Initiating event of Endotoxic shock
Endothelial injury
Peripheral vasodilata on
Cytokinin action
Decreased pumping of hea
The receptor for the endotoxin in humans is the TLR-4 located on the surface of antigen presenting cells. b. Binding to the receptor activates a cascade of enzymatic reactions which finally leads to the activation of the genes for the proinflammatory cytokines. Ref ganong's review of medical physiology 25e p465
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