Which of the following diuretics acts on nephron through interstitium
Thiazide
Furosemide
Acetazolamide
Spironolactone
Ans. is 'd' i.e., Spironolactone(Ref: KDT Vh/e p. 587)Spironolactone is mineralocoicoid (aldosterone) antagonist. It opposes the action of Aldosterone without requiring access to the tubular lumen.Spirinolactone (as well as aldosterone) act from the interstitial side.