Mechanism of action in pathogenesis of Pseudomembranous colitis by CI difficle ?
Due to invasiveness
Due to endotoxin
Due to exotoxin
Due to NM blockade
Ans. is 'c' i.e., Due to exotoxin Pathogenesis of pseudomembranous colitis is due to production of two large toxins by C. difficile : i) Toxin A (an enterotoxin) Is a potent neutrophil chemoattractant Causes disruption of cell cytoskeleton by glycosylation of GTP - binding proteins that regulate the actin cell cytoskeleton. ii) Toxin B (a cytotoxin) Causes disruption of cell cytoskeleton by similar mechanism.