Amphoterecin B toxicity can be lowered by:
Giving it with Glucose
Decreasing the dose
Using Liposomal delivery systems
Combining with flucytosine
Nephrotoxicity is the most impoant toxicity associated with the use of amphotericin B. Use of liposomal amphotericin B is associated with much lower nephrotoxicity, minimal anemia and minimal acute reaction on i.v infusion. Ref: Essentials of Medical Pharmacology By KD Tripathi, 5th Edition, Page 716, 717; Lippincott's Pharmacology, 4th Edition, Page 408; Basic and Clinical Pharmacology By Beram G. Katzung, 11th Edition, Page 838, 839, 836, 837.