The first step in alcohol metabolism by the liver is the formation of acetaldehyde from alcohol, a chemical reaction catalyzed by:
Cytochrome P450
NADPH-cytochrome reductase P450
Alcohol oxygenase
Alcohol dehydrogenase
Ans. D. Alcohol dehydrogenaseAlcohol dehydrogenase catalyzes the conversion of alcohol to acetaldehyde, which is then converted to acetate. Acetate is then metabolized by hepatocytes. Cytochrome P450 is a primary component of the oxidative enzyme system involved in the metabolism of drugs. NADPH-cytochrome P450 reductase is an enzyme involved in phase I reactions of drug metabolism. There is no such enzyme as alcohol oxygenase. Glycogen phosphorylase is an enzyme involved in glycogen breakdown, not alcohol metabolism.
Endocrinology metabolism