Which diuretic acts without requiring access to renal tubular lumen
Thiazide
Carbonic anhydrase inhibitors
Aldosterone antagonists
Loop diuretics
Mechanism of action of diuretics: Aldosterone antagonists: Aldosterone acts by combining with an intracellular mineralocoicoid receptor It induces the formation of aldosterone-induced proteins (AIP) . These AIPs promote Na+ reabsorption and K+ secretion Spironolactone is an aldosterone antagonist It acts from the interstitial side of the tubular cell It combines with Mineralocoicoid Receptor and inhibits the formation of AIPs
Kidney