Atracurium is metabolized by -
Conjugation
Hoffman degradation
Pseudocholineaterase
Methylation
Ans. B. Hoffman degradationThe unique feature of atracurium is inactivation in plasma by spontaneous non enzymatic degradation (Hofmann elimination).Consequently its duration of action is not altered in patients with hepatic/renal insufficiency or hyperdynamic circulation ---> Hence, preferred muscle relaxant for such patients as well as for neonates and the elderly.Atracuum is metabolised to laudanosine that is responsible for seizures.Cause histamine release > Hypotension, bronchoconstriction & flushing.