Indomethacin reduce the diuretic action of furosemide by
Preventing prostaglandin mediated heamodynamic actions
Blockade of furosemide action in loop of henle
Enhancing water reabsorption in distal tubule
Increasing aldosterone secretion
NSAIDS inhibit specifically PGE2, PGI2 synthesis in renal tubules effecting the hemodynamic changes done by Prostaglandins for water, sodium reabsorption Ref: katzung 12th ed, Autocoids.
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