The citric acid cycle is inhibited by which of the following?
Fluoroacetate
Fluorouracil
Arsenic
Aerobic conditions
Fluoroacetate can be conveed to fluorocitrate, which is an inhibitor of aconitase. Arsenic is not a direct inhibitor, but arsenite is an inhibitor of lipoic acid-containing enzymes such as a-ketoglutarate dehydrogenase. Malonate, not malic acid, is an inhibitor of succinate dehydrogenase. The citric acid cycle requires oxygen and would be inhibited by anaerobic, not aerobic, conditions. Fluorouracil is a suicide inhibitor of thymidylate synthase and blocks deoxythymidylate synthesis. Ref: Bender D.A., Mayes P.A. (2011). Chapter 17. The Citric Acid Cycle: The Catabolism of Acetyl-CoA. In D.A. Bender, K.M. Botham, P.A. Weil, P.J. Kennelly, R.K. Murray, V.W. Rodwell (Eds), Harper's Illustrated Biochemistry, 29e.