True about methicillin-resistance Staphylococcus aureus (MRSA) is
Isoxazolyl penicillin is highly effective
All MRSA are multidrug resistance
Vancomyin is effective
MRSA are more virulent then sensitive strains
Penicillin resistance may also be due to alterations in penicillin-binding protein PBP2a and changes in bacterial surface receptors, reducing the binding affinity 0f beta-lactam antibiotics to cells. This mechanism impas resistance to all beta-lactam antibiotics and has been named methicillin-resistant S.aureus{MRSA}as it was found to be resistant to penicillinase-resistant penicillins like methicillin and cloxacillin. The majority of these strains also show resistance to other antibiotics like erythromycin, tetracyclines, aminoglycosides and cause outbreaks of hospital infection. Ref: Textbook of Microbiology; Ananthanarayanan and Panicker; Tenth Edition pg no 202
Bacteriology