The tubuloglomerular feedback is mediated by:
Sensing of Na+ concentration in the macula densa
Sensing of Cl+ concentration in macula densa
Sensing NaCl concentration in the macula densa
Opening up of voltage gated Na+ channels in afferent aeriole
C i.e. Sensing NaC1 concentration in the macula densa'To perform the function of auto regulation, the kidneys have a feed back mechanism (tubuloglomerular feed back) that links changes in sodium chloride concentration at the macula densa (tubular component) with the control of renal aeriolar resistance. (glomerular component).