Which of the following vitamins is the precursor of CoA?
Riboflavin
Pantothenate
Thiamine
Cobalamin
Pantothenate is the precursor of CoA, which paicipates in numerous reactions throughout the metabolic scheme. CoA is a central molecule of metabolism involved in acetylation reactions. Thus a deficiency of pantothenic acid would have severe consequences. There is no documented deficiency state for pantothenate, however, since this vitamin is common in foodstuffs. Note: Pantothenic acid has a central role in acyl group metabolism when acting as the pantetheine functional moiety of coenzyme A or acyl carrier protein (ACP). Ref: Bender D.A. (2011). Chapter 44. Micronutrients: Vitamins & Minerals. In D.A. Bender, K.M. Botham, P.A. Weil, P.J. Kennelly, R.K. Murray, V.W. Rodwell (Eds), Harper's Illustrated Biochemistry, 29e.