Which of the following mutations in a tumour suppressor agent causes breast carcinoma-
p43
p53
p73
p83
Robbins and Cotran pathologic basis of disease South Asia edition. Breast cancer may be hereditary arising in women with germline mutation in tumour suppressor gene or sporadic. after a cell sustains DNA damage it must undergo cell cycle arrest and either repair its DNA or for by apoptosis by P53 . In its mutated form P53 ceases to act as a protector or as growth suppressor but instead acts like a growth promoter or onco gene..
General pathology