In multiple myeloma following are seen -(
Increase Calcium
Bone pain
Renal failure
All of the above
In multiple myeloma ,hypercalcemia occurs due to destruction of bone. Bone pain is the most common symptom.The pain usually involves the back & ribs. Pathological fracture may occur causing localised pain.Bone pain results from the proliferation of tumour cells in the marrow & activation of osteoclasts which destroy the bone. Renal failure occurs due to hypercalcaemia, glomerular deposits of amyloid,hyperuricaemia, & infiltration of kidney by myeloma cells.Reference:Harsh mohan textbook of pathology sixth edition pg no 383.
Haematology