Congenital 17-hydroxylase deficiency leads to hypeension due to accumulation of?
Deoxycoicosterone
Coisol
17 hydroxy pregnediol
17 hydroxy progesterone
* Two forms of adrenal hyperplasia (ie, 11-hydroxylase and 17-hydroxylase deficiency) result in hypeension due to the accumulation of supraphysiologic concentrations of deoxycoicosterone. * This weak mineralocoicoid has little consequence at physiologic concentrations but causes sodium retention and hypeension at the supraphysiologic concentrations that occur in these conditions.
Disorders of Adrenal Gland