The clinical sign of hyaline membrane disease generally first appears –
In the first 6 hours of life
Between 12 and 24 hours of life
Between 36 and 48 hours of life
After 48 hours of lilfe
Clinical features of HMD 

Respiratory distress occurs within the first 6 hours of life.
Clinical features include -


Tachypnea                                                           
o Decreased air entry          a BP may fall

a Retraction                                 
o Fatigue                                                              
o Oliguria                  If untreated

Grunting                                                               

o Pollor 
o Ileus

Cyanosis              
Mixed respiratory & metabolic acidosis