All of the following statements about immunosuppressants are true EXCEPT :
Sirolimus acts by inhibiting the action of IL–2
Tacrolimus inhibits calcineurin pathway
Mycophenolate acts by inhibiting GMP dehydrogenase
Cyclosporine is an integeral component of transplant rejection regimen
Mycophenolate mofetil acts by blocking IMP dehydrogenase.
Cyclosporine and tacrolimus are calcineurin inhibitors that act by decreasing the transcription of IL-2 gene. Cyclo­sporine is commonly used to prevent rejection in transplant recipients.
Sirolimus acts by inhibiting mTOR (a tyrosine kinase) that is the target of IL-2.