Which of the following is not synthesised from mevalonate?
Farnesyl pyrophosphate
Geranyl pyrophosphate
Dolichol
Ubiquitin
Cholesterol synthetic pathway is also involved in the synthesis of many other impoant compounds such as: Farnesyl pyrophosphate and geranyl pyrophosphate - involved in prenylation of proteins. Dolichol - involved in N-glycosylation of proteins in endoplasmic reticulum. Ubiquinone (Q10) - is the electron carrier in the mitochondrial respiratory chain. Inhibition of ubiquinone synthesis is one of the reasons for statin-induced myopathy. Ubiquitin protein is not synthesized by any of the cholesterol synthesis pathway intermediate.
Cholesterol synthesis and bile acids