Cryosurgery is used in treatment of cervical intraepithelial neoplasia. It is appropriate in all except
Transformation zone lying entirely on ectocervix.
Smooth cervical surface without deep crevices.
Cervical intraepithelial neoplasia -3.
CIN limited to two quadrants of the cervix.
Cryosurgery is generally not favoured for treatment of CIN-3 due to higher rates of disease persistence following treatment, and lack of histologic specimen to exclude occult invasive cancer.