24 hours estimation of urinary hydroxyproline levels is a good indicator to
Poor outcome of paget's disease
Diagnosis of the pagets disease
Recurrence of the pagets disease
Extent and severity of the disease
(Extent and severity of the disease) (2281-H)PAGET'S DISEASE (osteitis deformans) - characterized by enlargement and thickening of the bone, but the internal architecture is abnormal and the bone is unusually brittle.* * Pelvis and tibia being the commonest site, and the femur, skull, spine and clavicle the next commonestComplication:* Nerve compression (impaired vision facial palsy trigeminal neuraligia or deafness) spinal stenosis** Factures - femoral neck.* * Osteoarthritis - atrophic arthritis with sparse remodelling* * Bone sarcoma - malignant change in probably around 1%* * High output cardiac failure - due to prolonged, increased bone blood flow* * Hyper calcemiaBiochemical investigation - Disease activity is gauged by the increased in serum alkaline phosphate and urinary hydroxy proline levels.* The degree of bone markers (ALP & hydroxyproline) elevation reflects the extent and severity of the disease (228-H)* Total serum ALP remains the test of choice both for diagnosis and assessing response to therapy* Lower values suggests less extensive involvement or a quiescent phase of the disease
Metabolic Bone Disease