On follow up study, elevated CA 125 in a case of epithelial ovarian tumour should be fuher evaluated with
MRI
CT Scan
Yearly follow up
Clinical examination and serial CA 125 monitoring
CT Scan Evaluation of patients with suspected ovarian cancer should include measurement of serum levels of the tumour marker CA-125. CA-125 determinants are glycoproteins with molecular masses from 220 to 1000 kDa, and a radioimmunoassay is used to determine circulating CA-125 antigen levels. Between 80 and 85% of patients with epithelial ovarian cancer have levels of CA-125 _ 35 U/mL. Other malignant tumours can also elevate CA-125 levels, including cancers of the endometrium, cervix, fallopian tubes, pancreas, breast, lung, and colon. Ceain nonmalignant conditions that can produce moderate elevations of CA-125 levels include pregnancy, endometriosis, pelvic inflammatory disease, and uterine fibroids. About 1% of normal females have serum CA-125 levels _35 U/mL.
All India exam