Which of the following statement is TRUE about iron response element?
Stem loop structure in the messenger RNA
Located at the 5' untranslated region(UTR) of transferrin mRNA
Located at the 3' untranslated region(UTR) of ferritin mRNA
IRE-binding protein causes degradation of IRE
mRNAs of ferritin and tfR 1 contain a stem-loop structure known as Iron Response Element (IRE). IRE of ferritin mRNA is located at its 5' UTR. (Ferritin ->Five) - option c is wrong IRE of transferrin receptor is located at its 3'UTR. (TfR ->Three) - option b s wrong. IRP-IRE interaction prevents the translation of ferritin mRNA. IRP-IRE interaction stabilises the mRNA of transferrin receptor-more intracellular iron absorption.- option d is wrong.
Transcription