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Are 3g mesalazine granules superior to 9mg budesonide for achieving remission in active ulcerative colitis : a double-blind , double-dummy , randomised trial?
Once-daily 3g mesalazine administered as granules is superior to 9mg budesonide OD administered as capsules for achieving remission in mild-to-moderately active UC. However, it is noteworthy that remission of UC was attained in about 40% of budesonide-treated patients with a rapid onset of resolution.
Is variation in the ICAM1-ICAM4-ICAM5 locus associated with systemic lupus erythematosus susceptibility in multiple ancestries?
These findings are the first to suggest that an ICAM-integrin-mediated pathway contributes to susceptibility to SLE.
Does a modified embryo cryopreservation method increase post-thaw survival with a concomitant increase in implantation?
Greater post-thaw embryo survival was achieved, with a concomitant increase in implantation and pregnancy rates, by modifying the various steps in the standard cryopreservation methodology. This has important implications in IVF practice.
Are peripheral blood dendritic cell subtypes significantly elevated in subjects with asthma?
This study shows for the first time that subjects with asthma display a large increase in peripheral blood DC proportions. Cigarette smoking in asthma did not affect the peripheral blood DC profile but did suppress pDC proportions in non-asthmatic subjects. Asthma is associated with a significant increase in circulating DCs, reflecting increased endobronchial levels and the importance of DCs to the development and maintenance of asthma. (Clinical trials.gov identifier: NCT00411320)
Does pituitary adenylyl cyclase activating polypeptide inhibit gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures?
Primary tumorspheres derived from ptch1+/-/p53+/- mice exhibit constitutive HH pathway activity. PACAP antagonizes HH signalling in these cells in a manner blocked by the PKA antagonist H89. PACAP and pharmacological activation of PKA also inhibited proliferation. Our data suggests that regulation of HH signaling by PACAP/PKA signaling may provide an alternative to SMO inhibition for the treatment of MB.
Is bulky disease an adverse prognostic factor in patients treated with chemotherapy comprised of cyclophosphamide , doxorubicin , vincristine , and prednisone with or without radiotherapy for aggressive lymphoma?
The independent prognostic factors in the current study suggest that either the M. D. Anderson tumor score system or the IPI can be used to select which aggressive lymphoma patients are at high risk for disease recurrence based on their having more than two adverse factors and who consequently are candidates for more intensive frontline therapy. Involved-field radiotherapy should be considered in those patients with bulky lymphomas.
Do near-normal urinary albumin concentrations predict progression to diabetic nephropathy in Type 1 diabetes mellitus?
Elevation of urinary albumin concentration just above the normal range is associated with an increased risk of developing diabetic nephropathy. Identifying patients with any abnormalities of urinary albumin excretion will provide a clear rationale for early therapeutic interventions.
Does species-specific differential AhR expression protect human neural progenitor cells against developmental neurotoxicity of PAHs?
Our findings suggest that in contrast to wild-type mNPCs, hNPCs were protected against polycyclic aromatic hydrocarbon-induced DNT because of an absence of AhR This difference may contribute to species-specific differences in sensitivity to POPs.
Does follicle stimulating hormone stimulate the production of gonadotrophin surge attenuating factor ( GnSAF ) in vivo?
These results demonstrate that in superovulated women, a marked attenuation in the pituitary response to GnRH occurs as early as 12 hours from a single injection of FSH before any significant increase in serum oestradiol levels. It is suggested that FSH is a potent stimulus of GnSAF production in women.
Does global left atrial strain correlate with CHADS2 risk score in patients with atrial fibrillation?
LA strain is a reproducible marker of dynamic LA function and a predictor of stroke risk and cardiovascular outcomes in patients with AF.
Does cross-talk between Notch and Hedgehog regulate hepatic stellate cell fate in mice?
The Notch and Hedgehog pathways interact to control the fate of key cell types involved in adult liver repair by modulating epithelial-to-mesenchymal-like/mesenchymal-to-epithelial-like transitions.
Is prostacyclin an autocrine regulator in the contraction of oviductal smooth muscle?
Human oviductal smooth muscle produces prostacyclin, which, in turn, decreases its contractility. Prostacyclin may regulate embryo transport.
Do role of autophagy and apoptosis in wound tissue of deep second-degree burn in rats?
