Primary biliary cirrhosis is most commonly associated with______
Systemic sclerosis
Sjogren syndrome
Ulcerative colitis
Pancreatitis
Primary Biliary Cirrhosis Autoimmune disorder Clinical manifestation - obstructive jaundice F > M Antibody seen in antimitochondrial ab which is formed against E2 subunit of PDH enzyme. Interlobular bile ducts are actively destroyed by lymphoplasmacytic inflammation with or without granulomas.
Bilirubin Metabolism