E cadherin gene deficiency is seen in-
Gastric ca
Intestinal ca
Thyroid ca
Pancreatic ca
Harshmohan textbook of pathology 7th edition. Familial gastric cancer is strongly associated with germline loss of function mutation in the tumor suppressor gene CDH1, which encoded the cell adhesion protein E- catherin. Loss of function mutation in CDH1 are also present in about 50% of sporadic diffuse gastric tumor, while E- Catherin expression is drastically decreased in the rest. often by hyper methylation and silencing of the CDH1 promoter. This the loss of E Catherin is the key step in the development of diffuse gastric cancer..
General pathology