Ivermectin act by ?
Inhibition of pyruvate ferridoxin oxidoreductase
Inhibition of Nicotinic Acetycholine receptor
Activation of Glutamate gated Chloride channels
Inhibition of heme polymerase
Ivermectin : MOA :induce paralysis by activating Glutamate-gated Cl- channels foundonly in Inveebrates(Nematode nerve or muscle cells) and causes hyperpolarizationby increasing intracellular Chloride concentration, resulting in paralysis.It also binds with high affinity to GABA-gated and other ligand-gated Cl- channels in nematodes such as Ascaris . USES: It is drug of choice for Strongyloidiasis and Onchocerciasis. It is also useful for Ascariasis, Enterobiasis, Cutaneous Larva Migrans and Uncomplicated Scabies.
Anti-Parasitic Drugs