A reduction in autophagy and blood flow and an increase in apoptosis and inflammation were observed in burn wounds early during the course of burn injury progression. This suggests that autophagy, complemented by apoptosis, play important roles in burn progression. Enhanced autophagy in the deep dermis may be a prosurvival mechanism against ischemia and inflammation after burn injury.
Is genetic heterogeneity of surgically resected prostate carcinomas and their biopsy specimens related to their histologic differentiation?
Prostate carcinoma is a genetically multicentric carcinoma, and the genetic heterogeneity is well correlated with histologic differentiation. The frequency of LOH events increased according to the degree of tumor progression.
Does coronal 2D MR cholangiography overestimate the length of the right hepatic duct in liver transplantation donors?
Coronal 2D MRC overestimates the RHD in liver donors. We suggest adding axial 2D MRC to conventional coronal 2D MRC in the preoperative workup protocol for living liver donors to avoid unexpected confrontation with multiple ductal openings when harvesting the graft.
Does polyarterial clustered recurrence of cervical artery dissection seem to be the rule?
More often than previously thought, the recurrence of spontaneous cervical artery dissection (sCAD) involves multiple cervical arteries in sequence. sCAD recurrence frequently appears to cluster within the first 2 months after the index event, rather than occurring steadily over time. The prognosis of recurring sCAD appears benign, particularly in patients already receiving antithrombotic therapy.
Is axial myopia an extremely significant risk factor for young-aged pseudophakic retinal detachment in taiwan?
The results showed that axial myopia is an extremely significant risk factor for young-aged pseudophakic RD in Taiwan.
Are vDR polymorphisms associated with bone mineral density in post-menopausal Mayan-Mestizo women?
The results showed that the TT genotype of rs731236 of VDR and one haplotype formed by rs731236 and rs2228570 polymorphisms were associated with higher BMD at TH and FN.
Does intermittent high glucose promote expression of proinflammatory cytokines in monocytes?
The results indicated that exposure to fluctuating glucose concentrations enhanced activation of monocytes compared with stable elevation of glucose concentrations. The effects were partly attributable to the inherent osmotic changes.
Does intervertebral disc and macrophage interaction induce mechanical hyperalgesia and cytokine production in a herniated disc model in rats?
IVD-macrophage interaction plays a major role in sciatica and in the production of TNFα, IL-6, IL-8, and PGE(2) . TNFα is required for IL-6 and PGE(2) production, but not for IL-8 production, during IVD-macrophage interaction. Neutralization of TNFα and IL-8 can be a valuable therapy for herniated disc disease.
Does a cell-permeant peptide corresponding to the cUBP domain of USP5 reverse inflammatory and neuropathic pain?
Our findings reveal a crucial region in the cUBP domain of USP5 that is important for substrate recognition and binding to the III-IV linker of Cav3.2 channels. Targeting the interaction of this region with the Cav3.2 channel can be exploited as the basis for therapeutic intervention into inflammatory and neuropathic pain.
Is regression in left ventricular mass after aortic valve replacement for chronic aortic regurgitation unrelated to prosthetic valve size?
Left ventricular mass regression after aortic valve replacement for chronic aortic regurgitation is unrelated to indexed prosthetic valve area. Although incomplete, regression is greatest in patients with the largest preoperative indexed left ventricular mass.
Are e-selectin gene polymorphisms associated with essential hypertension : a case-control pilot study in a Chinese population?
C602A and T1559C may be independent risk factors for essential hypertension in the Chinese population, whereas T1880C is not.
Do relationship between muscle length and moment arm on EMG activity of human triceps surae muscle?
It is well recognized that changes in muscle length affect both the muscle's force generating capacity as well as its twitch speed. This relationship is well established in animal preparations. Contrary to animal experiments where length can be directly manipulated in isolated muscles, human experiments require that all muscle length changes be secondary to changes in a joint angle. Such experimental manipulations therefore produce changes in not only muscle length, but also in the muscle's MA. The relative effect of muscle length and MA changes on muscle EMG has not been determined in previous experiments.
Do carboplatin Hypersensitivity Reactions in Pediatric Low Grade Glioma Are Protocol Specific and Desensitization Shows Poor Efficacy?
Hypersensitivity reactions to carboplatin are more common in this cohort than previously reported and rates are protocol-dependent. Desensitization showed limited effectiveness in this cohort.
