Antiarrhythmic classification into class1a,1b,1c,2,3,4,5 were given by:
Vaughan Williams
Ramnath chopra
Oswald
David sackett
The Vaughan Williams classification was introduced in 1970 by Miles Vaughan Williams. five main classes in the Vaughan Williams classification of antiarrhythmic agents are: Class I agents interfere with the sodium (Na+) channel. Class II agents are anti-sympathetic nervous system agents. Most agents in this class are beta blockers. Class III agents affect potassium (K+) efflux. Class IV agents affect calcium channels and the AV node. Class V agents work by other or unknown mechanisms. Vaughan Williams, EM (1970) Classification of antiarrhythmic drugs. In Symposium on Cardiac Arrhythmias (Eds. Sandoe E, Flensted- Jensen E, Olsen KH). Astra, Elsinore. Denmark (1970) Ref: Tripati 8th ed.
Cardiovascular system