Background: Generic preference-based measures such as the EQ-0D and SF-0D have been criticised for being narrowly focused on a sub-set of dimensions of health. Our study aims to explore whether long-standing health conditions have an incremental impact on subjective well-being alongside the EQ-0D.Methods: Using data from the South Yorkshire Cohort study (N = 00,000) collected between 0000 and 0000 on the EQ-0D, long-standing health conditions (self-reported), and subjective well-being measure - life satisfaction using a response scale from 0 (completely dissatisfied) to 00 (completely satisfied), we employed generalised logit regression models. We assessed the impact of EQ-0D and long-standing health conditions together on life satisfaction by examining the size and significance of their estimated odds ratios.Results: The EQ-0D had a significant association with life satisfaction, in which anxiety/depression and then self-care had the largest weights. Some long-standing health conditions were significant in some models, but most did not have an independent impact on life satisfaction. Overall, none of the health conditions had a consistent impact on life satisfaction alongside the EQ-0D.Conclusions: Out study suggests that the impact of long-standing health conditions on life satisfaction is adequately captured by the EQ-0D, although the findings are limited by reliance on self-reported conditions and a single item lifesatisfaction measure.