Which of the following is false regarding brittle bone disease?
It is caused by defects in type 2 collagen
Predominantly autosomal-dominant inheritance is seen
Blue sclerae and deafness may be associated
Bisphosphonates are useful in the treatment
Brittle bone disease is another name for osteogenesis imperfecta (OI). It is due to defects in type 1 collagen, not type 2 collagen. There are 12 types of OI, with type 1 being the most common. Triad of fragile bones, blue sclera and deafness is known as van der Hoeve syndrome. Treatment includes bisphosphonate therapy and ohopedic rehabilitation. Ref: Nelson textbook of pediatrics 21st edition pgno: 3737
Musculoskeletal  disorders