In type 2 DM, increased fasting plasma glucose is predominantly due to
Increased hepatic glucose output
Decreased peripheral utilization of glucose
Decreased insulin secretion
Decreased transpo of glucose to tissue
Insulin resistance impairs glucose utilization by insulin-sensitive tissues and increases hepatic glucose output; both effects contribute to the hyperglycemia. Increased hepatic glucose output predominantly accounts for increased FPG levels, whereas decreased peripheral glucose usage results in postprandial hyperglycemia. Glucose metabolism in insulin-independent tissues is not altered in type 2 DM.Ref: Harrison 19e pg: 2405
Endocrinology