Drug of choice for treatment of neuroleptic malignant syndrome is -
Dantrolene
Beta blocker
Central anticholiergic
None of the above
Ans. is 'a' i.e., DantroleneNeurological side effects of Neuroleptic DrugsReactionFeaturesTime of Maximal RiskProposedMechanismTreatmentAcute dystoniaSpasm of muscles of tongue, face, neck, back, may mimic seizures; not hysteria1 to 5 daysUnknownAntiparkinsonian ages are diagnostic and curativeAkathisiaMotor restlessness; not anxiety or "agitation"5 to 60 daysUnknownReduce dose or change drug; antiparkinsonian agents, benzodiazepines or propranolol may helpParkinsonismBradykinesia, rigidity, variable tremor, mask facies, shuffling gait5 to 30 days; can recur even after a single doseAntagonism of dopamineAntiparkinsonian agents helpfulNeurolepticmalignantsyndromeCatatonia, stupor, fever unstable blood pressure myoglobinemia; can be fatalWeeks; can persist for days after stopping neurolepticAntagonism of dopamine may contributeStop neuroleptic immediately; dantrolene orbromocriptine may help; antiparkinsonism agents not effectivePerioral tremor"rabbitsyndrome"Perioral tremor (may be a late variant of parkinsonism)After months or years of treatmentUnknownAntiparkinsonian agents often helpTardivedyskinesiaOral-facial dyskinesia; widespread choreo- athetosis or dystoniaAfter months or years of treatment (worse on withdrawal)Excess function of dopamine hypothesizedPrevention crucial; treatment unsatisfactory
Symptoms & Signs 