Which is seen in chediak Higashi syndrome
Neutopenia
Defective microbial killing
Presence of large granules in neutrophils
All of the above
Ref Harrison 16/e p,353:,354, Robbins 9/e p238 Chediak Higashi syndrome: Autosomal recessive inheence Due to defect in lysosomal transpo protein LYST. Clinical feature include: primary immune deficiency, neutropenia , defective microbial killing,impaired chemotaxis,hypopigmentation, photophobia, nystagmus. Microscopic examination shows giant peroxidase positive inclusion in the cytoplasm of leukocytes
General anatomy