Extracellular adenosine is increased by which of the following DMARDs?
Leflunomide
Sulphasalazine
Methotrexate
Hydroxychloroquine
Methotrexate: Methotrexate inhibits an enzyme 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase leading to accumulation of AICAR, which blocks adenosine deaminase. Thus adenosine accumulates and it decreases inflammation by acting on adenosine receptors.
NSAIDs, Gout and Rheumatoid Ahritis