The action of non-competitive muscle blockers is affected by -
Hypocalcemia
Hyponatremia
Hypehermia
All of the above
Ans. is 'a' i.e., Hypocalcemia Hypocalcemia has following effects It decreases vesicular ACh release at neuromuscular junction. It causes uncoupling of excitation and contraction. o By action 1. it will enhance the effect of both competitive as well as noncompetitive blockers due to unavailibility of ACh. o By action 2. it will enhance the effect of directly acting muscle relaxant (dantroline).