Anti-TNF alpha drugs are used for the treatment of all of following diseases except -
Systemic lupus erythematosis
Seronegative arthritis
Psoriatic arthritis
Crohn's disease
Ans. is 'a' i.e., Systemic lupus erythematosis The major defect in systemic lupus erythematosis is under expression of TNFa, therefore anti TNF-a have no role in their managementAnti TNF-a drugs may be used in inflammatory bowel disease, arthritis and vasculitis as these diseases are caused by overexpression ofTumour necrosis factor (TNF-a).Use of anti TNF-a have been approved by FDA in these cases.Anti TNF-a drugs *Infliximab - FDA approved for RA and Crohn's diseaseAdalimumab - FDA approved for Rheumatoid arthritisEtanercept - FDA approved for Rheumatoid arthritis, juvenile rheumatoid arthritis and psoriasis.
SLE