A 15 yr old boy suffering from epiliepsy is on treatment with a combination of Phenytoin and Valproate. Both the drugs levels are in the level of therapeutic range. Which of the following is not an adverse effect of Valproate?
Weight gain of 5 kg
Serum alanine aminotransaminase 150IU/L
Rise in serum ammonia level by 20 mcg/dL
Lymphadenopathy
Neurologic side effects of valproic acid are ataxia, sedation, tremor and Systemic side effects of valproic acid are hepatotoxicity, thrombocytopenia, gastrointestinal irritation, weight gain, transient alopecia and hyperammonemia. Ref: Harrison's Internal Medicine, 18th Edition, Page 3263 Tables 369-9