A 25 year old male is diagnosed to have osteosarcoma involving his right femur. Mutation of which of the following gene can be related to the development of osteosarcoma?
APC gene
Bcl 2 gene
RB gene
C myc gene
Mutation of the Rb gene can result in retinoblastoma, osteosarcoma, breast cancer and small cell carcinoma. Mutation of APC gene is found in 70-80% of non familial colon carcinomas, 50% of hepatoblastomas and 20% of hepatocellular carcinomas. Mutation of Bcl 2 gene is associated with the development of follicular lymphoma. C myc gene is associated with Burkitt's lymphoma Mutation of p53 gene is found in more than 70% of tumors. Mutation of NF1 gene is associated with the development of neurofibromas and malignant peripheral nerve sheath tumors. Mutation of VHL gene is associated with nonfamilial renal cell carcinomas. Ref: Wyatt C., Kemp W.L., Moos P.J., Burns D.K., Brown T.G. (2008). Chapter 4. Neoplasia.