Use of valproate during pregnancy may result in
Mental retardation
Respiratory depression
Hydantoin syndrome
Neural tube defect
Valproate crosses the placenta and has been repoed to have caused teratogenic effects, including neural tube defects (anencephaly, meningomyelocele, and spina bifida) in the fetus when the mother received valproate during the first trimester of pregnancy.
Fetus