Target fibres are characteristicaly seen in a muscle biopsy of-
Dermatomyositis
Motor neuron disease
Myaesthenia gravis
Drug induced myopathy
Ans. is 'b' i.e., Motor neuron disease Target fibers During denervation atrophy there is cytoskeletal reorganization of some muscle cells, which results in a rounded zone of disorganized filaments in the center of the fiber (target fiber). o Amongst the given options only motor neuron disease can result in denervation of the muscle