All of the following drugs can precipitate acute attack of asthma except:
Phenylbutazone
Naproxen
Glucocorticoids
Aspirin
Ans. (C) Glucocorticoids(Ref: KDT 8th/e p250)COX inhibitors like aspirin, indomethacin, naproxen and phenylbutazone etc. inhibit the formation of PGs from arachidonic acid. This results in diversion of metabolism of arachidonic acid to produce LTs. Large excess of LTs are therefore produced with the use of NSAIDs. These drugs therefore, can result in precipitation of acute attack of asthma (because LTs are bronchoconstrictors).Glucocorticoids are useful in the treatment and prophylaxis of bronchial asthma.
Asthma