Which of the following statements about anti-epileptics is false?
Phenytoin and carbamazepine act by prolonging the inactivated state of Na+ channels
Carbamazepine can be used in trigeminal neuralgias
Diazepam is an anticonvulsant drug
Lamotrigine mainly acts by causing GABA mediated Cl- channel opening
prolongation of Na+ channel inactivation and suppression of high frequency firing has been demonstrated. In addition, it may directly block voltage sensitive Na+ channels, thus stabilizing the presynaptic membrane and preventing release of excitatory neurotransmitters, mainly glutamate and aspaate. Ref KD Tripati 8thh ed.
Central Nervous system