Local anesthetic acts by:
Blocking sodium gated channel
Blocking calcium gated channel
Blocking potassium gated channel
Blocking chloride gated channel
NORMAL LOCAL ANESTHETIC Sodium passess through voltage gated sodium channel and cause change in membrane potential and cause depolarization. Local anesthetic attatches to sodium channel and prevents propogation & depolarization. LA also has mild action on potassium calcium and NMDA channels
JIPMER 2018