All are TRUE about Antineutrophil Cytoplasmic Antibodies, EXCEPT:
Proteinase-3, in neutrophil azurophilic granules, is the major cANCA antigen
The major target for pANCA is the enzyme myeloperoxidase
A pANCA pattern of staining has been associated with nonvasculitic entities such as rheumatic and nonrheumatic autoimmune diseases
There are three major categories of ANCA
There are two major categories of ANCA. Other statements are true. Ref: Harrisons Principles of Internal Medicine, 18th Edition, Page 2786