Administrative GUI: Should I use Bootstrap?
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I need to make a administrative GUI with lots of functionality like lists, forms, navigation, etc.

I have looked at twitter Bootstrap and this looks really good, but it is missing some features that I must incorporate. I could integrate Jquery for Bootstrap and this helps but all the (minified) resource files together in my solution are over 250KB.

I looked at some commercial products like Wijmo which I am also considering, but I am woried that I get stuck somewhere down the line.

What is the best CSS3 + Javascript (jquery) + HTML5 framework for administrative GUIs?
Only new browsers need to be supported, not ie6 - ie8.