True statement about clonidine are all except ?
Increases parasympathetic outflow
Decreases sympathetic outflow by blocking central alpha receptor
Used in hypeension
Prazosin is used to antagonize side effects of clonidine
Ans. is 'd' i.e., Prazosin is used to antagonize side effects of clonidine Clonidine is an a-2 agonist, while prazosin blocks the a-1 receptors. o Clonidine enhances vagal tone (parasympathetic outflow) which can cause bradycardia. o The major haemodynamic effects result from stimulation of a2a receptors present mainly postjunctionally in medulla --> decrease sympathetic outflow --> fall in BP and bradycardia. o Clonidine is used in hypeension.