The immunosuppressant action of cyclosporin appears to be due to
Activation of NK cells
Blockade of tissue response to inflammatory mediators
Inhibition of Gene transcription of interleukin
Interference with antigen recognition
Ref-KDT 6/e p838,839,840 Cyclosporine and tacrolimus acts by inhibiting calcineurin, which is involved in the activation of NFAT. Final result of this process is increased transcription of IL-2 gene. Sirolimus does not inhibit the transcription of IL-2 but interferes with its action. It inhibits the enzyme tyrosine kinase, known as mTOR (which is activated by IL-2).
Other topics and Adverse effects