Action of metalloproteinase ?
Degradation of collagen
Polymerization of collagen
Oxidation of collagen
Stimulation of collagen
Ans. is 'a' i.e., Degradation of collagenDegradation of collagen and other ECM (extracellular matrix) proteins is achieved by matrix metalloproteinases (MMPs).MMPs is a family of enzymes that have in common a 180-residue zinc protease domain.Matrix metalloproteinases include :-Interstitial collagenase (MMP-1, 2, and 3) : Cleave the fibrillar collagen types I, II and III.Gelatinases (MMP-2 and 9) : Degrade amorphous collagen and fibronectin.Stromelysins (MMP-3, 10 and 11) : Act on proteoglycans, laminin, fibronectin and amorphous collagen.Membrane-bound MMPs (ADAMs) : Cleave membrane-bound precursor forms of TNF and TGF-a, releasing the active molecule.