Which one the following does NOT primarily involve an action K+ channels?
Hypoxic Pulmonary Vasoconstriction
Insulin secretion by Sulfonylurea
Carotid body discharge with reduced O2
Dantrolene in the treatment of Malignant Hypehermia
Hypoxic pulmonary vasoconstriction and carotid body discharge are brought about by the O2-sensitive K+ channel. Insulin secretion by sulfonylurea is brought about by its action the ATP-sensitive K+ channel on the pancreatic b-cell. Malignant hypehermia is a disorder of excitation-contraction coupling, resulting from genetic defect of RyR (a Ca++-release channel). Dantrolene uncouples the excitation from contraction, by acting on the Ca++ channel.
Cell Membrane and transpo protiens