Thioamide drugs:
Aggregate endocrine exophthalmos.
Are safe in children.
Produce irreversible hypothyroidism.
Do not produce relapse.
Thioamide drugs block the synthesis of thyroid hormones and are safe in children. If hypothyroidism develops, stopping the drug can reverse it. Despite adequate treatment, relapse is seen in 40-60% of the cases. Worsening of ophthalmopathy has been reported with radioactive iodine but not with thioamides.