Which of the following is an effect of dinitrophenol on oxidative phosphorylation?
Inhibition of cytochrome b
Blockade of both electron transpo transpo and ATP synthesis
Inhibition of ATP synthesis with normal electron transpo
Inhibition of electron transpo but not ATP synthesis
Mechanism of Action of DNP as uncoupler Dinitrophenol (DNP) a potent uncoupler is amphipathic and increase the permeability of the lipoid inner mitochondrial membrane to protons (H+), thus reducing the electrochemical potential and sho-circuiting the ATP synthase. In this way, oxidation can proceed without phosphorylation. Note: DNP was used for weight loss. But it was discontinued due to hypehermia and other side effects. Inhibitors of electron transpo chain and oxidative phosphorylationRef: MN Chatterjea Textbook of Medical Biochemistry, 8th Edition, Page no: 146
Respiratory chain