All of the following statements about unfractionated heparin are true except:-
It is a powerful anticoagulant only in vivo
Protamine sulfate is the antidote
It should not be given by intramuscular route
It acts by inhibiting factor IIa and Xa
Heparin Warfarin 1. Route of administration parenteral (IV, SC) Oral 2. Onset of action Rapid Delayed (1-3 days) 3. Activity In vitro and in vivo In vivo only 4. MOA Activates Antihrombin III | Activation of II, VII, IX, X 5 Monitoring by aPTT PT 6. Antagonist Protamine sulphate Vit. K1 (Phytonadione) 7. Placental barrier Does not cross placenta Fetal warfarin syndrome 8. Use To initiate therapy For maintenance
Hematology