Which of the following drugs is used for treatment of myoclonus?
Valproate
Levetiracetam
Primidone
All of the above
Treatment primarily consists of treating the underlying condition or removing an offending agent. Pharmacologic therapy involves one or a combination of GABAergic agents such as valproic acid (1200-3000 mg/d), piracetam (8-20 g/d), clonazepam (2-15 mg/d), or primidone (500-1000 mg/d). Recent studies suggest that levetiracetam may be paicularly effective. Ref: Harrison's principle of internal medicine 17th edition, chapter 367.