All of the following statement about vincristine are true except
It is cell cyclic specific and kills cells in the S phase
Its toxicity primarily affects bone marrow and epithelial structure
Folic acid reverses its toxic effects
It is a drug of choice for choriocarcinoma
Ref-KDT 6/e 824,825 Vincristine is a vinca allkaloid. It acts in M-phase of cell cycle by inhibiting the formation of spindle. It is a marrow sparing drug and causes peripheral neuropathy as a prominent adverse effect. It is used for the treatment of hematological malignancies like Hodgkin's lymphoma and leukemias.It is ineffective against solid tumors.
Other topics and Adverse effects