Low Vd means
The drug has low half life
The drug does not accumulate in tissues
The drug has low bioavailability
The drug has weak plasma protein binding
The volume of distribution (V) relates the amount of drug in the body to the concentration of drug (C) in blood or plasmaVd = amount of drug in body/concentration of drug (C)Drugs with low volumes of distribution have much lower concentrations in extravascular tissue than in the vascular compament.Katzung Pharmacology 12th edition Pg: 38
General pharmacology