All are true regarding Toxoplasmosis, except ?
Subclinical in most cases among adults
Intracerebral calcification in children
IgM antibody in new born suggests congenital infection
NOT infective in 3" trimester in pregnancy
Ans. is d i.e., Not infective in third trimester in pregnancy . The incidence of transplacental infection is highest in third trimester but the infant is not severely affected. . The presence of IgM (which does not cross placenta) in the infants circulation is diagnostic. Clinical manifestation of toxoplasmosis 1. Adults a) Immunocompetant host - Asymptomic in 90% of patients. - M.C. clinical featur is cervical lymphadenopathy. - Other less common manifestations are pneumonia, myocarditis, encephalitis. b) Immunocompromised host - M.C. signs and symptoms are principally within CNS Encephalopathy, Meningoencephalitis. 2. Children a) Congenital - May present with hydrocephalus, microcephaly mental retardation, deafness, blindness, epilepsy. - Intracerebral calcification may occur. b) Acquired - Mostly asymptomatic - C/Fs are chorioretinitis (most common), cataract, glaucoma.