Wilson's disease is characterized by ?
Increased serum ceruloplasmin
Decreased copper excretion in urine
Increased copper in liver
Autosomal dominant
Ans. is 'c' i.e., Increased copper in liver Diagnosis of Wilson disease The gold standard for diagnosis is liver biopsy with quantitative copper assay - concentration of copper in a liver biopsy sample > 200 mg/g dry weight. Other tests are ? Serum ceruloplasmin level - low Urine copper excretion - increased KF rings DNA Haplotype analysis.