The drug effective for treatment as well as prophylaxis of angina pectoris is:
Isosorbide dinitrate
Pentaerythritol tetranitrate
Diltiazem
Dipyridamole
Isosorbide dinitrate Can be used sublingually at the time of attack (peak in 5-8 min) Orally for chronic prophylaxis. t 1/2 is 40 min, but sustained release formulation may afford protection for 6-10 hours. Nitrates are effective in classical as well as variant angina. Nitrates increase exercise tolerance and postpone ECG changes of ischemia.
CHF, Angina Pectoris and Myocardial Infarction