Nitrates act by -
Activate guanyl cyclase and decrease cGMP
Activate guanyl cyclase and increase cGMP
Activate adenyl cyclase and decrease cAMP
Activate adenyl cyclase and decrease cAMP
Ans. is 'b' i.e., Activate/Guanyl/cyclase and increase cGMP Mechanism of action of nitrates:* Organic nitrates are rapidly denitrated enzymatically in the smooth muscle cell to release nitric oxide (NO) which activates cytosolic guanyl cyclase - | cGMP - Vasodilatation.* Veins express greater amount of the enzyme that generates NO from organic nitrates than arteries - Account for the predominant venodilatory effect.
C.V.S