For which one of the following tumors Gastrin is a biochemical marker :
Medullary carcinoma of thyroid
Pancreatic neuroendocrine tumour
Pheochromocytoma
Gastrointestinal stromal tumor
Ans. is 'b' i.e., Pancreatic neuroendocrine tumor Gastrin is secreted by Gastrinomas.Gastrinomas are neuroendocrine tumors found in the duodenum (50 to 70%) pancreas (20 to 40%) andOther intraabdominal sites (mesentery, lymph nodes, biliary tract, liver, stomach, ovary)Excess gastrin secretion leads to Zollinger Ellison SyndromeAlso, knowVerner-Morrison syndrome caused by secretion ofVasoactive intestinal polypeptide (VIP) Verner-Morris on syndrome is also known as pancreatic cholera or WDHA syndrome (excessive watery diarrhea, hypokalemia & achlorhydria)