All of the following are true about Sickle cell disease, Except:
Single nucleotide change results in change of Glutamine to Valine
RFLP results from a single base change
'Sticky patch' is generated as a result of replacement of a non polar residue with a polar residue
HbS confers resistance against malaria in heterozygotes
C i.e. 'Sticky patch' is generated as a result of replacement of a non polar residue with a polar residueIn sickle cell anemia- Glutamic acid is replaced by valine at sixth position in /3 - globin chainQ.Sticky patch is generated as a result of replacement of polar residue (negatively charged glutamate amino acid) with a nonpolar hydrophobic residue (valine)Q. This change makes HbS (sickle cell hemoglobin) less soluble, when deoxygenated and cause sicklingQ.HbS confers resistance against malaria in heterozygotesQ.