A 45-year-old woman presents to her primary care physician with jaundice, pruritus, and periocular and intra digital xanthomas. Her laboratory results indicate a significantly increased alkaline phosphatase as well as a positive test for antimitochondrial antibodies. The most likely cause of her symptoms is
Leptospirosis
Macronodular cirrhosis.
Primary biliary cirrhosis.
Primary sclerosing cholangitis
Primary biliary cirrhosis Autoimmune condition that typically presents in middle-aged women and with anti-mitochondrial antibodies. The itching and hypercholesterolemia are secondary to severe obstructive jaundice. Leptospirosis is a condition caused by a treponemal bacterium that results in jaundice, renal failure, Macronodular cirrhosis is usually a result of hepatitis B or hepatitis C infection. Primary sclerosing cholangitis is associated with ulcerative colitis and with an increased incidence of cholangiocarcinoma.
Hepatitis