A 6-year-old boy presents with acute abdomen and nonhealing ulcer on medial malleolus. Peripheral smear is shown. The most likely cause of this condition is?
Trinucleotide repeat
Antibody to RBC membrane
Substitution of single amino acid base
Genomic imprinting
Ref: Robbins, 8th ed. pg. 645-647Point mutation in 6th codon of b-globin that leads to replacement of glutamate by valine residue.
Blood