Year
int64
2.02k
2.03k
UI
stringlengths
7
10
UPDATED_FIELD
stringclasses
13 values
REPLACED_VALUE
stringlengths
1
912
REPLACEMENT_VALUE
stringlengths
1
910
NOTES
stringclasses
19 values
2,023
D000084602
MS
A collection of the SYMPATHETIC NERVOUS SYSTEM and the ADRENAL MEDULLA of the ADRENAL GLANDS. Intra-adrenal connection from the medulla to the cortex connects the system to other neuroendocrine systems, which in concert participate in FLIGHT REACTION in stress situations. CATECHOLAMINES are the principle hormone in the system.
A connection of the SYMPATHETIC NERVOUS SYSTEM and the ADRENAL MEDULLA of the ADRENAL GLANDS. Intra-adrenal connection from the medulla to the cortex connects the system to other neuroendocrine systems, which in concert participate in FLIGHT REACTION in stress situations. CATECHOLAMINES are the principle hormone in the system.
MeSH scope note updated on a descriptor
2,023
D000086882
MS
Papain-like proteases that occur in species of CORONAVIRIDAE. Some species have more than one papain-like protease gene.
Papain-like proteases that occur in species of CORONAVIRIDAE. Some species have more than one papain-like protease gene.
MeSH scope note updated on a descriptor
2,023
D000087443
MS
A super-family of non-enzymatic proteins found in ELAPIDAE VENOMES. They possess a unique tertiary structure resembling a hand with three fingers and have diverse biological activities due to sequence and structural variations; some are ALPHA-NEUROTOXINS that bind NICOTINIC ACETYLCHOLINE RECEPTORS.
A super-family of non-enzymatic proteins found in ELAPIDAE VENOMS. They possess a unique tertiary structure resembling a hand with three fingers and have diverse biological activities due to sequence and structural variations; some are ALPHA-NEUROTOXINS that bind NICOTINIC ACETYLCHOLINE RECEPTORS.
MeSH scope note updated on a descriptor
2,023
D000087523
MS
Reduced capacity to respond to subsequent ENDOTOXIN challenges after an initial exposure. It is characterized by reduced responsiveness of INNATE IMMUNE RESPONSES, a shift from pro- to anti-inflammatory cell phenotype and impaired ANITGEN PRESENTATION.
Reduced capacity to respond to subsequent ENDOTOXIN challenges after an initial exposure. It is characterized by reduced responsiveness of INNATE IMMUNE RESPONSES, a shift from pro- to anti-inflammatory cell phenotype and impaired ANTIGEN PRESENTATION.
MeSH scope note updated on a descriptor
2,023
D000088642
MS
Persons 90 years of age and older.
Persons between 90 and 99 years old.
MeSH scope note updated on a descriptor
2,023
D000089382
MS
Extent to which HEMOGLOBIN is saturated with OXYGEN typically as measured in arterial blood. It can be measured by various methods (e.g., PULSE OXYMETER, blood gas analysis). A low blood oxygen saturation level indicates a condition called HYPOXEMIA.
Extent to which HEMOGLOBIN is saturated with OXYGEN typically as measured in arterial blood. It can be measured by various methods (e.g., PULSE OXYMETER, blood gas analysis). A low blood oxygen saturation level indicates a condition called HYPOXEMIA.
MeSH scope note updated on a descriptor
2,023
D000089582
MS
Substances consist of different components, e.g. aluminum salts, EMULSIONS such as MF59 and AS03, Toll-like receptor (TLR) agonist or combinations of IMMUNOPOTENTIATORS (QS-21 and MPL in AS01), that helps increase the magnitude of an ADAPTIVE IMMUNE RESPONSE to a VACCINE.
Substances consisting of different components, e.g. aluminum salts, EMULSIONS such as MF59 and AS03, Toll-like receptor (TLR) agonist or combinations of IMMUNOPOTENTIATORS (QS-21 and MPL in AS01), that helps increase the magnitude of an ADAPTIVE IMMUNE RESPONSE to a VACCINE.
