Pethidine is pharmacologically different from morphine because it
Causes more sedation
Causes more constipation
Has additional Anticholinergic action
Causes spasm of sphincter of Oddi
Uses of opioids IV morphine Myocardial infarction, Acute pulmonary edema Codeine, Pholcodeine, Dextromethorphan, Noscapine Cough suppressants Loperamide, Diphenoxylate Noninfective diarrhea Morphine Pre-anesthetic medication Pethidine Reduces shivering after anesthesia ( a2 receptor action) Methadone Neuropathic / Cancer pain Methadone Opioid abuse & Opioid rotation treatment (Refer: K. D. Tripathi&;s Essentials of Medical Pharmacology, 7th edition, pg no: 475)
All India exam