All of the following are metabolic effects of progesterone in normal pregnancy, EXCEPT:
It increases basal insulin levels
Norgestrel increase glucose tolerance
Stimulates lipoprotein lipase activity
Does not alter glucose tolerance
Progesterone increases basal insulin levels and the rise in insulin after carbohydrate ingestion, but it does not normally alter glucose tolerance. However, long-term administration of more potent progestins, such as norgestrel, may decrease glucose tolerance. Progesterone stimulates lipoprotein lipase activity and seems to enhance fat deposition. Ref: Levin E.R., Hammes S.R. (2011). Chapter 40. Estrogens and Progestins. In L.L. Brunton, B.A. Chabner, B.C. Knollmann (Eds), Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e.