Which of these is true regarding CML -
Size of splenomegaly indicates prognosis
Phagocytic activity of WBC is reduced
Sudan black stain is specific for myeloblast
All
Ans. is 'a' i.e., Size of splenomegaly indicates prognosis SOKAL INDEX is used for assessing the prognosis in CML. It includes 1. % of circulating blasts 3. platelet count 5. cytogenetic clonal evaluation 2. spleen size 4. age o The cytogenic hallmark of CML is presence of philadelphia chromosome (9:22). It is present in all the cell lines. Whether erythroid series, myeloid series or megakaryocytes. Also know o Other index used for assessing the prognosis of CML is HASFORD SYSTEM. It was developed based on IFN-alpha treated patients. It includes:- i) % of circulating blasts iii) Spleen size v) Age % of eosinophils & basophils iv) Platelet count