Which of the following is true for Klinefelter's syndrome?
45X0
Arm span and height more
Attains puberty normally
Normal testis and genitalia
Ans. b. Arm span and height moreKlinefelter Syndrome (47, XXY) is seen in 1 in 1,000 births.Genetics; most common findings manifested at pubertyFindingsDecreased IQ (average IQ 85-90)Behavioral/psychiatric problemsLong limbs (decreased upper: lower segment ratio)Slim (weight/height ratio low)Hypogonadism and hypogenitalism (testosterone replacement at age 11-12 years)=hypergonadotropic hypogonadism (increased FSH and LH, and decreased testosterone)Infertility in almost allGynecomastiaExtra MileTall statureUsually a normal variant (familial tall stature)Other causes: exogenous obesity, endocrine causes (growth hormone excess , androgen excess [tall as children, short as adults)Syndromes: Homocystinuria, Sotos, Klinefelter
Sex Intersexuality