Which of the following antiepileptic agents acts on the GABAergic system to decrease the uptake of GABA into neurons and glial cells?
Vigabatrin
Progabide
Gabapentin
Tiagabine
It potentiates GABA mediated neuronal inhibition by depressing GABA transpoer GAT 1 which removes synaptically released GABA into neurons and glial cells REF: KD TRIPATHI 8TH ED. page 421
Central Nervous system