Koilocytes with dyskeratosis and perinuclear halo on pap smear is pathognomonic of which of the following?
HPV infection
Metaplasia
Dysplasia
Bacterial vaginosis
The presence of abnormal koilocytes (keratinocytes with pyknotic, deeply blue nuclei surrounded by a halo and clear cytoplasm with a paucity of keratohyaline granules), or koilocytosis, is a characteristic feature of productive HPV infection. Other cytologic markers of HPV infection include acanthosis, dyskeratosis, and multinucleation. Virus multiplication is confined to the host cell nucleus. Consequently, infected cells exhibit a high degree of nuclear atypia.