When nitrates are combined with Calcium channel blockers
Aerial pressure will decrease
Hea rate will increase
Ejection time will decrease
End diastolic volume will increase
Really Kk sharma 1e p276 Recommendations for combination therapy decisively depend on the choice of the first-line drug. Only nitrates reduce myocardial preload by venodilation and substitute for EDRF-deficiency. ... Therefore, the combination of nitrates with hea-rate-increasing calcium channel blockers, such as nifedipine, should be avoided.
General anatomy