Secondaries are common in all, except:
Skull
Hand and feet bones
Proximal limb bones
Veebrae
Metastasis may occur any bone but most commonly involve axial skeleton (e.g. veebra, pelvis, ribs,skull, sternum) > Proximal femur > humerus. Metastasis in small bone of hand and feet are uncommon and usually originates in cancer of lung, kidney and colon
Etiological Factors of Neoplasia