Which anti-tubercular drug combination is safer in a patient who develops hepatitis while on ATT?
Streptomycin + Isoniazid
Streptomycin + Ethambutol
Ethambutol + Isoniazid
Ethambutol + Rifampicin
Streptomycin and Ethambutol are the only antitubercular drugs which have no hepatotoxicity thus are safer in a patient who develops hepatitis while on ATT as they dont have hepatic metabolism and are excreted by kidneys only. IMPOANT POINTS ABOUT FIRST LINE ATT: Drug Action Hepatotoxic Bacteria Inhibited Isoniazid CIDAL Yes Both Rifampicin CIDAL Yes Both Pyrazinamide CIDAL Yes Intracellular Ethambutol STATIC No Both Streptomycin CIDAL No Extracellular
Mycobacterial Diseases (TB, Leprosy and MAC)