All of the following statements about vinristine are true EXCEPT:
It acts by inhibiting mitosis
Its prominent adverse effect is peripheral neuropathy
It does not suppress bone marrow
It is a drug of choice for solid tumors.
(Ref: KDT 6/e p824, 825) Vincristine is a vinca alkaloid. It acts in M-phase of cell cycle by inhibiting the formation of spindle. It is a marrow sparing drug and causes peripheral neuropathy as a prominent adverse effect. It is used for the treatment of hematological malignancies like Hodgkin's lymphoma and leukemias. It is ineffective against solid tumors.
Other topics and Adverse effects