Development of diaphragmbegins at 4 weeks of gestation. Diaphragm has contributions from different structures. Central tendon of diaphragm develops from?
Dorsal mesooesophagus
Septum transversum
Pleuro peritoneal membrane
Cervical myotomes
Development of Diaphragm
Diaphragm develops from
Septum transversum: it is a mass of mesodermal tissue arising from coelomic wall at the 4rd week of gestation. It forms the central tendon of diaphragm.
Dorsal mesooesophagus forms the median portion of diaphragm & the crurae.
Cervical myotomes (from C3-C5 somites) of lateral body wall form the peripheral parts of diaphragm.
Pleuro-peritoneal membranes.
Chromosome 15q plays a major role in diaphragm development
- During the initial period of development, it lies at a higher level (cervical) and then migrates caudally and hence the nerve supply is from C3, C4, C5 (Phrenic nerve).