A patient having prinzmetal angina is started with ISMN. Patient got symptomatic relief from angina. What is the MOA?
Endothelium independent coronary vasodilatation
Reduced cardiac contractility
Increased left ventricular end diastolic volume
Decreased diastolic perfusion pressure
ANS. A# Important points on nitrates1. All nitrates have high FPM metabolism except ISMN (Isosorbide mononitrate)2. Skin rashes are maximum with Pentaerythritol tetranitrate3. Nitrates used in acute attack: NTG and ISDN (Isosorbide dinitrite)
C.V.S