All of the following statements about amlodipine are true except:
It acts by conversion to an active metabolite in the liver
It has a very large volume of distribution
It undergoes very little first pass metabolism and possesses high and consistent oral bioavailability
It has a very long elimination half life
(Ref: KDT 6/e p531) Amlodipine is the longest acting DHP. It undergoes little first pass metabolism and is distributed widely. metabolites of amlodipine are inactive.
Other topics and Adverse effects