An immunocompromised person with history of seizures had an MRI that revealed a temporal lobe lesion. Brain biopsy results showed multinucleated giant cells with intranuclear inclusions. The most probable cause of the lesion is
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Herpes simplex virus causes primary and recurrent disease. The typical skin lesion is a vesicle that contains virus paicles in serous fluid. Giant multinucleated cells are typically found at the base of the herpesvirus lesion. Encephalitis, which usually involves the temporal lobe, has a high moality rate. Severe neurologic sequelae are seen in surviving patients. Reference: Ananthanarayan and Paniker&;s Textbook of Microbiology Tenth edition
Virology