Which of the following adverse effects is characteristically associated with methysergide?
Pulmonary hypeension
Retroperitoneal fibrosis
Hepatotoxicity
Ischemic hea disease
All ergot derivatives can cause fibrosis on long term use. Due to risk of retroperitoneal fibrosis, methysergide should never be given continuously for more than 6 months.
Histamine, 5-HT and PGs