Which of the following condition is associated with an increased risk of developing adenocarcinoma of esophagus?
Barret's esophagus
Long standing achalasia
Corrosive structure
Alcohol abuse
The metaplasia of esophageal squamous epithelium to columnar epithelium (Barrett's esophagus) is a complication of severe reflux esophagitis, and is a risk factor for esophageal adenocarcinoma. Endoscopic biopsy is the gold standard for confirmation of Barrett's esophagus. The hallmark of Barret's esophagus is the presence of mucus secreting goblet cells. Ref: Schwaz's Principles of Surgery, 9th Edition, Chapter 25