Coarse facies, hepatosplenomegaly and tall QRS on ECG are characteristic feature of-
Glycogen storage disease type II
Hurler's disease
Hunters disease
Hemochromatosis
Ans. is 'b' i.e., Glycogen storage disease type II o Hepatosplenomegaly, characteristics E.C.G. findings and coarse facies are seen in Glycogen storage Type II or pompe's ds. o Death of infant before 2 yrs of age. o Pompe's disease is caused due to absent or reduced level of acid alpha glucosidase (acid maltase) activity. o Hurler's and Hunter syndrome are mucopolysaccharidosis that presents with hepatomegaly and coarse facies, but characteristic ECG pattern of Pompe's disease clinches the diagnosis in our of Pompe's disease.