Linezolid inhibits bacterial protein synthesis by :
Binds to the 23S fraction of the 30S ribosome at P site
Binds to the 23S fraction of the 50S ribosome at A site
Binds to the 23S fraction of the 30S ribosome at A site
Binds to the 23S fraction of the 50S ribosome at P site
Linezolid : Inhibits bacterial protein synthesis By acting at an early step and a site different from that of other AMAs. Binds to the 23S fraction P site of the 50S ribosome and interferes with formation of the ternary N- formylmethionine-tRNA (tRNAfMet) -70S initiation complex Binding of linezolid distos the tRNA binding site Overlapping both 50S and 30S ribosomal subunits and stops protein synthesis before it stas
Protein Synthesis Inhibitors