Which of the following are slow reacting substances of anaphylaxis?
LTB4 and C4
LT A4 and B4
LT A4 and C4
LT C4 and D4
Answer- D. LT C4 and D4Slow-reactine substance of anaohvlaxis (SRS-A)A mixture of the leukotrienes LTC4, LDD4 and LTE4 are called slow reacting substances of anaphylaxis (SRS-A).These are the most potent mediators causing bronchospasm.They are produced lipoxygenase pathway (LOX pathway) of arachidonic acid metabolism during inflammation.