A 75-year-old man presents to his GP for a routine check-up. On examination the GP hears a high-pitched diastolic murmur, heard loudest at the right sternal edge and on expiration. Given the likely diagnosis, which of the following is NOT a risk factor for this condition?
Ankylosing spondylitis
Marfan's syndrome
Holt Oram Syndrome
Infective endocarditis
Aoic regurgitation, High pitched diastolic murmur heard in case of AR Best heard on the left side. Option A: MC cardiovascular disease in Ankylosing spondylitis =A.R. Option B: Marfan syndrome is a Risk factor. Option C: ASD+ skeletal defects/Absent radius bone - Holt Oram Syndrome = In ASD shunt murmur is absent, in ASD it is flow murmur | Mid diastolic murmur Option D: Inf. endocarditis- bacteria will invade the valve leaflet & will contribute to developing Diastolic Murmur.
Murmurs