A patient of prinzmetal's angina is started on isosorbide mononitrate. What is the mechanism of action of nitrates in this condition?
Reduced cardiac contractility
Increased left ventricular end diastolic volume
Decreased diastolic perfusion pressure
Endothelium independent coronary vasodilation
Ans. (D) Endothelium independent coronary vasodilation(Ref: KDT 7th/e p541)Predominant mechanism of action of nitrates in angina:*In Classical angina: Decrease in preload*In Variant angina: Coronary vasodilation
C.V.S