True about corynebacterium diptheriae is
All types produce toxin
Toxin production is dependent upon critical concentration of iron
Heat stable toxin
Inhibit cAMP
Toxin production is also influenced by the concentration of iron in the medium. The optimum level of iron for toxin production is 0.1mg/ l. The concentration of 0.5 mg / l inhibits the formation of the toxin. Only virulent strain produce powerful exotoxin. It inhibits protein synthesis. It is heat liable. Incubation at 37deg C for 4-6 weeks conve toxin to toxoid. Reference: Textbook of Microbiology; Anathanarayan and panicker's; 10th edition; Page no: 240
Bacteriology