A 28-year-old man is evaluated for recurrent peptic ulcer disease, apparently refractory to pharmacologic intervention. Serum gastrin is markedly elevated. These findings are most characteristic of which of the following?
Cushing syndrome
Glucagonoma
Whipple triad
Zollinger-Ellison syndrome
- Recurrent intractable peptic ulcer disease is suggestive of Zollinger-Ellison syndrome characterized by excess gastrin production, most often from a gastrinoma. - Cushing syndrome results from excess of coisol caused d/t adrenal/ pituitary adenoma. - Glucagonoma is rare neuroendocrine tumor of pancreatic alpha cells, that can cause hyperglycemia. - Whipple triad (episodic hyperinsulinemia + hypoglycemia causing CNS dysfunction, reversible by glucose administration) is seen with insulinoma.
Adrenal Gland