In Wilms tumor the following leads to emergence of resistance to chromotherapy
Nehprogenic rests
Monoblastic morphology
Anpalsia
Capsular infiltration
5 percnt of tumors have Anpalsia, defined as the presence of cells with large hyperchromatic pleomprphic nuclei and abnormal mitosis and the presrnc of anapladsia coreltes with p53 mutation
Urinary tract