All the following effects are produced by inhibitors of prostaglandin synthesis except
Prolongation of bleeding time
Prolongation of prothrombin time
Prolongation of labour
Gastric mucosal damage
(Ref:. KDT 6/e p186) Prothrombin time is increased by the drugs interfering with the coagulation pathway (e.g. warfarin). As cox has no role in coagulation, inhibitors,of PG svnthesis do not prolong PI. However, bleeding time (BT) is prolonged by the drugs interfering with platelet function. Aspirin increases,.BT by acting as an antiplatelet agent.
Other topics and Adverse effects