Do sex-specific diurnal immobility induced by forced swim test in wild type and clock gene deficient mice?
This study highlights the differences in the circadian characteristics of immobility induced by FST in WT, ClockΔ19, Per1, and Per2 deficient mice.
Does grapefruit juice greatly increase serum concentrations of lovastatin and lovastatin acid?
Grapefruit juice can greatly increase serum concentrations of lovastatin and its active metabolite, lovastatin acid, probably by preventing CYP3A4-mediated first-pass metabolism in the small intestine. The concomitant use of grapefruit juice with lovastatin and simvastatin should be avoided, or the dose of these 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors should be reduced accordingly.
Do depression and anxiety levels increase chronic musculoskeletal pain in patients with Alzheimer 's disease?
It seems that depression and anxiety are associated with chronic musculoskeletal pain intensity in dementia, thus need to be taken into consideration by health professionals for patient's management.
Do antibodies against PM/Scl-75 and PM/Scl-100 are independent markers for different subsets of systemic sclerosis patients?
Anti-PM/Scl antibodies are common in distinct SSc subsets and are associated with several clinical symptoms. They are directed mainly to the PM/Scl-75 antigen. Consequently, the detection of anti-PM/Scl antibodies by tests based only on PM/Scl-100 as an antigen source may miss a relevant number of SSc patients positive for these antibodies.
Are genetic variants in insulin-like growth factor binding protein-3 associated with prostate cancer susceptibility in Eastern Chinese Han men?
This study suggests that IGFBP-3 genetic variants are significantly associated with PCa risk in the Chinese population.
Does rosiglitazone enhance glucose uptake in glomerular podocytes using the glucose transporter GLUT1?
In conclusion, rosiglitazone has a direct and protective effect on glucose uptake in wild-type human podocytes. This represents a novel mechanism by which PPARgamma agonists may improve podocyte function in diabetic nephropathy.
Does right atrial anatomical remodeling affect early outcomes of nonvalvular atrial fibrillation after radiofrequency ablation?
RA anatomical remodeling might affect the early recurrence of AF after RFA. However, the chronicity of AF, rather than RA and LA anatomical remodeling, is a determinant of 1-year recurrence of AF after RFA.
Is metabolic syndrome associated with increased mortality or cardiovascular risk in nondiabetic patients with a new diagnosis of coronary artery disease?
In a population of consecutive patients with a new diagnosis of coronary artery disease by angiography, MetSyn without DM was not an independent predictor of mortality or cardiovascular events.
Does deletion of TRPC3 in mice reduce store-operated Ca2+ influx and the severity of acute pancreatitis?
These findings establish the native TRPC3 as an SOC in vivo and a role for TRPC3-mediated Ca(2+) influx in the pathogenesis of acute pancreatitis and suggest that TRPC3 should be considered a target for prevention of pancreatic damage in acute pancreatitis.
Does elevated serum cystatin C at continuous renal replacement therapy initiation predict lack of renal recovery?
Elevated cystatin C at CRRT initiation predicts lack of renal recovery, but its diagnostic performance is suboptimal. Our study was limited by the small sample size and the lack of strict protocols on the initiation and cessation CRRT.
Does management of glucocorticoid replacement in adrenal insufficiency show notable heterogeneity - data from the EU-AIR?
We have shown significant heterogeneity in the type, dose, frequency and timing of glucocorticoid replacement in real-world clinical practice. This reflects dose individualization based on patient symptoms and lifestyle in the absence of data supporting the optimal regimen.
Does risk factors and correlate of violence among acutely ill adult psychiatric inpatients?
Clinicians' judgment about an inpatient's potential for violence may be augmented by knowledge of the risk factors identified in this study. Medication variables could be especially useful predictors, particularly when information about other risk factors is not available. Factors other than mental illness per se may be crucial determinants of violence in acute inpatient settings.
Do novel USH2A compound heterozygous mutations cause RP/USH2 in a Chinese family?
This study identified two novel mutations: p.G1734R and IVS32+1G>A of USH2A in a four-generation Chinese RP family. In this study, the heterozygous mutation and the homozygous mutation in USH2A may cause Usher syndrome Type II or RP, respectively. These two mutations expand the mutant spectrum of USH2A.
