Which of the following best denotes classical complement pathway activation in immune inflammatory condition:
C2, C4 and C3 decreased
C2 and C4 normal, C3 is decreased
C3 normal and C2, C4 decreased
C2, C4, C3 all are elevated
Classical complement pathway involves reduction in all complement components C1 to C9 Alternate pathway causes depletion of all components except C1, C2 and C4Complements(heat labile proteins found in serum/produced by the liver):Classical pathway Alternate pathwayActivated by antigen antibody reaction does not need antigen antibody reaction Antigen antibody binding activates *activated by Complement C1 and initiates the cascade IgG complexes Complex carbohydrates Endotoxins Properidin Serum factors B & D Magnesium ions activation occurs directly at C3 level And doesnot involve early factors C1, C4 & C2ref: Harrison's 18/e p1011
All India exam