Which diuretic could be considered appropriate for combining with ACE inhibitors?
Spironolactone
Eplerenone
Hydrochlorothiazide
Amiloride
Ans. (C) Hydrochlorothiazide(Ref: Katzung 10/e p571; KDT 8/e p632)*ACE inhibitors are contra-indicated in the presence of hyperkalemia. Aldosterone antagonists (like spironolactone and epleronone) and epithelial sodium channel blockers (like amiloride and triamterene) are potassium sparing diuretics and should not be combined with ACE inhibitors. Thiazides on the other hand cause hypokalemia and can be combined with ACE inhibitors.
Diuretics and Antidiuretics