True statement regarding first order kinetics is:
Rate of elimination is independent of plasma concentration
A constant proportion of plasma concentration is eliminated per unit time
Half life increases with dose
Clearance decreases with dose
Ans. (B) A constant proportion of plasma concentration is eliminated per unit time(Ref: RID 8th/e p38-39)In first order kinetics, rate of elimination is proportional to plasma concentration of the drug. Half life and clearance are constant in first order kinetics.
General Pharmacology