Regarding POEMS syndrome, which of the following are true or false? a) Organomegaly is described as a feature but rare in POEMS syndrome b) Patients usually have a severe, progressive sensorimotor polyneuropathy c) Type 2 diabetes mellitus occurs in about one-third of patients d) Amenorrhea in women and impotence and gynecomastia in men is seen e) The lymphadenopathy although rare, resembles Castleman's disease histologically
b,c,d,e-True a-False
c,d,e-True a,b-False
a,e-True b,c,d-False
a,b,e-True c,d-False
Polyneuropathy, Organomegaly, Endocrinopathy, Multiple myeloma, and Skin changes (POEMS). Patients usually have a severe, progressive sensorimotor polyneuropathy associated with sclerotic bone lesions from myeloma. Unlike typical myeloma, hepatomegaly and lymphadenopathy occur in about two-thirds of patients, and splenomegaly is seen in one-third. The lymphadenopathy frequently resembles Castleman's disease histologically, a condition that has been linked to IL-6 overproduction. The endocrine manifestations include amenorrhea in women and impotence and gynecomastia in men. Type 2 diabetes mellitus occurs in about one-third of patients. Ref: Harrisons Principles of Internal Medicine, 18th Edition, Page 943