Which of the following does not describe a documented mechanism of tumor-mediated immune evasion?
Down regulation of class I MHC
Secretion of TGF-b
Secretion of decoy molecules
Antigenic variation
Tumor cells have evolved mechanisms to escape and evade immune recognition. These mechanisms include various molecular genetic processes of eliminating MHC I from the tumor cell surface. Mutations inhibit efficient antigen processing and presentation. Tumor cells also block immune cells by secretion of suppressor proteins, most commonly TGF-b1, and other cytokine like "decoy" molecules to confuse the immune system. Antigenic variation is an immune escape mechanism ascribed to pathogenic microbes such as viruses for example.
Immunology