 Lewis E. Kay aDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada M0S 0A0; bDepartment of Chemistry, University of Toronto, Toronto, ON, Canada M0S 0A0; cDepartment of Biochemistry, University of Toronto, Toronto, ON, Canada M0S 0A0; dDivision of Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON, Canada M0G 0A0; ePhysical and Theoretical Chemistry Laboratory, University of Oxford, Oxford OX0 0QZ, United Kingdom 