All are TRUE about CA breast, EXCEPT -
Affected sibling is a risk factor
Paget's disease of nipple is intraductal type of CA
Common in aged nulliparous
Increased incidence with prolonged breast feeding
Ans. is 'd' i.e., Increased incidence with prolonged breast feeding Prolonged breast feeding has a protective effect. Earlier it was controversial whether breast feeding had any beneficial effect or not. But many trials have now proved that longer durations of breast feeding have a protective effect. [Ref: Robbins 8/e p1077(7/e, p 1132); Cancer of Breast by Donegan & Spratt, 5/e, p 117; Bailey & Love 25/e p837 (24/e, p 835); NMS 4/e, p 449; Washington Manual of Surgery 4/e, p 525; Schwaz 8/e, p 466J Paget's disease of nipple -Paget's disease of the breast is a superficial manifestation of an underlying breast carcinoma. The underlying breast carcinoma is intraductal carcinoma. - it presents clinically as a chronic eczematous eruption of nipple, which may be subtle but may progress to an ulcerated, weeping lesion. - Paget's disease usually is associated with extensive DCIS and may be associated with an invasive cancer." The carcinoma may or may not be palpable. - Pathognomonic histological feature is presence of Paget's cells in the epithelium. Paget's cells are large pale vacuolated cells. Treatment is described ahead.