Isotretinoin is:
All trans retinoic acid
All cis retinoic acid
13 trans retinoic acid
13 cis retinoic acid
Isotretinoin is a synthetic retinoid i.e. 13 cis retinoic acid uses:- Acne vulgaris Oral leukoplakia Pityriasis rubra pilaris Side effects:- Alopecia Tendon rupture/tendinitis Elevation of Lipoprotein (a) Teratogenicity. All-trans retinoic acid is involved in cell differentiation. All-trans retinoic acid binds to nuclear receptors (retinoic acid receptors). The activated retinoic acid-receptor complex interacts with response elements on the DNA and regulates the transcription of specific genes in different tissues. Ex: Control of expression of keratin gene in epithelial tissues. NOTE: All-trans retinoic acid (ATRA) is used in the treatment of acute promyelocytic leukemia.
Vitamins and Minerals