Which of the following about tobacco and oral cancer are true? i. MC histological type - adenocarcinoma ii. Dose-response relationship iii. Synergistic interaction with alcohol iv. Associated with mutations in p53 gene. No association with smokeless tobacco
i, ii, iii, iv
ii, iii, iv
ii, iii
i, iii, iv,
Risk Factors for CA Oral Cavity- Tobacco- Alcohol- Betelnut/ Areca nut- Pan Masala- Sharp Jagged tooth- Plummer Vinson syndrome- Ill-fitting denture- Syphilitic glossitis- HPV infections- EBV- Poor nutrition Impoant points of carcinoma of oral cavity:- MC mutation: In CA oral cavity - P53- MC site of CA Oral cavity - Tongue > lip- MC histological type - SCC- MC type of cancer in India - CA oral cavity (Buccal Mucosa > Anterior Tongue> LowerAlveolus)- MC pattern of spread - local extension and regional lymphatic spread- MC site of LN metastasis - lungs- MC lymph node metastasis - CA Tongue- Least common lymph node metastasis - CA lip (CA Hard Palate)- B/L lymphatic spread* lower lip* Supraglottis* Soft Palate- IOC for Dx - Edge Biopsy (Not from centre to avoid taking sample from necrotic areas)- IOC for staging of Head and Neck Malignancies including CA Oral Cavity - MRI- MC flap used for Head & Neck reconstruction - PMMC flap (Pectoralis major myocutaneousflap) - Based on Pectoral branch of Thoraco-Acromial vesselsSkin andvermillion
Oral cavity