Which of the following is the most likely effect of insulin at the cellular receptor level?
stimulating tyrosine kinase
binding to ion channels
binding to intracellular erb A receptors
stimulating guanylate cyclase
Insulin binding to its receptor stimulates tyrosine kinase activity. Other stimulators of protein kinases include platelet-derived growth factor and epidermal growth factor. Tyrosine phosphorylation results from this interaction. Insulin-resistant states can be caused by pre-receptor resistance (mutated insulin, anti-insulin antibodies) or receptor and post receptor resistance.
Endocrinology