Botulinum toxin produces skeletal muscle paralysis by:
Enhancing release of norepinephrine
Inhibiting release of acetylcholine
Direct damage to nerve endings
Producing hemolysis
Ref: KD Tripathi pharmacology 7th edition (page.no: 99) Botulinum toxin A and B are highly potent exotoxins produced by Clostridium botulinum that is responsible for Botulism. These neurotoxic proteins cause long-lasting loss of cholinergic transmission by interacting with an axonal protein involved in the exocytic release of Ach
Autonomic nervous system