After giving treatment for Syphilis, the response to treatment can be best assessed by -
FTA- ABS
VDRL
TPHA
Immobilization test
VDRL can be used for treatment monitoring as specific tests remains positive (reactive) after the treatment. A fourfold decrease in titre following therapy suggests adequate therapy, whereas a fourfold increase in titre of reaginic antibodies following therapy suggests reinfection or relapse. FTA-ABS: Treponema-specific test. First test to be positive: FTA-ABS. TPHA: After successful therapy, the hemagglutinating antibodies continue to persist in the serum for a longer time; hence this test is of no prognostic value. T. pallidum immobilization test: TPI test was the first specific treponemal test, that detects the treponemal antibodies in patient's serum, which immobilize motile virulent T. pallidum.
Systemic Bacteriology (Haemophilus, Yersinia, Spirochaetes, Ricketssia, Chlamydia, Mycoplasma and Miscellaneous Bacteria)