An old patient Ram Kishore having asthma and glaucoma is to receive a b blocker. Regarding b blocking drugs:
Metoprolol blocks b2 receptors selectively
Esmolol's pharmacokinetics are compatible with chronic topical use
Nadolol lacks b2 blocking action
Timolol lacks the local anaesthetic effects of propanolol
Metoprolol is a cardioselective (b1 selective) blocker and not b2 selective. Esmolol is the shoest acting b -blocker and is useful for acute treatment. Nadolol is a non-selective b-blocker. It blocks both b1 as well as b2 receptors. Propanolol possesses maximum local anaesthetic activity whereas timolol lacks this propey.
ANS