The plasma half life of aspirin:
Is independent of dose
Is longer for anti-inflammatory doses compared to that for analgesic dose
Is shoer for anti-inflammatory doses compared to that for analgesic dose
Can be increased by alkalinizing the urine
Aspirin and other salicylates show saturation kinetics (zero order) and thus, their half life is not constant. Clearance at high doses (anti-inflamatory) is lesser than at low (analgesic) doses. Thus t1/2 is more for anti-inflammatory dose than for analgesic dose.
NSAIDs, Gout and Rheumatoid Ahritis