In which of the following condition is SHBG synthesis decreased?
Hypehyroidism
Increased estrogen
Increased androgen
Pregnancy
Increase in androgen level is associated with decrease in SHBG synthesis. Other factors leading to decreased SHBG synthesis are: Obesity Hypothyroidism Excess glucocoicoids Also know: Factors leading to increased SHBG synthesis are: Estrogen Pregnancy Hypehyroidism Ref: Endocrine Pathophysiology, Second Edition By C. B. Niewoehner, page 285