In hereditary spherocytosis, an inherited abnormality is seen in which of the following red blood cell component?
a-globin chain
b-globin chain
Phosphatidyl inositol glycan A
Spectrin
Hereditary spherocytosis (HS) is caused by diverse mutations that lead to an insufficiency of membrane skeletal components. The pathogenic mutations most commonly affect ankyrin, band 3, spectrin, or band 4.2.
Hemoglobinopathies: Sickle cell anemia