Which of the following is not true about IgA nephropathy
The pathological changes are proliferative and usually confined to mesangial cells; usually focal and segmental
Hematuria may be gross or microscopic
On immunofluorescence depodits contain IgA and IgG
Absence of associated proteinuria is pathognomic
IgA nephropathy, characterized by mesangial deposits of IgA-containing immune complexes, is the most common cause of nephritic syndrome worldwide; it is also a common cause of recurrent hematuria; it commonly affects children and young adults and has a variable course. Histologically, the lesions in IgA nephropathy vary considerably.The glomeruli may be normal or may show mesangial widening and segmental inflammation confined to some glomeruli (focal proliferative GN); diffuse mesangial proliferation (mesangioproliferative GN); or (rarely) ove crescentic GN. The characteristic immunofluorescence picture is of mesangial deposition of IgA, often with C3 and properdin and smaller amounts of IgG or IgM. Ref: Robbins basic book of pathology 10th edition page 530
Urinary tract