Acetaminophen poisoning causes which of the following changes in the liver?
Centrilobular necrosis in liver
Microvesicular fatty infiltration in hepatocytes
Cholestasis
Peripoal inflammation
Acetaminophen poisoning typically causes centrilobular necrosis in liver. Ref: Harrison's Principles of Internal Medicine, 18th Edition, Page 2560, see Table: 305-1.