Source of ATP in RBC&;s is
Beta oxidation of fatty acids
TCA cycle
Anaerobic glycolysis
Gluconeogenesis
Glycolysis is the only source of energy in erythrocytes. During anaerobic (oxygen deficient) condition, when one molecule of glucose is conveed to 2 molecules of lactate, there is a net yield of 2 molecules of ATP. 4 molecules of ATP are synthesized by the 2 substrate level phosphorylations (steps 6 and 9). But 2 molecules of ATP are used in the steps 1 and 3, hence the net yield is only 2 ATP (Table 9.4). The whole reaction is summarized as Glucose + 2 Pi + 2 ADP --> 2 Lactate + 2 ATPRef: DM Vasudevan Textbook of Medical Biochemistry, 6th edition, page no: 93 & 96
Respiratory chain