All of the following are advantages of transdermal drug delivery systems EXCEPT:
They produce high peak plasma concentration of the drug
They produce smooth and nonfluctuating plasma concentration of the drug
They minimize inter-individual variations in the achieved plasma drug concentration
They avoid hepatic first pass metabolism of the drug
Transdermal route is employed for highly lipid soluble drugs that can traverse intact skin. The size of the pores in transdermal patch is adjusted to produce a uniform and smooth absorption of the drug. This will thus, produce a delayed and smaller peak in the plasma concentration. As the drug is going directly in the bloodstream, first pass metabolism is avoided. Eg : Transdermal patch- Rotigotine is used in Parkinson disease
Pharmacokinetics