HPV-related cervical intraepithelial neoplasia can be diagnosed by the presence of which of the following histologic features?(NOT RELATED-PATHOLOGY)
Central, basophilic intranuclear cellular inclusions
Cowdry type A intranuclear cellular inclusions
Enlarged multinucleated cells
Cytoplasmic vacuolization and nuclear enlargement of cells
HPV produces characteristic cytoplasmic vacuolization and nuclear enlargement of squamous epithelial cells referred to as koilocytosis. Both Cowdry type A intranuclear inclusions and enlarged multinucleated cells can be seen with herpes simplex virus (HSV) and varicella-zoster virus (VZV) infections; central, basophilic intranuclear inclusion bodies are seen in CMV infections, whereas the presence of atypical lymphocytes is seen specifically in Epstein-Barr virus (EBV) infections.
All India exam