MeSH scope note updated on a descriptor
2,023
D000090263
MS
A protein with a three-dimensional structure that forms an alpha/beta horseshoe fold. It is found in a large number of proteins with diverse functions, including INNATE IMMUNITY RESPONSE and NERVOUS SYSTEM.
A protein with a three-dimensional structure that forms an alpha/beta horseshoe fold. It is found in a large number of proteins with diverse functions, including in INNATE IMMUNITY RESPONSE and NERVOUS SYSTEM.
MeSH scope note updated on a descriptor
2,023
D000090502
MS
An adaptive mechanism used by microbes to avoid detection by the host or adapt to changes in environment by randomly and rapidly switch on and off of a gene by various mechanisms. between on and off phases. For instance, drug tolerant MYCOBACTERIUM TUBERCULOSIS arises though rapid reversible mutations in the glpK gene through phase variation.
An adaptive mechanism used by microbes to avoid detection by the host or adapt to changes in environment by randomly and rapidly switch on and off of a gene by various mechanisms between on and off phases. For instance, drug tolerant MYCOBACTERIUM TUBERCULOSIS arises through rapid reversible mutations in the glpK gene through phase variation.
MeSH scope note updated on a descriptor
2,023
D000090982
RN
N38TVC63NU
0
Registry number updated on a descriptor
2,023
D000090983
LT
NON
TRD
Lexical type updated on a descriptor
2,023
D000090984
RN
0
JT2NS6183B
Registry number updated on a descriptor
2,023
D000091202
MH
Health Disparity, Minority and Vulnerable Populations
Health Disparate, Minority and Vulnerable Populations
Preferred Term (MH) updated on a descriptor
2,023
D000091346
MS
Lysosomal Serine proteases that release N-terminal tripeptide from a polypeptide and cleave peptides between hydrophobic residues. An enzyme that in humans encoded by the TPP1 gene. It is involved in the degradation of bone collagen. Mutations in this gene are associated with the CEROID LIPOFUSCINOSIS, NEURONAL, 2; and SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVECEROID LIPOFUSCINOSIS, NEURONAL, 2; AND SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 7.
Lysosomal Serine proteases that release N-terminal tripeptide from a polypeptide and cleave peptides between hydrophobic residues. An enzyme that in humans encoded by the TPP1 gene. It is involved in the degradation of bone collagen. Mutations in this gene are associated with the CEROID LIPOFUSCINOSIS, NEURONAL, 2; and SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE CEROID LIPOFUSCINOSIS, NEURONAL, 2; AND SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 7.
MeSH scope note updated on a descriptor
2,023
D000671
MH
Amputation
Amputation, Surgical
Preferred Term (MH) updated on a descriptor
2,023
D000784
MH
Aneurysm, Dissecting
Aortic Dissection
Preferred Term (MH) updated on a descriptor
2,023
D001213
MH
Asian Americans
Asian
Preferred Term (MH) updated on a descriptor
2,023
D001741
LT
HIST
NON
Lexical type updated on a descriptor
2,023
D001741
LT
NON
HIST
Lexical type updated on a descriptor
2,023
D001741
MH
African Americans
Black or African American
Preferred Term (MH) updated on a descriptor
2,023
D002586
MS
A member of the alkali metals. It has an atomic symbol Cs, atomic number 50, and atomic weight 132.91. Cesium has many industrial applications, including the construction of atomic clocks based on its atomic vibrational frequency.
A member of the alkali metals. It has an atomic symbol Cs, atomic number 55, and atomic weight 132.91. Cesium has many industrial applications, including the construction of atomic clocks based on its atomic vibrational frequency.
