Macrophages containing large quantities of undigested and partial digested bacteria in the intestine are seen in -
Whipple's disease
Amyloidosis
Immunoproliferative small intestinal disease
Vibrio cholerae infection
The hallmark of Whipple’s disease is a small intestinal mucosa laden with distended macrophages in the lamia propria.
The macrophages contain periodic acid– Schiff (PAS) positive granules and small rod shaped bacilli)