Does the interferon stimulated gene 12 inactivate vasculoprotective functions of NR4A nuclear receptors?
These findings identify a previously unrecognized feedback loop activated by interferons that inhibits the vasculoprotective functions of NR4A nuclear receptors, providing a potential new therapeutic target for interferon-driven pathologies.
Is early allograft dysfunction associated with excess resource utilization after liver transplantation?
EAD is associated with longer hospitalization after LT. MELD score, preoperative recipient location, and postoperative complications were significantly associated with LOS. From a cost-containment perspective, these findings have implications on resource allocation.
Does c5a receptor deficiency alter energy utilization and fat storage?
These observations point towards a role (either direct or indirect) for C5aR in energy expenditure and fat storage, suggesting a dual role for C5aR in metabolism as well as in immunity.
Do dietary manipulation and social isolation alter disease progression in a murine model of coronary heart disease?
HypoE mice provide a powerful, surgery-free, diet-'titratable' small animal model that can be used to study the onset of recovery from occlusive, atherosclerotic CHD and heart failure due to MI. HypoE mice can be used for the analysis of the effects of environment (diet, social isolation) on a variety of features of cardiovascular disease.
Is aP-1 ( c-Fos/c-Jun ) required for corneal epithelial spreading?
AP-1 (c-Fos/c-Jun) is required for the corneal epithelial spreading.
Is systematic spatial bias in DNA microarray hybridization caused by probe spot position-dependent variability in lateral diffusion?
Reciprocal adjustment of the size of the microarray hybridization chamber to the area of surface-bound probes is a simple and effective measure to minimize or eliminate the diffusion-based bias, resulting in increased uniformity and accuracy of quantitative DNA microarray hybridization.
Does use of cast in the necropsy diagnosis of fetal congenital heart disease?
With increasing echocardiographic detection of congenital heart disease in early prenatal life, an increasing number of fetal heart specimens of small size are dissected for pathological confirmation. The use of silicone rubber casts to reproduce the internal anatomy proved a useful addition to dissection, providing a three dimensional model of the cardiac defect.
Do antibodies to piloerector muscle in a patient with lupus-lichen planus overlap syndrome?
This is the first case reporting autoantibodies to the piloerector muscle in a patient having mixed clinical and histopathological diagnoses of lupus/lichen planus overlapping syndrome with strong IgE immune response.
Does pathway-specific analysis of gene expression data identify the PI3K/Akt pathway as a novel therapeutic target in cervical cancer?
Activation of the PI3K/Akt pathway is associated with incomplete metabolic response in cervical cancer. Targeted inhibition of PI3K/Akt may improve response to chemoradiation.
Does fatigue in patients with inactive sarcoidosis correlate with lung ventilation ability or walking distance . Pilot Study?
Fatigue in patients with sarcoidosis does not correlate with the results of lung function tests or with walking distance in 6MWT.
Does inhibition of heat shock protein 90 decrease ACTH production and cell proliferation in AtT-20 cells?
CCT018159 inhibits ACTH production and corticotroph tumor cell proliferation in vitro and in vivo.
Is the NFATc2 gene involved in a novel cloned translocation in a Ewing sarcoma variant that couples its function in immunology to oncology?
A new translocation involving EWSRI and NFATc2 was cloned. NFATc2 is a transcription factor that is not a member of the ETS family and functions in T-cell differentiation and immune response. Direct involvement of NFATc2 has not yet been observed in oncogenesis. We show that due to the shared sequence recognition of NFATc2 and the ETS family, shared transcriptional control is possible using activating protein complex 1.
Are increased circulating Th1/Th2 ratios but not other lymphocyte subsets during controlled ovarian stimulation linked to subsequent implantation failure after transfer of in vitro fertilized embryos?
The ratios of Th1/Th2 were fluctuated during COS, and they might affect the pregnancy outcome of IVF. The circulating NK cytotoxicity and percentage of lymphocyte subsets were relatively stable during the COS.
Do circulating microparticles carry a functional endothelial nitric oxide synthase that is decreased in patients with endothelial dysfunction?
Our data further support the concept that circulating MPs may not only retain phenotypic markers but also preserve the functionality of enzymes of the cells they originate from, including eNOS.
Does a novel diketopiperazine improve functional recovery given after the onset of 6-OHDA-induced motor deficit in rats?
