Knife edge pattern of neuronal atrophy is associated with which of the degenerative disease of the coex
Alzheimer's disease
Frontotemporal dementia
Pick's disease
Progressive supranuclear palsy
Pick's disease is characterized by a progressive frontotemporal lobar atrophy, gliosis, severe neuronal loss, aB-crystallin-immunoreactive ballooned neurons, and the presence of argyrophilic (but Gallyas-negative) neuronal inclusions, the Pick bodies, in the cerebral coex and some subcoical structures. The "knife-edge" coical atrophy is frequently asymmetric and predominates in the frontal and temporopolar regions Refer robbins 9/e 840
Nervous system