Melanized sclerotic cells / Medlar bodies (4-12 mm diameter) evident in this H & E stained cutaneous biopsy are of which disease?
Rhinosporidiosis
Coccididomycosis
Chromoblastomycosis
Sporotrichosis
The histological image above shows the fungus as spherical or irregular, dark brown, yeast like bodies with septae called sclerotic bodies/ copper penny bodies/muriform bodies/medlar bodies seen in Chromoblastomycosis. Chromoblastomycosis: Characterised by verrucous lesions and chronic localized infection of the skin and subcutaneous tissue. Seen commonly in wood workers. Caused by following dematiaceous fungi - Phialophora verrucosa Fonsecaea pedrosoi Cladophialophora carrionii Rhinocladiella aquaspersa
Mycology