Steady state concentration of a drug is achieved in:-
2-3 half lives
3-4 half lives
4-5 half lives
5-6 half lives
STEADY STATE - If fixed dose of a drug is administered after regular intervals, its plasma concentration stas increasing. - However, as plasma concentration rises, rate of elimination also stas increasing. When rate of administration becomes equal to rate of elimination, plasma concentration stabilizes. This is called steady state. - Time to reach steady state depends on t 1/2 . It takes approximately 4-5 half lives. - Steady state plasma concentration achieved depends on dose rate. - Variation between peak and trough concentration at steady state depends on dosing interval. However, average steady state plasma concentration remains same irrespective of dosing interval provided dose rate remains same.
Pharmacokinetics