Atropine is useful in organophosphate poisoning because it
Reactivates Acetylcholineesterase
Competes with acetyl chloline release
Binds with both nicotinic and muscarinic acetylcholine receptors
Is a competitive antagonist of acetylcholine
Atropine acts as an antagonist at muscarinic receptors. It has no activity on nicotinic receptor and do not interfere with the release of ACh Ref-KDT 6/e p106
Autonomic nervous system