Spironolactone should not be given with -
Chlorothiazide
b-blocker
ACE inhibitors
Amlodipine
Ans. is 'c' i.e., ACE inhibitors o Spironolactone is a potassium sparing diuretic, therefore, it can cause hyperkalemia decreasing the potassium diuresis.o ACE inhibitors can also cause hyperkalemia by inhibiting the production of angiotensin I, an inmmediate precursor of angiotensin II. Angiotensin causes excretion of K+ by increasing the secretion of aldosterone (Normally aldosterone enhances absortion of Na+ in distal tubules in exhange of active secretion of K+).o ACE inhibitors decrease potassium excretion by inhibiting the generation of Angiotensin.o Therefore, More pronoundced hyperkalemia can occur in patients receiving ACE inhibitors with sprironolactone
ACE Inhibitors