Anemia in chronic renal failure is due to
Decreased erythropoietin production
Iron deficiency
Hypoplastic bone marrow
Decreased folate levels
Ref Harrison 19 th ed pg 630 The anemia is primarily due to a failure of EPO production by the diseased kidney and a reduction in red cell survival. In ceain forms of acute renal failure, the correlation between the anemia and renal function is weaker. Patients with the hemolytic-uremic syndrome increase eryth- ropoiesis in response to the hemolysis, despite renal failure requiring dialysis.
Haematology