Mechanism of action of teduglutide in sho bowel syndrome:-
GLP-2 analogue
HT la inhibitor
GLP-1 analogs
C- peptic analogs
RCT's have shown that, teduglutide, a GLP-2 analogue (Glucagon like peptide -2) is resistant to degradation by the proteolytic enzyme dipeptidyl peptidase 4 and therefore has a longer half-life than GLP-2. It is well tolerated and has led to the restoration of intestinal functional and structural integrity through intestinotrophic and proabsorptive effects. Sho bowel syndrome: Caused by resection / bypass surgery of small intestine Causes severe diarrhoea and impaired nutrient absorption leading to severe malnutrition Usually appears if length of small intestine < 200 cms Medical management Anti-diarrhoeal agents Cholestyramine Vitamin supplements Mainstay treatment: Teduglutide (GLP -2 analogue)
NEET 2019