Aspirin irreversibly inhibits the following enzyme in the formation of eicosanoids:
Lipoxygenase
Cyclooxygenase
Phospholipase-A2
Peroxidase
Ans. B. CyclooxygenaseCyclooxygenase is required for the synthesis of prostaglandins by arachidonic acid. Aspirin, indomethacin, brufen, phenyl butazone and other NSAIDS inhibits COX (Cyclooxygenase). Aspirin inhibits COX of both PGHS-1 and PGHS-2 by acetylation
Enzymes