What is the mechanism of acute rheumatic lever -
Cross reactivity with host antigen
Innocent by slender effect
Due to toxin secretion by streptococci
Release of pyrogenic cytokines
Rheumatic fever is an acute, immunologically mediated, multisystem inflammatory disease that occurs after group A b-hemolytic streptococcal infections (usually pharyngitis, but also rarely with infections at other sites such as skin). Rheumatic hea disease is the cardiac manifestation of rheumatic fever. Acute rheumatic fever is a hypersensitivity reaction classically attributed to antibodies directed against group A streptococcal molecules that also are cross-reactive with host antigens. (Robbins basic pathology,9th edition,pg no.391)
Cardiovascular system