Folinic acid is specifically indicated for
Anaemia associated with renal failure
Pernicious anaemia
Counteracting toxicity of high dose methotrexate
Prophylaxis of neural tube defect in the offspring of women receiving anticonvulsant medication
Methotrexate toxicity:- Folinic acid (Leucovorin, citrovorum factor, 5-formyl-THFA) is an active coenzyme form which does not need to be reduced by DHFRase before it can act. Methotrexate is a DHFRase inhibitor; its toxicity is not counteracted by folic acid, but antagonized by folinic acid. Ref:- kd tripathi; pg num:-611
Hematology