Out of the four layers, which cells of are the most active for protein synthesis:
Spinous cell.
Basal cell.
Granular cell.
Corneum cell.
The spinous (prickle) cells resemble a cocklebur or sticker that has each spine ending at a desmosome. Of the four layers, the spinous cells are the most active in protein synthesis. These cells synthesize additional proteins that differ from those made in the basal cells.