True statement about cyclooxygenase-2 is
It Is not inhibited by indomethacin
It I'd inducible
It generate cytoprotective prostaglandins in gastric mucosa
It is found only in fatal tissues
Ref-KDT 6/e p185 COX-1 is a house-keeping enzvme that is responsible for the generation of gastroprotective PGs. COX-2 is an inducible enzyme whose production is markedly increased at inflammatory sites. Indomethacin is a non-selective inhibitor of both isoforms of COX.
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