Mouse is used for pathogenicity testing in ?
M. Tuberculosis
C diptheriae
Bordetella peussis
Brucella
Ans. is 'c' i.e., Bordetella peussis Bordetella peussis is an obligate human parasite, but infection can be produced experimentally in several species of animals, the white mouse being most often employed. Intranasal inoculation produces a patchy interstitial pneumonia. Intraperitoneal inoculation of large doses is fatal due to toxemia. Intracerebral inoculation causes a fatal infection. Immunized mice are protected. This forms the basis for intracerebral mouse potency assay for peussis vaccines.