Nicotinic acid -
Increases HDL
Increased triglyceride synthesis
Type II hyperlipoproteinemia
Decreased hydrolysis of VLDL
Ans. is 'a1 i.e., Increases HDL Nicotinic acid (Niacin)o There are three main type of lipases related to metabolism of lipoproteins -1. Lipoprotein lipase - Present in blood vessels and causes hydrolysis of tryglvceride content of VLDL and chylomicrones.2. Hepatic lipase - Converts IDL to LDL by hydrolysing the triglyceride content of IDL,Hormone sensitive lipase - Present intraceliularly in peripheral tissue and causes intracellular lipolysis by hydrolysing triglycerides.o Niacin (Nicotinic acid) inhibits intracellular lipolysis by inhibiting hormone sensitive lipase - |- intracellular FFA to liver -| triglyceride synthesis.o Niacin also increases the activity of lipoprotein lipase - | hydrolysis of VLDL triglyceride.o Nicotinic acid also reduces the production of VLDL in liver by inhibiting TG-synthesis - indirectly the VLDL degradation products IDL and LDL are also reduced,o Nicotinic acid is the most effective drug to raise HDL-CH.o Increased HDL is due to interference of direct pathway of HDL cholesterol to liver which involves apo-Al - Niacin decreases apo-A1 mediated hepatic clearance,o Nicotinic acid is used in type I, III, IV & V hyperlipoproteinemias.
Hypolipidemic