Aspirin is contraindicated in-
Fever
Peptic ulcer
Unstable angina
Myalgia
Ans. is 'b' i.e., Peptic ulcer Contraindications of AspirinPeptic ulcero Prostaglandin has cytoprotective function for gastric mucosa by inhibiting acid secretion and promoting secretion of mucus.o Aspirin inhibits synthesis of cytoprotective PG - bleeding & perforation may occur.Children with chicken pox & influenzao Aspirin can cause Reye's syndrome (hepatic encephalopathy),o Acknowledging this aspirin should not be given to children < 12 years, e.g. in JRA.Bleeding tendencieso By its antiplatelet action, aspirin can exacerbate bleeding.Chronic liver diseaseo Long-term therapy with high dose aspirin can cause insidious onset hepatic injury.PrecautionsIn CHF & low cardiac reserve patientso Aspirin reduces renal blood flow by inhibiting synthesis of vasodilator PGs -fluid & salt retention - worsening of CHF and renal failure may occur.Aspirin should be stopped 1 week before elective surgery so that platelet function becomes normal.In G-6-PD deficiencyo High doses can cause hemolysis.In diabeticso Aspirin causes increased utilization of glucose by increasing cellular metabolism, especially in skeletal muscle, due to uncoupling of oxidative phosphorylation - blood sugar may decrease and liver glycogen may be depleted, especially in diabitics - dangerous hypoglycemia may occur.
Adverse Drug Effect