MDR TB is defined as-
Resistance to INH and Ethambutol
Resistance to Rifampicin and Ethambutol
Resistance to Pyrazinamide and Rifampicin
Resistance to INH and Rifampicin
Ans. is 'd' i.e., Resistance to INH and Rifampicin Treatment of multidrug resistance (MDR) TBo MDR-TB is defined as resistance to at least both INH and rifampicin. Previously it was classified as Category IV under DOTS (DOTS-PLUS).o The treatment is given in two phases, the intestive phase (IP) and the continuation phase (CP). The total duration of treatment for regimen for MDR-TB is 24-27 months, depending on the IP duration,o Treatment regimen comprises :-Intensive phase (6-9 months) : Six drugs : Kanamycin (Km), levofloxacin (Lvx), ethionamide (Eto), pyrazinamide (Z), ethambuto! (E), and cycloserine (Cs).Continuation phase (18 months): Four drugs : Levofloxaxcin, ethionamide, ethambuto! and cycloserine,o Total duration of treatment is 24-27 months.Treatment of extensive drug resistance (XDR) TBo XDR-TB is defined as resistance to any fluoroquinolone and at least one of the following three second-line drugs (capreomycin, kanamycin, amikacin), in addition to multidrug resistance,o The Regimen for XDR-TB would be of 24-30 months duration, with 6-12 months Intensive Phase (IP) and 18 months Continuation Phase (CP),o Regimen is :-intensive phase (6-12 months) : Seven drugs : Capreomycin, PAS. moxifloxacin, high dose INH, clofazimine, Linezolid, amoxyclav.Continuation phase (18 months) : Six drugs : PAS, moxifloxacin, high dose INH, clofazimine, linezolid, amoxyclav.
Mycobacteria