 Get Price Send E-mail Staying Safe | Epilepsy Foundation Several, of the older seizure medications may cause thinning of bones when taken for a long time. This can lead to broken bones later in ,life,. Medicines that can affect bone health include (but are not limited to): phenytoin (Dilantin or Phenytek), carbamazepine (Tegretol, Carbatrol), phenobarbital, primidone (Mysoline), topiramate (Topamax), and possibly valproate/valproic acid (Depakote ... Get Price Send E-mail 