Irreversible cell injury is indicated by -
Accumulation of calcium in mitochondria
Myelin figures
ATP depletion
Shifting of ribosomes
Ans. is 'a' i.e., Accumulation of calcium in mitochondrion Large, flocculant, amorphous densities in mitochondrial matrix develop due to increased Ca+2 influx. Note : o Small (not large) phospholipid rich amorphous densities are found in reversible injury.