All of the following are prion associated disease except:
Kuru
Creutzfeldt-Jacob disease
Alzheimer's disease
Scrapie
Ans. C. Alzheimer's diseasePrionsa. Infectious proteins that cause CNs degenerationb. Prion diseases are disorder of protein conformationc. Reproduce by binding to normal, cellular isoforms of prion protein (PrPc) & stimulating conversion of (PrPc) into disease causing isoform (PrPSc)d. (PrPc )-rich in alpha helixe. (PrPSc )- rich in beta structure.f. Properties: - -devoid of NA- Infectious, genetic or sporadic- Disease result with accumulation of (PrPSc)* PrP gene- PRNP, located on chromosome 20* Most patients present with de mentia and myoclonus* Prion diseases:i. Kuruii. Familial fatal insomniaiii. Transmissible Mink Encephalopathyiv. Creutzfeldt- Jacob disease (CJD)v. Gerstmann- Straussler- Scheinker diseasevi. Scrapievii. Bovine Spongiform Encephalopathy
Virology