A 45-year-old man has hypeension. A thiazide diuretic agent had been prescribed with continued elevated blood pressure. The inclusion of spironolactone to the thiazide diuretic is done to achieve wof
Reduce hyperuricemia
Reduce Mg + loss
Reduce K + loss
Decrease the loss of Na +
Potassium sparing diuretics Spironolactone,eplerenone and amiloride but not triamterene themselves lower BP slightly. However, they are used only in conjunction with a thiazide diuretic to prevent K+ loss and to augment the anti- hypeensive action. Spironolactone side effects Include gynaecomastia, impotence, menstrual irregularities. This problem has been offset in the newer aldosterone antagonist eplerenone. Ref:- kd tripathi; pg num:-561
Cardiovascular system