First line of treatment of osteoporosis in postmenopausal woman?
Estrogen
Calcium and vitamin D supplementation
Bisphosphonates
Ulipristal
Hormone replacement therapy is cornerstone in both prophylaxis and treatment of osteoporosis in menopausal women. Estrogen delays and protects against osteoporosis by 50% in all skeletal and not limited to trabecular bones of spine, wrist and upper hip. Rest of the drugs used in H for osteoporosis are natural estrogens, progesterone, tibolone and raloxifene. Bisphosphonates may be used are primary treatment in late osteoporosis in postmenopausal women Bisphosphonates include: Alendronate, Risedronate, Ibandronate, Zoledronate. These agents chemically bind to calcium hydroxyapatite in bone and decrease bone resorption by blocking the function and survival but not the formation of osteoclast.
NEET Jan 2020