Nitroglycerine is effective when administered sublingually because it is:
Non ionized and lipid soluble
Ionized and lipid soluble
Non ionized and Water insoluble
Ionized and water insoluble
Ans. (A) Non ionized and lipid soluble(Ref: KDT 8th/e p28)Nitroglycerin is effective when retained sublingually because it is non-ionized and has very high lipid solubility. Thus, the drug is absorbed very rapidly.
General Pharmacology