Compared to high molecular weight heparin following is true about low molecular weight heparin ?
Monitoring is not needed for low molecular weight heparin
Daily two subcutaneous doses are essential
They are easily filtered at the glomerulus
They do not interact with plasma proteins
Ans. is 'b' i.e., Daily two subcutaneous doses are essential Advantages of LMWH Longer, more consistent and predictable response --> Single daily dose is sufficient by subcutaneous route. o Lower risk of osteoporosis and HIT syndrome. Bleeding chances are less : LMW heparins have a different anticoagulant profile. They selectively inhibit factor Xa with little effect on antithrombin and coagulation in general. They act only by inducing conformational change in AT III. They appear to have lesser antiplatelet action. As a result they have a small effect on a PTT and whole blood clotting time. Since a PTT/clotting times are not prolonged (much) laboratory monitoring is not needed, and the incidence of haemorrhagic complication is less. They are easily filtered from glomerular capillaries because of there smaller molecular weight. LMW heparins do not interact with plasma proteins.