Which one of the following statements about phenytoin is accurate?
Displaces sulfonamides from plasma proteins
Drug of choice in myocionic seizures
Half-life is increased if used with phenobarbital
Toxicity may occur with only small increments in dose
high frequency discharges are inhibited with little effect on normal low frequency discharges which allow Na+ channels to recover even when inactivation is prolonged. This effect has been noted at therapeutic concentration of phenytoin, while other effects like reduction in Ca2+ influx, inhibition of glutamate and facilitation of GABA responses have been demonstrated at higher I toxic concentrations. Intracellular accumulation of Na+ that occurs during repetitive firing is prevented. REF KD TRIPATHI 8TH ED.
Central Nervous system