THEME AND FOCUS: GLYCOLYSIS Case Study: A 42-year-old man presented with symptoms of weakness, fatigue, shoness of breath, and dizziness. His hemoglobin level was less than 7 g/dl (normal for a male being greater than 13.5 g/dl). Red blood cells of the patient showed abnormally low level of lactate production. Heinz bodies were not found in PBF. Lead Question: Deficiency of which one of the following enzymes would be the most likely cause of this patient's anemia?
Phosphoglucose isomerase
G6PD
Pyruvate kinase
Hexokinase
Pyruvate kinase deficiency would be most likely cause of patient's anemia | lactate production in the erythrocyte indicates a defect in glycolysis. Pyruvate kinase deficiency 2nd most common cause (after glucose 6-phosphate dehydrogenase deficiency) of enzyme deficiency related to hemolytic anemia. In G6PD deficiency - Heinz bodies
Glycolysis