Which drug has maximum propensity to cause peripheral neuropathy
Didanosine
Zidovudine
Stavudine
Lamivudine
"Peripheral neuropathy strongest association is seen stavudine and zalcitabine" Major dose limiting side effects of retroviral drugs 1. Didanosine - pancreatitis, neutropenia 2. Stavudine peripheral neuropathy, pancreatitis 3. Zidovudine bone marrow suppression 4. Lamivudine -- nil and least toxic 5. Zalcitabine - peripheral neuropathy, apthous ulcers 6. Abacavir - rash, fever 7. Saquinavir - headache, GI disturbance 8. Ritonavir - peripheral paresthesias 9. Indinavir - renal stones 10. Nelfinavir - diarrhea