True about metastatic calcification
Serum ca level is normal
Occurs in dead/dying tissue
Occurs in damaged hea valves
Calcification stas in mitochondria
Metastatic calcification is associated with hypercalcemia and occur in normal tissues and stas in the mitochondria. Metastatic Calcification Metastatic calcification can occur in normal tissues when- ever there is hypercalcemia. The major causes of hypercal- cemia are (1) increased secretion of parathyroid hormone, due to either primary parathyroid tumors or production of parathyroid hormone-related protein by other malignant tumors; (2) destruction of bone due to the effects of acceler- ated turnover (e.g., Paget disease), immobilization, or tumors (increased bone catabolism associated with multiple myeloma, leukemia, or diffuse skeletal metastases); (3) vitamin D-related disorders including vitamin D intoxication and sarcoidosis (in which macrophages activate a vitamin D precursor); and (4) renal failure, in which phosphate reten- tion leads to secondary hyperparathyroidism. Ref: Textbook of Pathology HARSH MOHAN 7th Edition page no.36
General physiology