Awakening from a single bolus dose in rapid from Propofol due to;-
Redistribution
Excretion
Biotransformation
D- Methylation
It is redistributed from the brain to tissues which are less perfused like muscles, resulting in rapid recovery within 20 minutes. All intravenous anaesthetic agent undergo rapid redistribution. Thus awakening from Thiopentone, Propofal, Etomidate, ketamine is very fast.
Intravenous Anesthetic Agents