Which of the following is false regarding nitric oxide?
Derived from endothelium
Acts by increasing cAMP levels
Vasodilator
Derived from arginine
Nitric oxide acts by increasing cGMP not by increasing cAMP. Nitric Oxide: Also known as Endothelium-derived relaxing factor (EDRF) Synthesized in endothelial cells from arginine in a reaction catalyzed by nitric oxide synthase(NOS) Mechanism of Action: NO causes activation of guanylyl cyclase - Increased cGMP - relaxation of smooth muscle - vasodilation. Effects of NO: Vasodilation Neuromodulator in brain Antimicrobial and cytotoxic activity of various inflammatory cells. In GIT, relaxation of smooth muscle. Penile erection. Ref: Ganong&;s Review of Medical Physiology 26th edition Pgno: 583-584
Cardiovascular system