Which finding on electron microscopy indicates irreversible cell injury?
Dilatation of endoplasmic reticulum
Dissociation of ribosomes from rough endoplasmic reticulum
Large amorphous densities in the mitochondria
Myelin figures becomes sparse
IRREVERSIBLE INJURYCytoplasmic changes:1. Cells appear glassy and homogeneous mostly because of loss of glycogen molecules. 2. Myelin figures become more prominent 3. Cytoplasm becomes vacuolated and appears "moth-eaten".By electron microscopy1. Discontinuity in plasma and organelle membrane.2. Marked dilatation of mitochondria with an appearance of large amorphous densities.3.Disruption of lysosomes. 4.Intracytoplasmic myelin figures. Nuclear changes: -Karyolysis: Basophilia of chromatin fade. -Pyknosis: nuclear shrinkage and increased basophilia. -Karyorrhexis: Pyknotic nucleus undergo fragmentation. {Reference: Robbins basic pathology 9Edition pg: 5}
General pathology