Which of the following statement about phenytoin is true
It follows zero order kinetics
It is not teratogenic
It is excreted unchanged in urine
It does not induce microsomal enzymes
Zero-order elimination kinetics: Elimination of a constant quantity per time unit of the drug quantity First order elimination kinetics: Elimination of a constant fraction per time unit of the drug quantity Phenytoin is metabolized in the liver by hydroxylation and glucuronide conjugation. The kinetics of metabolism is capacity limited; changes from first order to zero order over the therapeutic range ref: KD Tripathhi 8thh ed.
Central Nervous system