CSF examination of a severely ill patient shows albumino-cytologic dissociation. It occurs in cases of:
Guillain Barre syndrome
TBM
Motor neurone disease
Demyelinating disorder
The cerebrospinal fluid (CSF) often shows a characteristic abnormality, termed cytoalbuminologic dissociation, with an elevated CSF protein level without accompanying pleocytosis. The CSF is often normal when symptoms have been present for 48 h; by the end of the first week, the level of protein is usually elevated. Ref: Amato A.A., Hauser S.L. (2012). Chapter 385. Guillain-Barre Syndrome and Other Immune-Mediated Neuropathies. In D.L. Longo, A.S. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, J. Loscalzo (Eds), Harrison's Principles of Internal Medicine, 18e.