Most effective HDL raising drug is:
Omega three fatty acids
Niacin
Fenofibrate
Rosuvastatin
Niacin is the most effective HDL raising drug currently available. Niacin is the only drug currently available that lowers Lipoproteinp(a), and can be considered as an addition to a statin in patient with elevated Lp(a). Statins have a modest HDL-raising effect (5-10%). Fibrates are the most effective drugs available for reducing triglyceride levels and also raise HDL-C levels modestly. Omega three fatty acids are also effective in raise HDL level. Ref: Harrisons principles of internal medicine, 18th edition, Page: 3161