Tangier disease is characterised by:
Extremely low circulating level of plasma cholesterol
Low level of LDL but high HDL level
Extremely low level of triglycerides
Very high level of triglycerides
Tangier disease is a very rare autosomal dominant form of extremely low plasma HDL-Cholesterol caused by mutations in the gene encoding ABCA1. Reference: Harrisons Principles of Internal Medicine, 18th Edition, Page 3154