Wire loop thickening of glomerular basement membrane is seen in -
Systemic lupus erythematosus (SLE)
Non Insulin Dependent Diabetes Mellitus
Rapidly progressive glomerulonephritis
Malignant hypeension
Ans. is 'a' i.e., Systemic lupus erythematosus o Wire loop thickening is a characteristic features of lupus nephritis. o It occurs because extensive subendothelial deposit in kidney causes a peculiar thickening of the capillaries which on light microscopy appear as wire loop lesions. o Wire loop lesions indicate active disease and poor prognosis. o Wire loop lesions are especially common in diffuse proliferative glomerulonephritis, but can also occur in focal proliferative and membranous glomerulonephritis.