Which of the following statements about fibromyalgia is true:
More common in males
Sleep EEG studies have shown disruption in REM sleep
Increased coisol response to stress
SPECT studies have reduced blood flow to the thalamus
Pathogenetic features in fibromyalgia:Disruption of normal stage IV NREM sleepLow levels of serotonin metabolites in CSFReduced levels of growth hormoneIncreased levels of neurotransmitter substance P in CSFDecreased coisol response to stress and coicotrophin-releasing hormoneAutonomic dysfunctionReduced blood flow to the thalamus, caudate nucleus, and tectum on SPECTPsychiatric disturbances(ref:Harrison's 18/e p2849-2851, 17/e p2180)
All India exam