A 15-year-old boy presented with 1 day history of bleeding gums, subconjunctival bleed and purpuric rash. Investigations revealed: Hb 6.4 gm/dL; TLC-26,500/mm3; prothrombin time-20 sec with a control of 13 sec; partial thromboplastin time-50 sec; and fibrinogen 10 mg/dL. Peripheral smear was suggestive of acute myeloblastic leukemia. Which of the following is the most likely?
Myeloblastic leukemia without maturation
Myeloblastic leukemia with maturation
Promyelocytic leukemia
Myelomonocytic leukemia
c. Promyelocytic leukemia(Ref: Nelson's 20/e p 2442-2443, Ghai 8/e p 605-607)This patient has complaints of bleeding along with thrombocytopenia, decreased fibrinogen & increased PT & APTT. This is consistent with DIC; DIC is most commonly seen with M3 AML
C.V.S.