Long standing goitre leads to
Follicular carcinoma
Colloid carcinoma
Medullary carcinoma
Papillary carcinoma
Long standing goitre leads to cancer, usually follicular. Dominant or rapidly growing nodules in longstanding goitres should always be subjected to aspiration cytology. Reference: Bailey & Love's Sho Practice of Surgery, 27th Edition, page no= 807.
Endocrinology and breast