All the following are premalignant lesions except
Extramammary Paget's disease
Giant congenital pigmented naevus
Dysplastic naevus
Salmon patch
Extramammary Paget's disease (intraepidermal adenocarcinoma)This occurs in cutaneous sites rich in apocrine glands such as the axillae, genital and perianal regions. Approximately 25% are associated with an underlying in situ or invasive adenocarcinoma.Giant congenital pigmented naevus (GCPN) or giant hairy naevusIt is a hamaoma of naevo - melanocytes that has a tendency to dermatomal distribution. It has a similar histology to compound naevi, but the naevus cells are distributed variably from the epidermis throughout all layers and into the subdermal fat and muscle. GCPNs are precursors of melanoma, a 3-5% lifetime risk of melanoma is quoted.Atypical (dysplastic) naevusTo be 'atypical naevi', lesions must have three of the following characteristics: variegated pigmentation; ill-defined borders; undulating irregular surfaces; or measure >5 mm. They can be sporadic or familial (familial atypical multiple mole melanoma (FAMMM) syndrome).Possession of more than five confers a relative risk of melanoma six times greater than usual; within FAMM syndrome, they confer a life-long 10% risk of MM.Ref: Bailey and Love, 27e, page: 603
General surgery