True about syphilis is A/E – a) VDRL is sensitive but not specificb) Infection leads to life long immunityc) IgM & IgAd) T. pallidium when inoculated in rabbit produce progressive disease
a
c
bc
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Infection with syphilis does not provide life long immunity reinfection with syphilis is not uncommon especially in patients who have been treated early.
Non-specific serological tests measure IgG & IgM (not IgM & IgA).
Intradermal and intraperitoneal inoculation of T.pallidum into experimental rabbit produce progressive lesions.
VDRL is a sensitive test with sensitivity upto 100% in secondary syphilis. But it is not specific as nontreponemal antigen is used, infact it is one of the non-specific test for diagnosis of syphilis.