Patient is treated with dentrolene. All the following are adverse effects except:
Hypokalemia
Muscle weakness
Breathlessness
Bradycardia
- Central muscle relaxant - Used in malignant hypehermia, neuroleptic malignant syndrome etc- Cause respiratory muscle weakness - breathlessness- Chronic dantrolene use - liver dysfunction, kidney dysfunction- Bradycardia Dantrolene contributes to prolonged non depolarizing neuromuscular blockade, In addition to volatile anesthetics, other drugs, such as aminoglycoside antibiotics, local anesthetics, cardiac antiarrhythmic drugs, dantrolene, magnesium, lithium, and tamoxifen (an anti-estrogenic drug), may enhance the neuromuscular blockade produced by nondepolarizing NMBDs. A few drugs may diminish the effects of a nondepolarizing NMBD, including calcium, coicosteroids, and anticonvulsant (phenytoin) drugs.
JIPMER 2017