A middle aged old man, with chronic renal failure is diagnosed to have sputum-positive pulmonary tuberculosis. His creatinine clearance is 25ml/min. All of the following drugs need modification in doses except:
Isoniazide
Streptomycin
Rifampicin
Ethambutol
Ans. is 'c' i.e. Rifampicin This question has been repeated several times. Its advised to go through tables in C.M.D.T. and in Harrison mentioned above in Ref.More question related to this topic.Most nephrotoxic cephalosporin - cephaloridine*Most nephrotoxic aminoglycoside - Gentamycin*Least nephrotoxic aminoglycoside - Tobramycin*Only tetracycline safe in Renal failure- Doxycycline*Least nephrotoxic antitubercular - Rifampicin*
Anti-Tuberculosis