The endothelins are secreted mainly by endothelial cells. All of the following are true, EXCEPT:
Enhances renal pressure natriuresis
Vasoconstriction
Decreased GFR
Act on the hea to cause hyperophy
Endothelin-1 (ET-1), the most powerful vasoconstrictor produced in humans. ET-1 decreases GFR and renal plasma flow through stimulation of vascular smooth muscle and mesangial cell contraction. ET-1 can also act on the hea to cause hyperophy, on the adrenal gland to release aldosterone, and on the kidney to promote sodium and water retention. Ref: Hall J.E., Granger J.P., Jones D.W., Hall M.E. (2011). Chapter 69. Pathophysiology of Hypeension. In V. Fuster, R.A. Walsh, R.A. Harrington (Eds), Hurst's The Hea, 13e.