Esmolol is a sho acting b blocker because
It has more plasma protein binding
Its plasma hydrolysis by esterases is rapid
It has high lipid solubility
It has high oral bioavailability
* Esmolol - Shoest acting b blocker * Nadolol - Longest acting b blocker * Esmolol is metabolized by pseudocholinesterase hence it is sho acting. * Drugs metabolized by pseudocholinesterase SUCCINYLCHOLINE ESMOLOL REMIFENTANIL
Sympathetic System