Which of the followign drugs require dose adjustment in renal failure?
Cefoperazone
Doxycycline
Streptomycin
Rifampicin
Ans. (C) Streptomycin(Ref: Katzung 10/e p835 KDT 8/e p746)Streptomycin is an aminoglycoside and require dose adjustment in renal failure whereas doxycycline, rifampicin and cefoperazone are secreted in bile and do not require dose adjustment in renal failure.
Chemotherapy: General Principles