What is true about thalidomide
It exes antitumour activity in some solid malignant tumours
It exes antileprotic action
It ameliorates cancer associated cachexia
All of the above
Thalidomide It is reintroduced as immunomodulator. uses:- 1)Angiogenesis inhibitor antitumour activity 2)anxiolytic 3)antiemetic 4)adjuvant analgesic/antipyretic propey 5 )improves cancer associated cachexia 6) used in erythema nodosum leprosum 7) multiple myeloma Mech of action:- It acts by suppressing TNFa and by modulating IL-2. contraindication:- In Pregnancy due to phocomelia(seal like limbs). Ref:- kd tripathi; pg num:-877
Immunomodulators