Which of the following is observed during sleep induction?
| Norepinephrine and serotonin
| Acetyl Choline
| Histamine
| GABA
The cholinergic neurons in pontine reticular formation on stimulation, induce sleep. When the activity of norepinephrine and serotonin containing neurons (locus coeruleus and raphe nuclei) is dominant, there is a reduced level of activity in acetylcholine-containing neurons in the pontine reticular formation leading to wakefulness. The reverse of this pattern leads to REM sleep. A more even balance in the activity of these groups of neurons is associated with NREM sleep. Ref: Ganong's Review of Medical Physiology 25th edition Pgno: 279
Nervous system