Which of the following is the commonest genetic mutation in a 50 year old obese female presenting with postmenopausal bleeding and diagnosed with endometrial cancer?
P53
PTEN
CHD4
Beta catenin
50 year old obese female with endometrial cancer most likely to be type I Endometrial cancer rather than type II which happens in elderly female >65yrs. Type I Type II - 55-56 yo - Endometroid - Hyperplasia - Indolent - PTEN Genetic Mutation - 65-75 yo. - Clear cell serous - Atrophy - Aggressive - P 53 gene mutation
JIPMER 2018