Endothelium derived relaxing factor (EDRF) induced vasodilatation is mediated by:
Increased intracellular cGMP
Decreased intracellular cGMP
Increased extracellular cyclic AMP
Decreased intracellular cyclic AMP
Endothelial cells produce endothelium ­derived relaxing factor (EDRF), a substance that is now known to be nitric oxide (NO).
NO and ANP hormone act via increasing intracellular cGMP.