Denosumab is used in:-
Osteomalacia
Osteoahritis
Osteoporosis
Osteosarcoma
Denosumab is a monoclonal antibody against RANK - ligand which inhibits binding to RANK receptor and inhibits the activation of osteoclasts and inhibits bone resorption so it is used in treatment of Osteoporosis.
NSAIDs, Gout and Rheumatoid Ahritis