Oxygen-hemoglobin dissociation curve shifted to Right side in all EXCEPT
Fresh blood transfusion
Anemia
Acidosis
Alkalosis
(Alkalosis) (667 - Ganong 22nd) (611- Ganong 23rd)* Alkalosis - (Decrease in H1 concentration and increase in pH) shift oxygen dissociation curve left sideRight sided shift of oxygen- hemoglobin dissociation curve1. Increased CO2 concentration2. Increased temperature (Hyperthermia)3. Increase 2-3 DPG is a by product in EMP pathway of carbohydrates metabolism. It is present in RBC, in condition like muscular exercise and in high altitude, the DPG increased in RBC, so the oxygen - hemoglobin dissociation curve shifts to right to a great extent4. Decrease in partial pressure of oxygen5. Increase in hydrogen ion concentration and decrease in pH (Acidosis)6. In Anemia, curve shifted to right sideLeft sided shift of oxygen - hemoglobin dissociation curve1. In fetal blood** because fetal hemoglobin has got more affinity for oxygen than the adult hemoglobin.2. Decrease in H+ concentration and increase in pH (Alkalosis)3. Hypothermia4. Blood transfusion - In stored blood*, the 2, 3, DPG levels falls and the ability of this to release O2 to the tissue is reduced, this leads to curve shifted to left side
Respiratory System