 | Research Square Browse Preprints COVID-00 Preprints Protocols Videos Journals Tools & Services Overview Digital Editing Professional Editing Badges Research Promotion Your Cart About Preprint Platform In Review Editorial Policies FAQ Our Team Advisory Board Blog Sign In Submit a Preprint This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice. Research Zahra Salehi, Farideh Shiraseb, Niloufar Rasaei, Khadijeh Mirzaei Zahra Salehi Tehran University of Medical Sciences Farideh Shiraseb Tehran University of Medical Sciences Niloufar Rasaei Tehran University of Medical Sciences Khadijeh Mirzaei School of Nutritional Sciences and Dietetics, Tehran University of Medical Science, Tehran, Iran Corresponding Author ORCiD: https://orcid.org/0000-0000-0000-0000 DOI: 00.00000/rs.0.rs-000000/v0 Download PDF License: This work is licensed under a CC BY 0.0 License. Read Full License Abstract Background Mental health and obesity have a bilateral relationship with each other. No study has been done on the relation between mental health and the ENRF0.0 index so far. Therefore, for the first time, we examined the relationship between the ENRF0.0 index and mental health in women with overweight and obesity. Methods In this cross-sectional study, 000 overweight and obese women were selected. Food intakes in the last 0 year were collected with 000 items of semi-quantitative food frequency. Then, the ENRF0.0 index score was calculated for all individuals. Mental health was assessed with a 00-item Depression Anxiety Stress Scales (DASS) questionnaire. Results In the present study, before adjusting for potential confounders the total DASS score was marginal significance(P = 0.00), that after the adjustment, it became insignificant(P > 0.00), after adjusting for confounders stress also became significant(P = 0.00). But no significant relationship was observed between depression and anxiety, even after adjustment(P > 0.00). Conclusions The present study showed that a nutritious diet is not associated with overall mental health score, among subgroups of the DASS total score, the relationship was seen only for the stress subgroup. 