A highly ionized drug
Is excreted mainly by kidney
Can carry placental barrier easily
Is well absorbed from intestine
Accumulates in cellular lipids
Ionized molecules cannot cross the biological membranes .therfore they are less likely to be absorbed . Entry of the molecules through blood brain barrier and blood placental barrier is also restricted .these drugs cannot be reabsorbed in the nephron,thus are excreted by the kidney . Refer kDT 7/e p29
General anatomy