Which of the following is not a feature of Papillary carcinoma of thyroid?
Rearrangement of RET gene
Rearrangement of NTRK1 gene
Mutation of BRAF gene
Mutation of RAS gene
Most papillary carcinomas have gain-of-function mutations or rearrangements involving: RET gene NTRK1 receptor tyrosine kinases Serine/threonine kinase BRAF, which is component of MAPK pathway. RAS mutations are seen in follicular carcinoma of thyroid.
Thyroid Tumor