What is the line of treatment for intractable Sydenham chorea?
Haloperidol
Valproate
Warfarin
Risperidone
Ans. b. ValproateRef: Inflammatory and Autoimmune Disorders of the Nervous System in Children by Russell; Page No- 130Sydenham chorea remains the most common cause of acute chorea in children world-wide.It has been firmly established that Sydenham chorea is a complex neuropsychiatric condition, encompassing motor, sensory, and behavioural abnormalities.Although Sydenham chorea is an immune-mediated complication of streptococcus infection, details of its pathogenesis remain to beelucidated.Treatment with Valproic acid, neuroleptics, or, in selected cases, corticosteroids, is effective in the majority cases.
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