Increased ratio of insulin to glucagon causes:
Decreased levels of cyclic AMP
Decreased levels of lipoprotein lipase
Decreased amino acid synthesis
Enhanced lipolysis in adipose tissue
Glucagon acts via increase in intracellular cAMP. So, in high insulin glucagon ratio, cAMP level in the cell decreases. Insulin causes activation of lipoprotein lipase and inhibition of hormone­-sensitive lipase. Because of this, there is increased fatty acids synthesis in adipose tissue. Insulin also increases amino acid uptake and protein synthesis in muscles. Normal insulin­ glucagon molar ratio on a balanced diet is approximately 2.3.