Danazol used in the treatment of endometriosis causes which of the following changes within the endometrium and endometriosis tissue?
Aplasia
Atrophy
Hyperplasia
Neoplasia
Danazol Isoxazole derivative of 17 - alpha ethinyl testosterone propeies Causes atrophy of endometrium It is strictly antigonadotropin but acts as an androgen agonist Mode of action Acting on the hypothalamo - pituitary - gonadal axis - depression of frequency of GnRh pulses - suppression of pituitary FSH and LH surge. There is however no change in the basal gonadotropin level Indication of danazol Endometriosis DUB Symptomatic fibroid Precocious pubey
Endometriosis & H