Physostigmine was therapeuticallyused for the first time in treatment of glaucoma in 1877 by –
Laqueur
Posselt and Reiman
Ahlquist
Sir James Black
Laqueur
Posselt and Reiman isolated nicotine from the leaves of Nicotiana tabacum.
Ahlquist gave the hypothesis that adrenaline acts on different sets of receptors, later named as α and β.
Sir James Black synthesized the first β-blocker, dichloroisoproterenol, and subsequently, propranolol.