Richter's syndrome refers to which of the following malignant transformation?
CLL evolving into aggressive lymphoma
Hairy cell leukemia evolving to AML
Blast crisis in CML
Splenic infiltration in NHL
Richter's transformation or Richter's syndrome is a complication of B cell chronic lymphocytic leukemia (CLL) or hairy cell leukemia (HCL) in which the leukemia changes into a fast-growing diffuse large B cell lymphoma.