Bisphosphonates act by
Increasing the osteoid formation
Increasing the mineralization of osteoid
Decreasing the osteoclast mediated resorption of bone
Decreasing the parathyroid hormone secretion
Bisphosphonates (BPNs) are analogues of pyrophosphate: carbon atom replacing oxygen in the P-0-P skeleton. They inhibit bone resorption by inhibiting osteoclast function- useful to prevent osteoporosis in addition to metabolic bone diseases and hypercalcaemia. (REF.Essentials of Pharmacology TD TRIPATHI 6th EDITION page no 333)
Endocrinology