Carbimazole as compared to propylthiouracil:
Is less potent
Is shoer acting
Does not produce an active metabolite
Does not inhibit peripheral conversion of T4 to T3
(Ref: KDT 6/e p250) Carbimazole Propylthiouracil Produces an active metabolite, methimazole No active metabolite Less plasma protein binding (PPB) More PPB Crosses placenta Does not cross placenta More potent Less potent Does not inhibit 5'-deiodinase Inhibits 5'-deiodinase
Other topics and Adverse effects