A boy after playing football complaining fatigue and abdominal pain. He also had a history of hand swelling in past. On ultrasonography, he has shrunken spleen. What is the likely diagnosis of this patient?
Sickle cell anemia
Iron deficiency anemia
Acute pancreatitis
Intermittent porphyria
Sickle cell anemia b-globin hemoglobinopathy(mutation in coding sequence ofb-globin gene, GAG - GTG ) Anemia and reticulocytotic;sickle-shaped erythrocytesdemonstrable on peripheral blood smear; homozygosity forhemoglobin Sdemonstrable by electrophoresis Characterized bysevere anemia, recurrent painful and aplastic crises, and nonhealing leg ulcers; recurrent splenic infarcts with progressive fibrosisresult inauto splenectomy
NEET Jan 2020