Which of the following is the leading cause of GHRH mediated acromegaly?
Hypothalamic Hamaoma
Choristoma
Carcinoid tumour
Pluri-hormonal adenoma
The leading cause of GHRH mediated acromegaly is chest or abdominal carcinoid tumour. It will present with elevated GH levels and pituitary enlargement on MRI leading to high probability of misdiagnosis as pituitary adenoma. GHRH levels can be used to differentiate a pituitary vs extra pituitary aetiology.
Disorders of pituitary gland