A new born presented with bloated abdomen sholy after bih with passing of less meconium. A full thickness biopsy of the rectum was carried out. Which one of the following rectal biopsy findings is most likely to be present -
fibrosis of submucosa
Hyalinisation of the muscular coat
Thickened muscularis propria
Lack of ganglion cells
Ans. is 'd' i.e. lack of ganglion cells The diagnosis of Hirschprung's disease is suspected in this neonate, which is confirmed on rectal biopsy by the finding of - lack of ganglion cells.