Familial amyloidotic polyneuropathy is due to amyloidosis of nerves caused by deposition of ?
Amyloid associated protein
Mutant Calcitonin
Mutant Transthyretin
Normal transthyretin
Ans. is 'c' i.e., Mutant transthyretinTransthyretin (ATTR) amyloid Transthyretin (TTR) is normal serum protein that binds and transpo thyroxine and retinol.o TTR can cause following types of amyloidosis : ?1. Mutant TTR : - Mutation in TTR can cause syndrome of familial amyloidotic polyneuropathy or familial amylodotic cardiotnyopathy.2. Wild (non-mutant) TTR : - There is no mutation of TTR and wild type TTR forms fibrils which results in senile systemic amyloidosis (senile cardiac amyloidosis).