The primary cause of anemia in chronic kidney disease (CKD) is:
Chronic inflammation
Iron deficiency
Erythropoetin deficiency
Diminished red blood survival
All are causes of anemia in CKD, the primary cause is insufficient production of erythropoetin by the diseased kidneys. Other causes are; Bleeding diathesis Hyperparathyroidism/bone marrow fibrosis Folate or vitamin B12 deficiency Hemoglobinopathy Ref: Harrisons principles of internal medicine, 18th edition, Page: 2316.