MeSH scope note updated on a descriptor
2,023
D003906
LT
NON
ABB
Lexical type updated on a descriptor
2,023
D004930
HN
2023; use ESKIMOS 1965-2003, INUITS 2004-2023
2023; use ESKIMOS 1965-2003, INUITS 2004-2022
History note updated on a descriptor
2,023
D004930
MH
Inuits
Inuit
Preferred Term (MH) updated on a descriptor
2,023
D004930
PM
2023; see ESKIMOS 1965-2003, INUITS 2004-2023
2023; see ESKIMOS 1965-2003, INUITS 2004-2022
public MeSH note updated on a descriptor
2,023
D005202
MH
Far East
Asia, Eastern
Preferred Term (MH) updated on a geographic type
2,023
D006442
MH
Glycated Hemoglobin A
Glycated Hemoglobin
Preferred Term (MH) updated on a descriptor
2,023
D006476
MH
Hantavirus
Orthohantavirus
Preferred Term (MH) updated on a descriptor
2,023
D006703
MH
Homeless Persons
Ill-Housed Persons
Preferred Term (MH) updated on a descriptor
2,023
D007780
MH
Lactobacillus casei
Lacticaseibacillus casei
Preferred Term (MH) updated on a descriptor
2,023
D007780
PM
2023; see Lactobacillus casei 1974-2022
2023; see Lacticaseibacillus casei 1974-2022
public MeSH note updated on a descriptor
2,023
D008342
MS
A hereditary disorder occurring in two forms: the complete form (Franceschetti's syndrome) is characterized by antimongoloid slant of the palpebral fissures, COLOBOMA of the lower lid, MICROGNATHIA and hypoplasia of the ZYGOMATIC ARCHES, and CONGENITAL MICROTIA. It is transmitted as an autosomal trait. The incomplete form (Treacher Collins syndrome) is characterized by the same anomalies in less pronounced degree. It occurs sporadically, but an autosomal dominant mode of transmission is suspected. (Dorland, 27th ed)
A hereditary disorder occurring in two forms: the complete form (Franceschetti's syndrome) is characterized by a slant of the palpebral fissures, COLOBOMA of the lower lid, MICROGNATHIA and hypoplasia of the ZYGOMATIC ARCHES, and CONGENITAL MICROTIA. It is transmitted as an autosomal trait. The incomplete form (Treacher Collins syndrome) is characterized by the same anomalies in less pronounced degree. It occurs sporadically, but an autosomal dominant mode of transmission is suspected. (Dorland, 27th ed)
MeSH scope note updated on a descriptor
2,023
D012900
MS
A live VACCINIA VIRUS vaccine of calf lymph or chick embryo origin, used for immunization against smallpox. It is now recommended only for laboratory workers exposed to smallpox virus. Certain countries continue to vaccinate those in the military service. Complications that result from smallpox vaccination include vaccinia, secondary bacterial infections, and encephalomyelitis. (Dorland, 28th ed)
A VACCINIA VIRUS vaccine used for immunization against SMALLPOX. It is now recommended only for laboratory workers exposed to SMALLPOX VIRUS. Certain countries continue to vaccinate those in the military service. Rare complications most often associated with older generation smallpox vaccines include VACCINIA, secondary bacterial infections, and ENCEPHALOMYELITIS. Because MONKEYPOX VIRUS and SMALLPOX VIRUS are both ORTHOPOXVIRUS and are closely related smallpox vaccines provide effective CROSS-PROTECTION against MONKEYPOX (https://www.cdc.gov/poxvirus/monkeypox/clinicians/smallpox-vaccine.html).
MeSH scope note updated on a descriptor
2,023
D017367
MH
Serotonin Uptake Inhibitors
Selective Serotonin Reuptake Inhibitors
Preferred Term (MH) updated on a descriptor
2,023
D017394
MH
RNA, Guide
RNA, Guide, Kinetoplastida
Preferred Term (MH) updated on a descriptor
2,023
D017406
MS
A form of discrimination in the workplace which violates the Civil Rights Act of 1964. Offensive sexual conduct may include unwelcome advances, comments, touching, questions about marital status and sex practices, etc. Both men and women may be aggressors or victims. (Slee and Slee, Health Care Terms, 2d ed, p.404). While civil rights legislation deals with sexual harassment in the workplace, the behavior is not restricted to this; it may take place outside the work environment: in schools and colleges, athletics, and other social milieus and activities.
