 and hence cause the loss of tumor suppressor activity. Alterations of this geneoccur not only as somatic mutations in human malignancies, and oligomerizationdomains. It is postulated to bind to a p00-binding site and activate expression of downstreamgenes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants ofp00 that frequently occur in a number of different human cancers fail to bind the consensus DNAbinding site, a