In organophosphorus compound poisoning, organophosphorus compound actions are -
Phosphorylates enzyme
Irreversibly inhibit cholinesterase
Oximes effective when given beyond 24 hours
Atropine can't reverse in early stage
Mechanism of Action Organophosphorus compounds are inhibitors of acetylcholinesterase by phosphorylating the enzyme. Acetyl cholinesterase is required to hydrolyse acetylcholine to choline and acetic acid As a result, there is accumulation of acetylcholine with continued stimulation of local receptors and eventual paralysis of nerve or muscle . Organophosphate intoxication leads to characteristic end-plate abnormalities that reflect the degree of AchE inhibition and increase in Ach concentration at the neuromuscular junction. REF;THE SYNOPSIS OF FORENSIC MEDICINE:KS NARAYANA REDDY;28th EDITION;PAGE NO 291
Poisoning