H.pylori causes all except;
Peptic ulcer
Maltoma
Carcinoid tumor
Gastric CA
H.pylori is gram negative bacteria, non sporing, micro aerophilic, extra cellular bacteria. H.pylori releases urease enzyme which conves urea to ammonia and ammonia stimulates G cells of stomach which in turn stimulates parietal cells and cause secretion of HCl and Hyperchlorydia. This acid travels into stomach & duodenum and causes peptic ulcers. * H.pylori is a type I carcinogen, which, if present in stomach or long term can cause cancer called MALTOMA (Mucosa Associated Lymphoid Tumor), which is a B-type NHL. Also Know mc site of duodenal ulcer in duodenum: D1 If ulcer at atypical site like D2, suspect Zollinger Ellison Syndrome IOC for H. pylori: Urease test (invasive procedure) Urea breath test: test for eradication of infection S. ELISA: Screening test for H.Pylori
Peptic Ulcer Disease