Most common cause of Vaccine failure is:
Improper storage
Improper administration
Inappropriate manufacturing
Maternally derived antibodies
- Primary vaccination failure: Failure to serologically respond to vaccine: Too young age where Maternal antibodies interfere (MC Cause) Vaccine production problems Cold chain failure Inappropriate administration technique Immunodeficiency Poor health - Secondary vaccination failure: 'Waning immunity' where there is loss of vaccine induced protection in an individual who had previously seroconveed to vaccination. Causes are not well understood.
Contraindications, AEFIs