These studies reveal that early treatment with NNZ-2591 protects against the motor deficit induced by 6-OHDA and that treatment initiated after the establishment of motor impairment significantly improves long-term motor function. These effects of NNZ-2591 on functional recovery were independent of dopamine depletion and also appeared not to be symptomatic as the improved motor function was long-lasting. NNZ-2591 has potential as a therapeutic agent for neurodegenerative disorders.
Is epidermal growth factor-induced cyclooxygenase-2 expression mediated through phosphatidylinositol-3 kinase , not mitogen-activated protein/extracellular signal-regulated kinase kinase , in recurrent respiratory papillomas?
Overexpression of COX-2 in papillomas seems to be a consequence of enhanced EGFR-->phosphatidylinositol 3-kinase signaling. We propose a positive feedback loop for COX-2 expression, with induction of COX-2 resulting in enhanced PGE2 synthesis and further expression of COX-2 that contributes to the growth of papillomas in vivo. These data strengthen the rationale for evaluating whether nonsteroidal anti-inflammatory drugs, prototypic COX inhibitors, will be useful in the management of respiratory papillomas.
Do [ Effects of calcium hydroxide and Hoshino 's paste on the proliferation of porcine dental papilla cells ]?
Each concentration of Ca(OH)₂in the study has no effect on pDPCs proliferation, while Hoshino's paste can inhibit cell proliferation.
Does hepatocyte apoptosis after bile duct ligation in the mouse involve Fas?
During extrahepatic cholestasis, hepatocyte apoptosis is mediated by Fas. However, in the absence of the Fas receptor, additional mechanisms of hepatocyte apoptosis occur. Inhibition of multiple apoptotic pathways is necessary to attenuate chronic cholestatic liver injury.
Does occupational health care identify risk for type 2 diabetes and cardiovascular disease?
The renewed health check-up process effectively identified those employees with increased T2D and CVD risk who would benefit from lifestyle intervention. The use of FINDRISC questionnaire was a feasible first-step screening method in occupational health care setting.
Are advanced glycation end products assessed by skin autofluorescence in type 1 diabetics associated with nephropathy , but not retinopathy?
This study suggests an independent association between skin AF levels and diabetic nephropathy and neuropathy, but not retinopathy, in T1D patients. Prospective studies are needed to confirm the ability of skin AF levels to predict microangiopathy.
Is conscientiousness modified by genetic variation in catechol-O-methyltransferase to reduce symptom complaints in IBS patients?
These findings potentially broaden our understanding of the factors underlying clinical complaints to include the personality dimension of conscientiousness and its modification by COMT.
Does observational research rigour alone justify causal inference?
At least in nutrition research, associations derived from observational studies may not be reliable indicators of causal effects, even with the most rigorous study designs achievable.
Does sensitization pattern affect the asthma risk in Finnish adult population?
The large number of sensitizations to several types of allergens distinguishes subjects with asthma. Mite sensitization had little independent association with asthma in Finland.
Does optic nerve crush induce spatial and temporal gene expression patterns in retina and optic nerve of BALB/cJ mice?
A number of detrimental gene expression changes occur that contribute to trauma-induced neurodegeneration after injury to ON axons. Nrn1 (synaptic plasticity gene), Synpr and Syt1 (synaptic vesicle fusion genes), and Vsnl1 (neuron differentiation associated gene) were a few of the potentially unique genes identified that were down-regulated spatially and temporally in our rodent ONC model. Bioinformatic meta-analysis identified significant tissue-specific and time-dependent gene clusters associated with regenerative changes, synaptic plasticity, axonogenesis, neuron projection, and neuron differentiation. These ONC induced neuronal loss and regenerative failure associated clusters can be extrapolated to changes occurring in other forms of CNS trauma or in clinical neurodegenerative pathological settings. In conclusion, this study identified potential therapeutic targets to address two key mechanisms of CNS trauma and neurodegeneration: neuronal loss and regenerative failure.
Do both darbepoetin alfa and carbamylated erythropoietin prevent kidney graft dysfunction due to ischemia/reperfusion in rats?
DA and CEPO when given both to the donor and to the recipient, prevented renal graft dysfunction, tubular oxidative stress, and apoptosis after I/R injury in kidney transplantation. Their cytoprotection was mediated by tubular p-Akt activation and PTC density preservation.
