A 5-day-old term male neonate presents with delayed passage of meconium, abdominal distension and bilious vomiting. Barium enema and intestinal biopsy findings are shown below: What is the diagnosis?
Congenital aganglionic megacolon
Hyperophic pyloric stenosis
Cystic fibrosis
Intestinal malrotation
1st picture shows narrow distal segment with dilated proximal segment of intestine in Ba enema. 2nd picture shows hyperophied nerve bundles between muscular layer & submucosa and enteric nerve plexuses lacking ganglion cells in H&E stain. Both the above findings are suggestive of Hirschsprung disease (Congenital aganglionic megacolon)
Disorders of Gastrointestinal System Including Diarrhea