Which of the following chemotherapeutic agents is associated with secondary leukemia
Vinblastine
Paclitaxel
Cisplatin
Bleomycin
Alkylating agents bind to DNA and has the potential to introduce mutations. Therefore, these agents can cause sec­ondary leukemias. Procarbazine is most important drug implicated in causation of secondary leukemias.
Cisplatin acts by similar mechanism and can cause leukemia.