Peripheral neuritis induced by isoniazid is prevented by giving which vitamin along with it?
Vitamin B1
Vitamin B6
Vitamin B3
Vitamin B12
Ans. is 'b' i.e., Vitamin B6 Isoniazid induced peripheral neuritis/ neuropathy* Peripheral neuritis is a well documented adverse effect of INH, which is also the most important dose dependant toxic effect.* Peripheral neuropathy is observed in 10 to 20% of patients given dosages greater than 5 mg/kg/d, but it is infrequently seen with the standard 300-mg adult dose.* Peripheral neuropathy is more likely to occur in slow acetylators and patients with predisposing conditions such as malnutrition, alcoholism, diabetes, AIDS, and uremia.* Neuropathy is due to a relative pyridoxine deficiency. It is due to interference with production of active co - enzyme PLP (Pyridoxal phosphate) from pyridoxine.* It is readily reversed by administration of pyridoxine in a dosage as low as 10 mg/d.
Anti Microbial