Which of the following is the drug of choice for the treatment of inappropriate anti-diuretic hormone secretion:
Frusemide
Hydrochlorothiazide
Spironolactone
Demeclocycline
Answer is D (Demeclocycline): The treatment of choice for S1APH is water restriction. The drug of choice for SIAPH (when water restriction is unsuccessful is demeclocycline). Demeclocycline (a tetracycline) acts as an ADH antagonist.