Macrophages with abundant cytoplasm containing dusty brown pigment are seen in
Desquamative Interstitial Pneumonia
Pulmonary Alveolar Proteinosis
Pulmonary Langerhans Cell Histiocytosis
Pulmonary Eosinophilia
Desquamative interstitial pneumonia is characterized by large collections of macrophages in the airspaces in a current or former smoker. The macrophages were originally thought to be desquamated pneumocytes, thus the misnomer "desquamative interstitial pneumonia."The most striking finding is the accumulation of a large number of macrophages with abundant cytoplasm containing dusty brown pigment (smokers' macrophages) in the airspaces.Ref: Robbins and Cotran Pathologic basis of DIsease; 9th edition; Chapter 15; The lung; Change 682
Respiratory system