True statement about cyclooxygenase -2 is:
It is not inhibited by indomethacin
It is inducible
It generates cytoprotective prostaglandins in gastric mucosa
It is found only in fetal tissues
COX-1 is a house-keeping enzyme that is responsible for the generation of gastroprotective PGs. COX-2 is an inducible enzyme whose production is markedly increased at inflammatory sites. Indomethacin is a nonselective inhibitor of both isoforms of COX.
NSAIDs, Gout and Rheumatoid Ahritis