The rate-limiting step for norepinephrine synthesis
Conversion of phenylalanine to Tyrosine
Conversion of Tyrosine to DOPA
Conversion of DOPA to dopamine
Conversion of dopamine to norepinephrine
In the synthesis of Norepinephrine, Tyrosine is hydroxylated to 3,4dihydroxyphenylalanine by tyrosine hydroxylase. This enzyme catalyses the rate limiting reaction and require tetrahydrobiopterin as coenzyme.Ref: Biochemistry, U. Satyanarayana, Fouh edition, page no: 349
Metabolism of protein and amino acid