Mechanism of action of Acyclov ir is
Inhibitor of viral DNA polymerase
Inhibitor of viral thymidine kinase
Inhibitor of viral reverse transcriptase
Inhibitor of HSV polymerase
(D) Inhibitor of HSV polymerase # Mechanism of action:> Acyclovir differs from previous nucleoside analogues in containing only a partial nucleoside structure: the sugar ring is replaced with an open-chain structure. It is selectively converted into acyclo-guanosine monophosphate (acyclo-GMP) by viral thymidine kinase, which is far more effective (3000 times) in phosphorylation than cellular thymidine kinase.ANTIVIRAL AGENTS ACTIVE AGAINST HERPESVIRUSESAgentDescription* AcyclovirInhibits HSV polymerase* FamciclovirProdrug of penciclovir (a guanosine analogue)* ValacyclovirProdrug of acyclovir; better absorption* GanciclovirMore potent polymerase inhibitor; more toxic than acyclovir* ValganciclovirProdrug of ganciclovir; better absorption* CidofovirNucleotide analogue of cytosine* FoscarnetPhosphonoformic acid; inhibits viral DNA polymerase
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