Does ellagic acid prevent cognitive and hippocampal long-term potentiation deficits and brain inflammation in rat with traumatic brain injury?
Our findings suggest that EA can prevent cognitive and LTP deficits and also prevent brain inflammation following TBI.
Do glutamate and histidine improve both solvent yields and the acid tolerance response of Clostridium beijerinckii NCP 260?
Glutamate and histidine specifically enhance the ATR in Cl. beijerinckii NCP 260, and the genes encoding glutamate synthase and the NitR regulator are both upregulated, predicted to lead to increased endogenous glutamate pools during acidogenesis. This may enhance the ATR and allow more viable cells to enter solventogenesis, thereby increasing butanol titres. Glutamine, glutamate and histidine may also afford protection from butanol stress directly.
Is restless legs syndrome related to obstructive sleep apnea symptoms during pregnancy?
Increasing awareness of restless legs syndrome among obstetricians is essential as it might be related to obstructive sleep apnea syndrome, which is associated with adverse pregnancy outcomes.
Do synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location?
Given the distinctive subsynaptic localization of dysbindin-1A, -1B, and -1C across brain regions, the observed pSTG reductions in dysbindin-1A are postsynaptic and may promote dendritic spine loss with consequent disruption of auditory information processing, while the noted HF reductions in dysbindin-1B and -1C are both presynaptic and postsynaptic and could promote deficits in spatial working memory.
Does deuterium-labeled phylloquinone fed to α-tocopherol-injected rats demonstrate sensitivity of low phylloquinone-containing tissues to menaquinone-4 depletion?
We propose that α-T-dependent vitamin K depletion is likely mediated at an intermediate step in MK-4 production; thus, tissues with high PK are unaffected.
Does leptin deficiency promote central sleep apnea in patients with heart failure?
In patients with HF and CSA, leptin concentration is low and is inversely related to NP concentration. Counterregulatory interactions of leptin and NP may be important in ventilatory control in HF.
Is cENP-O , a protein localized at the centromere throughout the cell cycle , a novel target antigen in systemic sclerosis?
CENP-O protein is a novel centromere antigen that is recognized by a very minor population of ACA-positive patients with scleroderma. Because CENP-O is an ICEN component, ICEN may be a large antigenic structure in systemic autoimmunity.
Are polymorphisms in mitochondrial genes encoding complex I subunits maternal factors of voluntary alcohol consumption in the rat?
Amino acid variations in four complex I subunits encoded in the mitochondrial genome may contribute to explain the differences between UChA and UChB rats in their capacity to reoxidize NADH and in their alcohol intake, suggesting that mitochondrial genes may constitute maternal factors of alcoholism.
Does central administration of resistin promote short-term satiety in rats?
Taken together, these results provide the first evidence documenting a central action of resistin, which could be involved in a feedback loop targeting the hypothalamus. On the other hand, since we observed resistin mRNA in the arcuate and ventromedial nuclei of the hypothalamus, it is also possible that brain-derived resistin serves as a neuropeptide involved in the regulation of energy homeostasis. However, since resistin-induced satiety was modest and transient, as central administration for several days did not affect body weight, the physiological relevance and therapeutic potential of the observed principal phenomenon may be limited.
Does helicobacter pylori play a part in the dyspeptic complaints of rheumatology patients receiving long term treatment with non-steroidal anti-inflammatory drugs?
Helicobacter pylori infection does not seem to play any part in the gastric symptoms of patients treated long term with NSAIDs.
Is dietary intake of saturated fat associated with risk of coronary events or mortality in patients with established coronary artery disease?
There was no association between dietary intake of SFAs and incident coronary events or mortality in patients with established CAD.
Does direction of threat attention bias predict treatment outcome in anxious children receiving cognitive-behavioural therapy?
Findings suggest that pre-existing differences in the direction of attention towards versus away from threat could have important implications for the treatment of anxious children.
Does the receptor TGR5 protect the liver from bile acid overload during liver regeneration in mice?
TGR5 is crucial for liver protection against BA overload after PH, primarily through the control of bile hydrophobicity and cytokine secretion. In the absence of TGR5, intrahepatic stasis of abnormally hydrophobic bile and excessive inflammation, in association with impaired bile flow adaptation and deficient urinary BA efflux, lead to BA overload-induced liver injury and delayed regeneration.
