Which of the following cephalosporins does not need dose modifications even in presence of raised levels of GFR?
Cefipime
Cefoperazone
Cefotaxim
Cefuroxime
Cefoperazone does not require dose adjustment when used in a patient with reduced GFR, as this drug is primarily excreted through the bile. Ref: Goodman and Gilman's The Pharmacological Basis of Therapeutics, 10th Edition, Page 1210; Essentials of Medical Pharmacology By K D Tripathi, 5th Edition, Pages 664-6; KDT 6th Edition, Page 706