Leber's optic neuropathy-
Typically presents in the fourth decade of life
Males do not transmit the disease
Is inherited in autosomal X-link fashion
The optic disc is pale early in the disease
Leber's hereditary optic neuropathy is a mitochondrial disorder. Since mitochondrial DNA is exclusively derived from mothers, males do not transmit the disease.
The optic disc becomes pale and atrophic in late atrophic phase (not early).