A 45-year-old female underwent hysterectomy for dysfunctional uterine bleeding. Following are the gross and histological findings. Which of the following is the most likely diagnosis?
Leiomyosarcoma
Leiomyoma
Mixed Mullerian tumor
Vaginal carcinoma
Diagnosis- Leiomyoma of uterus Well circumscribed growth arising in uterine wall from myometrium Can be Multiple in number hanges which can be seen- hyaline degeneration, calcification. Common signs and symptoms include abnormal bleeding, urinary frequency due to compression of the bladder, sudden pain from infarction of a large or pedunculated tumor, and impaired feility. Mutations in the gene MED12 occur in roughly 70% of uterine leiomyomas. Microscopic Examination: Well differentiated spindle shaped smooth muscle cells in a whorl pattern. Individual muscle cells are uniform in size and shape and have a characteristic oval nucleus and long, slender bipolar cytoplasmic processes. Mitotic figures are scarce.
Systemic Pathology