Oxygen dissociation curve shifts to left in all except:
Alkalosis
Hypercapnia
Fetal Hb
CO poisoning
When the O2 affinity for Hb is increased, the dissociation curve shifts to the left. O2 has less affinity for Hb which is in "T-state". When Hb is snapped into "R-state", O2 affinity for it increases. Increased affinity of O2 for Hb/shift to the left Decreased H+/alkalosis Decreased PCO2 Decreased temperature Decreased 2,3-DPG HbF CO poisoning Stored blood (2,3-DPG decreases) NO & H2S (bind to Hb; snap it into "R-state")
Respiratory System Pa 1