Which of the following drugs have high plasma protein binding to serum albumin?
Lignocaine
Warfarin
Quinidine
All of the above
Acidic drugs bind to albumin and basic drugs bind to alpha 1 acid glycoprotein. Drugs ending with 'ine' are basic drugs. So, lignocaine and quinidine bind to alpha 1 acid glycoprotein whereas warfarin binds to albumin. High albumin bound drugs High alpha 1 glycoprotein CNS- Barbiturates, BZD, Phenytoin, Valproate,lorazepam Anti-arrhythmic drugs-lignocaine, verapamil, beta blockers, quinidine Antibiotics-Penicillin, tetracycline, naproxen,sulfonamide Warfarin, NSAIDs,ceftriaxone CNS- opioids, TCA significanty decrease with disease & malnutrition increases in disease (chronic inflammatory disorders, malignancy) doesnot significantly decrease with healthy aging no effect seen with healthy aging
Hematology