Which of the following differentiates Hodgkin's lymphoma from non Hodgkin's lymphoma?
Fever, night sweat, weight loss
Generalized lymphadenopathy
Elderly
Reed stern berg cells
In classic Hodgkin lymphoma, the neoplastic cell is the Reed-Sternberg (RS) cell. Reed-Sternberg cells comprise only 1-2% of the total tumor cell mass. Most Reed-Sternberg cells are of B-cell origin. The Reed-Sternberg cells consistently express the CD30 (Ki-1) and CD15 (Leu-M1) antigens. Age-specific incidence rates of Hodgkin lymphoma and non-Hodgkin lymphoma have a bimodal distribution in both sexes, peaking in young adults (aged 15-34 y) and older individuals (>55 y). Asymptomatic lymphadenopathy may be present in both. Constitutional symptoms (eg, unexplained weight loss, fever, night sweats) are present in 40% of patients.