BRCA1 gene is associated with
Lobular carcinoma
Mucinous carcinoma
Tubular carcinoma
Papillary carcinoma
Ans is 'b' i.e. Mucinous carcinoma "Medullary carcinomas and mucinous carcinomas histological types are more commonly found in BRCA1 carrier". -- Robbings 1134Familial breast cancero About 25% offamilial cancers (or around 3% of all breast cancer) can be attributed to two highly penetrant autosomal dominant genes BRCA-1 on chromosome 17 (52%) and BRCA-2 on chromosome 13 (32%).o Germ line mutation in p53 also increases the risk of breast cancer along with cancers of colon, leukemia, sarcoma and brain tumors (Li fraumeni syndrome)o Somatic mutation in p53 - Sporadic breast cancero Germ line mutation in BRCA-1, BRCA-2, and p53 - Familial breast cancer.
Carcinogenesis