True about COX–2 are all EXCEPT :
It is constitutionally expressed on some cell surfaces
Activation of COX–2 leads to ulceroprotective effect on gastric mucosa
Induced at the site of inflammation
It is utilized in generation of eicosanoids with a ring structure
COX-2 is constitutively active within kidney, endothelium and brain. Recommended doses of COX-2 inhibitors cause renal toxicities similar to those associated with other NSAIDs.
COX-2 inhibitors have been shown to have less gastrointestinal side effects because COX-1 is mainly involved in protection from gastric ulcers.
Constitutive COX-1 isoform tend to be house keeping in function while COX-2 is induced during inflammation.
COX have role in synthesis of PG’s from arachidonic acid, PGs have 20C fatty acids containing cyclopentane ring.
Selective COX-2 inhibitors increase the risk of MI.