Use of tiotropium is contra–indicated in:
Bronchial asthma
Hypertension
Urinary retention
Peptic ulcer disease
SPIRIVA HANDIHALER (tiotropium bromide inhalation powder) is indicated for the long-term,
once-daily, maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), 
including chronic bronchitis and emphysema. SPIRIVA HANDIHALER is indicated to reduce exacerbations in COPD patients