A form of discrimination in the workplace which violates the Civil Rights Act of 1964. Offensive sexual conduct may include unwelcome advances, comments, touching, questions about marital status and sex practices, etc. Both men and women may be aggressors or victims. (Slee and Slee, Health Care Terms, 2d ed, p.404). While civil rights legislation deals with sexual harassment in the workplace, the behavior is not restricted to this; it may take place outside the work environment: in schools, athletics, and other social milieus and activities.
MeSH scope note updated on a descriptor
2,023
D018551
MH
Lycopersicon esculentum
Solanum lycopersicum
Preferred Term (MH) updated on a descriptor
2,023
D019066
MS
The appearance of the face that is often characteristic of a disease or pathological condition, as the elfin facies of WILLIAMS SYNDROME or the mongoloid facies of DOWN SYNDROME. (Random House Unabridged Dictionary, 2d ed)
The appearance of the face that is often characteristic of a disease or pathological condition, as the elfin facies of WILLIAMS SYNDROME or facies of DOWN SYNDROME. (Random House Unabridged Dictionary, 2d ed)
MeSH scope note updated on a descriptor
2,023
D019651
MH
Reconstructive Surgical Procedures
Plastic Surgery Procedures
Preferred Term (MH) updated on a descriptor
2,023
D020935
MS
An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
An intracellular signaling system involving the mitogen-activated protein kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
MeSH scope note updated on a descriptor
2,023
D044383
MH
Blacks
Black People
Preferred Term (MH) updated on a descriptor
2,023
D044465
MH
Whites
White People
Preferred Term (MH) updated on a descriptor
2,023
D044466
MH
Asians
Asian People
Preferred Term (MH) updated on a descriptor
2,023
D044467
MH
American Native Continental Ancestry Group
American Indian or Alaska Native
Preferred Term (MH) updated on a descriptor
2,023
D044468
PM
2022; for ABORIGINES, AUSTRALIAN see OCEANIC ANCESTRY GROUP 2006-; see ABORIGINES 1991-2003; for AUSTRALOID RACE see AUSTRALOID RACE 1978-2003, see AUSTRALIAN RACE 1963-1977, see OCEANIC ANCESTRY GROUP 2004-2021
2022
public MeSH note updated on a descriptor
2,023
D045473
MH
SARS Virus
Severe acute respiratory syndrome-related coronavirus
Preferred Term (MH) updated on a descriptor
2,023
D052196
HN
2023; was LACTOBACILLUS BREVIS 2006-2022
2023(2006)
History note updated on a descriptor
2,023
D052196
MH
Lactobacillus brevis
Levilactobacillus brevis
Preferred Term (MH) updated on a descriptor
2,023
D052197
MH
Lactobacillus fermentum
Limosilactobacillus fermentum
Preferred Term (MH) updated on a descriptor
2,023
D052200
MH
Lactobacillus reuteri
Limosilactobacillus reuteri
Preferred Term (MH) updated on a descriptor
2,023
D052200
PM
2023(2006)
2023; see LACTOBACILLUS REUTERI 2006-2022
public MeSH note updated on a descriptor
2,023
D052201
MH
Lactobacillus rhamnosus
Lacticaseibacillus rhamnosus
Preferred Term (MH) updated on a descriptor
2,023
D052201
PM
2023(2006)
2023; see LACTOBACILLUS RHAMNOSUS 2006-2022
public MeSH note updated on a descriptor
2,023
D055964
HN
2023; use AILIEN HAND SYNDROME 2010-2022
2023(2010)
History note updated on a descriptor
2,023
D055964
MH
Alien Hand Syndrome
Alien Limb Phenomenon
Preferred Term (MH) updated on a descriptor
2,023
D055964
PM
2023; see AILIEN HAND SYNDROME 2010-2022
2023; see ALIEN HAND SYNDROME 2010-2022
public MeSH note updated on a descriptor
2,023
D062065
MH
Waste Water
Wastewater
Preferred Term (MH) updated on a descriptor