All of the following are predictable adverse effects of tricyclic antidepressants, EXCEPT:
Decrease in seizure threshold
Weight gain
Insomnia
Dry mouth
Tricyclic antidepressants produce sedation rather than arousal. Use of tricyclics can be therapeutic for insomnias associated with depression. Other effects include antimuscarinic effects (dry mouth, blurred vision, tachycardia, urinary retention), a-adrenergic effects (ohostatic hypotension), weight gain, and a decrease in seizure threshold, which means that patients are more susceptible to having seizures. Ref: O'Donnell J.M., Shelton R.C. (2011). Chapter 15. Drug Therapy of Depression and Anxiety Disorders. In L.L. Brunton, B.A. Chabner, B.C. Knollmann (Eds),Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e.