Which drug is used for Mvaesthenia Gravis testing-
Edrophonium
Adrenaline
Phycostigmine
Acetylcholine
Ans is 'a' i.e., Edrophonium Diagnosis of myasthenia graviso Myasthenia gravis presents with characteristic clinical featuresSeveral special diagnostic Tests for mysthenia gravisElectrophysiological Testingo Characteristic of myasthenia on electrophysiological testing is rapid reduction in the amplitude of muscle action potentials evoked during a series of repetitive stimulations of a peripheral nerve at a rate of 3 per second (decrementing response)o The traditional and simple method is to stimulate the nerve at 3 Hz and to measure the compound muscle action potential (a decrement of more than 10% when comparing the fifth to the first response is abnormal)Single fibre electromyographyo This is more sensitive but technically more difficult than electrophysiological testingo Confirmatory but not specific, often performed in conjuction.o This technique demonstrates an inconstancy in the firing of fibres connected to the same motor unit or a blocking of successive discharges from single muscle fibre belonging to the same motor unit.Edrophonium and Neostigmine test/Tensilon testo When edrophonium and neostigmine are given intravenously, it produces a transient improvement in strength in patients with myasthenia.o Edrophonium and neostigmine are anticholinesterase so they prolong and exaggerate the effect of acetylcholine in the synapse and therefore provide an increment in muscle power in patient with myasthenia.o Diagnosis is highly sensitive with 85% sensitivity inocular and 95% sensitivity in systemic myaesthenia.Measurement of receptor antibodies in the blood:o Measurement of antiacetylcholine receptor antibodies provides a sensitive and highly specific test for the diagnosis of myasthenia. Presence of Ach antibodies is virtually diagnostic of Myaesthenia graves.o Sensitivity is limited to about 50% in purely occular myasthenia and about 85% in generalized myasthenia.o Definitive if positive but negative test does not rules out the diagnosis.
C.N.S.