Which of the following is not seen on hemoglobin electrophoresis in sickle cell anemia
HbA
HbA2
HbF
HbS
Ref Harrison 19 th ed pg 634 sickle cell syndromes are caused by a mutation in the b-globin gene that changes the sixth amino acid from glutamic acid to valine. HbS (a2 b2 6 Glu-Val) polymerizes reversibly when deoxygenated . No beta chains and therfther no HbA
Haematology