Which of the following is true for plummer vinson syndrome true is -
Oesophageal web of lower oesophagus
Megaloblstic anemia is a feature
It increases risk of squamous cell carcinoma of oesophagus
It increases risk of adenocarcinoma of oesophagus
Ans. is 'c' i.e., It increases risk of squamous cell carcinoma of oesophagus Plummer-Vinson syndrome* Plummer-Vinson syndrome, also known as Brown-Kelly-Paterson syndrome or sederopenic dysphagia, seen in middle aged edentulous women.* The plummer Vinsion Paterson Brown Kelly Syndrome is characterized by: -# Dysphagia# Chronic iron deficiency anemia# Atrophic oral mucosa and glossitis# Brittle, spoon-shaped fingernails (Koilonychia)* The cause of dysphagia is usually a cervical esophageal web, but abnormal pharyngeal and esophageal motility may play a role.* The syndrome characterstically occurs in middle aged edentulous (without teeth) women.* It is a premalignant lesion. Approximately 10% of patient develop squamous cell Ca of esophagus, oral cavity or the hypopharynx.* As iron-deficiency anemia is a common finding, it is also known as sideropenic dysphagia.* Carcinoma develops in post-cricoid region.
G.I.T.