A 78-year-old man repos anorexia, fatigue, and generally feeling unwell. On examination he has a large spleen, appears pale, and the rest of the examination is normal. His blood count is abnormal; the WBC is 46000/ml with increased mature granulocytes, hemoglobin 9.0 g/dL, and platelets 450,000/mL. Fuher investigations reveal BCR-ABL transcripts. T315I mutation is also seen. What is the drug of choice for this condition?
Bosutinib
Ponatinib
Boezomib
Chlorambucil
All Investigation points towards the diagnosis of CML. Management of CML: Tyrosine kinase inhibitors 1st line: Imatinib 2nd line: Dasatinib Nilotinib Bosutinib (DOC for imatinib resistant CML) 3rd line : Ponatinib DOC for T315I mutation DOC when there is failure of >2 TKIs Allogenic stem cell transplantation for patients who have progressed to blast cell crisis stage.
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