Resistance to acyclovir is most commonly due to mutation in the viral gene that encodes a protein that
Conves viral RNA into DNA
Phosphorylates acyclovir
Transpos acyclovir into the cell
Transpos acyclovir out of the cell
Ref-KDT 6/e p768 Nucleoside/tide analogues act by conveing to NTPs. First phosphorylation step occurs inside the virus and resistance occurs if there is mutation in this gene
Other topics and Adverse effects