocyte*) OR ABS(erythrocyte*))) AND ((TITLE(fusion) OR ABS(fusion)) OR (TITLE(interaction) OR ABS(interaction))) AND (LIMIT-TO(LANGUAGE,"English"))
  - Results: 600

- **EMBASE** (October 5, 2024)
  - Search terms: ('liposome*' OR 'lipid vesicle*') AND ('red blood cell*' OR 'erythrocyte*') AND ('fusion' OR 'interaction*')
  - Results: Top 500 most relevant articles from 915 total results

#### Step 2: Additional Sources
- Previous Studies (June 22, 2024 - September 16, 2024)
  - 77 additional records from preliminary literature review

#### Step 3: Deduplication
1. EndNote 20 deduplication
   - Initial records: 3,230
   - Duplicates removed: 802
   - Remaining: 2,428

2. Rayyan deduplication
   - Initial records: 2,428
   - Duplicates removed: 276
   - Final unique records: 2,152

#### Step 4: Screening
- Dual independent screening by human reviewer and Claude AI
- Disagreements arbitrated by third reviewer
- Edge cases without consensus excluded

## Dataset Structure

### JSON Schema
Each entry contains:
- Study identifiers (title, key, DOI, abstract)
- Title/abstract screening details (context, thoughts, summary)
- Inclusion/exclusion criteria met
- Final decision with rationale

### Statistics

#### Overall Numbers
- Total Studies: 2,152
- Included Studies: 487 (22.6%)
- Excluded Studies: 1,665 (77.4%)
- Studies with DOI: 2,140 (99.4%)

#### Inclusion Criteria Distribution (% of Included Studies)
- English language: 96.1%
- Effects on RBC properties/function: 88.3%
- Liposome-RBC interaction: 87.9%
- Relevant study type: 76.8%
- Liposome/RBC properties with interaction implications: 56.3%
- Applications of liposome-RBC interactions: 47.4%
- Theoretical/computational study: 3.3%

#### Exclusion Criteria Distribution (% of Excluded Studies)
- No liposome-RBC interaction implications: 93.9%
- Other cell types without RBC component: 61.9%
- Passing mention only: 31.9%
- Full text unavailable: 4.1%
- Duplicate publication: 0.3%
- Non-peer-reviewed or preprint: 0.1%

#### Most Common Exclusion Criteria Combinations
1. No liposome-RBC interaction implications + Other cell types without RBC component: 919 occurrences
2. No liposome-RBC interaction implications + Passing mention only: 420 occurrences
3. No liposome-RBC interaction implications alone: 118 occurrences
4. No liposome-RBC interaction implications + Other cell types without RBC component + Passing mention only: 101 occurrences
5. Full text unavailable alone: 66 occurrences

#### Most Common Inclusion Criteria Combinations
1. English language alone: 1,467 occurrences
2. Effects on RBC properties/function + English language + Liposome-RBC interaction + Liposome/RBC properties with interaction implications + Relevant study type: 121 occurrences
3. Applications of liposome-RBC interactions + Effects on RBC properties/function + English language + Liposome-RBC interaction + Relevant study type: 107 occurrences
4. All criteria except Theoretical/computational study: 49 occurrences
5. Effects on RBC properties/function + English language + Liposome-RBC interaction + Relevant study type: 37 occurrences

## Usage

### Direct Applications
- Training/evaluating automated screening models
- Meta-analysis of liposome-RBC interaction research
- Bibliometric analysis of the field
- Methodology research on systematic reviews

### Sample Code
```python
import json
import pandas as pd

# Load dataset
with open('Liposome-RBC_Scoping_Review_Screening.json', 'r') as f:
    data = json.load(f)

# Convert to DataFrame
df = pd.DataFrame(data)

# Basic statistics
print(f"Total studies: {len(df)}")
print(f"Included studies: {len(df[df['final_decision.decision'] == 'Include'])}")
print(f"Excluded studies: {len(df[df['final_decision.decision'] == 'Exclude'])}")
```

## Limitations and Biases

### Known Limitations
- Limited to English language publications
- Search cutoff date: October 5, 2024
- Focuses on title/abstract screening only
- May not capture all grey literature
- Google Scholar and EMBASE results limited to most relevant articles

### Potential Biases
- Publication bias toward positive results
- Language bias (English only)
- Database coverage limitations
- Temporal bias (recent literature emphasis)
- Selection bias in Google Scholar and EMBASE subset selection

## Citation

```bibtex
@dataset{routt2024liposome,
  title={Liposome-RBC Interaction Studies Screening Dataset},
  author={Routt, Austin and Eshelman, Shannen},
  year={2024},
  publisher={Hugging Face},
  url={https://huggingface.co/datasets/UtopiansRareTruth/Liposome-RBC_Scoping_Review_Screening}
}
```

## Contact
- **Creator**: Austin Routt
- **Repository**: [Hugging Face Dataset](https://huggingface.co/datasets/UtopiansRareTruth/Liposome-RBC_Scoping_Review_Screening)
- **Issues**: Please use the Hugging Face discussion forum for questions and issues
```