Veepofrin Dye is used in:
Fluoresceina Angiography
Indocyanin Angiography
Photodynamic therapy
All
Veepofrin dye is used in photodynamic therapy. Photo Dynamic Therapy Choroidal Neo Vascular (CNV) membrane secondary to wet ARMD. New or recurrent subfoveal CNV Predominantly classic Lesion <5400 in Greatest Linear Diameter Primary ocular histoplasmosis syndrome. Pathological Myopia. Photodynamic therapy (concept) Involves injection of photosensitizing drug Two step, out patient procedure , I/V photo active drug | Complexes with LDL present in blood | Complex accumulates in choroidal neovascular lesions |After 15 minutes of IV inj. Activation of drug by non thermal (689nm) light in presence of oxygen | Formation of free radicals-cytotoxic, Singlet oxygen species | | Platelet activation Direct cytotoxicity | Neo-vasculature thrombosis Photodynamic therapy: Technique (PGI potential question) Photosensitising dye (Veeporfin) 6 mg/m2 BSA (30 ml) I.V. over 10 minutes. Diode laser at 689 nm, Slit lamp delivery system designed to deliver 50 J/cm2 Intensity of 600 mW /cm2 Over 83 seconds, Advantages High selectivity and no to minimal collateral damage. Temperature rise is only 2 degrees. Minimal side effects: Infusion related back pain. Extravasation and phototoxic reactions Visual disturbances, eye pain, RPE tears Visual field defects. Disadvantages Expensive Protective clothing/eye protection after treatment for five days.
Diagnosis and Treatment of Retina