The therapeutic efficacy of antihypeensive drugs is blunted by NSAIDs because of :
Cause sodium excretion
Increase in the clearance of antihypeensive drugs
Decrease in the absorption of antihypeensive drugs
Decrease in the synthesis of vascular prostacyclin
NSAIDs inhibit Prostaglandin production including PGI2 which causes vasodilatation Ref: KD Tripathi 8th ed
Autacoids