Which of the following biochemical test is used to diagnose Dubin Johnson syndrome?
Serum transaminases
Bromsulphalein test (BSP)
Hippurate test
Gamma glutamyl transferase level
Bromsulphalein test (BSP) is the diagnostic test for Dubin-Johnson Syndrome. Biliary excretion of numerous anionic compounds such as Bromsulphalein (BSP) is compromised in Dubin-Johnson Syndrome (DJS). In this test, BSP is administered as IV bolus and its clearance from plasma is determined. BSP levels show a characteristic rise in patients with DJS after 90 minutes of injection, due to reflux of conjugated BSP into the circulation from the hepatocyte. Ref: Davidson's principles and practice of Medicine, 20th Edition, Chapter 23, Page 945; Harrison's Principles of Internal Medicine, 16th Edition, Page 1821; Digestive Diseases and Sciences Vol/17 numbers 6.