Which of the following is not an established antimicrobial drug synergism at clinical level?
Amphotericin B and flucytosine in cryptococcal meningitis
Carbenicillin and gentamicin in pseudomonal infections
Penicillin and tetracycline in bacterial meningitis
Trimethoprim and sulfamethoxazole in coliform infections
Combination of a bacteriostatic and a bactericidal drug in most cases is antagonistic. Bactericidal drugs act on fast multiplying organisms whereas bacteriostatic drugs inhibit the growth. Here, penicillins are bactericidal whereas tetracyclines are bacteriostatic.
Cell Wall Synthesis Inhibitors