Prenatal diagnosis of Hemophilia is best done by:
PCR
Linkage analysis
Cytometry
Microarray
PCR is used in prenatal diagnosis of hemophilia. All direct testing methods are dependent on PCR, so it is the best test for the detection of this disease. Ref: Textbook of Hemophilia By Christine A. Lee, Erik E. Berntorp, W. Keith Hoots, Page 39; Molecular Diagnosis of Genetic Diseases By Rob Elles, Roger Mountford, Page 347; Wintrobe's Atlas of Clinical Hematology By Douglas C. Tkachuk, Jan V. Hirschmann, Page 213.