True regarding Sjogren's syndrome are all of the following except:
Autoimmune condition
Males are commonly affected
Progressive destruction of lacrimal and salivary gland
No single laboratory investigation is pathognomonic
Ans. (b) Males are commonly affectedRef: Bailey 261e p737Sjogren's Syndrome:* Most common in women* Chronic disease characterized by dry eyes, dry mouth (xerostomia) due to immunological destruction of Lacrimal and Salivary glands* Rheumatoid arthritis is commonly associated.* Characterized by lymphocytic infiltration of salivary and lacrimal glands.* Antibodies - SS-A and SS-B are seen in 90%* Parotid enlargement is seen in >50% cases* Lip biopsy is used to diagnose this syndrome (by examining minor salivary glands)
Salivary Gland