Cisatracurium, pure CIS isomer of atracurium all true except:-
Is metabolized primarily by Hoffman degradation
Is cardiovascular stable
Produces more laudanosine than an equipotent dose of atracurium
Has onset & duration similar to atracurium
Atracurium molecule is mixture of 10 stereoisomers in which Cis isomer is only 15 %. A total Cis isomer was seperated and new drug was prepared which is Cisatracurium. Cisatracurium a pure CIS isomer of atracurium produces no /minimal histamine release and is more potent than atracurium. Thus it is given in less dose and causes less by product laudanosine production at equipotent dose.
Neuromuscular Blocker