Anti-diabetic effect of sulfonylureas is by reducing:
Glucagon production
Insulin secretion
Tissue sensitivity to insulin
Tissue sensitivity to glycogen
Ans. (A) Glucagon production(Ref: KDT 8/e p294)Sulfonylureas act byIncreasing insulin release from pancreas (not by decreasing insulin secretion), so 'option b' ruled out.A minor action reducing glucagon and increasing somatostatin release has been demonstrated.
Endocrinology