Which of the following disorders is least likely associated with progression to lymphoma
Sjogren's syndrome
Araxia telangiectasia
Severe combined immunodeficiency
Lynch II syndrome
Ans. is 'c' i.e., Severe combined immunodeficiency Choice Cancers associated Sjogren syndrome NHL mainly MALT-oma involving salivary glands>stomach Ataxia telengectasia Elevated incidence of cancers, approximately 100-fold in comparison to the general population. In children, more than 85% of neoplasm cases are acute lymphocytic leukemia or lymphoma. In adults with ataxia-telangiectaisa, solid tumors are more frequent Lynch-II syndrome Gastrointestinal cancer associated with endometrial/ovarian carcinoma. Early onset brain tumor and lymphoma also seen in children