Which of the following has the least malignant potential?
Adenomatous polyps in HNPCC
Juvenile polyps in Juvenile Polyposis Syndrome
Adenomatous Polyps in Familial colonic Polyposis
Hamaomatous Polyps in Peutz Jegher's Syndrome
Among the options given in the question hamaomatous polyps in Peutz Jegher's syndrome has only a small chance of being malignant (39%). Juvenile Polyps given in this question are not solitary polyps, but pa of juvenile polyposis syndrome, which has a risk of about 30 to 60 % to develop into a carcinoma. In HNPCC, there 80% lifetime risk of developing colorectal carcinoma. Adenomatous polyps in Familial adenomatous polyposis, if left untreated has a 100% relative risk of turning into malignancy. Ref: Current Surgical Diagnosis& Treatment, 12th Edition, Page 696, 697, 709, 710; Cancer Epidemiology and Prevention By David Schottenfeld, 3rd Edition Page 568; Principles and Practice of Clinical Medicine in Asia: Treating the Asian Patient By Joseph Jao Yiu Sung, page 276; Harrison's Principles of Internal Medicine 18th edition, Chapter 91.