Does busulfan administration flexibility increase the applicability of scid repopulating cell assay in NSG mouse model?
We showed that a period of up to 7 days did not modify engraftment efficiency of human HSCs in NSG model. Moreover, retro orbital cell injection to female mice pre-conditioned with 2x25 mg/kg of busulfan seems to be the best adapted schema to detect the human HSC in xenotransplantation experiments.
Do volumetric measurement of root resorption following molar mini-screw implant intrusion using cone beam computed tomography?
Volume measurement using CBCT was able to effectively evaluate root resorption caused by mini-screw intrusion. The highest volume loss was observed in the mesiobuccal root among the three roots of the investigated first molar teeth.
Does mucosal healing predict late outcomes after the first course of corticosteroids for newly diagnosed ulcerative colitis?
No mucosal healing after corticosteroid therapy is associated with a more aggressive disease course.
Does the novel PARP inhibitor 5-aminoisoquinolinone reduce the liver injury caused by ischemia and reperfusion in the rat?
Taken together, these results show that 5-AIQ, a new water-soluble potent inhibitor of poly-(ADP-ribose) polymerase, reduces the tissue injury associated with ischemia-reperfusion of the liver. We propose that 5-AIQ may be useful in the therapy conditions associated with ischemia-reperfusion of the liver which remains an important clinical problem during shock, liver surgery, and liver transplantation.
Does nOV/CCN3 attenuate inflammatory pain through regulation of matrix metalloproteinases-2 and -9?
This study identifies NOV as a new actor against inflammatory pain through regulation of MMPs thus uncovering NOV as an attractive candidate for therapeutic improvement in pain relief.
Does parathyroid hormone-related protein ( PTHrP ) signal cascade modulate myocardial dysfunction in the pressure overloaded heart?
PTHrP contributes to the progression of cardiac dysfunction in the pressure overloaded heart.
Does clozapine discrimination with a low training dose distinguish atypical from typical antipsychotic drugs in rats?
In contrast to previous clozapine drug discrimination studies with higher training doses, the atypical antipsychotics olanzapine, sertindole, and risperidone reliably substituted for clozapine while typical antipsychotics did not. These results suggest that low-dose clozapine drug discrimination may be a more sensitive assay for distinguishing atypical from typical antipsychotic drugs.
Does clinical risk stratification optimize value of biomarkers to predict new-onset heart failure in a community-based cohort?
Risk stratification increases the incremental value per biomarker to predict new-onset HF, especially HF with reduced ejection fraction. We suggest that routine biomarker testing should be limited to the use of natriuretic peptides and troponin-T in patients with increased cardiovascular risk.
Is `` Knife to skin '' time a poor marker of operating room utilization and efficiency in cardiac surgery?
Procedure times are a better marker of OR efficiency than knife to skin in cardiac cases. Strategies to increase OR utilization and efficiency should address procedure times in addition to knife to skin times.
Does ultrasound-guided placement of a permanent percutaneous femoral nerve stimulator lead for the treatment of intractable femoral neuropathy?
Here we described a novel non-invasive percutaneous approach for femoral nerve stimulation with ultrasound guidance which allowed precise placement of the stimulating lead very close to the femoral nerve without the need for surgical exploration.
Are plasma levels of corticotroph-type pro-opiomelanocortin derivatives such as beta-lipotropin , beta-endorphin ( 1-31 ) , or adrenocorticotropic hormone correlated with severity of postoperative pain?
We conclude that the melanotroph-type pro-opiomelanocortin system is not activated under postoperative pain; the increase of corticotroph-type pro-opiomelanocortin fragment levels is different in quantity and proportion under preoperative conditions or postoperative pain, respectively.
Do performance measures provide assessments of pain and function in people with advanced osteoarthritis of the hip or knee?
Given the limitations of self-report alone as a method of obtaining reasonably distinct assessments of pain and function, the extent to which performance-specific assessments could accomplish this goal was examined in this study. It was found that collectively the walk test, Timed "Up & Go" Test, and Six-Minute Walk Test yielded 2 factors consistent with the health concepts of pain and function. The authors believe that the application of these tests may provide clinicians and clinical researchers with more distinct impressions of pain and function that complement information from self-report measures.