Which among the following is false regarding Huntington's disease?
Chorea
Early onset of memory loss
Cog-wheel rigidity
Behavioral disturbance
HD patients eventually develop behavioral and cognitive disturbances and the majority progress to dementia. So early onset of memory loss is not a feature of Huntington's disease. HD is characterized by rapid, nonpatterned, semipurposeful, involuntary choreiform movements. Dysahria, gait disturbance, and oculomotor abnormalities are common features. With advancing disease, there may be a reduction in chorea and emergence of dystonia, rigidity, bradykinesia, myoclonus, and spasticity. Depression with suicidal tendencies, aggressive behavior, and psychosis can be prominent features. Ref: Harrison's Internal Medicine, 18th Edition, Page 3330