beta - Lactamases cause resistance to penicillins and cephalosporins by
Breaking one chemical bond
Breaking two chemical bonds
Adding amino (NH2) groups to a molecule
Inhibiting transpeptidase enzymes
Penicillins and cephalosporins are called beta-Iactam drugs because of the importance of the intact BETA-lactam ring for antimicrobial activity. -Lac­tamases inactivate these drugs by breaking the single bond in their BETA-lactam ring. BETA-Lactamases are coded for by either a transferable plasmid or by the genome of the organism. Plasmids are extrachromosomal genetic elements that may be transferred among unrelated bacteria.