A 56-year-old man presented with bony pain. X-ray of skull showing which lesions in brain:
Paget's disease
Multiple myeloma
Osteosarcoma
Osteomyelitis
Ans. a. Paget's diseasePAGET DISEASE OF BONE (OSTEITIS DEFORMANS)Common, localized disorder of bone remodeling caused by increases osteoclastic activity followed by increasing osteoblastic activity that forms poor-quality bone.In Paget disease; Serum Ca2+, phosphorus, and PTH levels are normal.ALP value elevated in Paget disease.Mosaic pattern of woven and lamellar bone (osteocytes within lacunae in chaotic juxtapositions); chalk-stick fractures seen in long bone.Increases blood flow from increases arteriovenous shunts may cause high-output heart failure.It Increases risk of osteogenic sarcoma.Due to skull thickening; Hat size increaseHearing loss is more commonly seen due to auditory foramen narrowing.STAGES OF PAGET DISEASELytic--osteoclastsMixed--osteoclasts +osteoblastsSclerotic--osteoblastsQuiescent--minimal osteoclast/osteoblast activity Treatment: Bisphosphonates
Skeletal System